Clinical trials: Diabetes Type I
Type1 Diabetes
Euglycemic Clamp Study Comparing Two New Insulin Glargine Formulations in Subjects With Type 1 Diabetes Mellitus
Primary Objective: To demonstrate equivalence in exposure to insulin glargine given as test formulation T and reference formulation R in steady state conditions after 6 once-daily subcutaneous (SC) doses Secondary Objective: To…
- Trial name
- NCT01838083
- Testing
- Insulin glargine new formulation HOE901
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Sanofi
Type 1 Diabetes Mellitus
Best Timing of Insulin Bolus Before Meals of Different Contents
Post-meal glucose excursions may contribute to the development of diabetes-related complications. These glucose excursions are affected by the food content of the meal and the timing of insulin injection (or insulin pump-bolus)…
- Trial name
- NCT01406496
- Testing
- insulin
- Where
- Israel
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Type 1 Diabetes
Assessing the Impact of Control-IQ Technology
This is a single-centre, mixed-methods, prospective study in pediatric patients with T1D initiating Control-IQ technology on the Tandem t-slim X2 insulin pump.
- Trial name
- NCT04838561
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Children's Hospital of Eastern Ontario
Diabetes Mellitus, Type 1
Efficacy and Safety of Insulin Glulisine in Type 1 Diabetes Mellitus
To evaluate non-inferiority in the efficacy of HMR1964 as compared with Insulin lispro in terms of the change in HbA1C from baseline to endpoint. To compare the safety of HMR1964 with insulin lispro.
- Trial name
- NCT00290979
- Testing
- insulin glulisine
- Where
- Japan
- Volunteers
- 250 people
- Sponsor
- Sanofi
Diabetes Type 1
Home and School Visits Intervention for Children With DM TYPE 1
Home and school visits by multidisciplinary team will improve metabolic control in kids having insulin dependent diabetes mellitus
- Trial name
- NCT02137174
- Testing
- Home and school visits
- Where
- Israel
- Volunteers
- 92 people
- Sponsor
- Ben-Gurion University of the Negev
Type 1 Diabetes
Use of Control-IQ Technology 2.0 in Adults, Children, and Preschoolers With Type 1 Diabetes
The goal of this clinical trial is to assess safety of and explore glycemic outcomes with Control-IQ technology 2.0 in adults, children and preschoolers with type 1 diabetes.
- Trial name
- NCT05683392
- Testing
- t:slim X2 insulin pump with Control-IQ technology 2.0
- Where
- 4 sites in United States
- Volunteers
- 72 people
- Sponsor
- Tandem Diabetes Care, Inc.
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Pharmacokinetic Properties of FIAsp in Japanese Subjects With Type 1 Diabetes
This trial is conducted in Japan. The aim of the trial is to evaluate the pharmacokinetic (the exposure of the trial drug in the body) and pharmacodynamic (the effect of the trial drug on the body) properties of FIAsp…
- Trial name
- NCT01934712
- Testing
- Faster-acting insulin aspart, insulin aspart
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Clinical Assessment of a Novel Advanced Bolus Calculator for Type 1 Diabetes 5
The main objective of this study is to assess safety and efficacy of the ABC4D compared to standard therapy (standard bolus calculator) in adults with type 1 diabetes on multiple daily injections (MDI) of insulin in an…
- Trial name
- ABC4D5 (NCT03963219)
- Testing
- ABC4D, Standard Bolus Calculator
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Imperial College London
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) During Postprandial Exercise in Adults With Type 1 Diabetes
Regular physical activity is associated with many health benefits for individuals with type 1 diabetes including improved cardiovascular fitness and vascular health, decreased insulin requirements, improved body composition and…
- Trial name
- NCT02855307
- Testing
- 60-minute exercise, Insulin pump, Dexcom G4 Platinum glucose sensor
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes
Continuous Subcutaneous Infusion of Pramlintide and Insulin
The purpose of this study is to see if giving the study drug in a slow and steady dose will lower blood sugars during the meal and after-meal time.
- Trial name
- NCT00291772
- Testing
- Pramlintide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor College of Medicine
Type1 Diabetes Mellitus
Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes
The goal of this longitudinal clinical trial is to measure variability of interstitial glucose levels with a user-friendly real-time continuous glucose monitoring (CGM) technology at regular intervals in normo- and dysglycemic…
- Trial name
- NCT05777330
- Testing
- Oral glucose tolerance test (OGTT), Hyperglycemic clamp test, Continuous glucose monitoring
- Where
- 6 sites in Belgium
- Volunteers
- 75 people
- Sponsor
- Universitair Ziekenhuis Brussel
Diabetes Mellitus, Type 1, Diabetes Complications
Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes
Minoritized individuals with type 1 diabetes (T1D) have approximately 2% higher average A1c levels and twice the rate of hospitalizations, complications, and mortality as their white counterparts.
- Trial name
- NCT06236607
- Testing
- Device specific training, Study clinician/educator visit
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Boston Medical Center
Diabetes Mellitus
Insulin Detemir Compared to Insulin Glargine: Appetite and Calories Consumed in Type 1 Diabetes
Patients with diabetes treated with insulin often gain weight, which may deter patients from adhering to insulin treatment. Detemir is one type of long acting insulin approved by the Food and Drug Administration for use in people…
- Trial name
- NCT00659165
- Testing
- Insulin Detemir, Insulin Glargine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of New Mexico
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
The Effect of Mobile Online Training Applied to Patients With Diabetes on Insulin Therapy
This study aims to investigate the effect of health belief model-based mobile online training applied to patients with diabetes on insulin therapy.
- Trial name
- NCT05787067
- Testing
- Health Belief Model-Based Mobile Online Training
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Ataturk University
Type 1 Diabetes
Continuous Glucose Monitoring in Adolescents With Poorly Controlled Type 1 Diabetes
The purpose of this study is to see if children and adolescents with poorly controlled type 1 diabetes will benefit from using a continuous glucose monitor (CGM), a device that can be used to check blood sugars.
- Trial name
- NCT01586065
- Testing
- Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nemours Children's Clinic
Diabetes Mellitus, Type 1
Type 1 Together: A Peer Mentorship Program to Bolster Use of CGM
The goal of this clinical trial is to evaluate a new way of helping adolescents with type 1 diabetes consistently use continuous glucose monitoring systems (CGM).
- Trial name
- NCT06203067
- Testing
- Standard of Care, Type 1 Together
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Nemours Children's Clinic
Diabetes Mellitus
The Effects of High and Low Blood Glucose Values on the Brain in Children With Type 1 Diabetes Mellitus
Simplified Brochure Neuropsychological Testing/Assessment is like games for the child. They are asked to complete the sequence, identify pictures, explain what is happening, etc. There is no personality testing involved.
- Trial name
- NCT01690481
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Stanford University
Breast Cancer, Head and Neck Cancer
A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6
This study evaluated the intratumoral administration of escalating doses of a novel, experimental drug, INT230-6. The study was conducted in patients with several types of refractory cancers including those at the surface of the…
- Conditions
- Breast Cancer, Head and Neck Cancer, Squamous Cell Carcinoma, Lymphoma
- Trial name
- IT-01 (NCT03058289)
- Testing
- INT230-6, anti-PD-1 antibody, anti-CTLA-4 antibody
- Where
- 8 sites in United States, Canada
- Volunteers
- 111 people
- Sponsor
- Intensity Therapeutics, Inc.
Closed Loop, Diabetes Mellitus, Type 1
Diabeloop for Teens
An open-label, three-centers, controlled, randomized, and crossover study containing 14 days of baseline period with standard of care (SOC) therapy followed by two-sessions of 4-weeks home study phase with Diabeloop closed-loop…
- Conditions
- Closed Loop, Diabetes Mellitus, Type 1, Adolescents (12 to 17 Years Old)
- Trial name
- DBL4T (NCT04725591)
- Testing
- Dexcom G6 Continuous Glucose Monitoring, MEDISAFE WITH External Insulin Pump, Diabeloop Software (Model predictive control)
- Where
- 3 sites in Belgium, France and 1 more
- Volunteers
- 49 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Primary Biliary Cirrhosis
Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis
The purpose of this study is to determine if abatacept (Orencia) is effective in patients with primary biliary cirrhosis who do not respond adequately to standard treatment with ursodeoxycholic acid (UDCA, Urso, Ursodiol…
- Trial name
- PBC (NCT02078882)
- Testing
- abatacept
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Christopher Bowlus, MD
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