Clinical trials: Diabetes Mellitus Patients With Kidney Transplantation
Type 1 Diabetes, Organ Transplantation
Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation
This single center phase 2 clinical trial, is designed for confirming the efficacy and safety of sequential islet allotransplantation with steroid free immunosuppression in patients with previous kidney transplantation.
- Conditions
- Type 1 Diabetes, Organ Transplantation, Immunosuppression
- Trial name
- NCT01123187
- Testing
- islet transplantation
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Lille
New Onset Diabetes Mellitus After Renal Transplantation
Improving Secretion of Insulin in New Onset Diabetes After Renal Transplantation
New onset diabetes after transplantation (NODAT) is a frequent and feared complication after kidney transplantation and leads to an increase in cardiovascular complications as well as in the rate of graft loss.
- Trial name
- ISINODAT (NCT01268995)
- Testing
- Cyclosporine A, Tacrolimus
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Medical University of Vienna
Diabetes Mellitus Patients With Kidney Transplantation
Hybrid Closed-Loop in Diabetes Post-Kidney Transplant: A Randomized Trial
Objective: To evaluate the short-term blood glucose control effect of the closed-loop system combined with a regular insulin pump and continuous glucose monitoring (CGM) in hospitalized patients with diabetes after kidney…
- Trial name
- NCT06962410
- Testing
- Hybrid Closed-Loop Artificial Pancreas System
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanxi Bethune Hospital
Post-transplant Diabetes Mellitus
SGLT2i in Diabetic Patients with Renal Transplantation
Post-transplant diabetes mellitus (PTDM), previously known as New Onset Diabetes After Transplantation defined as the diagnosis of diabetes mellitus (DM) in a previously non-diagnosed diabetic person after transplantation.
- Trial name
- NCT06731231
- Testing
- SGLT2 inhibitor
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Ain Shams University
Type 1 Diabetes Mellitus, End-stage Renal Disease
Simultaneous Islet-Kidney Transplantation in Patients of Type 1 Diabetes With End-stage Renal Disease
The aim of this study was to evaluate the efficiency and safety of simultaneous islet-kidney transplantation in patients of type 1 diabetes with end-stage renal disease using a glucocorticoid-free immunosuppressive regimen with…
- Trial name
- NCT00692562
- Testing
- simultaneous islet-kidney transplantation
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Fuzhou General Hospital
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Diabetes, Immunosuppression
Evaluate Tolerability of Myfortic®/Simulect® and Tacrolimus Without Steroids in Three Patient Populations
This study is designed to evaluate the tolerability of Myfortic®/Simulect® combination in diabetic patients in a steroid free regimen.
- Trial name
- NCT01387659
- Testing
- Gastric emptying test
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Diabetes Mellitus
Post-operative Complications and Graft Survival With Conventional Versus Continuous Glucose Monitoring in Patients With Diabetes Mellitus Undergoing Renal Transplantation
This will be a prospective, randomized, single-blinded controlled trial in which the investigators evaluate post-operative serum glucose control using conventional point-of-care glucose monitoring in the morning and before meals…
- Trial name
- NCT04742023
- Testing
- Continuous Glucose Monitor Application, Finger Stick Glucose Measurement, Insulin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwell Health
Type 1 Diabetes, Insulin-requiring Type 2 Diabetes Mellitus
Use of Closed Loop Insulin Delivery for Glucose Control in Patients With Insulin Dependent Diabetes Mellitus After Kidney Transplantation
This study will be a prospective, single center, randomized controlled parallel group open-label trial. Participants with insulin requiring diabetes mellitus who have been offered an organ for living or deceased donor kidney…
- Conditions
- Type 1 Diabetes, Insulin-requiring Type 2 Diabetes Mellitus, End Stage Renal Disease (ESRD)
- Trial name
- NCT04189510
- Testing
- Artificial Pancreas, Multiple Daily Injections
- Sponsor
- University of Virginia
Chronic Kidney Diseases, Kidney Transplant
Safety and Tolerability of Vertebral Bone Marrow-derived Mesenchymal Stem Cells (BM-MSC) in Real World Scenarios of Patients With Chronic Kidney Disease (CKD)
The purpose of this protocol is to treat an intermediate-sized population with chronic kidney disease (CKD) including kidney transplant recipients. The protocol uses allogeneic bone marrow-derived mesenchymal stem cells (MSCs).
- Trial name
- NCT06752577
- Testing
- Allogeneic, vertebral bone marrow-derived mesenchymal stem cells (MSC)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes
Pancreas Allotransplantation for Diabetic Nephropathy and Mild Chronic REnal fAilure Stage Study
Current medical therapies are not able to prevent progression of established macroproteinuira (i.e. diabetic nephropathy) to end-stage renal failure in type 1 (insulin dependent) diabetic patients.
- Trial name
- PANCREAS (NCT01067950)
- Testing
- Isolated Pancreas Transplant, Intensive Insulin Therapy
- Where
- 7 sites in United States, Brazil and 3 more
- Volunteers
- 180 people
- Sponsor
- Nantes University Hospital
CKD, Diabetic Kidney Disease
Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy
This randomized study evaluates the effect of subcutaneous semaglutide /in combination with lifestyle counseling in patients with type 2 diabetes mellitus (T2DM), overweight/obesity, and stage 4-5 chronic kidney disease (CKD) or…
- Conditions
- CKD, Diabetic Kidney Disease, Type 2 Diabetes Mellitus in Obese, Obesity
- Trial name
- RAISE-KT (NCT04741074)
- Testing
- Semaglutide 2 mg/1.5 ml (1.34 mg/ml), prefilled pen-injector for subcutaneous injection solution
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Geisinger Clinic
Diabetes Mellitus, Type 1, Diabetic Nephropathy
European Trial of Immunosuppression in SPK Tx
1. To determine and compare the efficacy of Tacrolimus/Rapa versus Tacrolimus/MMF-based immunosuppression (in conjunction with initial short-term steroids and polyclonal antibody administration) in Type 1-diabetic patients…
- Trial name
- NCT00140543
- Testing
- sirolimus versus mycophenolate mofetil
- Where
- 14 sites in Austria, Belgium and 5 more
- Volunteers
- 228 people
- Sponsor
- EUROSPK Study Group
Type 1 Diabetes Mellitus
Transplantation of Pancreatic Islets in Patients With Type 1 Diabetes Mellitus and Functional Kidney Graft
This research project is supported by a multicentric network of collaborators whose goal is to assess the efficacy of transplanting allogenic pancreas islets to restore insulin secretion in patients with type 1, insulin-dependent…
- Trial name
- GRAGIL1 (NCT00639600)
- Testing
- human pancreatic islet transplantation
- Where
- 7 sites in France, Switzerland
- Volunteers
- 21 people
- Sponsor
- University Hospital, Grenoble
Type 1 Diabetes Mellitus
Islet After Kidney Transplant for Type 1 Diabetes
The purpose of this study is to determine if prolonged administration of the anti TNF (tumor necrosis factor)-Alpha agent etanercept is associated with enhanced graft survival in patients undergoing islet after kidney…
- Trial name
- NCT00784966
- Testing
- etanercept
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Diabetes Mellitus, Type 1
Islet Transplantation for Patients With Type 1 Diabetes
This protocol will test whether Type 1 diabetes (T1DM) can be reversed in patients with stable renal allografts by islet transplantation.
- Trial name
- NCT00073281
- Testing
- Islet transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 1
Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation
The purpose of this study is to reverse hyperglycemia and insulin dependency, by islet cell transplantation, in patients with type 1 diabetes mellitus who have a stable kidney allograft.
- Trial name
- NCT00315588
- Testing
- Islet Transplantation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Rodolfo Alejandro
Post-transplant Diabetes Mellitus, New Onset Diabetes After Transplant
The POWERED Study: Prophylaxis With Metformin to Prevent PTDM
PrOphylaxis With mEtformin to pREvent PTDM: a single site, placebo controlled, double blind randomised clinical trial evaluating the effectiveness of metformin to prevent post-transplant diabetes in a cohort of patients…
- Conditions
- Post-transplant Diabetes Mellitus, New Onset Diabetes After Transplant, New Onset Diabetes After Transplantation, Kidney Transplant; Complications
- Trial name
- POWERED (NCT05240274)
- Testing
- Metformin
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Barts & The London NHS Trust
Non-Alcoholic Fatty Liver Disease, Chronic Kidney Diseases
NAFLD Among Patients With Chronic Kidney Disease and the Effect of Kidney Transplantation
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries affecting approximately 30 % of the general adult population.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Chronic Kidney Diseases, PreDiabetes, Kidney Transplant
- Trial name
- NCT03866421
- Testing
- MR spectroscopy of the liver, Fibroscan of the liver, Continuous glucose monitoring (CGM) for four days.
- Where
- Denmark
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Kidney Transplant
Evaluation of Cyclosporine Microemulsion and Tacrolimus on the Rate of New Onset Diabetes Mellitus in Kidney Transplantation Recipients
The purpose of this study is to evaluate the impact of tacrolimus and cyclosporine microemulsion on glucose metabolism in kidney transplant recipients and the efficacy and safety in preventing organ rejection
- Trial name
- NCT00171496
- Testing
- Cyclosporine microemulsion, Tacrolimus
- Volunteers
- 693 people
- Sponsor
- Novartis