Clinical trials: Diabetes Mellitus Progression
Diabetes Mellitus, Type 2
An Observational Study to Understand Challenges Associated With Progression of Insulin Therapy in Type 2 Diabetes
The purpose of this study is to identify specific patient, physician, and health system related factors associated with the progression to a more intensive regimen from initial insulin therapy for patients with type 2 diabetes.
- Trial name
- MOSAIc (NCT01400971)
- Where
- 153 sites in United States, Argentina and 17 more
- Volunteers
- 4,299 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes
Progression and Etiology of Cortical Porosity in Diabetic Bone Disease
Type 2 diabetes is associated with increased cortical bone porosity and increased fracture risk. The goal of this proposed study is to understand the longitudinal evolution of cortical bone porosity and to investigate the…
- Trial name
- PREPT2D (NCT04208230)
- Testing
- XtremeCT
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity, Visceral, Chronic Kidney Diseases
The Association of Visceral Adiposity Index With Progression of Chronic Kidney Disease
The visceral adiposity index (VAI) has been developed, an indicator for the metabolic function of VAT. Previous studies have confirmed the association between the VAI and CKD prevalence.
- Conditions
- Obesity, Visceral, Chronic Kidney Diseases, Diabetes Mellitus
- Trial name
- NCT04592107
- Testing
- eGFR
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Uşak University
Diabetes Mellitus, Type 1, Diabetes Mellitus
Diamyd Administered Into Lymph Nodes in Combination With Vitamin D in Type 1 Diabetes
The objective of DIAGNODE-2 is to evaluate the efficacy of Diamyd compared to Placebo, upon administration directly into a lymph node in combination with an oral vitamin D/Placebo regimen, in terms of preserving endogenous…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Autoimmune Diseases, Metabolic Disease
- Trial name
- NCT03345004
- Testing
- Diamyd, Vitamin D
- Where
- 18 sites in Czechia, Netherlands and 2 more
- Volunteers
- 109 people
- Sponsor
- Diamyd Medical AB
Diabetic Retinopathy
Prediction of Progression of Retinal Ischemia in Diabetes
Diabetes Mellitus (DM) is a major public health problem with significant socioeconomic implications due to its increased prevalence.
- Trial name
- PREDICTION (NCT05581225)
- Where
- Portugal
- Volunteers
- 62 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetes
RetroMASTER - Retrospective Cohort MRC ABPI STratification and Extreme Response Mechanism in Diabetes
This study will examine extreme responders to second- and third-line Type 2 Diabetes (T2D) therapy using a retrospective approach and patients with slow or fast diabetes progression.
- Trial name
- RetroMASTER (NCT02109978)
- Where
- 3 sites in United Kingdom
- Volunteers
- 562 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Coronary Artery Disease, Atherosclerosis
Coronary Artery Disease Progression in Patients With Prediabetes
Prediabetes is a disorder of glucose metabolism that reflects the natural history of progression from normoglycaemia to type 2 diabetes mellitus.
- Conditions
- Coronary Artery Disease, Atherosclerosis, Prediabetic State
- Trial name
- NCT02744976
- Testing
- Metformin, Lifestyle recommendations
- Where
- Latvia
- Volunteers
- 70 people
- Sponsor
- Pauls Stradins Clinical University Hospital
CKD Progression
Hyperuricemia as Early Indication of CKD Progressing in Prediabetic
Chronic kidney disease (CKD) is a major global health problem, and hyperuricemia has emerged as both a consequence and a potential driver of its progression.
- Trial name
- NCT07199205
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Type 1 Diabetes
T1D Risk Assessment in Kids With Relatives
The purpose of this study is to determine whether early immunological markers (activation of autoreactive T lymphocytes) precede and are predictive of the appearance of autoantibodies in children born from type 1 diabetic parents.
- Trial name
- TRAKR (NCT02184676)
- Testing
- Analysis of early immune modifications, Collection of clinical and socio-demographic data
- Where
- France
- Volunteers
- 512 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes, Coronary Artery Bypass Grafting
Vein-Coronary Atherosclerosis And Rosiglitazone After Bypass Surgery: The VICTORY Trial
HYPOTHESES Rosiglitazone in diabetic patients with previous coronary bypass surgery may prevent or slow the progression of atherosclerosis in SVGs and native coronary arteries.
- Trial name
- VICTORY (NCT00169832)
- Where
- 9 sites in Canada, Spain
- Volunteers
- 193 people
- Sponsor
- Laval University
Type 1 Diabetes Mellitus
A Phase III Study to Investigate the Impact of Diamyd in Patients Newly Diagnosed With Type 1 Diabetes (EU)
The purpose of this study is to determine whether Diamyd (rhGAD65 formulated in alum) is effective in preserving the body's own insulin producing capacity in patients recently diagnosed with type 1 diabetes.
- Trial name
- NCT00723411
- Testing
- rhGAD65
- Where
- 70 sites in Finland, France and 7 more
- Volunteers
- 334 people
- Sponsor
- Diamyd Therapeutics AB
Diabetes
PROMASTER - PROspective Cohort MRC ABPI STratification and Extreme Response Mechanism in Diabetes
This study will examine extreme responders to second- and third-line Type 2 diabetes therapy using a prospective approach, and patients with slow or fast diabetes progression using a retrospective approach.
- Trial name
- PROMASTER (NCT02105792)
- Testing
- second- or third-line glucose-lowering diabetes treatment
- Where
- 5 sites in United Kingdom
- Volunteers
- 820 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Coronary Arteriosclerosis, Endothelial Dysfunction
Effect of Aged Garlic Extract (AGE) on Improving Coronary Atherosclerosis in People With Type 2 Diabetes Mellitus
The purpose of this research study is to see the effect of taking Aged Garlic Extract (AGE) on the progression of coronary plaque, a condition called atherosclerosis, in people diagnosed with Diabetes.
- Conditions
- Coronary Arteriosclerosis, Endothelial Dysfunction, Type 2 Diabetes Mellitus
- Trial name
- NCT03931434
- Testing
- Aged Garlic Extract (AGE)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), CKD Stage 3
Plant-Focused Nutrition in Patients With Diabetes and Chronic Kidney Disease
In this pilot clinical trial, the investigators will recruit and randomize 120 patients with diabetes mellitus and chronic kidney disease (CKD/DM) stages 3 to 5 to a patient-centered and flexible Plant-Focused Nutrition in…
- Conditions
- Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), CKD Stage 3, CKD Stage 4, CKD Stage 5
- Trial name
- PLAFOND (NCT05514184)
- Testing
- PLAFOND diet
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine
Diabetic Kidney Disease (DKD)
Mechanisms Underlying SGLT2i Kidney Effect in DKD Progression
This is a multicentre and multi-national non-pharmacological, uncontrolled interventional study conducted in a clinical practice setting in DKD patients with CKD stages 1 to 3 with moderate or severe risk of renal function…
- Trial name
- PERSONALISEDKD (NCT07270198)
- Testing
- MRI
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
type1diabetes
Sexual Dimorphism in Cardiovascular Autonomic Neuropathy in Patients With Type 1 Diabetes
Sex might interact with cardioautonomic neuropathy (CAN) in the development of macrovascular disease in patients with type 1 diabetes (T1D).
- Trial name
- NCT04950634
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Diabetes Mellitus, Type 1
Insulin-Glucose-Glucagon Network: Defining a Type 1 Diabetes Progression Index
The type 1 Diabetes (T1D) TrialNet Pathway To Prevention (PTP) Study assesses and recruits at-risk subjects into clinical trials aimed at preventing the development of full blown T1D.
- Trial name
- NCT02663661
- Testing
- Metabolic Challenge Admission, CGM home test
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type 1 Diabetes
Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes
The purpose of this study is to find out if very tight blood glucose control from the onset of Type 1 Diabetes can preserve beta cell function.
- Trial name
- NCT00891995
- Testing
- Closed loop, Home glucose monitoring, Insulin pump
- Where
- 5 sites in United States
- Volunteers
- 71 people
- Sponsor
- Jaeb Center for Health Research
Type 2 Diabetes Mellitus, Mild Nonproliferative Diabetic Retinopathy
Biomarkers of Diabetic Retinopathy Progression
The purpose of this study is to validate a predictive model of diabetic retinopathy progression in patients with diabetes mellitus type 2 patients to clinically significant macular edema (CSME) needing treatment either…
- Trial name
- C-Tracer (NCT01607190)
- Where
- 2 sites in India, Portugal
- Volunteers
- 200 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetes Mellitus, Type 1
Assessing Effectiveness of a Diabetes Navigator in Increasing Progression of Advanced Diabetes Technologies
The goal of this randomized control trial is to determine if the support of a Diabetes Navigator is more effective than standard care in improving uptake and use of advanced diabetes technology among patients with type 1 diabetes.
- Trial name
- IMPACT-T1D (NCT06229236)
- Testing
- Diabetes Navigator
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Johns Hopkins University