Clinical trials: Diabetes Mellitus Risk
Body Weight, Obesity
Meta Analysis of the Effect of a Low Glycemic Index Diet and Glycemic Load on Body Weight
A low glycemic index (GI) diet has been associated with improved glycemic control in type 2 diabetes patients and a reduced risk of cardiovascular disease (CVD).
- Conditions
- Body Weight, Obesity, Cardiovascular Diseases, Diabetes Mellitus, Type 2
- Trial name
- NCT02557022
- Testing
- GI and/or GL
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Type-2 Diabetes
Liraglutide and Cardio-Metabolic Risk Markers
Incretin-based therapies have shown significant effects beyond those on glucose metabolism. We aim in the present study to evaluate the effects of liraglutide on several cardio-metabolic risk markers.
- Trial name
- NCT01715428
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Palermo
Psychotic Disorders, Schizophrenia
Antipsychotics and Risk of Hyperglycemic Emergencies
The purpose of this study is to determine whether the use of atypical antipsychotic medication increases the risk of hospitalization for a hyperglycemic emergency.
- Conditions
- Psychotic Disorders, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT02582736
- Testing
- Olanzapine, Risperidone, atypical antipsychotics (other)
- Where
- Canada
- Volunteers
- 725,489 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Type 2 Diabetes
Risk of CKD in Diabetic Patients With MAFLD
This cross-sectional study of 300 participants investigates the risk of chronic kidney disease (CKD) in individuals with metabolic dysfunction-associated fatty liver disease (MAFLD) and type 2 diabetes.
- Trial name
- NCT06304844
- Testing
- transient elastography (Fibroscan)
- Volunteers
- 300 people
- Sponsor
- Sohag University
Diabetes, Hypertension
Effects of Dengzhanxixin Capsule on Platelet Function in Individuals at High Risk for Cardiovascular Disease
The main objective of this clinical trial is to evaluate whether the antiplatelet efficacy of the Dengzhanxixin capsule is better than that of placebo in individuals at high-risk for atherosclerotic cardiovascular disease (ASCVD).
- Conditions
- Diabetes, Hypertension, Hypercholesterolemia
- Trial name
- FUTURE (NCT05459519)
- Where
- China
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Obesity, Diabetes
Translating the Diabetes Prevention Program Into a Virtual Lifestyle Management Program
The objective of this study is to evaluate the effectiveness of Virtual Lifestyle Management (VLM) as a behavior modification tool to promote weight loss, healthy eating and physical activity patterns, in the interest of reducing…
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT00867425
- Testing
- Virtual Lifestyle Management
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Overweight, PreDiabetes
Hydroxytyrosol Dietary Supplement and Prevention of Age-Related Diseases
The primary objective of this study is to ascertain the effects of chronic consumption of a hydroxytyrosol-rich extract from olive in a population at high risk of developing age-related pathologies such as type 2 diabetes and…
- Trial name
- HT15 (NCT06295913)
- Testing
- Group 1, hydroxytyrosol-rich extract capsule
- Where
- Spain
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function.
- Trial name
- NCT06383390
- Testing
- Retatrutide
- Where
- 742 sites in United States, Argentina and 25 more
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes
M1no-Study - Early Identification of Infants With High Type 1 Diabetes Risk for Participation in Primary Prevention Trials
The goal of this observational study is to identify newborns at increased genetic risk of developing type 1 diabetes-specific beta-cell autoantibodies in order to determine eligibility for participation in primary prevention…
- Trial name
- M1N0 (NCT07670143)
- Where
- 5 sites in Italy
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Diabetes Mellitus, Type 1
Teplizumab in Pediatric Stage 2 Type 1 Diabetes
The purpose of this study is to assess the safety and pharmacokinetics (PK) of teplizumab in participants with Stage 2 type 1 diabetes who are <8 years of age.
- Trial name
- PETITE-T1D (NCT05757713)
- Testing
- teplizumab
- Where
- 10 sites in United States
- Volunteers
- 23 people
- Sponsor
- Sanofi
Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Diseases
Inspire HER: Inspiring the Heart and Emotions for Radical Health
Poor heart health puts Black women at risk for a shorter life with more illness than people of any other non-indigenous racial group.
- Conditions
- Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Diseases, Hypertension, Diabetes
- Trial name
- NCT06966258
- Testing
- Inspire HER Intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Alabama at Birmingham
Diabetes Mellitus, Type 2
Glucagon-like Peptide (GLP) Utilization and Safety
This study will assess the utilization patterns (adherence, source of the index antidiabetic agent (ADA) and treatment modification) of the marketed glucagon-like peptide-1 (GLP-1) receptor agonists (exenatide and liraglutide)…
- Trial name
- NCT01767389
- Testing
- The GLP-1 receptor agonist users, DPP-4 inhibitor users, Other ADA users
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Aerobic Exercise, Strength Training
Home-Based Circuit Training in Overweight/Obese Older Adult Patients With Knee Osteoarthritis and Type 2 Diabetes
Background: Obesity and type 2 diabetes mellitus (T2DM) are considered two of the most prevalent metabolic diseases linked to the onset of knee pain caused by osteoarthritis.
- Conditions
- Aerobic Exercise, Strength Training, Glycemic Control, Blood Pressure
- Trial name
- NCT06309654
- Testing
- 12-week home-based circuit training (HBCT), Standard of care (CONT)
- Where
- Saudi Arabia
- Volunteers
- 70 people
- Sponsor
- Princess Nourah Bint Abdulrahman University
Diabetes Mellitus Risk, Obesity
Novel Intervention Linking Public Housing With Primary Care to Prevent Diabetes
(Sisters Health And Primary CarE Uniting and Preventing Diabetes; aka SHAPE UP) will consist of: 1) Neighborhood DPP Intervention: group DPP sessions and individual coaching; 2) Preventive Care Coordination to FQHC: referral…
- Conditions
- Diabetes Mellitus Risk, Obesity, Cardiovascular Risk Factor
- Trial name
- SHAPE-Up (NCT03526237)
- Testing
- 24 week community based DPP Group Lifestyle Balance Program, Wait-List Control community based DPP Group Lifestyle Balance Program
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Type 1 Diabetes Mellitus
Nutritional Prevention Pilot Trial for Type 1 Diabetes
The overall objective of the study is to assess whether complete avoidance of cow's milk (CM) proteins, for at least the first 6 months of life, prevents type 1 diabetes (insulin-dependent diabetes mellitus, IDDM) in genetically…
- Trial name
- MIP (NCT00570102)
- Testing
- A highly hydrolyzed formula, A regular cow's milk based formula
- Where
- 18 sites in Finland
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Gestational Diabetes
Patterns and Glycaemic Endpoints for Diagnosing Gestational Diabetes
Gestational diabetes (GDM) develops during pregnancy and is becoming increasingly common. The condition is associated with adverse outcomes for mother and baby during both the pregnancy and delivery period.
- Trial name
- PAGED-GDM (NCT05981547)
- Testing
- Libre 3 continuous glucose monitoring sensor
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Type 2 Diabetes Mellitus
A Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participants With Type 2 Diabetes and Increased Cardiovascular Risk
The purpose of the trial is to assess the efficacy and safety of tirzepatide taken once a week to insulin glargine taken once daily in participants with type 2 diabetes and increased cardiovascular risk.
- Trial name
- SURPASS-4 (NCT03730662)
- Testing
- Tirzepatide, Insulin Glargine
- Where
- 216 sites in United States, Argentina and 13 more
- Volunteers
- 2,002 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 1
At-Risk for Type 1 Diabetes Extension Study (TN-10 Extension)
This study was an extension of the NIH-sponsored At-Risk (TN-10) type 1 diabetes study (NCT 01030861). Teplizumab-treated and placebo-treated participants in the NIH trial who developed clinical type 1 diabetes after the…
- Trial name
- NCT04270942
- Testing
- teplizumab 1 mg/mL
- Where
- 8 sites in United States
- Volunteers
- 6 people
- Sponsor
- Provention Bio, a Sanofi Company
PreDiabetes
Small Steps for Big Changes: A Lifestyle Program to Reduce the Risk of Developing Type 2 Diabetes
The purpose of this study is to address whether inactive individuals with prediabetes who take part in the Small Steps for Big Changes program, which is a 3-week supervised exercise and lifestyle change program with brief…
- Trial name
- NCT03096002
- Testing
- Lifestyle change
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of British Columbia
Gestational Diabetes
A Pragmatic Approach to Lowering the Risk of Diabetes Mellitus After A Diagnosis of Gestational Diabetes Mellitus
A Pilot of Metformin Postpartum
- Trial name
- NCT04615351
- Testing
- Metformin
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island