Clinical trials: Diabetes Treatment (Pilot Study)
Type 1 Diabetes
Closed Loop Insulin Therapy in Type 1 Diabetics Based on Blood Microdialysis, Online Sensors and an eMPC Algorithm
The EU funded project CLINICIP (Closed Loop Insulin Infusion for Critically Ill Patients) aims to develop a low-risk monitoring and control device which allows maintaining metabolic control in intensive care units.
- Trial name
- NCT00535483
- Where
- Austria
- Volunteers
- 4 people
- Sponsor
- Medical University of Graz
Diabetic Macular Oedema
Noctura400 Treatment for Diabetic Retinopathy (CANDLE)
In this study, the investigators aim to use light masks (Noctura 400) to test the hypothesis that preventing the dark adaptation and associated hypoxia of the rods in the eye could in turn prevent or halt the progression of…
- Trial name
- CANDLE (NCT02207712)
- Testing
- Noctura 400 Eye Mask, Ranibizumab
- Where
- 18 sites in United Kingdom
- Volunteers
- 252 people
- Sponsor
- PolyPhotonix Medical
Cystic Fibrosis-related Diabetes, Cystic Fibrosis
SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes
This will be a placebo-controlled, randomized, double blind, crossover study with a 4 week wash out period. Collect pilot data on the safety, tolerability, and feasibility of empagliflozin therapy in overweight/obese patients…
- Trial name
- NCT06149793
- Testing
- Empagliflozin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Hyperbaric Oxygen Therapy, Diabetic Foot Ulcer
Short Duration Hyperbaric Oxygen Therapy to Improve HbA1c, Leukocyte, and Serum Creatinine
The investigators want to evaluate the short duration HBOT can improve glycohemoglobin (HbA1c) levels, leukocyte count, and serum creatinine levels in patients with DFU (diabetic foot ulcer) Wagner 3-4.
- Conditions
- Hyperbaric Oxygen Therapy, Diabetic Foot Ulcer, Type II Diabetes Mellitus
- Trial name
- NCT03615755
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Volunteers
- 30 people
- Sponsor
- Hendry Irawan
Cataract, Diabetes Mellitus Type 2
Role of Metformin in Posterior Capsule Opacification
Determination of concentrations of systemically applied metformin in human lens capsule and its ability to lower the proliferation rate of human lens epithelial cells in vitro.
- Trial name
- NCT07176338
- Testing
- Blood and lens capsule samples for PK testing
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Diabetes Mellitus Type II
Investigation of the Effect of E.-Coli-Nissle as Supporting Therapy to Standard Care of Diabetes Mellitus Type II
This is a pilot study to investigate the effect of e.-coli-nissle as supporting therapy to antidiabetic standard care in patients with diabetes mellitus type II
- Trial name
- PUNiDIA (NCT02144948)
- Testing
- e.-coli-nissle
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- GWT-TUD GmbH
Post-Intensive Care Syndrome (PICS), Critical Illness Recovery
I-WEAR: Evaluating Wearables and Health Summaries in ICU Survivors
This pilot study investigates the use of wearable health technology and bi-weekly digital health summaries in patients recovering from intensive care.
- Conditions
- Post-Intensive Care Syndrome (PICS), Critical Illness Recovery, Coronary Artery Disease
- Trial name
- I-WEAR (NCT07035106)
- Testing
- Wearable Health Monitoring, Digital Health Summary and Lifestyle Counseling
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Ludwig Boltzmann Gesellschaft
Diabetic Foot Ulcer
A Study Measuring the Effectiveness of Combined Modulated Ultrasound and Electric Current Stimulation as an Adjunctive Treatment in Treating Diabetic Foot Ulcers
The study aims to investigate if combined modulated ultrasound and electric current stimulation (CUSECS) is an effective adjunctive treatment to use to treat diabetic foot ulcers when compared against usual care.
- Trial name
- NCT03458286
- Testing
- BRH-A2 wound healing device
- Volunteers
- 50 people
- Sponsor
- Royal College of Surgeons, Ireland
Diabetic Gastroparesis
Continuous Glucose Monitoring and Insulin Pump Therapy in Diabetic Gastroparesis
A pilot study to assess the safety, feasibility, and potential (uncontrolled) efficacy of continuous glucose monitoring (CGMS) in conjunction with an insulin pump to improve glycemic control for treatment of type 1 and type 2…
- Trial name
- GLUMIT-DG (NCT01030341)
- Testing
- CGMS and insulin pump
- Where
- 7 sites in United States
- Volunteers
- 45 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Diabetes
Evaluation of Neurodevelopmental Trajectories in Children According to the Glycemic Profile Associated With Early Treatment Using an Automated Delivery System in Children With Type 1 Diabetes
ore than half of all new cases of type 1 diabetes (T1D) are diagnosed within the first decade of life. It has been reported that early onset of this disease may be associated with a decline in cognitive performance in adulthood…
- Trial name
- PROCEDE (NCT06461065)
- Testing
- AIDS, Brain MRI
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Patients Who Consented to Undergo Laparoscopic Gastric Banding Surgery for Weight Loss and Consent to Participate in This studyBMI ≥35 kg/m2, Confirmed Type 2 Diabetes Treated With Oral Agents and/or Only Diet Therapy
A Pilot Study of Metabolic Effects of Omentectomy
PROTOCOL SUMMARY Type of Study: Pilot, randomized and single center trial Test Procedure: Omentectomy Aim 1. Determine the effect of omentectomy on 1) insulin sensitivity, 2) beta cell function and 3) plasma markers of…
- Conditions
- Patients Who Consented to Undergo Laparoscopic Gastric Banding Surgery for Weight Loss and Consent to Participate in This studyBMI ≥35 kg/m2, Confirmed Type 2 Diabetes Treated With Oral Agents and/or Only Diet Therapy, Age 18-64 Years
- Trial name
- OMT (NCT00565799)
- Testing
- Omentectomy, No intervention
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- NYU Langone Health
Peripheral Neuropathy, Type 1 Diabetes
Pilot Study to Determine Effects of Salsalate in Type 1 Diabetes and Painful Peripheral Neuropathy
This 12 week study will examine the effects of daily Salsalate treatment on markers of neuropathic pain and intra-epidermal nerve fiber density.
- Trial name
- SALP (NCT01480297)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Michigan
Type-2 Diabetes, Cardiovascular Diseases
Feasibility of a Preventive Program Against Lifestyle Related Diseases
The continuously increasing prevalence of cardiovascular diseases, type-2 diabetes, and COPD is a major health problem in developed countries and is mainly caused by an unhealthy lifestyle.
- Conditions
- Type-2 Diabetes, Cardiovascular Diseases, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT02797392
- Testing
- Lifestyle intervention
- Where
- 6 sites in Denmark, Norway and 1 more
- Volunteers
- 9,400 people
- Sponsor
- University of Southern Denmark
Diabetic Nephropathy
Acthar for Treatment of Proteinuria in Diabetic Nephropathy Patients
This Phase 2A study is an adaptive design pilot study investigating the efficacy and safety of daily Acthar administration in diabetic patients with nephropathy and proteinuria.
- Trial name
- NCT01601236
- Testing
- Repository Corticotropin Injection
- Where
- 10 sites in United States
- Volunteers
- 34 people
- Sponsor
- Mallinckrodt
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Semaglutide in CFRD
This open label, single arm pilot study, will examine the safety and tolerability of GLP-1RA semaglutide as an add-on therapy to insulin for overweight/obese adult patients with cystic fibrosis related diabetes (CFRD).
- Trial name
- NCT05788965
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Pulsatile Insulin Infusion Therapy in Patients With Type 1 and Type 2 Diabetes Mellitus
This study is an open label, prospective, randomised comparative, single center study. In the present study, the impact of a 12-week pulsatile insulin infusion therapy (PIT) with Humulin R 100 from
- Trial name
- NCT04030091
- Testing
- 3 hours humulin R 100 IU/mL PIT, 2 hours humulin R 100 IU/mL PIT
- Where
- 2 sites in United States, Germany
- Volunteers
- 24 people
- Sponsor
- Sciema UG
Diabetes Mellitus, Insulin-Dependent
Insulin Pump Therapy in Adolescents With Newly Diagnosed Type 1 Diabetes (T1D)
Within 4 weeks after diagnosis of type 1 diabetes, 10 subjects (pubertal males, 12-17 years old) will be randomized to either receive multiple daily injection (MDI) using Lantus insulin, or continuous subcutaneous insulin…
- Trial name
- NCT00357890
- Testing
- Insulin pump therapy, Multiple daily injections using insulin glargine + rapid acting analog
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nemours Children's Clinic
PreDiabetes, Lifestyle, Healthy
Study of a Diabetes Prevention Patient Activation Clinical Decision Support Tool
The investigators overarching goal is to increase the percentage of patients engaging in diabetes prevention activities to reduce the incidence of diabetes.
- Conditions
- PreDiabetes, Lifestyle, Healthy, Activation, Patient
- Trial name
- NCT06358261
- Testing
- Diabetes Prevention Patient Activation Clinical Decision Support Tool
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Type 2
RF Vapor Ablation Retreatment of Duodenal Mucosa in Non-responders With Type-2 Diabetes Mellitus
The purpose of this study is to test the hypothesis that re-treatment of the duodenal mucosa with RF vapor ablation will result in improvement in glycemic parameters, without complications (bleeding/ stricture / perforation)…
- Trial name
- NCT06724822
- Testing
- RF Vapor Ablation
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- Aqua Medical, Inc.
Cystic Fibrosis Related Diabetes, Pancreatic Insufficiency
Pilot and Feasibility Study for the Treatment of Pre-diabetes in Patients With Cystic Fibrosis
The purpose of this study is to provide the necessary data and experience to design a larger, full scale clinical trial to determine if a certain medicine (repaglinide), which increases the amount of insulin secreted by the…
- Trial name
- NCT00763412
- Testing
- repaglinide
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Arbelaez, Ana Maria