Clinical trials: Diabetes Mellitus Risk
Diabetes
Pioglitazone and Serum Asymmetric Dimethylarginine (ADMA) in Patients With Diabetes
SPECIFIC AIMS 1. To determine whether pioglitazone will reduce levels of asymmetric dimethylarginine(ADMA) in patients with diabetes. 2. To determine whether nitric oxide(NOx) products are increased with pioglitazone treatment.
- Trial name
- NCT00770367
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Medical University of South Carolina
Type 2 Diabetes, Coronary Heart Disease
NMR Metabolomics-Based Risk Assessment and Stratified Digital Health Interventions in Middle-Aged Adults (PREMAP)
PREMAP invites residents of the Eloisa region (South Savo, Finland) turning 45, 50, or 55 years of age in 2026 to undergo a blood-based NMR metabolomics risk assessment for five interlinked cardio-renal-metabolic conditions (type…
- Conditions
- Type 2 Diabetes, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Disease
- Trial name
- PREMAP (NCT07820800)
- Testing
- Digital health interventions
- Where
- Finland
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Diabetes Mellitus, Type 2
Effect of Repaglinide Versus Metformin Treatment in Non-Obese Patients With Type-2-Diabetes
Aim: The United Kingdom Prospective Diabetes Study (UKPDS) showed a reduction in cardiovascular events in obese patients with type-2-diabetes treated with metformin compared with other hypoglycaemic treatments with no difference…
- Trial name
- NCT00118963
- Testing
- Metformin, Insulin BIAsp30 (Novolog 70/30), Repaglinide
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Steno Diabetes Center Copenhagen
Hypertension, Diabetes Mellitus, Type 2
Effectiveness of a Case Management Model for Patients With Hypertension and Type II Diabetes in Chile
The purpose of this study is to evaluate whether a new model of health care for chronic patients, based on Case Management and guided by a nurse which targets the patient´s risk, is more effective than usual care at Primary…
- Trial name
- NCT02762695
- Testing
- Case Management, Usual Care
- Where
- Chile
- Volunteers
- 616 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Type 2 Diabetes
Cohort Study in Type 2 Diabetes in China
This study is designed to assess the incidence of cardiovascular events occurred within an 12 month follow up period in type 2 diabetic patients with either high risk of cardiovascular disease (CVD) or history of coronary artery…
- Trial name
- CCDC (NCT01076023)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- China Cardiometabolic Registries
Type 2 Diabetes
Improving Risk Factors for Diabetes Complications in Primary Care
The purpose of this study is to test an intervention in primary care clinics to improve three risk factors for diabetes complications: glucose control, blood pressure and cholesterol.
- Trial name
- NCT00482768
- Testing
- Practice Facilitation
- Where
- United States
- Volunteers
- 2,493 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Prediabetes, Obesity
Diabetes Prevention Program in Adults of the Yaqui Tribe of Hermosillo, Sonora at Risk of Diabetes
Diabetes is a major non communicable chronic diseases in the world. It occupies the fourth or fifth leading cause of death in most high-income countries and there is strong evidence that has epidemic proportions in many…
- Conditions
- Prediabetes, Obesity, Overweight
- Trial name
- NCT02899390
- Testing
- Lifestyle Intervention
- Where
- 3 sites in Mexico
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Centro de Investigación en Alimentación y Desarrollo A.C.
Prediabetes
We Can Prevent Diabetes: A Behavioral Intervention to Reduce Diabetes Risk in African Americans
Pre-diabetes, characterized by glucose levels that are above normal but below the diagnostic criteria for diabetes, is an increasingly common condition, particularly among African Americans.
- Trial name
- NCT01227473
- Testing
- Mindfulness-based diabetes prevention education group, Conventional diabetes prevention education group
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of North Carolina, Chapel Hill
Sedentary Lifestyle
The Health Action Process Approach and Movement Patterns in Adult Office Workers
Societal changes have resulted in reduced demands to be active and increased daily time spent sitting. Excessive sitting has been shown to be a health hazard.
- Trial name
- NCT03091686
- Testing
- HAPA SB Intervention Slideshow, HAPA MVPA Attention-Control Slideshow
- Where
- Canada
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Sub-optimal Vitamin D Status, Pre-diabetes
Effect of Vitamin D3 Supplementation on Insulin Resistance- The DIR Study
Insulin resistance is a state where the body does not respond as it should to the insulin it produces. Individuals who are insulin resistant are at increased risk of both heart disease and type 2 diabetes; importantly, diabetes…
- Conditions
- Sub-optimal Vitamin D Status, Pre-diabetes, Insulin Resistance
- Trial name
- NCT01889810
- Testing
- Vitamin D3 supplementation
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Type 2 Diabetes
Glucose Response, Excursions And Treatment (GREAT) Study
Patients with type 2 diabetes have very variable endogenous insulin secretion. While some patients have relatively preserved endogenous insulin with marked insulin resistance others may develop the very severe insulin deficiency…
- Trial name
- GREAT (NCT02506296)
- Testing
- DPPIV inhibitor -, Continuous glucose monitoring system.
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Diabetes, Prediabetes
Meta-analyses of Pasta as Part of Low Glycemic Index Diets and Adiposity
Pasta is an important example of a food which can lower the glycemic index (GI) of the diet, a property that has been exploited extensively in studies of low GI dietary patterns.
- Conditions
- Diabetes, Prediabetes, Overweight, Obesity
- Trial name
- NCT02961088
- Testing
- Pasta as part of a low GI/GL diet
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cardiovascular Diseases, Heart Diseases
Reducing Total Cardiovascular Risk in an Urban Community
PLEASE NOTE: THIS STUDY IS ONLY ENROLLING PATIENTS CURRENTLY BEING TREATED AT BELAIR-EDISON FAMILY HEALTH CENTER. The purpose of this study is to compare the clinical effectiveness and cost effectiveness of two cardiovascular…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Diabetes Mellitus
- Trial name
- COACH (NCT00241904)
- Testing
- Lifestyle Changes, Antiplatelet Agents, Beta Blocker
- Where
- United States
- Volunteers
- 525 people
- Sponsor
- Johns Hopkins University
Type 1 Diabetes, Pregnancy, High Risk
Intravenous Insulin vs Subcutaneous Insulin Infusion in Intrapartum Management of Type 1 Diabetes Mellitus
The purpose of this study is to perform a randomized trial to investigate if intrapartum insulin delivery mechanisms reduces adverse outcomes associated with type 1 diabetes in pregnancy.
- Trial name
- NCT04599075
- Testing
- Insulin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Gianna Wilkie
Type 1 Diabetes, Celiac Disease
General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery
In partnership with Helmsley Charitable Trust, the Sanford PLEDGE Study is a large-scale, observational, feasibility study of general population screening for T1D and celiac autoantibodies.
- Trial name
- PLEDGE (NCT04477928)
- Testing
- Sera and whole blood sampling, Differential Gene Expression (DGE)
- Where
- 4 sites in United States
- Volunteers
- 33,000 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Coronary Artery Disease, Stroke
The SMART-ORACLE Study
After having had a first cardiovascular event, there is a considerable risk of developing a subsequent event. Only recently, a risk prediction model was developed for this group of patients.
- Conditions
- Coronary Artery Disease, Stroke, Peripheral Arterial Disease, Hypertension
- Trial name
- SMART-ORACLE (NCT01932671)
- Where
- Netherlands
- Volunteers
- 1,500 people
- Sponsor
- UMC Utrecht
Gestational Diabetes
High Dose Cholecalciferol to Reduce the Incidence of Gestational Diabetes in High Risk Pregnant Women
Demonstrate dose-dependent relationship between vitamin D supplementation and rates of gestational diabetes.
- Trial name
- NCT03037593
- Testing
- 4000 IU vitamin D3
- Where
- United States
- Sponsor
- University of Minnesota
Cardiovascular Diseases, Cardiovascular Risk Factor
Digital Nudges to Improve Heart Health Actions After Community Screening in Malaysia (NADI-MyHeartRisk)
This is a pragmatic, risk-stratified, individually randomized controlled trial testing whether personalised WhatsApp-based digital behavioural nudges can improve completion of cardiovascular preventive actions after community…
- Trial name
- NADI-MHR (NCT07879144)
- Testing
- Personalised Digital Behavioural Nudges (NADI-MyHeartRisk Enhanced Pathway)
- Where
- 2 sites in Malaysia
- Volunteers
- 6,588 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Advancement and Research Excellence Institute
Gestational Diabetes Mellitus in Pregnancy, Diet- Controlled, Exercise Addiction
Modulation of the Intestinal Flora With the Probiotic VIVOMIXX™ in Pregnant Women at Risk of Metabolic Complications
The investigators aimed at evaluating the effectiveness of probiotics ingestion in changing maternal microbiota and preventing gestational diabetes in overweight and obese women.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Diet- Controlled, Exercise Addiction, High-Risk Pregnancy, Dietary Modification
- Trial name
- NCT02768818
- Testing
- Probiotic VIVOMIXX™
- Where
- Italy
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Type 2 Diabetes
Randomized Trial of Peer Led Education-Project Dulce
The purpose of this study is to evaluate the effect of a culturally sensitive diabetes self-management program on glucose control and metabolic parameters in low income Mexican-Americans with type 2 diabetes using the Project…
- Trial name
- NCT01238289
- Testing
- Peer Education, Control
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- Scripps Whittier Diabetes Institute
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