Clinical trials: Diabetes Mellitus II
Type II Diabetes Mellitus
cfMSC Therapy for Diabetes
The purpose of this study is to assess the feasibility, safety and clinical efficacy of the novel clonal fetal mesenchymal stem cell (cfMSC) therapy in patients with type II diabetes mellitus.
- Trial name
- NCT07495956
- Testing
- cfMSC therapy for diabetes
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Antiphospholipid (aPL)-Positive, Rheumatic Arthritis
MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)
The primary objective of this multicenter observational registry is to characterize the clinical, epidemiological, and biological profiles of individuals of Middle Eastern, North African, and Levantine ancestry, including…
- Conditions
- Antiphospholipid (aPL)-Positive, Rheumatic Arthritis, Celiac Disease, Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- MERIT (NCT07892651)
- Where
- Jordan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Axiom Bioregistry
Type 2 Diabetes, Type II Diabetes Mellitus
The GRoceries Aimed at Increasing Nutrition Study
Only 2% of Americans meet the recommended levels of whole grain consumption, despite its association with reduced risk of type 2 diabetes.
- Conditions
- Type 2 Diabetes, Type II Diabetes Mellitus, Type II Diabetes, Pre-diabetes
- Trial name
- GRAINS (NCT07167004)
- Testing
- Marketing Nudges Only, Marketing Nudges + Dynamically Adapted Financial Incentives
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- University of Pennsylvania
Type 2 Diabetes Mellitus, Hypercholesterolemia / Elevated LDL Cholesterol
Dual vs Triple Lipid-Lowering Therapy in Type 2 Diabetes Mellitus Patients With Elevated LDL Cholesterol
This Open-label, randomized clinical trial evaluates the comparative efficacy and safety of dual versus triple lipid-lowering therapy using rosuvastatin, ezetimibe, and bempedoic acid in patients with type 2 diabetes mellitus and…
- Trial name
- NCT07255820
- Testing
- Rosuvastatin + Ezetimibe, Bempedoic Acid + Ezetimibe, Rosuvastatin + Ezetimibe + Bempedoic Acid
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Bahria University
Breast Cancer, Diabetes Type II
A Study Evaluating the Safety of Inavolisib and Fulvestrant With or Without Palbociclib in Participants With Advanced Breast Cancer (ABC) and Type 2 Diabetes
This study will evaluate the safety of inavolisib in combination with fulvestrant, with or without palbociclib, in participants with PIK3CA-mutated, HR+, HER2-negative ABC and type 2 diabetes.
- Trial name
- NCT07748208
- Testing
- Inavolisib, Fulvestrant, Palbociclib
- Where
- 10 sites in United States, Puerto Rico
- Volunteers
- 40 people
- Sponsor
- Hoffmann-La Roche
Diabetes Mellitus, Type 2, Overweight and Obesity
Dietary Strategies for Remission of Type 2 Diabetes
In this project, the investigators will perform a multicenter randomised controlled trial to determine whether advice to consume a moderate, whole food-based low-carbohydrate high-fat (LCHF) ad libitum diet (CarbCount program)…
- Conditions
- Diabetes Mellitus, Type 2, Overweight and Obesity, Hypertension, Glucose Intolerance
- Trial name
- CARBCOUNT (NCT04943926)
- Testing
- Energy restricted diet, Low carbohydrate high fat diet
- Where
- Norway
- Volunteers
- 600 people
- Sponsor
- University of Bergen
Diabetes Mellitus Type II, Hypertension
Scaling Telehealth Models to Improve Co-morbid Diabetes and Hypertension (Phase II)
The purpose of this study is to test the effectiveness and implementation process of a culturally and contextually tailored telehealth-based community health worker (CHW) led coaching intervention for hypertension control among…
- Trial name
- NCT06542939
- Testing
- Integrated CHW Intervention, CHW Session 1 Only
- Where
- 2 sites in United States
- Volunteers
- 450 people
- Sponsor
- NYU Langone Health
Type II Diabetes Mellitus
Combination of Lactulose and Polyethylene Glycol Electrolytes Powder (PEG-ELS) for Bowel Preparation in Type II Diabetes Mellitus Patients
Compared to the general population, diabetic patients have a significantly higher rate of inadequate bowel preparation. The European Society of Gastrointestinal Endoscopy (ESGE) guideline recommends polyethylene glycol (PEG) as…
- Trial name
- NCT07084350
- Testing
- lactulose, PEG (solution given 4 L)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- General Hospital of Shenyang Military Region
Endocrinology, Diabetes, Type II
Efficacy, Safety and Tolerability of AZD6234 in Participants Living With Overweight or Obesity With Type 2 Diabetes Who Are on a Stable Dose of GLP-1 Receptor Agonist
This Phase II study is a randomized, parallel group, double blinded, placebo-controlled, multicenter to evaluate the efficacy, safety, and tolerability of AZD6234 in adults with overweight or obesity and type 2 diabetes on stable…
- Conditions
- Endocrinology, Diabetes, Type II, Obesity
- Trial name
- ARAY (NCT06851858)
- Testing
- AZD6234
- Where
- 18 sites in United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Diabetic Foot Ulcer Associated With Type II Diabetes Mellitus
Effect of Stress Ball Applied During Surgical Debridement/Dressing on Pain, Distress, and Physiological Parameters in Patients With Diabetic Foot Ulcers
Diabetes mellitus (DM) is a common metabolic disease characterized by hyperglycemia, resulting from a deficiency or insufficiency of insulin.
- Trial name
- NCT07119983
- Testing
- Stress ball
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Cukurova University
Type II Diabetes Mellitus
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
This study is testing whether a new medication called CX11 works and is safe for participants with type 2 diabetes who have not reached good blood sugar control while taking a steady dose of metformin, with or without a steady…
- Trial name
- NCT07340320
- Testing
- CX11
- Where
- 48 sites in United States, Poland
- Volunteers
- 240 people
- Sponsor
- Corxel Pharmaceuticals
Chronic Kidney Disease, Type II Diabetes
Heart-Kidney-Diabetes Multidisciplinary Care MOdels for CardiovascuLar Health In Patients With Chronic Kidney DiSease and Diabetes: A PragmaTIC Cluster Randomized Controlled Trial (HOLISTIC)
Our overarching goal of this study is to provide rigorous evidence for using an accelerated risk-based approach to implementing guideline directed medical therapies (GDMT) using a multidisciplinary care model (MCM) versus a usual…
- Trial name
- HOLISTIC (NCT07811427)
- Testing
- The intervention with the MCM is Kidney-Heart GDMT initiation and titration for dose optimization (as clinically tolerated), within 4 months of enrollment in the study.
- Volunteers
- 570 people
- Sponsor
- Baim Institute for Clinical Research
Diabetic Adhesive Capsulitis, Frozen Shoulder
Pain Neuroscience Education and Graded Motor Imagery Combined With Conventional Physiotherapy on Diabetic Adhesive Capsulitis
The purpose of this study is to determine the effects of Pain Neuroscience Education (PNE) and Graded Motor Imagery (GMI) combined with conventional physiotherapy on pain, kinesiophobia, central sensitization, functional…
- Conditions
- Diabetic Adhesive Capsulitis, Frozen Shoulder, Type II Diabetes Mellitus
- Trial name
- NCT07763366
- Testing
- Pain Neuroscience Education (PNE), Graded Motor Imagery (GMI), Conventional Physiotherapy
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Type II Diabetes
Safety, Pharmacokinetics, and Food Effect of PS1 in Subjects
This is a phase I, double-blind, placebo-controlled, randomized, single- and multiple-ascending dose study to evaluate new study intervention, PS1.
- Trial name
- NCT05176210
- Testing
- PS1
- Where
- Taiwan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Pharmasaga Co. Ltd.
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Type 1 Diabetes (T1D), Type 2 Diabetes
Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery
The goal of this randomized controlled trial is to compare the efficacy and safety of the iLet Bionic Pancreas (BP) System in adults with insulin-treated diabetes (type 1 diabetes or type 2 diabetes) compared to standard of care…
- Conditions
- Type 1 Diabetes (T1D), Type 2 Diabetes, Diabetes, Autoimmune, Diabetes Mellitus
- Trial name
- PREPARE 4 AID (NCT07011147)
- Testing
- Bionic Pancreas, Routine Care
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Colorado, Denver
Type II Diabetes
Impact of the Rapid Normalization of Chronic Hyperglycemia and the Practice of Moderate Physical Activity on the "Receptor Activator of Nuclear Factor-kappa B Ligand / Osteoprotégérine (RANKL / OPG) System in Patients Living With Type II Diabetes
The rapid normalization of hyperglycemia can cause a neuropathy called Diabetes Treatment-Induced Neuropathy (NITD). This phenomenon induces the presence of hyper vascularization and inflammation in contact with the nerve ends.
- Trial name
- RANKL-GLYC (NCT04893135)
- Testing
- pratice physical activity
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Sud Francilien
Diabetes Mellitus, Type 2, Diabetes
Dietary Approaches to Stop Hypertension for Diabetes
The objective of the DASH4D trial is to determine the effects, alone and combined, of (a) the DASH4D diet (a DASH-style diet modified for people with diabetes) vs.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes, Diabetes type2, Type2 Diabetes
- Trial name
- DASH4D (NCT04286555)
- Testing
- DASH4D diet, comparison diet, higher sodium
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Johns Hopkins University