Clinical trials: Diabetes Type I
Diabetes Mellitus, Type 1
First STEPS- Study of Type 1 in Early Childhood and Parenting Support
The incidence of type 1 diabetes (T1D) in young children (age <6 years) is rising. Disease management guidelines offered by the ADA and other diabetes care organizations place a high burden of responsibility onto these children's…
- Trial name
- NCT02527525
- Testing
- Stepped Care
- Volunteers
- 158 people
- Sponsor
- Children's National Research Institute
Type 1 Diabetes (T1D), Obesity (Disorder)
Vey Low-Energy Ketogenic Therapy in Adults With Type 1 Diabetes and Obesity on Intensive Insulin Therapy Using Advanded Hybrid Closed Loop System
Overweight and obesity are frequent in adults with type 1 diabetes (T1D), with prevalence exceeding 50% in recent studies. Excess weight in T1D is associated with higher cardiometabolic risk and therapeutic challenges, while…
- Trial name
- KET1D (NCT07185555)
- Testing
- VLEKT
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Diabetes (Insulin-requiring, Type 1 or Type 2)
APP-MNT: App-Enhanced Medical Nutrition Therapy on Glycemic Outcomes and Quality of Life
The purpose of the study is to see if using a diabetes app along with nutrition counseling from a registered dietitian nutritionist can help improve blood sugars and cholesterol levels, quality of life, physical activity, and…
- Trial name
- App-MNT (NCT07773779)
- Testing
- Undermyfork Care App, Usual Care
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Weill Medical College of Cornell University
Type1 Diabetes Mellitus
Comparison of Motor and Sensory Functions of the Hand in Children With Type 1 Diabetes Mellitus and Their Healthy Peers
Type 1 Diabetes Mellitus (T1DM) is a condition where the body cannot produce a hormone called insulin. Although it is commonly seen in children and young people, it can occur at any age.
- Trial name
- NCT06206317
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Erdal AYDIN
Type 1 Diabetes
Multivariable Artificial Pancreas: Detecting and Mitigating Unannounced Physical Activity and Acute Psychological Stress
The objective of this proposal is to demonstrate a viable, functionally integrated multivariable artificial pancreas (mvAP) that will address meal, physical activity (PA) and acute psychological stress (APS) challenges without…
- Trial name
- NCT05145374
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois Chicago
Type 1 Diabetes
Teaching Adolescents with Type 1 Diabetes Self-compassion
The purpose of this study is to see if a mindful self-compassion program given virtually can improve emotional distress for youth with type 1 diabetes, compared to routine care as usual.
- Trial name
- TADS (NCT05463874)
- Testing
- Mindful Self-Compassion Program
- Where
- Canada
- Volunteers
- 141 people
- Sponsor
- Children's Hospital of Eastern Ontario
Diabetic Nephropathy
Effect of Pyridorin in Patients With Diabetic Nephropathy
The primary objective of the study is to evaluate the safety and tolerability of Pyridorin (pyridoxamine dihydrochloride) 50 mg given orally twice daily in patients with diabetic kidney disease.
- Trial name
- NCT00320060
- Testing
- Pyridorin (pyridoxamine dihydrochloride)
- Volunteers
- 128 people
- Sponsor
- BioStratum
Type 1 Diabetes
Bet Cell Therapy in Diabetes Type 1
Primary outcome measurement is a parameter of functional beta cell mass at 6 months PT. Functional beta-cell mass will be calculated using the AUC/min between 150 and 160 min during hyperglycemic clamp at 180 mg/dl.
- Trial name
- NCT01379729
- Testing
- Transplantation of encapsulated beta cells.
- Where
- 2 sites in Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Type 1 Diabetes
A Study of Nasal Glucagon (LY900018) in Pediatric Participants With Type 1 Diabetes
The main purpose of this study is to evaluate the safety and tolerability of a study drug called nasal glucagon (Baqsimi) in pediatric participants with type 1 diabetes (T1D) aged 1 to less than 4 years.
- Trial name
- RescuiNGkids (NCT04992312)
- Testing
- Glucagon Nasal Powder [Baqsimi]
- Where
- 8 sites in United States
- Volunteers
- 7 people
- Sponsor
- Eli Lilly and Company
Self-regulation, Medication Adherence
Adolescent Interventions to Manage Self-regulation of T1D (AIMS T1D)
This goal of this project is to test whether self-regulation assays and interventions can be delivered and change self-regulation in a sample of adolescents, specifically to test in a small randomized clinical trial (RCT) whether…
- Trial name
- NCT03688919
- Testing
- Self-Regulation Intervention
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Michigan
Type 1 Diabetes
An ACT Based Application for Young People With Type 1 Diabetes
Study Objectives: This study aims to assess the feasibility and acceptability of an application utilising Acceptance and Commitment Therapy in young people with type 1 diabetes.
- Trial name
- ACT (NCT02526069)
- Testing
- Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Diabete Mellitus, Diabete Type 2
A Clinical Study to Evaluate the Safety and Efficacy of RGB-5088 in Patients With Type 2 Diabetes Mellitus
This Phase I clinical trial is a multi-center, single-arm, open-label study aimed at evaluating the safety and efficacy of RGB-5088 islet cell infusion in patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT07794254
- Testing
- RGB-5088
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Hangzhou Reprogenix Bioscience, Inc
Type 1 Diabetes
Testing State of the Art Remote Glucose Monitoring at Diabetes Camp
The incidence of low blood sugar and hypoglycemic seizures at diabetes camp has been reduced thanks to overnight blood glucose level testing.
- Trial name
- NCT01680653
- Testing
- Mini-glucagon, Remote monitoring, Carbohydrates
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Stanford University
Type 1 Diabetes
Adherence Intervention to Promote Optimal Use of Insulin Pumps in Adolescents With Type 1 Diabetes
The overall objective of this study is to address the critical need of improving insulin pump adherence in adolescents with Type 1 Diabetes (T1D) by providing personalized intervention using evidence-based techniques during…
- Trial name
- Pump It Up! (NCT02333539)
- Testing
- Adherence behaviors and recommendations for improvement., Adherence behavior that needs improvement is targeted
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes Mellitus
Islet Transplantation Using PKX-001
Islet Transplantation is a procedure used in people with difficult to control Type 1 Diabetes. Insulin producing cells (islets) are isolated from a deceased donor pancreas.
- Trial name
- NCT03073577
- Testing
- Antiaging Glycopeptide
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Alberta
Diabetes Mellitus, Type 1
Is Real-time CGM Superior to Flash Glucose Monitoring in Real Life Study (CORRIDA LIFE)
The aim of the investigator's study is to compare real-time continuous glucose monitoring (rt-CGM) and flash glucose monitoring (FGM) in adult patients with Type 1 Diabetes (T1D) in real life practice during 24 weeks of follow-up.
- Trial name
- NCT04759495
- Testing
- Continuous Glucose Monitoring Dexcom G5 and G6 system (real-time continuous glucose monitoring), Continuous Glucose Monitoring FreeStyle Libre Flash system (flash glucose monitoring)
- Where
- Czechia
- Volunteers
- 187 people
- Sponsor
- Charles University, Czech Republic
Hepatocellular Carcinoma, Immunotherapy
A Single-Arm, Multicenter, Exploratory Clinical Study of TACE Combined With Iparomlimab and Tuvonralimab Injection (QL1706) and Lenvatinib for Perioperative Treatment of Resectable Hepatocellular Carcinoma
This is a single-arm, multicenter, exploratory clinical study evaluating the efficacy and safety of TACE combined with Iparomlimab and Tuvonralimab Injection (QL1706) and lenvatinib for perioperative treatment of resectable HCC…
- Conditions
- Hepatocellular Carcinoma, Immunotherapy, Preoperative, PD-1
- Trial name
- NCT07131501
- Testing
- Radical surgery, TACE treatment, Iparomlimab and Tuvonralimab Injection (QL1706)
- Where
- China
- Volunteers
- 48 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Type 1 Diabetes (T1D)
Universal Type 1 Diabetes Screening in Pediatrics
This study examines how population-based screening for type 1 diabetes (T1D) using islet autoantibodies (i.e., immune system proteins) can be incorporated into pediatric primary care during routine well-child visits.
- Trial name
- NCT07612475
- Testing
- Set of implementation strategies
- Where
- 8 sites in United States
- Volunteers
- 9,500 people
- Sponsor
- Northwestern University
Diabetes Mellitus, Type 1
Renal and Peripheral Hemodynamic Function in Patients With Type 1 Diabetes Mellitus
Protein kinase C (PKC), an enzyme in the body, has been implicated in the process of diabetic microvascular complications. The purpose of this study will be to evaluate the renal hemodynamic and peripheral vascular effects of PKC…
- Trial name
- NCT00297401
- Testing
- ruboxistaurin
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Chromaderm, Inc.
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Local Registration Trial in China Humalog Mix 50
The primary objective of this study is to compare the 2-hour PPBG excursion following a standard test meal in insulin-requiring diabetic patients treated twice daily with human insulin mix 50/50, versus the 2-hour PPBG excursion…
- Trial name
- NCT00191581
- Testing
- Humalog Mix 50, Human Insulin Mix 50:50
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Eli Lilly and Company
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