Clinical trials: Diabetes Treatment (Pilot Study)
Skin Ulcer
Bio-ConneKt Wound Dressing for Treatment of Chronic Leg Wounds: A Pilot Study
The purpose of this study is to assess the performance of the bio-ConneKt™ wound dressing and compare its performance with the standard of care at NFRMC Wound Therapy Services, for the treatment of chronic foot/leg ulcers…
- Trial name
- NCT02309684
- Volunteers
- 20 people
- Sponsor
- MLM Biologics Inc.,
PreDiabetes
Effect of Melatonin and Metformin on Glycemic Control Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes
Melatonin is a hormone that regulates the circadian cycle in addition to having an antioxidant effect. Patients with prediabetes state, has a deregulation of glucose metabolism and an overproduction of reactive oxygen species…
- Trial name
- NCT03848533
- Testing
- melatonin, metformin
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- University of Guadalajara
Chronic Kidney Diseases, Diabetes Mellitus
Treating Patients With Renal Impairment and Altered Glucose MetAbolism With TherapeutIc Carbohydrate Restriction and Sglt2-Inhibiton - a Pilot Study
This randomized controlled trail will evaluate the efficacy and safety of a simultaneous therapeutic carbohydrate restriction and treatment with the Sodium-Glucose-Transporter-2-Inhibitor dapagliflozin in comparison to the…
- Conditions
- Chronic Kidney Diseases, Diabetes Mellitus, PreDiabetes, Overweight and Obesity
- Trial name
- NCT06094231
- Testing
- Therapeutic carbohydrate restriction combined with an SGLT-2-Inhibitor
- Where
- Austria
- Volunteers
- 4 people
- Sponsor
- Department of Nephrology Clinic Ottakring Vienna
Human Immunodeficiency Virus Infection, Diabetes Mellitus
Pilot Study of Bydureon to Treat Diabetes in HIV-infected Adults
This pilot study will evaluate the effects of the anti-diabetic drug Bydureon (exenatide extended-release formulation) on blood sugar levels and serum markers of inflammation in a cohort of 12 HIV-infected adults on combination…
- Trial name
- NCT01791465
- Testing
- extended-release exenatide
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University
Diet, Healthy, Health Behavior
A Food As Medicine Approach to Address Food Insecurity in Rural North Carolina
Increasing fruit and vegetable (FV) intake, and reducing saturated fat, salt, and added sugar are central lifestyle recommendations in the Dietary Guidelines for Americans to prevent chronic disease.
- Conditions
- Diet, Healthy, Health Behavior, Blood Pressure, Diabetes Mellitus Risk
- Trial name
- NCT07221045
- Testing
- PhytoRx Families: A Pilot Test to Address Food Security in Rural North Carolina
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Type 1 Diabetes
Effects of Metreleptin in Type 1 Diabetes Mellitus
This study will add leptin therapy to the current insulin therapy of Type 1 Diabetics with the aim of lowering the total insulin requirements and suppressing the steep fluctuations typically associated with Type 1 Diabetes.
- Trial name
- NCT01268644
- Testing
- Leptin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Texas Southwestern Medical Center
Type 2 Diabetes, Gastric Banding
Combinatorial Therapy for Peristent Type 2 Diabetes After Gastric Banding
The purpose of this study is to determine whether addition of 1 or 2 medicines after gastric banding can improve remission of type 2 diabetes.
- Trial name
- NCT01597531
- Testing
- Liraglutide, Orlistat, Liraglutide + Orlistat
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- East Carolina University
PreDiabetes, Insomnia
Cognitive Behavioral Sleep Intervention for Prevention of Type 2 Diabetes
The proposed study aims to evaluate if improving sleep could enhance the intensive lifestyle intervention for improving weight loss and glycemic control in prediabetic individuals who have insomnia with short sleep duration.
- Conditions
- PreDiabetes, Insomnia, Sleep Deprivation
- Trial name
- NCT04457440
- Testing
- Intensive Lifestyle Intervention, Intensive Lifestyle Intervention enhanced with Cognitive Behavioral Sleep Intervention
- Where
- 2 sites in Hong Kong
- Volunteers
- 36 people
- Sponsor
- The University of Hong Kong
Non-healing Wound, Diabetic Foot Ulcer
Use of AC5® Advanced Wound System in the Treatment of Diabetic Foot Ulcers
The purpose of this clinical evaluation is to collect and compare outcomes data from patients with UT 1A diabetic foot ulcers treated with 510K FDA cleared, commercially available self-assembling peptide, AC5®Advanced Wound…
- Trial name
- NCT06028386
- Testing
- AC5® Advanced Wound System, Fibracol Plus Collagen Dressing
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Arch Therapeutics
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Diabetes Mellitus, Diabetic Neuropathic Foot Ulcer
Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers
It's a pilot prospective opened multicentric randomised study. We measure the efficiency and the safety of a new concept of off-loading shoe (SANIDIAB) compared with an old one (BAROUK) to treat chronic diabetic foot ulcer which…
- Trial name
- SANIBA (NCT01586481)
- Testing
- SANIDIAB, BAROUK
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Foot Ulcers
Omnigen DFU Pilot Study
The Omnigen Pilot study aims to provide an evidence base for Omnigen as a treatment for Diabetic Foot Ulcers (DFU). It aims to achieve this by tailoring a regenerative therapy used for ocular surface repair to provide proactive…
- Trial name
- NCT03483467
- Testing
- Omnigen, Dummy Packaging
- Where
- 2 sites in United Kingdom
- Volunteers
- 31 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Type 2 Diabetes Mellitus, Hyperglycemia
Ex Vivo Immunotherapy for Hyperglycemia in Type 2 Diabetes Mellitus
Diabetes mellitus type 2 is a long-term metabolic disorder that is primarily characterized by insulin resistance, relative insulin deficiency and hyperglycemia.
- Trial name
- DISC (NCT02169531)
- Testing
- ex vivo Activated Immune Cells
- Where
- 2 sites in China
- Volunteers
- 25 people
- Sponsor
- B & Y Technologies
Diabetes Mellitus, Ischemic Heart Disease
Allopurinol in Diabetes Mellitus and Multivessel Coronary Artery Disease
Atherosclerosis is a progressive disease of the arterial wall, arising from the combination of endothelial dysfunction and inflammation. This link is exacerbated in diabetic patients.
- Conditions
- Diabetes Mellitus, Ischemic Heart Disease, Multi Vessel Coronary Artery Disease
- Trial name
- NCT03700645
- Testing
- Allopurinol
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Diabetic Foot Ulcers
A Pilot Study of the Provant Therapy System in Subjects With Diabetic Foot Ulcers
The objective of this study is to compare the reduction in wound surface areas between patients with diabetic ulcers utilizing Provant's pulsed radio frequency energy therapy (PRFE) as an adjunct to standardized basic wound care…
- Trial name
- NCT00761176
- Testing
- The Provant Therapy System
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Regenesis Biomedical, Inc.
Gestational Diabetes, Gestational Diabetes Mellitus in Pregnancy
Treatment Satisfaction and Treatment Adherence of Diabetic Women Through the Use of FGM
The incidence of gestational diabetes mellitus (GDM), a glucose tolerance disorder during pregnancy, is increasing. In Germany, it reached 8.58 % in 2019. Standardized treatment has reduced complications for mother and child.
- Trial name
- Flash (NCT05924724)
- Testing
- Flash Glucose Monitoring
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Type 2 Diabetes
The Effect and Safety of a Novel CGM-Based Titration Algorithm for Basal Insulin in T2DM Participants.
The goal of this clinical trial is to compare the effect of a continuous glucose monitor (CGM) based titration algorithm to standard titration by self-monitoring blood glucose (SMBG) in participants with Type 2 Diabetes already…
- Trial name
- CGM-DTx (NCT06111508)
- Testing
- Continuous Glucose Monitoring (CGM)-based titration algorithm implemented in DiAs
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), CKD Stage 3
Plant-Focused Nutrition in Patients With Diabetes and Chronic Kidney Disease
In this pilot clinical trial, the investigators will recruit and randomize 120 patients with diabetes mellitus and chronic kidney disease (CKD/DM) stages 3 to 5 to a patient-centered and flexible Plant-Focused Nutrition in…
- Conditions
- Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), CKD Stage 3, CKD Stage 4, CKD Stage 5
- Trial name
- PLAFOND (NCT05514184)
- Testing
- PLAFOND diet
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine
Diabetic Foot Ulcers, Diabetic Wound
The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot Ulcer
The aim of this study is to evaluate the chance of non-healing diabetic foot ulcers repair by improving the condition of lack of oxygen or hypoxia in the wound area caused by diabetes using methylene blue along with the use of…
- Trial name
- NCT05850611
- Testing
- Methylene Blue, Milk (control), Methylene Blue and Platelet-Rich Plasma-Fibrin Glue
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Mashhad University of Medical Sciences
Type 2 Diabetes Mellitus
Diabetes Mellitus Type 2 Basal Insulin Dosing Requirements Study
The main purpose of this study is to determine the number of daily basal insulin rate changes that are needed to achieve short-term near normal glucose control in insulin pump patients with type 2 diabetes
- Trial name
- NCT00874809
- Testing
- CGMS with an insulin pump using rapid acting insulin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Diabetes Care Center