Clinical trials: Diabetes Type I
Diabetes Mellitus, Type 1
Pre Transplant Rapamycin Treatment in Islet Transplantation Alone
Numerous changes to the original Edmonton protocol have been proposed in the attempt of improving the still unsatisfactory long-term function of ITA.
- Trial name
- ITA-Rp (NCT01060605)
- Testing
- rapamycin
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- IRCCS San Raffaele
Type 1 Diabetes Mellitus
Reducing Risks and Improving Glucose Control During Extended Exercise in Youth With T1DM: The AP Ski Camp
The biggest challenges for glycemic control during the day time involve meals and exercise variations, which are impacted by age, fitness level, duration, intensity and history of exercise.
- Trial name
- NCT02604524
- Testing
- Closed-Loop Control, Sensor Augmented Pump Therapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Daniel Chernavvsky, MD, CRC
Diabetes
Three-day, In-clinic Evaluation of the BD 2nd Generation Continuous Glucose Sensor Device in Type 1 Diabetics
The purpose of this study is to investigate the accuracy and performance of a new subcutaneous continuous glucose monitor (BD-CGM, Becton Dickinson) in hyperglycemic (high blood sugar) and hypoglycemic (low blood sugar) "clamp"…
- Trial name
- NCT01645696
- Testing
- BD CGM with Outer Layer, BD CGM without Outer Layer, Medtronic iPro2 Professional CGM
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Becton, Dickinson and Company
Diabetes Mellitus, Type 1
Evaluation of Fiasp® (Fast Acting Insulin Aspart) in 670G Hybrid Closed-Loop Therapy
This is a pilot outpatient study conducted at Stanford to obtain preliminary data on how Fiasp® works in a closed-loop system and to determine if any changes need to be made to the 670G pump to optimize the use of Fiasp®.
- Trial name
- NCT03554486
- Testing
- Fiasp, Novolog
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Stanford University
Type 1 Diabetes
Enhanced Epidermal Antigen Specific Immunotherapy Trial -1
The study is a two centre, open-label, uncontrolled single group phase 1A study of C19-A3 GNP peptide (10 μg peptide equivalent content) administered via Nanopass microneedles every 28 days for 8 weeks (3 doses), with follow-up…
- Trial name
- EE-ASI-1 (NCT02837094)
- Testing
- C19-A3 GNP
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Cardiff University
Type 1 Diabetes
Glycemic Outcomes and Safety With Minimed 780G System in Children With Type 1 Diabetes Aged 2-6 Years
The purpose of this study is to evaluate the effectiveness of advanced hybrid-closed loop system, Minimed 780G to glycemic control and safety in children aged 2-6 years with type 1 diabetes.
- Trial name
- NCT04949022
- Testing
- Medronic 780G insulin pump
- Where
- Finland
- Volunteers
- 38 people
- Sponsor
- Helsinki University Central Hospital
Type 1 Diabetes Mellitus
Artificial Pancreas Control System in an Outpatient Setting
The objectives of this outpatient research study are (1) to assess the ability of this automated system to be operated by a subject with limited professional oversight; (2) to assess whether the new devices (Dexcom Gen 4 sensors…
- Trial name
- NCT01871870
- Testing
- Artificial Pancreas Control Software
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Legacy Health System
Diabetes, Diabetes Mellitus, Type 1
Comparison of Efficacy and Safety of Insulin Detemir and NPH Insulin in Children and Adolescents With Type 1 Diabetes
The trial is conducted in Europe and Middle East. The aim of the trial is to compare the use of Insulin Detemir once or twice daily combined with mealtime Insulin Aspart against that of NPH Insulin once or twice daily combined…
- Trial name
- NCT00312156
- Testing
- insulin detemir, insulin NPH, insulin aspart
- Where
- 42 sites in Belgium, Croatia and 14 more
- Volunteers
- 347 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes (T1D), Type 1 Diabetes Mellitus
A Study of GNTI-122 in Adults Recently Diagnosed With T1D
This is a 78-week single arm, multi-center, Phase 1 study to evaluate the safety, tolerability, cellular kinetics, and biomarker changes in C-peptide over time of GNTI-122, an investigational cell therapy manufactured from a…
- Trial name
- POLARIS (NCT06919354)
- Testing
- GNTI-122
- Where
- 10 sites in United States
- Volunteers
- 16 people
- Sponsor
- GentiBio, Inc
Diabetes Mellitus, Bariatric Surgery Candidate
Paraoxonase and HDL Qualities in Glycaemia and Inflammation
The incidence of coronary heart disease (CHD) is significant in the super-obese and diabetics. Inflammation is believed to play an important part in the development of CHD, and the large collection of abdominal fat in the obese…
- Trial name
- PON1 (NCT02169518)
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Hypertension
Autoregulation of Glomerular Filtration Rate in Patients With Type 1 Diabetes During Spironolactone Therapy
To evaluate the impact of spironolactone treatment on renal autoregulation in hypertensive type 1 diabetic patients.
- Trial name
- NCT00335413
- Testing
- Spironolactone
- Volunteers
- 17 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes, Healthy
Cerebral Responses to Insulin Induced Hypoglycemia
This research study is designed to investigate the effect of hypoglycemia (low blood sugar) on blood flow to and biochemistry in the brain.
- Conditions
- Type 1 Diabetes, Healthy, Hypoglycemia Unawareness
- Trial name
- 1018 (NCT02747680)
- Testing
- hypoglycemia (low blood sugar) in MRI
- Where
- United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type 1 Diabetes
Reducing Stress in Adolescents and Young Adults With Type 1 Diabetes to Improve Diabetes Care
Adolescence and young adulthood may be particularly stressful developmental periods due to the numerous transitions into new roles and the need for increased independence.
- Trial name
- T1D (NCT02760303)
- Testing
- Cognitive Behavioral Therapy, Mindfulness Based Stress Reduction, Diabetes Support and Education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wayne State University
Type 1 Diabetes
Effects of Vitamin D Supplementation in Subjects With New Onset of Type 1 Diabetes
In this placebo controlled study the investigators aim to investigate the effects of vitamin D supplementation in subjects with new onset of type 1 diabetes on immunological, endocrine and metabolic parameters.
- Trial name
- NCT01390480
- Testing
- Cholecalciferol
- Where
- Austria
- Volunteers
- 31 people
- Sponsor
- Medical University of Graz
Type 1 Diabetes Mellitus, Metformin
Effect of Metformin as add-on Therapy on Glycemic Control and Other Outcomes in Type 1 Diabetes
Aim Evidence of a possible connection between gut microbiota and several physiological processes linked to type 1 diabetes is increasing.
- Trial name
- NCT03590262
- Testing
- Metformin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen People's Hospital
Type 1 Diabetes
Exercise in Adolescents With Type 1 Diabetes
Regular physical activity is an important part of diabetes management in adolescents with type 1 diabetes (T1D). Increased physical activity has several beneficial effects such as improved lipid profile, insulin sensitivity and…
- Trial name
- NCT04418869
- Testing
- Exercise bouts
- Volunteers
- 8 people
- Sponsor
- Region Örebro County
Type 1 Diabetes, Polycystic Ovary Syndrome
Prevalence of Hyperandrogenism in Type 1 Diabetes
The investigators aim to estimate the prevalence of functional ovarian hyperandrogenism [idiopathic hyperandrogenism, idiopatic hirsutism, and polycystic ovary syndrome (PCOS)] in adult patients with type 1 diabetes (T1DM) in an…
- Conditions
- Type 1 Diabetes, Polycystic Ovary Syndrome, Hyperandrogenism, Hirsutism
- Trial name
- NCT04979377
- Testing
- Clinical hyperandrogenism assessment, Total testosterone (ng/dL), A1c (%)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Diabetes Mellitus, Type 1
Influence of Diabetic Neuropathy on Activation of Brown Adipose Tissue
Influence of diabetic neuropathy on cold induced brown adipose tissue in type 1 diabetic patients.
- Trial name
- DIA-BAT (NCT03695731)
- Testing
- cold induced activation of brown adipose tissue
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Doctor Giacomo Gastaldi
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Magnetic Resonance Diagnostics of Diabetic Peripheral Neuropathy
This project aims to develop high field MR techniques to detect nerve lesions in diabetic patients. The MRI findings will be compared to results from conventional evaluations and nerve conduction studies to determine the validity…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Polyneuropathy, Hereditary Axonal Neuropathy
- Trial name
- NCT01847937
- Where
- 5 sites in Denmark, Germany
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Type 1 Diabetes
Insulet Artificial Pancreas Early Feasibility Study
The purpose is to perform an early investigation on the safety and performance of an Automated Glucose Control (AGC) algorithm using the OmniPod® Insulin Management System and gather clinical data that will be used to make…
- Trial name
- NCT02897557
- Testing
- Insulet Artificial Pancreas (AP) System
- Where
- 4 sites in United States
- Volunteers
- 59 people
- Sponsor
- Insulet Corporation
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.