Clinical trials: Diabetes Mellitus Type 2 (T2DM)
Acute Myocardial Infarction (AMI), Type 2 Diabetes Mellitus (T2DM)
SGLT2 Inhibitor Use After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Nationwide Cohort Study
This observational, retrospective cohort study aims to evaluate the impact of sodium-glucose cotransporter 2 (SGLT2) inhibitor use after acute myocardial infarction (AMI) in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- SGLT2i-AMI (NCT07198191)
- Testing
- SGLT2 inhibitors (e.g., dapagliflozin, empagliflozin), DPP4 inhibitors
- Where
- South Korea
- Volunteers
- 200,000 people
- Sponsor
- Yonsei University
Diabetes Mellitus, Type 2
A Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM)
The main purpose of this study is to compare the benefits and risks associated with the use of 2 treatment strategies to lower blood sugar in participants aged 65 and older with T2DM.
- Trial name
- IMPERIUM (NCT02072096)
- Testing
- Glimepiride, Metformin, Pioglitazone
- Where
- 34 sites in United States, Austria and 3 more
- Volunteers
- 192 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus (T2DM)
UBT251 Injection Phase II (Type 2 Diabetes Mellitus) Study
The purpose of this study is to evaluate the efficacy of UBT251 injection after 24 weeks of continuous administration in patients with type 2 diabetes mellitus and to recommend the dosing regimen for the Phase III clinical trial.
- Trial name
- T2DM (NCT07163624)
- Testing
- Semaglutide Injection (Ozempic®)
- Where
- China
- Volunteers
- 211 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Diabetes (DM), Diabetes Mellitus Type 2
Bridge Study to Evaluate the Efficacy and Safety of IN-B00009 Injection in Patients With T2DM Inadequately Controlled by Diet and Exercise Alone
This Phase 3 Bridge study is designed to evaluate the efficacy and safety of IN-B00009 Injection in Patients with T2DM Inadequately Controlled by Diet and Exercise Alone
- Trial name
- NCT07308184
- Testing
- IN-B00009
- Volunteers
- 110 people
- Sponsor
- HK inno.N Corporation
Diabetes, Diabetes Mellitus
Increasing CGM Use Among Patients With T2D
Study Overview: This interventional study aims to assess whether training healthcare professionals (HCPs) increases the number of continuous glucose monitor (CGM) prescriptions for patients with Type 2 Diabetes in a Federally…
- Conditions
- Diabetes, Diabetes Mellitus, Diabetes Mellitus Type 2, Diabetes Mellitus Type 2 (T2DM)
- Trial name
- SanDiegoSU (NCT06638099)
- Testing
- CGM Toolkit Prescriber Training
- Where
- 2 sites in United States
- Volunteers
- 195 people
- Sponsor
- San Diego State University
Type2diabetes, Pregnancy Related
Real Time Continuous Glucose Monitoring System in T2DM With Pregnacy
The prevalence of type 2 diabetes mellitus (T2DM) in women of childbearing age is increasing rapidly, and low glucose compliance leads to an increased risk of adverse pregnancy outcomes for mothers and infants during pregnancy in…
- Conditions
- Type2diabetes, Pregnancy Related, Continuous Glucose Monitoring, Time in Range
- Trial name
- NCT05947916
- Testing
- Real-time Continuous Glucose Monitoring System
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University Third Hospital
Diabetes Mellitus in Pregnancy, Diabetes, Gestational
Glycemic Targets for Pregnant Women With GDM and T2DM
The purpose of this randomized clinical trial is to determine whether glycemic targets that are lower than those currently recommended by the American Diabetes Association (ADA) and the American College of Obstetricians and…
- Conditions
- Diabetes Mellitus in Pregnancy, Diabetes, Gestational, Diabetes Mellitus, Type 2
- Trial name
- NCT04672031
- Testing
- Glycemic Targets
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Type 2 Diabetes Mellitus (T2DM)
Long-Term Benefits of Eccentric Cycling Exercise in Patients With Type 2 Diabetes Mellitus
The goal of this interventional study is to evaluate the long-term benefits of eccentric (ECC) cycling exercise on physiological responses, exercise capacity, and quality of life (QoL) in patients with type 2 diabetes mellitus…
- Trial name
- NCT07109102
- Testing
- Moderate-intensity eccentric cycling, High-intensity eccentric cycling, Moderate-intensity concentric cycling
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Universiti Sains Malaysia
Type 2 Diabetes Mellitus
A 12/24-weeks, Open, Multi-centre, Phase IV Study on Safety and Efficacy of 2mg Exenatide Once Weekly (Bydureon) in T2DM Patients.
As current study is conducted to provide additional information regarding safety and efficacy Bydureon, exenatide once weekly for injectable suspension, in the Korean population open label, non-comparative, multi-centre design is…
- Trial name
- Bydureon (NCT02533453)
- Testing
- Bydureon
- Where
- 15 sites in South Korea
- Volunteers
- 110 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Non Alcholic Fatty Liver Disease
Dapagliflozin in Nonalcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Mellitus Patients (T2DM).
Nonalcoholic fatty liver disease (NAFLD) encompasses conditions such as nonalcoholic steatohepatitis (NASH), which involves liver inflammation and fibrosis resulting from steatosis, potentially leading to cirrhosis and…
- Trial name
- NCT07020377
- Testing
- Dapagliflozin (DAPA), Negative control
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Amira Bisher,PhD
Type 2 Diabetes Mellitus, Obesity
RCT Evaluating Effects of Cosmos Caudatus (Ulam Raja) in T2DM Patients
The purpose of this study is to determine whether Cosmos caudatus is effective as an adjuvant therapy for type 2 Diabetes Mellitus.
- Trial name
- NCT02322268
- Testing
- Cosmos Caudatus
- Where
- Malaysia
- Volunteers
- 101 people
- Sponsor
- Universiti Putra Malaysia
Type 2 Diabetes
The Effect and Safety of a Novel CGM-Based Titration Algorithm for Basal Insulin in T2DM Participants.
The goal of this clinical trial is to compare the effect of a continuous glucose monitor (CGM) based titration algorithm to standard titration by self-monitoring blood glucose (SMBG) in participants with Type 2 Diabetes already…
- Trial name
- CGM-DTx (NCT06111508)
- Testing
- Continuous Glucose Monitoring (CGM)-based titration algorithm implemented in DiAs
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Type 2 Diabetes Mellitus (T2DM), Hyperglycemia
Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly
This is a single-center randomized controlled trial evaluating the efficacy and safety of short (3 days) versus long (10 days) courses of intermittent hypoxic-hyperoxic training (IHHT) in patients with type 2 diabetes mellitus…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Hyperglycemia, Metabolic Syndrome, Older Adults (65 Years and Older)
- Trial name
- EFIR (NCT07574333)
- Testing
- Intermittent Hypoxic-Hyperoxic Training (3 days), Intermittent Hypoxic-Hyperoxic Training (10 days), Normoxic gas breathing
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Type 2 Diabetes
Efficacy and Safety of Insulin Glargine/ Lixisenatide Fixed Ratio Combination Compared to Insulin Glargine Alone and Lixisenatide Alone on Top of Metformin in Patients With T2DM
Primary Objective: To compare the insulin glargine/lixisenatide fixed ratio combination to lixisenatide alone and to insulin glargine alone (on top of metformin treatment) in glycated hemoglobin (HbA1c) change from baseline to…
- Trial name
- LixiLan-O (NCT02058147)
- Testing
- Insulin glargine/lixisenatide Fixed Ratio Combination, Insulin glargine (HOE901), Lixisenatide (AVE0010)
- Where
- 273 sites in United States, Australia and 21 more
- Volunteers
- 1,170 people
- Sponsor
- Sanofi
Type II Diabetes Mellitus
A Study to Evaluate the Effect of a Digital Disease Management Tool in Patients With Type 2 Diabetes Mellitus
A real-world, point-of-care, randomized, parallel group, open, 6-month clinical study to evaluate if the provision of a digital disease management tool improves glycaemic control in participants with type 2 diabetes mellitus…
- Trial name
- NCT02749435
- Testing
- Use of digital disease management tool in participants with T2DM
- Where
- 14 sites in United Kingdom
- Volunteers
- 57 people
- Sponsor
- AstraZeneca
Obesity, Impaired Glucose Tolerance
Effects of Rosiglitazone on the Metabolic Phenotype of Impaired Glucose Tolerance in Youth
The purpose of the study is to determine whether treatment of children and adolescents with Impaired Glucose Tolerance (IGT) with rosiglitazone will lead to improvements in insulin sensitivity and glucose tolerance.
- Conditions
- Obesity, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
- Trial name
- NCT00413335
- Testing
- Rosiglitazone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
T2DM (Type 2 Diabetes Mellitus)
Efficacy and Safety of Berberine Ursodeoxycholate (HTD1801) in Patients With Type 2 Diabetes
The goal of this clinical study is to evaluate the efficacy and safety of Berberine Ursodeoxycholate (HTD1801) compared to placebo in patients with type 2 diabetes, inadequately controlled with diet and exercise alone.
- Trial name
- SYMPHONY-1 (NCT06350890)
- Testing
- HTD1801
- Where
- 56 sites in China
- Volunteers
- 408 people
- Sponsor
- Shenzhen HighTide Biopharmaceutical Ltd.
Pneumonia, Type 2 Diabetes Mellitus (T2DM)
Preadmission GLP-1 Receptor Agonist Plus SGLT2 Inhibitor Use and Early Outcomes After Pneumonia Hospitalization in Adults With Type 2 Diabetes
This retrospective observational target-trial emulation uses electronic health record data from the TriNetX US Collaborative Network to compare preadmission glucose-lowering treatment strategies in adults with type 2 diabetes…
- Trial name
- NCT07708610
- Where
- Taiwan
- Volunteers
- 71,775 people
- Sponsor
- Chung Shan Medical University
Diabetes Mellitus, Type 2
Canagliflozin (Invokana™) vs. Standard Dual Therapy Regimen for T2DM During Ramadan
This study aims to determine if the addition of Canagliflozin (Invokana™) therapy to monotherapy of metformin is more effective at achieving the double composite endpoint of a reduction in HbA1c (≥ 0.3%) and weight loss (≥1kg)…
- Trial name
- Can Do (NCT02694263)
- Testing
- Canagliflozin, Repaglinide, Pioglitazone
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Leicester
T2DM (Type 2 Diabetes Mellitus)
To Evaluate the Efficacy and Safety of Initial Combination Therapy With DWP16001 and DWC202518 Compared to DWP16001 Monotherapy and DWC202518 Monotherapy in Patients With Type 2 Diabetes Mellitus
This study aims to evaluate the efficacy and safety of initial combination therapy with DWP16001 and DWC202518 compared to DWP16001 monotherapy and DWC202518 monotherapy in patients with Type 2 Diabetes Mellitus
- Trial name
- NCT07619833
- Testing
- DWP16001, DWC202518
- Where
- South Korea
- Volunteers
- 510 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.