Clinical trials: Diabetes Mellitus Risk
Pregnancy, High Risk, Type 1 Diabetes
Permissive Versus Strict Intrapartum Glucose Management in Type 1 Diabetes (PRISM-T1D)
PRISM-TID is a single center non-inferiority randomized controlled trial of permissive intrapartum glucose management (intervention) versus strict intrapartum glucose management (standard of care) among pregnant individuals with…
- Trial name
- PRISM-T1D (NCT07293715)
- Testing
- Insulin, DEXCOM Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Ohio State University
Cardiovascular Diseases, Coronary Disease
20 Year Changes in Fitness & Cardiovascular Disease Risk - Ancillary to CARDIA
To understand the complex, longitudinal relations between physical fitness, physical activity, body mass and composition and fat distribution, and genetic factors and their independent or interactive effects on the development of…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- NCT00106457
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes Mellitus, Type 1
TrialNet Pathway to Prevention of T1D
Rationale: The accrual of data from the laboratory and from epidemiologic and prevention trials has improved the understanding of the etiology and pathogenesis of type 1 diabetes mellitus (T1DM).
- Trial name
- NCT00097292
- Where
- 22 sites in United States, Australia and 4 more
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Atherosclerosis, Metabolic Syndrome
Cardiometabolic Risk Factors Registry
CARFARE (CARDIOMETABOLIC RISK FACTORS REGISTRY) is a registry done in the context of a cardiovascular primary prevention program of the Cardiometabolic Unit Officia of the Cardiology Department of the Austral University Hospital.
- Conditions
- Atherosclerosis, Metabolic Syndrome, Diabetes, Cardiovascular Risk Factor
- Trial name
- CARFARE (NCT04040777)
- Where
- Argentina
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Austral University, Argentina
Cardiovascular Disease, Diabetes
Meta-Analyses of Low-risk Lifestyle Behaviours and Patient Important Outcomes
Public health policy is universal in recommending the adoption of low risk low-risk lifestyle behaviors for health promotion and prevention of chronic or non-communicable diseases (NCDs).These behaviors generally include…
- Conditions
- Cardiovascular Disease, Diabetes, Cancer, Mortality
- Trial name
- NCT03234101
- Testing
- Low-risk lifestyle behaviours
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetic Retinopathy, Diabetic Retinopathy Associated with Type 2 Diabetes Mellitus
Early Retinal Neurodegeneration As Risk Factor, Biomarker and Pharmacological Target of Diabetic Retinopathy
Despite the evidence that diabetic retinopathy (DR) remains the first cause of blindness among the working-age population, it lacks a specific preventive treatment.
- Trial name
- 2022-12376008 (NCT06582472)
- Testing
- Ophthalmological examination including imaging assessments, confocal analysis of cornea, Dynamic Vessel Analyzer (DVA)
- Where
- 2 sites in Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Diabetes, Gestational
A Culturally-tailored Personalized Nutrition Intervention in South Asian Women at Risk of Gestational Diabetes
This trial will assess the impact of a culturally tailored, personalized nutrition intervention on glycemic response to an oral glucose load (as measured by the area-under-the curve glucose) in high-risk pregnancies of South…
- Trial name
- DESI-GDM (NCT03607799)
- Testing
- Dietary Intervention, Control
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- McMaster University
Gestational Diabetes, Pregnancy Complications
Gestational Diabetes Monitoring and Management
The primary goal is to predict the clinical outcomes of mother and baby using blood glucose and other routinely collected clinical data in pregnancy to predict adverse outcomes at birth in women with GDM.
- Conditions
- Gestational Diabetes, Pregnancy Complications, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT06963528
- Where
- United Kingdom
- Volunteers
- 1,800 people
- Sponsor
- University of Oxford
Type 2 Diabetes, Gestational Diabetes
Exploring Nutritype Signature of Type 2 Diabetes Risks in Women Post-Gestational Diabetes Mellitus
Women post-gestational diabetes mellitus (GDM) have more than 7-fold increased risk of having future type 2 diabetes mellitus (T2DM).
- Trial name
- NCT04190199
- Testing
- Observational
- Where
- Malaysia
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
NAFLD, Diabetes Mellitus, Type 2
Liver Fat as a Dietary Target for Treating Cardiometabolic Disorders in Prediabetes and Type 2 Diabetes
The overall aim of this study is to investigate the long-term impact of a customized diet aimed at reducing liver fat specifically and a healthy Nordic diet on ectopic fat (liver, pancreatic and visceral) and cardiometabolic risk…
- Conditions
- NAFLD, Diabetes Mellitus, Type 2, PreDiabetes
- Trial name
- NAFLDiet (NCT04527965)
- Testing
- Customized diet to reduce liver fat, Healthy Nordic diet, Control
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Coronary Artery Disease, Diabetes
Cardiovascular Health and Text Messaging-Diabetes Mellitus (CHAT-DM) Study
The study is a two-arm, parallel, randomized clinical trial. The purpose of the study is to evaluate the effectiveness of automated mobile phone text message-based intervention for secondary prevention, including lifestyles…
- Trial name
- NCT02883842
- Testing
- Text messaging
- Where
- China
- Volunteers
- 502 people
- Sponsor
- China National Center for Cardiovascular Diseases
Diabetes, Cardiovascular Risk Factor
Diabetes Prevention Translation: the Healthy Lifestyle Project
The Diabetes Prevention Program (DPP), a large research study conducted in the United States, found that lifestyle intervention was effective in lowering risk for development of type 2 diabetes.
- Trial name
- NCT01050205
- Testing
- Current Intervention, Delayed Intervention
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- University of Pittsburgh
Diabetes Mellitus, Type 2
Effect of Exercise on Cardiometabolic Risk Factors in Type II Diabetic Patients
Background: Physical activity is known to modify some of the diabetes risk factors; however, solid evidence is still needed to precisely know the optimum form of training best fits the individual needs of type II diabetic (T2D)…
- Trial name
- NCT04759469
- Testing
- High-intensity interval training, Moderate intensity interval training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Diabetic Retinopathy
SLMAP and EPO Genetic Polymorphism in Diabetic Retinopathy
A case-control study to assess the association between the risk of diabetic retinopathy in Egyptians and genetic polymorphism of both EPO and SLMAP genes.
- Trial name
- NCT05344690
- Testing
- SLMAP and EPO genetic polymorphism
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 2, Dental Caries
Are Diabetics Type 2 More Prone to Dental Caries?
Background: Diabetes mellitus (DM) is well known for long-term complications to general and oral health. Periodontal disease has a bidirectional association with the development of type 2 diabetes (T2DM) (Mealey, 2006; Taylor…
- Trial name
- NCT04883086
- Where
- United Kingdom
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Nonalcoholic Fatty Liver Disease, Type 2 Diabetes
Weight Gain After Smoking Cessation and NAFLD
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common chronic liver disease. Considering that there are no approved pharmacological treatments, lifestyle modification is necessary and challenging to reduce…
- Trial name
- NCT05550688
- Where
- China
- Volunteers
- 12,941 people, healthy volunteers welcome
- Sponsor
- Ningbo No. 1 Hospital
Diabetes
Intensive Case Diabetes Management (ICDM) to Prevent Readmission
The purpose of this study is to assess whether intensive case management interventions by a diabetes team, led by an endocrinologist and certified diabetes educator, can prevent <31 day readmission in previously identified high…
- Trial name
- NCT02230488
- Testing
- Intensive Diabetes Case Management
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes Mellitus
Bexagliflozin Efficacy and Safety Trial
The purpose of this study is to investigate the effect of bexagliflozin in lowering hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes mellitus (T2DM) and increased risk of cardiovascular adverse events.
- Trial name
- BEST (NCT02558296)
- Testing
- Bexagliflozin
- Where
- 157 sites in United States, Canada and 8 more
- Volunteers
- 1,700 people
- Sponsor
- Theracos
PreDiabetes, Aging
Effects of Progressive Intensity Exercise Training on Glycemic Control in Older Adults
The purpose of this study is to compare the effects of moderate versus vigorous intensity exercise training on glycemic control in older adults.
- Trial name
- GLYDE (NCT03154073)
- Testing
- Moderate Intensity Exercise Training (MOD), Vigorous Intensity Exercise Training (VIG)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetic Retinopathy
Evaluating How the Treatments in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Affect Diabetic Retinopathy (The ACCORD Eye Study)
Diabetic retinopathy (DR) is an eye disease that can occur in people with diabetes and can cause poor vision or blindness. The Action to Control Cardiovascular Risk in Diabetes (ACCORD) study is examining the effect of various…
- Trial name
- NCT00542178
- Testing
- Hypoglycemic Agents, Standard glycemia control, Intensive BP treatment
- Where
- 7 sites in United States, Canada
- Volunteers
- 3,472 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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