Clinical trials: Diabetes Mellitus II
Oxidative Stress, Coronary Artery Disease
Efficacy of Pioglitazone on Myocardial Function in Patients Undergoing Coronary Stent Implantation.
The purpose of this study is to determine the effects of pioglitazone, once daily (QD), on heart functioning before, during and after stent implantation.
- Conditions
- Oxidative Stress, Coronary Artery Disease, Type 2 Diabetes
- Trial name
- NCT00771004
- Testing
- Pioglitazone
- Where
- 7 sites in Germany
- Volunteers
- 63 people
- Sponsor
- Takeda
Diabetes Mellitus, Type II
The Effects of a Regenerative Mitochondrial Medication on Physiological Parameters in Case of Diabetes Mellitus Type II
A treatment with the concept of mitochondrial medication developed by Dr Heinrich Kremer can demonstrably improve and successfully treat actual parameters of Diabetes Mellitus II as well as its risk factors.
- Trial name
- NCT01197092
- Testing
- Mitochondrial preparations, Infusion therapy, Webermedical device
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Center for Integrative Medicine, Germany
Diabetes Mellitus
Efficacy and Safety Study of SYR-619 in Treating Subjects With Type 2 Diabetes Mellitus
The purpose of this study is to determine the efficacy and safety of SYR-619, once daily (QD), in subjects with type 2 diabetes mellitus who have not achieved glycemic control with diet and exercise, or by taking metformin.
- Trial name
- NCT00763347
- Testing
- SYR-619, Alogliptin
- Volunteers
- 82 people
- Sponsor
- Takeda
Diabetes Mellitus
Safety and Efficacy of YH14617 in Diabetes Mellitus
The objective of this study is to assess the safety, efficacy and pharmacokinetic of YH14617 after once weekly or biweekly injection in patients with type 2 Diabetes Mellitus to investigate the optimal recommended dosage.
- Trial name
- NCT01507038
- Testing
- YH14617
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Yuhan Corporation
T2DM With Inadequate Glycemic Control
CS02 vs Placebo With Metformin in Type 2 Diabetes Mellitus (T2DM)
The objective of the study is to compare the efficacy and safety of 3 doses CS02 Tablet in combination with a stable dose of metformin monotherapy against CS02 PTM (placebo) Tablet in combination with a stable dose of metformin…
- Trial name
- NCT03317028
- Where
- 13 sites in United States, Taiwan
- Volunteers
- 201 people
- Sponsor
- Center Laboratories, Inc.
Type II Diabetes Mellitus
SGLT2 Inhibition and Stimulation of Endogenous Glucose Production: Protocol 2
In Protocol 2, the investigators will determine the role of pancreatic hormones (increase in plasma glucagon and decrease in plasma insulin concentration) in the stimulation of EGP following SGLT2 inhibition.
- Trial name
- NCT02592421
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetes Mellitus, Type 2
To Evaluate the Efficacy and Safety of Envlo Tablet or Envlomet SR Tablet in Patients With Type II Diabetes Mellitus
This observation study is designed as a prospective, multi-organ observation study to confirm the blood sugar control effect and safety of ENVLO tablet or Envlomet SR Tablet administration for 24 weeks in patients with type 2…
- Trial name
- NCT05926414
- Testing
- Enavogliflozin
- Where
- South Korea
- Volunteers
- 15,000 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Type 2 Diabetes Mellitus
Study of AC-201 in Patients With Type 2 Diabetes Mellitus
This is a 24-week randomized placebo-controlled study to investigate the effect of an oral IL-1beta inhibitor AC-201 in patients with type 2 diabetes mellitus already treated on different background diabetes therapies.
- Trial name
- NCT01276106
- Testing
- AC-201, 25mg, AC-201, 50mg, AC-201, 75mg
- Where
- 21 sites in United States, Taiwan
- Volunteers
- 259 people
- Sponsor
- TWi Biotechnology, Inc.
Muscle Protein Synthesis
Impact of Nitrate Ingestion on Protein Synthesis
A diet rich in leafy green vegetables has been shown to reduce the risk of developing chronic metabolic disease. The health benefits from these particular vegetables may be attributed to their high nitrate content.
- Trial name
- PRO-Nitrate (NCT01473576)
- Testing
- Nitrate, Sodium chloride
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Inhaled Technosphere Insulin in Subjects With Diabetes Mellitus and Asthma
The clinical trial is designed to evaluate the safety of inhaled Technosphere/Insulin compared with non-inhaled anti-diabetic therapies in subjects with type 1 or type 2 diabetes mellitus and concurrent asthma.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Asthma
- Trial name
- NCT00332826
- Testing
- Technosphere Insulin
- Where
- 78 sites in United States, Argentina and 9 more
- Volunteers
- 3 people
- Sponsor
- Mannkind Corporation
Type 2 Diabetes Mellitus
Exposure to Type II Diabetes for Two Siblings With the Same Parents
Individuals with a family history of type 2 diabetes mellitus (T2DM) are known to be at greater risk for the disease, and studies have shown that how the body responds to insulin, how the muscle creates energy, and the amount of…
- Trial name
- T2DM (NCT01275235)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Type II Diabetes Mellitus
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
This study is testing whether a new medication called CX11 works and is safe for participants with type 2 diabetes who have not reached good blood sugar control while taking a steady dose of metformin, with or without a steady…
- Trial name
- NCT07340320
- Testing
- CX11
- Where
- 48 sites in United States, Poland
- Volunteers
- 240 people
- Sponsor
- Corxel Pharmaceuticals
Type 1 Diabetes Mellitus
Safety and Efficacy Study of Autologous Stem Cell Transplantation for Early Onset Type I Diabetes Mellitus
The study evaluates the effect of inactivation of the immune system with chemotherapy and immunotherapy and infusion of bone marrow stem cells in early onset type 1 diabetes mellitus.
- Trial name
- NCT00315133
- Testing
- Immunosuppression and autologous stem cell transplantation
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- University of Sao Paulo
Vascular Function, Exercise Training
Evaluation of Effects of Exercise Training and ARB in DM Patients
The aims of this clinical trial are to assess the impacts on vascular function tests and circulating biomarkers of a short-term (12-week) low-to-median intensity exercise training or ARBs treatment in patients with DM and…
- Trial name
- NCT01053026
- Testing
- olmesartan
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Taiwan University Hospital
Diabetic Macular Edema
Efficacy & Safety Trial of Intravitreal Injections Combined With PRP for CSME Secondary to Diabetes Mellitus (DAVE)
This study is a Phase I/II, multicenter, randomized, study of the efficacy and safety of ranibizumab injection monotherapy verses a duel therapy of 0.3mg ranibizumab combined with ultra wide, 200° field angiography guided pan…
- Trial name
- DAVE (NCT01552408)
- Testing
- 0.3 mg ranibizumab, Targeted Pan Retinal Photocoagulation
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- David M. Brown, M.D.
Primary Hyperparathyroidism, Type 2 Diabetes
Glycemic Control, Type II Diabetes, Parathyroidectomy
The purpose of this study is to assess glycemic control after parathyroidectomy in patients with primary hyperparathyroidism and concomitant type 2 diabetes mellitus.
- Trial name
- NCT05761743
- Testing
- Urine and Blood Test
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic
Type II Diabetes, Periodontal Disease
Providing Preventive Periodontal Treatment to Hospitalized Patients With Diabetes
The purpose of this research intervention is to assess the oral health status and periodontal health of patients with diabetes hospitalized on a general medicine service, and to assess the effect of providing dental prophylaxis…
- Trial name
- NCT02914743
- Testing
- Motivational Interviewing, Dental cleaning
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus Type 2
Periodontal Treatment and Glycemic Control
The purpose of this study is to determine the effects of non surgical periodontal treatment on glycemic control in type II diabetics.
- Trial name
- NCT01901926
- Testing
- Non Surgical Periodontal Treatment
- Where
- Pakistan
- Volunteers
- 184 people
- Sponsor
- Pakistan Institute of Medical Sciences
Diabetes Mellitus, Type II
Evaluate HM-002-1005 in Subjects With Type 2 Diabetes Mellitus
The purposes of this study are to: Evaluate the safety and tolerability of the study drug. Measure how much of the study drug (HM-002-1005) and its breakdown product get into the bloodstream, and how long it takes the body to get…
- Trial name
- NCT06498284
- Testing
- HM-002-1005
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Hua Medicine Limited
Dyslipidemia Associated With Type II Diabetes Mellitus
Effectiveness of Nutritional Program Among Diabetic Patients
Dyslipidemia is very common in type 2 diabetes mellitus affecting around 72%-85% of diabetic patients.The exact mechanism of lipoprotein abnormalities in diabetes is not very well understood.
- Trial name
- NCT05128747
- Testing
- DASH diet
- Volunteers
- 190 people
- Sponsor
- Assiut University