Clinical trials: Diabetes Mellitus Risk
Type 2 Diabetes Mellitus in Obese
Lifestyle Intervention to Reduce the Risk of Sarcopenia in Adults With Diabetes & Obesity Treated With Semaglutide
This study aims to test whether a multi-disciplinary intervention involving exercise and nutrition can slow down the decline in physical function, muscle strength and mass in older adults (aged 65 and above) with Type 2 diabetes…
- Trial name
- STAY-STRONG (NCT06497595)
- Testing
- Wegovy (2.4 Mg Dose) + exercise & nutrition, Wegovy (2.4 Mg Dose) + usual care
- Where
- 2 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Prediabetic State, Dysglycemia
Mode of Action (MoA) Study of TOTUM-63 in Individuals at Increased Cardio-metabolic Risk
This clinical study aims to investigate the effects of TOTUM-63, a mix of 5 plant extracts, consumed at the daily regimen of three times per day, on cardiometabolic health and gut microbiota profile in overweight-obese…
- Conditions
- Prediabetic State, Dysglycemia, Overweight and Obesity
- Trial name
- NCT05369585
- Testing
- TOTUM-63
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Cardiovascular Diseases
Assessing the Effectiveness of Concurrent Peer Review for Patients With Cardiovascular Disease and Diabetes
We will assess the impact of concurrent peer review vists on blood pressure, cholesterol and diabetes control. Concurrent peer review (CPR) visits refer to special offic visits by patients to a clinician (physician, nurse…
- Trial name
- NCT00508014
- Testing
- Usual Care, Concurrent Peer Review visit
- Where
- United States
- Volunteers
- 727 people
- Sponsor
- University of Rochester
Diabetes Mellitus, Type 2
Post-authorisation Safety Study in Patients With Type 2 Diabetes to Assess the Risk of Liver Injury, Kidney Injury, Urinary Tract and Genital Infections, and Diabetic Ketoacidosis in Patients Treated With Empagliflozin, Compared to DPP-4 Inhibitors
Empagliflozin (Jardiance), a highly potent and selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), was approved in Europe in May 2014 for the treatment of type 2 diabetes mellitus (T2DM) to improve glycaemic…
- Trial name
- NCT02864914
- Testing
- Empagliflozin, DPP-4 inhibitors
- Where
- United Kingdom
- Volunteers
- 333,580 people
- Sponsor
- Boehringer Ingelheim
Nonalcoholic Fatty Liver Disease, Light-to-moderate Alcohol Consumption
Alcohol Consumption and Type 2 Diabetes Mellitus Risk in Nonalcoholic Fatty Liver Disease
This study explored the cross-sectional and prospective associations between light-to-moderate alcohol consumption (LMAC) and risk of type 2 diabetes mellitus (T2DM) in individuals with nonalcoholic fatty liver disease (NAFLD).
- Conditions
- Nonalcoholic Fatty Liver Disease, Light-to-moderate Alcohol Consumption, Type2 Diabetes Mellitus
- Trial name
- NCT03847116
- Where
- China
- Volunteers
- 14,014 people, healthy volunteers welcome
- Sponsor
- Ningbo No. 1 Hospital
Cardiovascular Diseases, Heart Diseases
Central Obesity and Disease Risk in Japanese Americans
To conduct a longitudinal study of central obesity and related risk factors found to be associated with hypertension and atherosclerotic cardiovascular disease (ASCVD) in a previously-examined cross-sectional cohort of…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Hypertension
- Trial name
- NCT00005365
- Sponsor
- University of Washington
Pregnant Patients at Risk of Gestational Diabetes
A Randomized Controlled Trial of Prepared vs. Unprepared Food
The goal of this study is to assess the feasibility of different food interventions, delivered through insurance providers, for addressing food insecurity in patients at risk of gestational diabetes (diabetes in pregnancy).
- Trial name
- NCT07800182
- Testing
- Prepared meals, Unprepared Pantry/Produce box
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Overweight, Glucose Intolerance
Diabetes Prevention In Estrie
This study compared the efficacy at one year of an interdisciplinary approach including individual counseling and group seminars versus group seminars alone to induce weight loss in subjects at high risk of developing type 2…
- Trial name
- NCT00991549
- Testing
- interdisciplinary intervention or meeting-seminars
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- Université de Sherbrooke
Pre-diabetes
Reducing Risk of Type 2 Diabetes: Hydroxychloroquine Use in Pre-Diabetes
The purpose of this study is to determine the short-term effects of the antimalarial medication, hydroxychloroquine (HCQ), compared with placebo using frequently sampled intravenous glucose tolerance testing (FSIGTT) methodology…
- Trial name
- NCT01326533
- Testing
- hydroxychloroquine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Fitness Trackers, Sedentary Behavior
Intervention Study: Genetic Risk Communication and Wearables
This study aims to determine the effects of communicating genetic risk for type 2 diabetes (T2D) alone or in combination with goal setting and prompts from a wearable device on objectively measured physical activity (PA) and…
- Conditions
- Fitness Trackers, Sedentary Behavior, Exercise, Genetic Predisposition to Disease
- Trial name
- NCT04879758
- Testing
- Genetic Risk Estimate, Genetic Risk Estimate + Fitbit Functions
- Where
- Hong Kong
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Asthma
Effect of Inhaled Steroids on Glucose Regulation in Asthma Patients
Inhaled steroid has been the cornerstone in the treatment of asthma, which carries a huge patient population worldwide including Hong Kong. In general, the safety of long-term use of inhaled steroid has been well documented.
- Trial name
- NCT00959348
- Where
- 4 sites in Hong Kong
- Volunteers
- 1,394 people
- Sponsor
- The University of Hong Kong
Cardiovascular Disease Risk Reduction, Diabetes
Interval Training and Electromagnetic Therapy on Cardiovascular Disease Risk in Diabetic Elderly
Aims: To evaluate the combined effect of moderate intensity interval training and low frequency pulsed electromagnetic field therapy on cardiovascular disease risk and lower extremity functioning in the elderly with type 2…
- Conditions
- Cardiovascular Disease Risk Reduction, Diabetes, Lower Extremity Dysfunction
- Trial name
- NCT06974435
- Testing
- Interval training and electromagnetic therapy, Interval exercise training, Electromagnetic therapy
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- Umm Al-Qura University
Type 2 Diabetes, Chronic Disease
Prevention Strategies for Adolescents at Risk of Diabetes
The primary aim of PRE-STARt Phase 1 is to pragmatically evaluate and refine a risk assessment tool to identify those children with chronic disease risk factors (including Type 2 Diabetes).
- Trial name
- PRE-STARt (NCT02545140)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Prediabetes
Preventing Diabetes in Those at Risk by Having a Facilitator and Family Doctor Encourage Healthy Activity and Eating Habits
Nearly six million Canadians are living with an increased risk of diabetes (prediabetes) and approximately 50% of these will develop type 2 diabetes within five years.
- Trial name
- FLIP (NCT01589835)
- Testing
- Lifestyle changes
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- University of British Columbia
Obesity, Overweight
Tirzepatide vs Semaglutide in Individuals at Cardiovascular Risk But Without Diabetes.
Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials.
- Trial name
- NCT07619508
- Testing
- Tirzepatide, Semaglutide
- Where
- United States
- Volunteers
- 100,000 people
- Sponsor
- Brigham and Women's Hospital
Hyperostosis, Diffuse Idiopathic Skeletal, Metabolic Syndrome
Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis (DISH)
Diffuse idiopathic skeletal hyperostosis (DISH) is a poorly understood, systemic condition characterized by progressive calcification and ossification of ligaments and entheses.
- Conditions
- Hyperostosis, Diffuse Idiopathic Skeletal, Metabolic Syndrome, Diabetes Mellitus
- Trial name
- NCT03237455
- Testing
- Thoracic spine x-rays+whole spine MRI, blood tests, constitutional and demographic data collection
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Diabetes Mellitus, Cardiovascular Diseases
Towards Optimal Screening and Management of Coronary Artery Disease in Diabetes: TOSCANA Study
There are currently only few data on the coronary artery calcium score in patient with diabetes in France, and the diagnostic and therapeutic attitudes towards a high coronary artery calcium score are not standardized and depend…
- Trial name
- TOSCANA (NCT05314140)
- Testing
- Coronary artery calcium score evaluation
- Where
- 9 sites in France
- Sponsor
- French Cardiology Society
Type 1 Diabetes (T1D), Glucose Control
Need-driven Treatment of the Patients With Type 1 Diabetes
This prospective study evaluates the safety of extending the interval of routine calendar-based follow-up visits from every 12 months to every 24 months in patients with type 1 diabetes who are in good glycemic control and…
- Trial name
- NCT07128992
- Testing
- Control visit interval
- Volunteers
- 125 people
- Sponsor
- Tampere University Hospital
Diabetes Mellitus, Type 2, Gestational Diabetes
Mechanisms Behind Severe Insulin Resistance During Pregnancy in Women With Glucose Metabolic Disorders (SIR-MET)
The aim of this study is to describe the metabolic changes during pregnancy in women with type 2 diabetes or gestational diabetes in order to detect the pathophysiological mechanisms behind severe insulin resistance during…
- Conditions
- Diabetes Mellitus, Type 2, Gestational Diabetes, Overweight and Obesity, Pregnancy in Diabetic
- Trial name
- NCT04924504
- Testing
- No interventions
- Where
- 2 sites in Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 2 Diabetes
Study to Weigh the Effect of Exercise Training on BONE (SWEET-BONE) Quality and Strength in Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) is associated with increased fracture risk despite normal to increased bone mass, thus suggesting poor bone quality.
- Trial name
- SWEET-BONE (NCT02421393)
- Testing
- supervised exercise training
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Metabolic Fitness Association, Italy
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