Clinical trials: Diabetes Treatment (Pilot Study)
Type 2 Diabetes
Laparoscopic Bariatric Surgery to Treat Type 2 Diabetes in Obese Patients
A large number of research studies on people who were morbidly obese (extremely overweight), and had bariatric surgery (anti-obesity surgery) have shown that patients who were diabetic before surgery often experienced significant…
- Trial name
- NCT00428571
- Testing
- laparoscopic gastric bypass surgery, laparoscopic adjustable gastric banding, Intensive Medical Management
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Hamilton Health Sciences Corporation
New Onset Type 1 Diabetes Mellitus
A Pilot Study to Determine the Safety of Campath-1H (Anti-CD52 Antibody) Therapy in Newly Diagnosed Subjects With Type 1 Diabetes Mellitus
The rationale for the study is to determine if Campath-1H can be used in patients recently diagnosed with type I DM, to induce a state of immunological unresponsiveness such that subjects can safely preserve beta cell mass and…
- Trial name
- NCT00214214
- Testing
- Campath 1H® (Alemtuzumab)
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Diabetes Mellitus, Type 2
Cynara Scolymus Extract for Treatment of Diabetes Mellitus Type 2
Edible parts of the artichoke plant (Cynara cardunculus, Cynara scolymus) are traditionally known in folk-medicine for lipid lowering and choleretic effects. Furthermore, antidiabetic effects are described.
- Trial name
- NCT04233658
- Testing
- Cynara Scolymus
- Volunteers
- 20 people
- Sponsor
- Stefan Fischli
Checkpoint Inhibitor, Pilot Study
Checkpoint Inhibitor Associated Diabetes Mellitus: Early Recognition and Treatment (CERT) Project: A Pilot Study
To find out if taking a drug called infliximab (the "study drug") is safe and effective in reversing insulin dependence in CIADM.
- Conditions
- Checkpoint Inhibitor, Pilot Study, Diabetes Melletus
- Trial name
- NCT07257068
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- M.D. Anderson Cancer Center
Light Chain Deposition Disease (LCDD or MIDD), Light Chain and Heavy Chain Deposition Disease (LHCDD or MIDD)
Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis
The goal of this clinical trial is to determine the toxicity and also the efficacy of a treatment that includes the following treatment: Two medications, bortezomib and dexamethasone (or BD), followed by autologous stem cell…
- Conditions
- Light Chain Deposition Disease (LCDD or MIDD), Light Chain and Heavy Chain Deposition Disease (LHCDD or MIDD), Monoclonal Immunoglobulin Deposition Disease (MIDD), Amyloidosis
- Trial name
- NCT01383759
- Testing
- Bortezomib/Dexamethasone (BD), Followed By Autologous STC & Maintenance Bortezomib/Dexamethasone
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Diabetes, Chemotherapy
Study on Glycemic Variations in Diabetic Patients Treated With Chemotherapy: Benefit of Continuous Interstitial Glucose Measurement
Over the last years, there has been a progressive increase in the prevalence of diabetes. Approximately 3.3 million French adults and approximately 425 million adults worldwide have been diagnosed with diabetes.
- Conditions
- Diabetes, Chemotherapy, Interstitial Glycemia, Freestyle
- Trial name
- ONCODIAB (NCT04315857)
- Testing
- interstitial glycaemia
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Overweight and Obesity, Pre Diabetes
Time Restricted EATing (TREAT) Pilot Study
The TREAT Pilot is a 3 months open-label pilot study to examine the effect of restricting the duration of eating (Time Restricted EATing) in metabolically unhealthy adults with overweight or obesity.
- Trial name
- NCT03956290
- Testing
- TREAT pilot intervention
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Columbia University
Type 2 Diabetes
Feasibility of Time-Restricted Eating in the Treatment of Type 2 Diabetes
The overall aim of this pilot study is to examine feasibility of a 12-week 10-hour time-restricted eating intervention in individuals with overweight or obesity and type 2 diabetes.
- Trial name
- RESET2pilot (NCT05375695)
- Testing
- Time-restricted eating
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Kristine Færch
Impaired Glucose Tolerance, Type2 Diabetes
Influence of Preprandial Metformin Administration on Carbohydrate Absorption
Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption.
- Trial name
- METTIME (NCT04018105)
- Testing
- Oral glucose tolerance test (OGTT) with or without metformin
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Type II Diabetes Mellitus
Application of Magnetic Fields as Adjunctive Treatment for Type II Diabetes
The purpose of this study is to see if using a device called the Resonator, that puts out a very low electromagnetic field, effects blood glucose and A1c levels in people with Type 2 Diabetes.
- Trial name
- NCT00863954
- Testing
- Resonator Device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- pico-tesla Magnetic Therapies, LLC
Diabetes Mellitus, Type 2
Lantus Effect on Myocardial Glucose Metabolism in T2
The primary objective of the present study is to assess changes of myocardial glucose uptake (MGU) during clamp studies using positron emission tomography (PET) scanning in patients with type 2 diabetes and idiopathic left…
- Trial name
- NCT00335465
- Testing
- Insulin glargine
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Sanofi
Chronic Hepatitis C
Retreatment of Chronic Hepatitis C Non-responders With Pegylated Interferon Alpha Plus Ribavirin Plus Pioglitazone
The aim of this study is to investigate the efficacy and safety of an insulin-sensitizer (Actos) added to a standard Pegasys/Copegus combination therapy of chronic hepatitis C in patients who have previously failed a…
- Trial name
- NCT00433069
- Testing
- Pioglitazone, Interferon Alfa-2a, Ribavirin
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University Hospital, Geneva
Type 1 Diabetes Mellitus
An Immunotherapy Vaccine (PIpepTolDC) for the Treatment of Patients With Type 1 Diabetes
This phase I trial investigates the side effects of PIpepTolDC vaccine in treating patients with type 1 diabetes who use insulin and don't have any other diabetes-related health complications.
- Trial name
- NCT04590872
- Testing
- Tolerogenic Dendritic Cell Vaccine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- City of Hope Medical Center
Diabetic Retinopathy
Pilot Study of Laser Photocoagulation Therapy for Diabetic Macular Edema
This study will compare the side effects of two laser treatments for diabetic macular edema, a common condition in patients with diabetes.
- Trial name
- NCT00069056
- Testing
- Laser Treatment
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- National Eye Institute (NEI)
Diabetes, Heart Failure
A Pilot Study: Metformin Therapy in Heart Failure Patients With Early Diabetes or at High Risk of Developing Diabetes (Pre-Diabetes)
The Ahmanson-UCLA Cardiomyopathy Center is conducting a clinical research study that will assess the use of the medication metformin to improve quality of life, exercise capacity, and improved outcomes in heart failure patients…
- Trial name
- NCT01573949
- Testing
- Metformin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, Los Angeles
Diabetes Mellitus, Type 2
Response To Oral Agents in Diabetes (ROAD)- Pilot Study
This proposal is to fund a pilot study to assess feasibility and refine methodology for an intended large Scotland wide study on Response to Oral Agents in Diabetes (ROAD).
- Trial name
- ROAD (NCT00780715)
- Testing
- Gliclazide MR, Sitagliptin, Pioglitazone
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Dundee
Diabetic Retinopathy
Sirolimus to Treat Diabetic Macular Edema
Objective: Diabetic macular edema (DME) is a frequent manifestation of diabetic retinopathy, a leading cause of blindness in the United States. The only proven treatment for DME is laser photocoagulation.
- Trial name
- SDME (NCT00711490)
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Type 1 Diabetes
Study the Feasibility of Permanent Use of inControl for the Treatment of Type 1 Diabetes
A new version of the DiAs artificial pancreas (AP) system has been developed in view of wide scale outpatient trials. Denominated as inControl , it includes improved user interface and communication modules while closed-loop…
- Trial name
- IDCLTraining (NCT02892604)
- Testing
- insulin pump to inControl AP platform
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Montpellier
Diabetes Mellitus Type 1
A Pilot Study of the Therapeutic Potential of Stem Cell Educator Therapy in Type 1 Diabetes
This is a prospective, single arm, open-label, single-center pilot study to assess the safety, feasibility, and efficacy of Stem Cell Educator therapy for the treatment of patients with Type 1 Diabetes.
- Trial name
- NCT02624804
- Testing
- Stem Cell Educator Therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Hackensack Meridian Health
Diabetes Mellitus, Type I, Program Evaluation
Evaluation of the Impact of a Therapeutic Education Program for Children With Type 1 Diabetes
The needs of children and teens with type 1 diabetes are very specific and different from the adults with type 1 diabetes. Many organizations such as the World Health Organization or the International Society for Pediatric and…
- Conditions
- Diabetes Mellitus, Type I, Program Evaluation, Therapeutic Education, Children
- Trial name
- PROGETE (NCT02970357)
- Testing
- DIAPASON Questionnaire, WHO-5
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace