Clinical trials: Diabetes Mellitus Risk
Obesity, Diet Modification
Metabolic Impact of Time Restricted Feeding
The investigators are interested in how time-restricted feeding will impact weight, sleep duration and efficacy, and activity levels in obese adults.
- Trial name
- NCT03129581
- Testing
- Dietary Counseling
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cardiovascular Diseases, Diabetes
Białystok PLUS - Polish Longitudinal University Study
The main goal of the study is to provide a unique multidimensional picture of the health of the population with simultaneous optimal standards of sampling, processing and storing of data and biomaterial that will allow…
- Conditions
- Cardiovascular Diseases, Diabetes, Neuro-Degenerative Disease, Obesity
- Trial name
- Bialystok+ (NCT03197363)
- Testing
- Discovering novel risk factors.
- Where
- Poland
- Volunteers
- 8,320 people
- Sponsor
- Medical University of Bialystok
Obesity, Insulin Resistance
Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study)
Given that glutamate carboxylation or decarboxylation is key to the metabolic role of osteocalcin (at least in mouse models) and that carboxylation is vitamin K dependent, it is critical to isolate the effect of vitamin K…
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Beta-Cell Dysfunction
- Trial name
- NCT02366481
- Testing
- Low-Dose Vitamin K2 Supplement (menaquinone-7; 90-mcg/d), High-Dose Vitamin K2 Supplement (menaquinone-7; 180-mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Cardiovascular Diseases, Coronary Disease
Coronary Artery Risk Development in Young Adults
To measure changes in coronary heart disease risk factors in cohorts of Black and White males and females 18 to 30 years of age at baseline.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Hypertension, Heart Diseases
- Trial name
- CARDIA (NCT00005130)
- Volunteers
- 5,115 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Influence of Prior Walking on Postprandial Metabolism in Centrally Obese Men
The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in centrally obese South Asian and White European men.
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Endothelial Dysfunction, Insulin Resistance
- Trial name
- NCT03952000
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Hyperlipidemia, Diabetes Mellitus
Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders
The purpose of the present study is to conduct a thorough and relevant physiology study of carriers and non-carriers of the gene variant X in order to determine the effect of the genetic variant on various metabolic parameters.
- Conditions
- Hyperlipidemia, Diabetes Mellitus, Metabolic Syndrome, Arterial Hypertension
- Trial name
- NCT01571609
- Testing
- first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diabetes, Diabetes Mellitus, Type 2
A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events
This trial is conducted globally. The aim of this trial is to compare cardiovascular safety of insulin degludec versus insulin glargine in subjects with type 2 diabetes at high risk of cardiovascular events.
- Trial name
- DEVOTE (NCT01959529)
- Testing
- insulin degludec, insulin glargine
- Where
- 446 sites in United States, Algeria and 18 more
- Volunteers
- 7,637 people
- Sponsor
- Novo Nordisk A/S
Diabetic Retinopathy, HIV
Diabetic Retinopathy in HIV Subjects Treated With EGRIFTA®
To show the non-inferiority of EGRIFTA® vs. placebo in the development or progression of Diabetic Retinopathy in HIV-infected subjects with concomitant abdominal lipohypertrophy and Type 2 diabetes mellitus (T2DM).
- Trial name
- NCT01591902
- Testing
- Tesamorelin
- Where
- 24 sites in United States
- Volunteers
- 129 people
- Sponsor
- Theratechnologies
Diabetes Mellitus, Hypertension
Efficacy of Exercise at a Fitness Club for Cardiovascular Risk Reduction
The purpose of the study is to determine whether exercise has further beneficial effects on improving cardiovascular risk factors such as hypertension, high cholesterol level or diabetes mellitus, when added to the standard…
- Conditions
- Diabetes Mellitus, Hypertension, Hyperlipidemia
- Trial name
- NCT00106236
- Testing
- exercise
- Where
- Japan
- Volunteers
- 561 people
- Sponsor
- Sapporo Health Promotion Foundation
Diabetes Mellitus
Impact of Self-care Education Program in Patients With Type 2 Diabetes in Primary Care in the Basque Country
Main objective:To evaluate the effectiveness of the "Diabetes Self-Management Programme" (DSMP) on the metabolic control, cardiovascular risk reduction, quality of life and self-efficacy in adult patients with type 2 diabetes…
- Trial name
- NCT01642394
- Testing
- Diabetes Self-Management Program
- Where
- Spain
- Volunteers
- 594 people
- Sponsor
- Osakidetza
Dietary Modification, Weight Loss
Feasibility of a Postpartum Lifestyle Intervention on the Cardiometabolic Risk Profile of GDM Women
The goal of the study is to investigate the effect of a lifestyle intervention program (adoption of exclusive breastfeeding, healthy diet and regular physical activity) on minimizing postpartum weight retention among women with…
- Conditions
- Dietary Modification, Weight Loss, Physical Activity, Breastfeeding
- Trial name
- DEPART (NCT02872402)
- Testing
- Lifestyle intervention, Active control lifestyle intervention
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laval University
Metabolic Syndrome X, Insulin Resistance
Impact of Meal Order on Postprandial Cardiometabolic Risk Markers
The order in which the different components of a meal are eaten may have impact on the postprandial metabolic responses to carbohydrates, fat and proteins.
- Conditions
- Metabolic Syndrome X, Insulin Resistance, Hyperinsulinism, Glucose Metabolism Disorders
- Trial name
- NCT03358745
- Testing
- Standard meal, bread/butter as starter, Standard meal with soup as starter, Standard meal with cheese as starter
- Where
- 2 sites in Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lund University
Cardiovascular Diseases, Diabetes
South Asian HeArt Risk Assessment Project - Pilot
People who originate from the Indian subcontinent known as South Asians are the fastest growing group of non-white Canadians. They suffer an excess prevalence of abdominal obesity, type 2 diabetes and heart disease.
- Conditions
- Cardiovascular Diseases, Diabetes, Abdominal Obesity
- Trial name
- SAHARA-Pilot (NCT01577719)
- Testing
- Multimedia Lifestyle Improvement, Usual Care
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- McMaster University
Type 2 Diabetes Treated With Insulin, Pregnancy, High Risk
Continuous Glucose Monitor Use in Pregnancy
The purpose of this study is to perform a randomized controlled trial among 180 pregnant women with type 2 diabetes mellitus (T2DM) comparing continuous glucose monitor (CGM) use to the standard of care of multiple daily…
- Trial name
- NCT05317585
- Testing
- Continuous Glucose Monitor, Routine Capillary Blood Glucose Monitoring (Fingerstick Glucose)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Massachusetts, Worcester
Heart Disease, Diabetes
Automated Guidance Tool for Medical Encounters Addressing Therapeutic Lifestyle Changes (AuGMEnT).
ABSTRACT Although most primary healthcare practitioners recognize the important relationship among nutrition, physical activity and health, few incorporate either dietary or physical activity counseling into routine practice.
- Trial name
- NCT00790491
- Testing
- guidance tool for providers for lifestyle changes
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Griffin Hospital
Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
Natural History of Autoimmune Diabetes and Its Complications
Background: Diabetes is a disease defined by abnormally high blood sugar (glucose) levels. Glucose is an essential source of energy for the body s cells, but insulin is required to move the glucose into the cells.
- Trial name
- NCT00896610
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Childhood Cancer Survivors Treated With Abdominal Radiation
Assessing Insulin Sensitivity and Diabetes Risk in Childhood Cancer Survivors Treated With Abdominal Irradiation
The purpose of this study is to better understand the risk factors and causes of diabetes in people who received radiation to the abdomen as children.
- Trial name
- NCT02248779
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Heart Diseases, Stroke
The HARMONY Study: A Intervention to Reduce Cardiometabolic Risk in African American Women
This study will test whether a culturally-tailored nutrition and exercise intervention designed for African-American women will lead to sustained improvements in exercise and healthy eating through improvements in self-management…
- Conditions
- Heart Diseases, Stroke, Pre-diabetes, Hypertension
- Trial name
- NCT04705779
- Testing
- HARMONY, Nutrition and Exercise Education (NEEW)
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of North Carolina, Chapel Hill
Cerebral Stroke, Thrombosis, Deep Vein
A Study of Adverse Events and Suspected Adverse Drug Reactions in Patients Under Apixaban for Prevention of Stroke and Systemic Embolism With Non-Valvular Atrial Fibrillation and Venous Thromboembolic Events in Patients Who Have Undergone Elective Hip or Knee Replacement Surgery
To characterize and analyze the number, type and incidence of adverse events/suspected adverse drug reactions in patients treated with Apixaban, according to therapeutic indications approved in Mexico.
- Conditions
- Cerebral Stroke, Thrombosis, Deep Vein, Pulmonary Embolism
- Trial name
- NCT03804125
- Sponsor
- Pfizer
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
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