Clinical trials: Diabetes Type 1
Type 1 Diabetes
A Trial Investigating the Accuracy of Continuous Glucose Monitor Systems ("Supersapiens" Abbott Libre Sense and Dexcom G6) During Exercise in People With Normal Glucose Tolerance
A two-phase, observational trial in an exercise laboratory and a prospective real-world setting to test the hypothesis that The Libre Sense Glucose Sport device has acceptable accuracy in people with normal glucose tolerance and…
- Trial name
- SuperComEx (NCT06034574)
- Testing
- Continuous glucose monitoring
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetes, Mellitus, Type 1
A Study About Patient Decision Aids Designed to Help Parents and Guardians in Canada Make Evidence-informed, Values-congruent Decisions About Screening Children for Type 1 Diabetes and Follow-up Decisions.
This study will design and test patient decision aids to help parents and guardians in Canada make decisions about screening their children for type 1 diabetes.
- Trial name
- NCT07317973
- Testing
- Web-based patient decision aid, Standard materials
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Laval University
Diabetes Mellitus, Type 1, Arrhythmia
Cardiovascular Effects of Exercise-related Hypoglycaemia in Patients With Type 1 Diabetes (Hypo Heart Exercise)
Patients with type 1 diabetes are recommended to perform at least 150 minutes of accumulated physical activity each week, however fear of hypoglycaemia is a well-known barrier to exercise in these patients.
- Trial name
- NCT04650646
- Testing
- Exercise-related hypoglycaemia, Hypoglycaemia under resting conditions
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Type1diabetes
IN Insulin in Type 1 Diabetes (T1D) Hypoglycemia Unawareness: Safety Only Phase
The purpose of this study is to determine how Humulin-R regular insulin affects the body's ability to feel low blood sugar (hypoglycemia) when delivered intranasally compared to placebo in subjects with Type 1 Diabetes (T1D) with…
- Trial name
- NCT04028960
- Testing
- Regular insulin (Humulin-R), intranasal route, SipNose intranasal device
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Diabetes Mellitus Type 1
Assessment of the Neurovascular Microcirculatory Response in Diabetes Type 1 Patients
This study aims to see whether or not the diabetes 1 patients have a neurovascular microcirculatory dysfunction using various microvascular tests which have been previously validated.
- Trial name
- NEURODIAB1 (NCT02538120)
- Testing
- Microvascular assessment
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Type I Diabetes
Epigenetic Modifications of Diabetes Mellitus Type I
This research is being done to find out if significant changes in blood glucose cause bad outcomes in patients with diabetes.
- Trial name
- NCT01623388
- Testing
- Oral glucose tolerance test for Phase I
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Diabetic Neuropathy
NIR- and Multifrequent Impedance Spectroscopy on the Skin in Type 1 Diabetes
The aim of the study is to examine the suitability to detect diabetic neuropathy using NIR and impedance.
- Trial name
- NIR (NCT01707979)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lise Tarnow
Type 1 Diabetes, Osteoporosis
Bone Health in Type 1 Diabetes
An increased skeletal fracture risk in diabetes has only recently been recognized. This human study is designed to elucidate the effect of Type 1 diabetes on bone remodeling and on structure.
- Trial name
- DMB (NCT00651196)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Creighton University
Diabetes Mellitus, Type 1
Postprandial Blood Glucose Control and Gastric Emptying in Type 1 Diabetes: Pathogenetic Factors and Therapeutic Options
This study evaluates the prevalence of gastric emptying (GE) in type 1 diabetic patients (DM1) free of chronic complications in comparison with a group of healthy control subjects.
- Trial name
- NCT02365740
- Testing
- gastric emptying test, gut hormones determination, Continuous Glucose Monitoring
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federico II University
Diabetes Mellitus, Type 1, Insulin
The Relationship Between Stage of Diabetic Retinopathy and Retinal Blood Flow in Patients With IDDM During Euglycemic Clamp
Impaired retinal blood flow has been implicated in the pathogenesis of diabetic retinopathy. Patel et al. (1992) showed that retinal blood flow increases with the level of diabetic retinopathy. Grunwald et al.
- Conditions
- Diabetes Mellitus, Type 1, Insulin, Retina, Regional Blood Flow
- Trial name
- NCT00814008
- Testing
- Insulin, Glucose
- Where
- Austria
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 1 Diabetes
Estrogen, Diabetes, and Endothelial Function
This study planned to learn more about women and how the drop in estradiol levels during menopause may affect their cardiovascular risk.
- Trial name
- EDEN (NCT04418908)
- Testing
- Cetrorelix acetate, 0.25 mg/day, Estradiol Patch, 0.025 Mg/24 Hours Weekly Transdermal Film, Extended Release
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type1diabetes
HIT on Hypoglycemic Risk in Type 1 Diabetes (T1D)
There is clear evidence that regular exercise improves wellbeing and reduces the risk of diabetes related complications in people with type 1 diabetes. However, many people with type 1 diabetes do not exercise regularly.
- Trial name
- NCT03598400
- Testing
- high intensity interval training, moderate intensity continous training
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Healthy
Glycemic and Insulinemic Responses of Low-Carbohydrate Snack Foods
The aim of this study is develop recipes containing CHO less than ICR, prepare new snacks alternatives that could be consumed without need for additional insulin doses, and evaluate the glycemic and insulinemic responses of these…
- Trial name
- NCT04175496
- Testing
- Blueberry Cake, Snacks with Cheese, Spicy Crackers
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Type 1 Diabetes Mellitus, Exercise Physiology
Using a Personalized Decision Support Tool to Help People With Type 1 Diabetes Manage Exercise
This study evaluates a clinician-facing decision-support toolkit designed to assist adults with type 1 diabetes in preparing for moderate-intensity exercise.
- Trial name
- NEXT (NCT07226583)
- Testing
- Standard-of-Care Guidance (SoC), Usual Care (UC), netIOB & Exercise Toolkit (NEXT)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Type 2 Diabetes
Montbretin Clinical Trial in Healthy Volunteers and Type 2 Diabetics
The goal of this clinical trial is to test the investigational product, Montbretin A (MbA) in either individuals with type 2 diabetes (T2D) or healthy participants.
- Trial name
- MbA (NCT05826054)
- Testing
- Montbretin A
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Robert Petrella
Type 1 Diabetes Mellitus
Biomarkers of Type 1 Diabetes in Children and Their Healthy Siblings
This prospective observational cohort study evaluated genetic, immunologic, and environmental factors associated with type 1 diabetes in children.
- Trial name
- NCT07627230
- Where
- Russia
- Volunteers
- 1,034 people, healthy volunteers welcome
- Sponsor
- Privolzhsky Research Medical University
Type 1 Diabetes Mellitus
The Diabetes Transition Study for Young People Aged Between 16-20 Years of Age.
Study into the use of a diabetes specialist transition nurse in the care of young people aged 16-20 years, with type 1 diabetes; undergoing transition from the paediatric to the adult diabetes services at the Northampton General…
- Trial name
- NCT04754919
- Testing
- Transition intervention group, Post transition group
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northampton General Hospital NHS Trust
Diabetes Type II
Novel Biomarker for Development of T2D
The investigators wants to determine if 11β-HSD1 activity will be positively associated, and 5α-reductase activity negatively associated, with (a) degree of insulin resistance defined by the homeostatic model assessment of…
- Trial name
- NCT02326129
- Where
- 3 sites in United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Duke University
Type 2 Diabetes Mellitus
Examination of Dermatologic Effects From Subcutaneous Injections of ISIS 113715
10 healthy volunteers will be enrolled to each receive two subcutaneous injections of ISIS 113715 in the abdomen on Study Day 1. Each subject will receive their two injections within a 5-minute period.
- Trial name
- NCT00365781
- Testing
- ISIS 113715
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ionis Pharmaceuticals, Inc.
Adolescent Type 1 Diabetes
Adolescent Self-Management of Type 1 Diabetes: an Intervention (Completed)
The goals of this R21 exploratory pilot and feasibility study were to: 1) design an Internet-based self-management intervention for adolescents with type 1 diabetes; 2) test that intervention in a small randomized trial to…
- Trial name
- YourWay (NCT00848705)
- Testing
- YourWay Internet Intervention
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)