Clinical trials: Diabetes Related Complications
Diabetic Foot, Therapeutics
Clinical Observation and Mechanism Study of Yunnan Baiyao in Different Stages of Diabetic Foot
Yunnan Baiyao has been treating all kinds of wounds for 120 years, but the evidence of Evidence-based medicine that is truly convincing is insufficient, making its best application method unclear.
- Trial name
- NCT06062576
- Testing
- Yunnan Baiyao
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Gestational Diabetes, Glucose Tolerance Impaired in Pregnancy
Food Product for Management of Gestational Diabetes
The goal of this pilot open pre-post clinical trial is to test effects of a wholegrain product in patients with newly diagnosed gestational diabetes.
- Conditions
- Gestational Diabetes, Glucose Tolerance Impaired in Pregnancy, Glucose Tolerance Impaired, Pregnancy Related
- Trial name
- NCT05917808
- Testing
- Ready-to-eat wholegrain porridge
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stoffwechselzentrum Rhein - Pfalz
Diabetes Mellitus, Diabetic Foot Ulcer
Contribution of Psychological Factors in the Healing of the Diabetic Foot Ulcer
Diabetic foot ulcers (DFU) are one of the most serious complications of diabetes and can lead to amputations in 85% of cases, resulting in physical, psychological, family, social and economic consequences.
- Trial name
- NCT04698720
- Testing
- Muscle Relaxation with Guided Imagery, Hypnosis with Guided Imagery, Neutral Guided Imagery
- Where
- 3 sites in Portugal
- Volunteers
- 69 people
- Sponsor
- University of Minho
Early Renal Dysfunction in Diabetes, Diabetic Nephropathy
MMP-9/NGAL Modulation by Piper Crocatum in Early Diabetic Nephropathy
The goal of this clinical trial is to determine whether functional foods made with Piper crocatum (red betel leaf) can reduce kidney damage markers in people with diabetes who have early kidney dysfunction.
- Conditions
- Early Renal Dysfunction in Diabetes, Diabetic Nephropathy, Inflammation and Oxidative Stress in Diabetic Patients
- Trial name
- MMP-9/NGAL (NCT06676124)
- Testing
- Piper crocatum Extract Cookie
- Where
- Indonesia
- Volunteers
- 387 people
- Sponsor
- Hasanuddin University
Diabetic Retinopathy, Diabetes Mellitus, Type 2
Confronting Unequal Eye Care in Pennsylvania
Pt. 1 Diabetic retinopathy is a common eye condition among diabetic adults and can lead to severe vision impairment and even blindness.
- Conditions
- Diabetic Retinopathy, Diabetes Mellitus, Type 2, Glaucoma
- Trial name
- NCT01179555
- Testing
- Behavioral Activation, Supportive Therapy
- Where
- 3 sites in United States
- Volunteers
- 206 people
- Sponsor
- Wills Eye
Diabetes Mellitus, With Complications
Effects of Pulsatile Insulin Delivery on Diabetic Neuropathy in Patients With Types 1 and 2 Diabetes Mellitus
Diabetic neuropathy is a progressive complication causing serious problems in 25-40% of diabetic patients. Anecdotal reports have indicated improvement with pulsatile IV insulin in patients otherwise resistant to all conventional…
- Trial name
- NCT00228891
- Testing
- Effect of Pulsatile IV insulin on diabetic neuropathy
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Florida Atlantic University
Painful Diabetic Neuropathy
Eslicarbazepine Acetate as Therapy in Diabetic Neuropathic Pain
The primary objective of this study is to assess the efficacy of Eslicarbazepine acetate (ESL) as therapy in subjects with Diabetic Neuropathic Pain (DNP) over a 15 week treatment phase.
- Trial name
- NCT01129960
- Testing
- Eslicarbazepine acetate (BIA 2-093)
- Where
- Portugal
- Volunteers
- 332 people
- Sponsor
- Bial - Portela C S.A.
Macular Degeneration, Diabetic Retinopathy
Iopidine to Decrease Intraocular Pressure Rise After Injections
This is a prospective, randomized, controlled, open-label, single-site investigator-initiated clinical trial. A total of 120 participants will be randomized in a 1:1 ratio either to receive one drop of apraclonidine 1% ophthalmic…
- Conditions
- Macular Degeneration, Diabetic Retinopathy, Retinal Vein Occlusion, Glaucoma
- Trial name
- NCT07891910
- Testing
- Apraclonidine 1.0% ophthalmic solution
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Retina Consultants of Delmarva
Wound, Foot, Diabetic Foot Ulcer (DFU)
CAMPR-II RWE TRIAL: A Saline-hydrated Allogeneic Dual-layer Amniotic Membrane Product or a Synthetic, Resorbable Polymeric Wound Matrix to a Coarsened Exact Matched Retrospective Control Cohort of Hard to Heal DFUs and VLUs
CAMPR-II Trial: A multicenter hybrid platform trial comparing the effects of a prospective cohort treated with a saline-hydrated allogeneic dual-layer amniotic membrane product or a synthetic, resorbable polymeric wound matrix to…
- Conditions
- Wound, Foot, Diabetic Foot Ulcer (DFU), Venus Leg Ulcer
- Trial name
- CAMPR-II (NCT07701590)
- Testing
- Microlyte®, IP 1: Membrane Wrap - Hydro
- Where
- 7 sites in United States
- Volunteers
- 147 people
- Sponsor
- Capsicure, LLC
Diabetic Nephropathy
Effect of Pyridorin in Patients With Diabetic Nephropathy
The primary objective of the study is to evaluate the safety and tolerability of Pyridorin (pyridoxamine dihydrochloride) 50 mg given orally twice daily in patients with diabetic kidney disease.
- Trial name
- NCT00320060
- Testing
- Pyridorin (pyridoxamine dihydrochloride)
- Volunteers
- 128 people
- Sponsor
- BioStratum
Diabetic Foot Ulcer
Bioburden Reduction of Diabetic Foot Ulcer
Study to see if a laser can get rid of bacateria called MRSA in your diabetic ulcer
- Trial name
- NCT00776854
- Testing
- Noveon laser
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nomir Medical Technologies
Diabetic Neuropathies
Effect of Spinal Cord Stimulation in Painful Diabetic Polyneuropathy
Rationale: Diabetic neuropathy is one of the most common complications of Diabetes Mellitis (DM). Pain is a common symptom of diabetic neuropathy, affecting 11-34% of patients suffering form DM.
- Trial name
- SCS (NCT00802022)
- Testing
- spinal cord stimulation
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht University Medical Center
Albuminuria, Diabetes Mellitus, Type 2
Stress-relief Management for Treatment of Late Complications in Type 2 Diabetes
The purpose of this study is to determine whether a structured stress relief management program can prevent the progression of late diabetic complications in patients with type 2 diabetes.
- Conditions
- Albuminuria, Diabetes Mellitus, Type 2, Diabetes Complications
- Trial name
- HEIDIS (NCT00263419)
- Testing
- Mindfulness Based Stress Reduction
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- Heidelberg University
Diabetes Mellitus, Diabetic Neuropathy
Anodyne Therapy in Diabetic Sensory Neuropathy
The purpose of this research study is to determine if the use of a series of the Anodyne Therapy System in-home treatments over a 90-day period will improve peripheral sensation and quality of life in persons with diabetes…
- Trial name
- NCT00120341
- Testing
- Anodyne Therapy System
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Scott and White Hospital & Clinic
Diabetic Foot Ulcers
Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Diabetic Foot Ulcers
The purpose of this study is to determine the systemic exposure of Granexin® gel after topical application to human subjects' diabetic foot ulcers.
- Trial name
- NCT02652754
- Testing
- Granexin® gel
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Xequel Bio, Inc.
Diabetic Macular Edema
A Multicenter Study to Compare Multiple Doses of Intravitreal Microplasmin Versus Sham Injection for Treatment of Patients With Diabetic Macular Edema (DME)
A multicenter study to compare multiple doses of intravitreal microplasmin for non-surgical PVD induction for treatment of patients with DME.
- Trial name
- MIVI-II (NCT00412451)
- Testing
- ocriplasmin
- Where
- 15 sites in Belgium, Germany and 4 more
- Volunteers
- 51 people
- Sponsor
- ThromboGenics
Diabetic Macular Edema, Age-Related Macular Degeneration
Effect of Corona Virus on Intravitreal Injections
During pandemic of corona virus, patients compliance may be affected. We aim to study the factors lead to unregulated visits and its implications on the final visual outcome.
- Conditions
- Diabetic Macular Edema, Age-Related Macular Degeneration, Choroidal Neovascularization, Myopic Choroidal Neovascularisation
- Trial name
- NCT05494775
- Testing
- Anti-vascular endothelial growth factors (Anti-VEGFs)
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Benha University
Diabetes, Diabetic Macular Oedema
Trial of Switching Between Intravitreal Bevacizumab (Avastin®)& Intravitreal Dexamethasone (Ozurdex™) for Persistent Diabetic Macular Oedema
The specific aim of the study is to test the following hypothesis: That switching between treatments from bevacizumab to Ozurdex or vice versa in eyes with diabetic macular oedema with no or incomplete response from one therapy…
- Conditions
- Diabetes, Diabetic Macular Oedema, Diabetic Macular Edema, Diabetic Retinopathy
- Trial name
- SwitchDMO (NCT01787669)
- Testing
- Avastin (Bevacizumab), Ozurdex (dexamethasone)
- Where
- 3 sites in Australia
- Volunteers
- 19 people
- Sponsor
- University of Sydney
Diabetic Foot, Diabetes Mellitus Type 2
The Effect of Web-Based and Face-to-Face Education Based on the Health Promotion Model on Foot Care Behavior in Individuals With Type 2 Diabetes
Diabetic foot is a complication that develops difficult-to-heal foot wounds, reduces the quality of life of individuals with diabetes, causes loss of productivity, and causes economic burden due to the repetition of the problem…
- Trial name
- NCT06780631
- Testing
- Web-based diabetic foot education based on health promotion model, Face to face diabetic foot education based on health promotion model
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Marmara University
Diabetic Nephropathy
An Investigation on the Effect of Candesartan on Early Diabetic Nephropathy
It is well understood that hypertension, dyslipidemia, and diabetes mellitus are the major risks of chronic kidney disease. Current guidelines recommend screening kidney estimated glomerular filtration function with serum…
- Trial name
- NCT01273675
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
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