Clinical trials: Diabetes Mellitus Type II,
Type 2 Diabetes Mellitus, Microangiopathy
Changes in the Retinal and Carotid Microcirculation After Restoring Normoglycemia in Patients With Type 2 Diabetes
This is a prospective and observational study in patients with type two diabetes. The study hypothesis is that chronic hyperglycemia causes an increase in the microcirculation on the carotid artery wall and retina, evaluated by…
- Conditions
- Type 2 Diabetes Mellitus, Microangiopathy, Diabetic Retinopathy, Arteriosclerosis
- Trial name
- OCTAUS-T2D (NCT03594591)
- Testing
- Antidiabetic treatment by usual care
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Clinic of Barcelona
Diabetes Mellitus, Type 2, Insulin Resistance
Exercise to Restore 24h Rhythms in Metabolism
This study will investigate the effect of exercise training on 24h rhythms in substrate metabolism in overweight subjects with impaired glucose tolerance. Subjects will perform exercise training for 12 weeks.
- Trial name
- RESTORE (NCT04565418)
- Testing
- High-intensity interval training
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Type 2 Diabetes Mellitus
Safety and Efficacy Study of Dutogliptin/PHX1149T to Treat Type 2 Diabetes Mellitus
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate Safety and Efficacy of PHX1149T as Monotherapy in Subjects with Type 2 Diabetes Mellitus
- Trial name
- NCT00690638
- Testing
- PHX1149T
- Where
- 62 sites in United States, Argentina and 7 more
- Volunteers
- 480 people
- Sponsor
- Phenomix
Diabetes, Diabetes Mellitus, Type 2
Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin
This trial is conducted in Asia, Europe, Oceania and South America. The aim of this clinical trial is to generate data demonstrating how to intensify diabetes treatment using BIAsp 30 (biphasic insulin aspart 30) by adding or…
- Trial name
- SIT2MIX (NCT01519674)
- Testing
- biphasic insulin aspart 30, sitagliptin, metformin
- Where
- 69 sites in Argentina, Australia and 8 more
- Volunteers
- 582 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes
A Two-armed Real-world Study of Ozempic (OW Semaglutide) to Evaluate Its Adherence and Persistence Compared With Other Anti-diabetic Drugs Among Adult T2DM Patients in China
The study is testing the incidence of MACE and incidence of renal events between Ozempic® users and users with other anti-diabetic medications in T2D patients.
- Trial name
- SPOTLIGHT (NCT07456774)
- Where
- China
- Volunteers
- 100,000 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Mellitus in Obese, Dyslipidemia Associated With Type II Diabetes Mellitus
Type 2 Diabetes Mellitus With Obesity and Dyslipidemia Treated by Chinese Herbal Medicine
This study is a retrospective review of participants who visited Department of Endocrinology, Guang'anmen Hospital and accepted traditional Chinese medicine formula for at least sis months, from January 2015 to December 2020.
- Trial name
- NCT05072990
- Testing
- Chinese herb medicine
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Type 2 Diabetes Mellitus
Arginase Inhibition and Microvascular Endothelial Function in Type 2 Diabetes
The present project is designed to test the hypothesis that arginase contributes to microvascular endothelial dysfunction in patients with type 2 diabetes and microvascular complications.
- Trial name
- NCT02687152
- Testing
- N-hydroxy-nor-L-arginine
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Karolinska Institutet
Type 2 Diabetes
High Protein Breakfast on Appetite, Postprandial Glycemia and Weight Loss in T2D
The investigators hypothesis is that eating whey protein in the breakfast versus other proteins will results in higher satiety, reduced overall postprandial glycemia and more weight loss in obese diabetic individuals
- Trial name
- HPB (NCT01623648)
- Testing
- Arm 1 Whey Breakfast, Arm 2 No Whey Breakfast, Arm 3 Low Protein Breakfast
- Where
- 2 sites in Israel, Venezuela
- Volunteers
- 58 people
- Sponsor
- Hospital de Clinicas Caracas
Diabetes Mellitus, Type 2, Insulin Resistance
Treatment of Type 2 Diabetes Mellitus by Duodenal Exclusion Associated With Omentectomy: Clinical and Hormonal Study
Based in a surgery technique studied in a non-obese diabetic mouse model by Rubino and Marescaux(2004), wich reversed diabetes in those animals, we have performed a previous study in human volunteers with type 2 diabetes and…
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Obesity
- Trial name
- NCT00566215
- Testing
- Duodenal exclusion plus omentectomy, Duodenal exclusion without omentectomy
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- University of Campinas, Brazil
Hypertension
Glycemic Control Of Carvedilol Versus Metoprolol In Patients With Type II Diabetes Mellitus And Hypertension
To evaluate the effects of two different antihypertensive medications in the drug class of beta-blockers on control of glucose in Type II diabetic patients with high blood pressure.
- Trial name
- NCT00060918
- Testing
- carvedilol, metoprolol
- Where
- 50 sites in United States
- Volunteers
- 1,210 people
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 2
Food As MedicinE for Diabetes
The investigators propose a single-site, open-label, Phase II, community-based randomized clinical explanatory trial to test the efficacy of a medically tailored meal (MTM) interventions for adults with food insecurity and T2DM…
- Trial name
- FAME-D (NCT04828785)
- Testing
- MTM, Food Subsidy
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- University of North Carolina, Chapel Hill
Type 2 Diabetes
Trancriptomics and Lipidomics of Epicardial Ectopic Fat
Cohort studies have shown that patients with obesity associated with metabolic abnormalities (metabolically unhealthy obesity) have an accumulation of ectopic fat deposits (EDF) linked to subcutaneous adipose tissue dysfunction.
- Trial name
- GENTLE (NCT06590415)
- Testing
- Subcutaneous adipose tissue biopsy, Blood sampling
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Stress, Diabetes Mellitus, Type 2
Decreasing Stress in Diabetes
The purpose of this study is to conduct a randomized controlled trial (RCT) to determine the effects of an online 6-month Mindfulness-based stress reduction (MBSR) intervention compared to an active control Stress Management…
- Conditions
- Stress, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- De-Stress (NCT04016415)
- Testing
- Mindfulness Based Stress Reduction, Stress Management Education
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- Milton S. Hershey Medical Center
Type 2 Diabetes Mellitus
Cholesterol Metabolism and Lipid Transfer in Diabetes
The diabetic dyslipidemia is one of the most important risk factor in the development of coronary artery disease. The low density lipoprotein (LDL)-like nanoemulsions is being used to study the clearance of cholesteryl ester and…
- Trial name
- NCT01010035
- Testing
- Plasma kinetic study
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Type II Diabetes, Diabetes Mellitus
Diabetes Mellitus Community Based Screening in Minority Populations
The purpose of the type II diabetes (T2D) screening study is to improve diabetes care in minority communities by identifying undiagnosed and uncontrolled T2D patients, as well as help patients without a regular primary care…
- Trial name
- NCT01591525
- Testing
- Education on risk factors for Type II Diabetes, Education on Type II Diabetes, Education on regular visits to a Primary Care Provider
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ethnicity and Disease Community Empowerment Center
Diabetes, Obesity
Efficacy of tDNA Care on Weight Loss and Metabolic Outcomes in Patients With Overweight, Obesity and Type 2 Diabetes
The aim of this study was to investigate the effectiveness of structured lifestyle intervention following a transcultural diabetes nutrition algorithm (tDNA) care compared to usual diabetes care in patients with overweight…
- Trial name
- NCT03881540
- Testing
- tDNA-MI group, tDNA-CC group, UC group
- Where
- Malaysia
- Volunteers
- 230 people
- Sponsor
- IMU University, Malaysia
Diabetes Mellitus, Type 2, Diabetic Nephropathy
Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants With Diabetic Nephropathy
The goal of this study is to assess whether canagliflozin has a renal and vascular protective effect in reducing the progression of renal impairment relative to placebo in participants with type 2 diabetes mellitus (T2DM), Stage…
- Trial name
- CREDENCE (NCT02065791)
- Testing
- Canagliflozin
- Where
- 575 sites in United States, Argentina and 32 more
- Volunteers
- 4,401 people
- Sponsor
- Janssen Research & Development, LLC
Uncontrolled Diabetes, Diabetes Mellitus Type 2
Efficacy of Diacerein Supplementation on Interleukin-1β, Hs-CRP, TNF-α Levels and Glycemic Control in Uncontrolled Type 2 Diabetes Mellitus Patients at Dr. Mohammad Hoesin General Hospital Palembang
The goal of this clinical trial is to learn if diacerein supplementation can help improve inflammation and glycemic control in adults with uncontrolled type 2 diabetes. It will also study the safety and tolerability of diacerein.
- Trial name
- NCT06912035
- Testing
- Diacerein 50 mg Capsule
- Where
- Indonesia
- Volunteers
- 34 people
- Sponsor
- Universitas Sriwijaya
Prediabetes
A Lifestyle Change Program to Prevent Type 2 Diabetes
The purpose of this study was to evaluate the effect of a diabetes prevention program provided by nurse practitioners in primary care to adults at risk for diabetes.
- Trial name
- NCT00886340
- Testing
- Enhanced standard care, Lifestyle counseling
- Volunteers
- 58 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes, Obesity
Remission of Diabetes With Lifestyle Intervention for Malaysian Patients
This study aims to evaluate the effectiveness of structured lifestyle intervention to induce remission of Type 2 Diabetes Mellitus (T2DM) among Malaysian adults.
- Trial name
- ReDiaL-MY (NCT07270068)
- Testing
- Total Diet Replacement, Standard of Care
- Where
- 2 sites in Malaysia
- Volunteers
- 92 people
- Sponsor
- Winnie Chee Siew Swee
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.