Clinical trials: Diabetes Mellitus Type 2 in Obese
Obesity and Type 2 Diabetes
Circuit Training and Motivational Interviewing to Reduce Type 2 Diabetes in Youth
The overall goal of this project is to examine the physiological and metabolic effects of a 16-week circuit-training (strength training + aerobic activities) program, with and without a behavioral component utilizing motivational…
- Trial name
- NCT00693511
- Testing
- Circuit Training, Circuit training + motivational interviewing
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Abdominal Obesity, Metabolic Syndrome
Growth Hormone Treatment in Men With High Risk of Developing Type 2 Diabetes Mellitus
The overall aim of this study is to investigate the effects of GH treatment in men with the Metabolic Syndrome and a high risk of developing type 2 DM.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Obesity
- Trial name
- GHDM (NCT00781547)
- Testing
- recombinant human growth hormone
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Göteborg University
Diabetes Mellitus Type 2, Overweight and Obesity
Cut Down on Carbohydrate in the Dietary Therapy of Type 2 Diabetes - The Meal Box Study
The cornerstone in the initial treatment of type 2 diabetes (T2D) is lifestyle modification, involving-among other things-a healthy diet.
- Trial name
- CutDM-MealBox (NCT05330247)
- Testing
- Carbohydrate-reduced high-protein (CRHP) Diet, Conventional diabetes (CD) Diet
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Bispebjerg Hospital
Obesity, Diabetes Mellitus, Type 2
A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who Also Have Diabetes to Lose Weight
This study is open to adults who are at least 18 years old and have a body mass index of 27 kg/m² or more. People can take part if they have type 2 diabetes and if they are currently being treated only with diet and exercise or…
- Trial name
- SYNCHRONIZE™-2 (NCT06066528)
- Testing
- Survodutide
- Where
- 143 sites in United States, Australia and 17 more
- Volunteers
- 755 people
- Sponsor
- Boehringer Ingelheim
Diabete Type 2, Obesity
Ph 2a Study of HU6 on Energy Metabolism, Muscle and Liver Substrate Metabolism, and Mitochondrial Function in Subjects Who Are Overweight or Obese With Type 2 Diabetes
This is a randomized, double-blind, placebo-controlled parallel group study of HU6 and placebo in subjects who are overweight or obese with T2D. The study will be conducted in 4 stages.
- Trial name
- NCT06104358
- Testing
- HU6
- Where
- United States
- Sponsor
- Rivus Pharmaceuticals, Inc.
Obesity, Type 2 Diabetes
A Three-part First-in-human Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GUB-UCN2 in Healthy Lean and Obese Participants and Participants With T2D
The trial will enroll healthy volunteers and individuals living with obesity, with and without Type 2 Diabetes. The study, with a treatment period of up to 16 weeks in selected cohorts, will investigate GUB-UCN2 as both a…
- Trial name
- NCT07702890
- Testing
- GUB-UCN2
- Where
- Germany
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Gubra A/S
Diabetes Mellitus, Type 2, Hemodialysis
Efficacy and Tolerance of Liraglutide for Weight Loss in Obese Type 2 Diabetic Hemodialysis Patients
Diabetes is the second leading cause of end stage renal disease in France (22% in the 2016 REIN register). In hemodialysis, its prevalence is higher, between 30-40% depending on the study.
- Conditions
- Diabetes Mellitus, Type 2, Hemodialysis, Obese
- Trial name
- LIRADIAL (NCT04529278)
- Testing
- Liraglutide
- Where
- 4 sites in France
- Volunteers
- 18 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Complications of Diabetes Mellitus
Clinical Study on Metabolic Surgery Compared to the Best Clinical Treatment in Patients With Type 2 Diabetes Mellitus
This is a prospective, open, randomized study involving 100 patients with microvascular complications of type 2 diabetes mellitus and obesity, who will undergo gastric bypass (Roux-en-Y gastric bypass ARM A) or receive best…
- Trial name
- MOMS (NCT01821508)
- Testing
- Clinical Treatment, Roux-En-Y gastric bypass surgery
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Alemão Oswaldo Cruz
Type 2 Diabetes, Obesity
The Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity in Type 2 Diabetes
Gastric bypass surgery induces remission of diabetes within days after surgery, before significant weight loss. The aim of the study is to examine whether improved insulin sensitivity of muscle and liver contributes to the…
- Trial name
- NCT01202526
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity, Morbid, Diabetes Mellitus, Type 2
Impact of an Increased Restrictive Factor of One Anastomosis Gastric Bypass on Metabolic Outcomes Type 2 Diabetes.
The purpose of the study is to evaluate the effect of an increased restrictive factor of one gastric anastomosis (OAGB) using a "FundoRing" fundoplication on metabolic outcomes in type 2 diabetes mellitus.
- Trial name
- NCT06176443
- Testing
- One anastomosis gastric bypass with combined fundoplication, One anastomosis gastric bypass without combined fundoplication
- Where
- Kazakhstan
- Volunteers
- 300 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Type 2 Diabetes, Hypertension
Free Fatty Acid-Induced Hypertension in Obese Subjects With Type 2 Diabetes
Insulin resistance has been implicated as the central pathogenetic feature of cardiovascular risk factor cluster that includes hypertension, impaired glucose tolerance, diabetes, dyslipidemia, and hemostatic disorders.
- Trial name
- NCT00738023
- Testing
- Rosiglitazone, Normal saline 0.9%, Intralipid 20%
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetes Mellitus, Type 2
Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus With Body Mass Index (BMI) < 35
The aim of this study is to evaluate the effect of Roux-en-y gastric bypass (RYGB) in controlling diabetes in subjects with mild obesity (BMI 26-35).
- Trial name
- NCT00999050
- Testing
- Gastric bypass for diabetic patients <35 BMI
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Diabetes Mellitus, Type 2, Obesity
"Effectiveness of Supervised and Unsupervised mHealth-based Exercise Interventions on Clinical Outcomes in Adults With Type 2 Diabetes and Obesity Within a Primary Care Context"
Type 2 diabetes (T2D) and obesity are two of the most common chronic conditions worldwide, and they frequently occur together. Both conditions are closely linked to physical inactivity, which is currently recognized as a major…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Insulin Resistance, Sedentary Behaviors
- Trial name
- NCT07685080
- Testing
- Supervised Exercise Training Program, mHealth Unsupervised Exercise Program (ActiVital App), Wearable Device Monitoring (Fitbit Charge 6)
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Escuela Universitaria de Osuna
Obesity, Prediabetic State
Lifestyle-Related Health Outcomes in Prediabetes and Diabetes
This study looks as how a health education intervention strategy effects health outcomes in overweight and obese adolescents.
- Conditions
- Obesity, Prediabetic State, Type 2 Diabetes
- Trial name
- NCT02535169
- Testing
- Health Education and Coaching Strategy, Dietary consult
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Indiana University
Obesity, Type 2 Diabetes Mellitus
The Influence of Fatty-Acids on Systemic and Subcutaneous Cytokines
This is a mono-center randomized controlled trial to be performed in the Center of Medical Research (ZMF) at Medical University Graz and is composed by one screening visit (V1) and two study visits (V2 and V3).
- Trial name
- TNF4 (NCT00708266)
- Testing
- Openflow microperfusion catheter, Intralipid 20%, 0.9% Saline Solution
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Obesity Without Type 2 Diabetes, With BMI>30
Impact of Metformin on Leptin Transport in Cerebrospinal Fluid of Obese Patients
Obesity, a major health problem, is gradually transforming into a global epidemic. The current obesity treatment with long term efficacy is the bariatric surgery, however, the operative risk of this procedure is high and the…
- Trial name
- LEPTOB (NCT03974139)
- Testing
- Metformin Oral Tablet
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Lille Catholic University
Type 2 Diabetes, Overweight
Effect of Liraglutide on Epicardial Fat in Subjects With Type 2 Diabetes
The purpose of this research study is to learn about the effect of Liraglutide, (Victoza®), on the fat surrounding the heart.Excessive amount of the fat around the heart is common in people with type 2 diabetes and can be…
- Conditions
- Type 2 Diabetes, Overweight, Obesity
- Trial name
- NCT02014740
- Testing
- Liraglutide, Metformin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
Cardiovascular Diseases, Coronary Disease
Genetics of Atherosclerosis in Mexican Americans
To identify individual genes that contribute to variation in susceptibility to coronary heart disease (CHD) in Mexican Americans.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Obesity, Atherosclerosis
- Trial name
- NCT00005462
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Type 2 Diabetes
An Open-Label Extension to Protocol 09-1, Efficacy and Safety Study of the EndoBarrier® Gastrointestinal Liner System
A multi-center, single-arm, open-label study to evaluate the safety and effectiveness of the EndoBarrier Gastrointestinal Liner System liner on glycemic control in control subjects from study #09-1 who are not treatment failures…
- Trial name
- OLE (NCT02293720)
- Testing
- EndoBarrier
- Sponsor
- Morphic Medical Inc.
Obesity, Morbid, Diabetes Mellitus, Type 2
Different Limb Lengths in Gastric Bypass Surgery
Obesity and type 2 diabetes mellitus (T2DM) are reaching epidemic proportions in the developed world. In morbidly obese patients only surgical treatment (bariatric operations) leads to a sustained weight loss and relief of…
- Conditions
- Obesity, Morbid, Diabetes Mellitus, Type 2, Hypertension, Dyslipidemias
- Trial name
- SLIM (NCT04219787)
- Testing
- Long BPL LRYGB, Short BPL LRYGB
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- Clarunis - Universitäres Bauchzentrum Basel
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