Clinical trials: Diabetes Related Complications
Foot Ulcer, Diabetes
Improving Diabetic Foot Ulcers With Atorvastatin
Lower limb complications are a substantial matter in the diabetic population and studies show that the annual incidence of foot ulcers ranges from 1.0-4.1% while the cumulative lifetime incidence is approximately 15%.
- Trial name
- NCT00134550
- Testing
- Atorvastatin (10 mg or 80 mg)
- Where
- 2 sites in Norway
- Volunteers
- 13 people
- Sponsor
- Asker & Baerum Hospital
Type 1 Diabetes
Reactive Oxygen Species in the Pathogenesis of Diabetic Complications
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy and incipient nephropathy in these models.
- Trial name
- NCT00703989
- Testing
- benfotiamine, α-lipoic acid
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Diabetic Nephropathy, Anemia
Roxadustat Versus Erythropoietin for Anaemia Treatment in Diabetic Nephropathy
This randomized controlled trial compared roxadustat with erythropoietin for the treatment of anaemia in patients with diabetic nephropathy and chronic kidney disease.
- Conditions
- Diabetic Nephropathy, Anemia, Chronic Kidney Disease
- Trial name
- NCT07786168
- Testing
- Roxadustat, Erythropoietin
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Hanzla Arshad
Diabetes (DM), Prediabetes
Artificial-Intelligence-based Early Detection of Diabetic Retinopathy (FUNDUS AI)
Examination of individuals with prediabetes and established diabetes for early signs of diabetic retinopathy.
- Trial name
- FUNDUS AI (NCT07378891)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Diabetic Foot Ulcer
The Purpose of This Study is to Assess Clinical Efficacy and Safety of Berovenal® Intended to Promote Treatment and to Expedite Chronic Diabetic Foot Ulcer Healing
The goal of this clinical investigation is to evaluate clinical efficacy of medical device Berovenal® intended to promote treatment and to expedite healing of chronic diabetic foot ulcer in male or female subjects aged 18-85…
- Trial name
- NCT06584617
- Testing
- Berovenal®, NU-GEL Hydrogel with Alginate
- Where
- 9 sites in Germany, Poland
- Volunteers
- 66 people
- Sponsor
- VULM s.r.o.
Proteinuria
Safety and Pharmacokinetic Study of Subcutaneous ALXN1720 in Participants With Proteinuria
The primary objective of this study is to assess the impact of proteinuria on the pharmacokinetic (PK) of a single dose of ALXN1720 in participants with proteinuria.
- Trial name
- NCT05314231
- Testing
- ALXN1720
- Where
- 2 sites in South Korea
- Volunteers
- 13 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Diabetic Nephropathies
Sympathetic Nervous System Inhibition for the Treatment of Diabetic Kidney Disease
The purpose of this study is to determine whether moxonidine is effective in reducing urine albumin levels in patients with diabetic kidney disease.
- Trial name
- NCT01094769
- Testing
- Moxonidine
- Where
- Australia
- Volunteers
- 48 people
- Sponsor
- Baker Heart and Diabetes Institute
Diabetic Nephropathy, Proteinuria
Effect of Turmeric on Diabetic Nephropathy
The purpose of this study is to investigate whether turmeric is effective in improvement of diabetic nephropathy and in decrease in the amount of proteinuria and cytokine levels.
- Trial name
- NCT01015937
- Testing
- Turmeric extract, Angiotensin-converting enzyme (ACE) inhibitor + Angiotensin-II type 1 receptor (ATI) blocker
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shaheed Faghihi Hospital
Diabetic Foot Ulcers, Hyperbaric Therapy
Hyperbaric Oxygen Therapy and Angiogenesis in Diabetic Patients With Foot Ulcers
Diabetic foot ulcers are a major cause of morbidity and mortality, accounting for approximately two-thirds of all non-traumatic amputations performed in the United States.
- Conditions
- Diabetic Foot Ulcers, Hyperbaric Therapy, Angiogenesis
- Trial name
- NCT00475202
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Diabetic Kidney Alarm (DKA) Study
The overarching goals of this study are to determine whether tubular dysfunction (elevated urine sodium, bicarbonate and amino acids) and injury (elevated kidney injury molecule 1 [KIM-1], neutrophil gelatinase-associated…
- Trial name
- DKA (NCT03128229)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Colorado, Denver
Diabetic Retinopathy
Pilot Assessment of EyeArt as an Automated Diabetic Retinopathy Screening Tool
More than 29 million people in the US are living with diabetes, many of whom will develop diabetic retinopathy (DR) or diabetic eye disease (DED), the leading cause of vision loss and blindness in working-age adults.
- Trial name
- NCT03078231
- Testing
- Color fundus photography, Mydriatic Agent
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Eyenuk, Inc.
Insulin-Dependent Diabetes Mellitus 1
Prevalence of DRP and DME Among Type 1 Diabetics Treated With Long-term Intensified Insulin Therapy
This study is designed to evaluate the prevalence of different stages of diabetic retinopathy and diabetic macular edema among patients suffering from type 1 diabetes (DM1) for 5 to 25 years and have been treated with intensified…
- Trial name
- NCT03437551
- Testing
- cross-sectional observation
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Vista Klinik
Diabetic Kidney Disease, Diabetic Nephropathies
Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease
The Researchers will assess the safety, tolerability, dosing effect, and early signals of efficacy of intra-arterially delivered autologous (from self) adipose (fat) tissue-derived mesenchymal stem/stromal cells (MSC) in patients…
- Conditions
- Diabetic Kidney Disease, Diabetic Nephropathies, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT03840343
- Testing
- Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Lower Dose, Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Higher Dose
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Infection, Soft Tissue, Infection, Wound
Direct Antibiotic Delivery of Cefazolin Into Soft Tissue Infections Using Subcutaneous Injection and Ultrasonic Dispersion
This study focuses on a new drug delivery system (Direct Antibiotic Delivery) to treat soft tissue infections. In this study, cefazolin is delivered directly to the target tissues using subcutaneous injection of antibiotic…
- Conditions
- Infection, Soft Tissue, Infection, Wound, Cellulitis, Diabetic Foot Ulcer
- Trial name
- DAD (NCT01238276)
- Testing
- Cefazolin, Silberg Tissue Preparation System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sonescence, Inc.
Diabetes Mellitus, With Complications
Effects of Pulsatile Intravenous Insulin Therapy on Cardiac Disease in Patients With Diabetes
The purpose of this study is to determine if restoring normal metabolic function in patients with either type I or type II diabetes can improve the impact of the consequences of diabetic complications on heart disease in diabetic…
- Trial name
- NCT00539435
- Testing
- Intravenous Insulin on cardiac disease in diabetic pts
- Where
- United States
- Sponsor
- Florida Atlantic University
Diabetic Kidney Disease, Diabetic Nephropathies
Clinical Outcome of Vinpocetine in Diabetic Nephropathy
The goal of this controlled, randomized, clinical trial is to evaluate the effect of vinpocetine on clinical outcomes on the diabetic nephropathy patients.
- Trial name
- NCT06441591
- Testing
- Vinpocetine, Standard Therapy
- Where
- 2 sites in Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Pressure Ulcer, Diabetic Foot Ulcer
An Open, Non-comparative, Multicenter Investigation to Evaluate the Safety and Performance of Exufiber Ag+, a Gelling Fiber Silver Dressing, When Used in Medium to High Exuding Chronic Wounds
An open, non-comparative, multicenter investigation to evaluate the safety and performance of Exufiber Ag+, a gelling fiber silver dressing, when used in medium to high exuding chronic wounds
- Conditions
- Pressure Ulcer, Diabetic Foot Ulcer, Venous Leg Ulcer
- Trial name
- NCT05494450
- Testing
- ExufiberAG+
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Molnlycke Health Care AB
Age-Related Macular Degeneration, Diabetic Retinopathy
Defining Retinal Structures Using Hyperspectral Retinal Imaging
This study evaluates hyperspectral retinal imaging as a novel, non-invasive imaging technique to characterise retinal and optic nerve structures in healthy individuals and patients with eye disease.
- Conditions
- Age-Related Macular Degeneration, Diabetic Retinopathy, Glaucoma, Retinal Diseases
- Trial name
- NCT07555574
- Testing
- Hyperspectral camera
- Where
- Australia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Center for Eye Research Australia
Microalbuminuria, Diabetic Nephropathy
Chicken-Diet vs. Enalapril to Reduce Albuminuria
Diabetic nephropathy (DN) is a chronic diabetic complication and affects up to 40% of patients. The first line treatment for DN is angiotensin blockers drugs that are used to reduce the protein concentration in urine.Previous…
- Trial name
- NCT00484068
- Testing
- enalapril, chicken diet
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Type 2 DM, Type 2 DM /Diabetic Nephropathy
Urinary Proteomics to Guide Early Intervention to Prevent Complications in Type 2 Diabetes - a Feasibility Study
Title: Body fluid proteome SIGnatures for persoNALised intervention to prevent cardiovascular and renal complications in diabetes.
- Conditions
- Type 2 DM, Type 2 DM /Diabetic Nephropathy, Albuminuria
- Trial name
- SIGNAL (NCT06954090)
- Testing
- Semaglutide, 1.34 mg/mL, Finerenone Oral Tablet, Dapagliflozin (DAPA)
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Steno Diabetes Center Copenhagen