Clinical trials: Diabetes in Adolescence
Type 1 Diabetes Mellitus, Coronary Artery Disease
Isometric Handgrip Exercise -MRI in Children and Adolescents
This project aims to assess coronary vessel response to isometric handgrip exercise (IHE) during magnetic resonance imaging (MRI) in children with T1D children and healthy controls.
- Trial name
- NCT03506711
- Testing
- Isometric Handgrip Exercise during magnetic resonance imaging
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Type 1 Diabetes Mellitus
Fake Carbs Practice With AID System - MiniMed 780G in Children and Adolescents With T1D.
Hybrid Closed Loop (HCL) systems, such as the MiniMed 780G, have significantly improved glycemic outcomes in Type 1 Diabetes (T1D) management.
- Trial name
- CHeatAID (NCT07179471)
- Where
- 3 sites in Greece
- Volunteers
- 40 people
- Sponsor
- Maria Chatzipsalti
Type 1 Diabetes Mellitus
Rilonacept in Diabetes Mellitus Type 1: Safety Study
This study is being done to see if an investigational drug called rilonacept is safe to use in patients with type 1 diabetes, and if it can slow the loss of the body's ability to secrete insulin in patients who are still able to…
- Trial name
- RID-A (NCT00962026)
- Testing
- Rilonacept
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes Mellitus, Type 1
Immunotherapy of the Recent-onset Type 1 Diabetes in Adolescents With Repeated Courses of Rituximab
Type 1 diabetes (T1D) is caused by destruction of pancreatic islet beta-cells that produce insulin - the hormone required for glucose uptake by body tissues and organs.
- Trial name
- NCT07041268
- Testing
- rituximab
- Where
- 2 sites in Russia
- Volunteers
- 116 people
- Sponsor
- Pirogov Russian National Research Medical University
Type 1 Diabetes Mellitus
Closed-loop Response to Unannounced Mixed and Carbohydrates-rich Breakfasts
The development of advanced hybrid closed-loop (a-HCL) systems represents a significant step toward in improving glucose control and reducing user-dependent variability, especially In pediatric patients.
- Trial name
- CRUMB (NCT07455643)
- Testing
- Unannounced meal
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Catania
Type 1 Diabetes Mellitus (T1DM), Anxiety
Drawing and Writing Activities in Adolescents With Type 1 Diabetes
This randomized controlled trial aims to evaluate the effects of drawing and writing activities on anxiety and positive and negative affect in adolescents with type 1 diabetes.
- Trial name
- NCT07830082
- Testing
- Drawing and Writing Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Gazi University
Type 1 Diabetes
Safety and Feasibility of a Self-Learning Bolus Calculator With Simplified Meal Announcement in Adolescents With Type 1 Diabetes Using Automated Insulin Delivery
To evaluate the safety and feasibility of a novel self-learning bolus calculator along with simplified meal announcement (AID+InsuLearn-SMA) in adolescents and young adults with T1D using Automated Insulin Delivery.
- Trial name
- InsuLearn-SMA (NCT07212179)
- Testing
- AID + InsuLearn-SMA, AID + CC
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Melissa J. Schoelwer
Type 2 Diabetes Mellitus
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Tolerability of Exenatide in Adolescent Subjects With Type 2 Diabetes Mellitus
This study will be the first evaluation of exenatide in adolescent subjects with type 2 diabetes mellitus and is designed to evaluate the blood levels of the drug (pharmacokinetics), the drug's biochemical and physiological…
- Trial name
- NCT00254254
- Where
- 5 sites in United States
- Volunteers
- 13 people
- Sponsor
- AstraZeneca
type1diabetes
Diabetes in African Youth
This RCT aims to improve T1D care in East African children and young adults by testing the hypothesis that enabling patients to continuously monitor glucose levels with flash CGM technology will improve glucose time-in-range…
- Trial name
- NCT05454176
- Testing
- Libre 2, Device for SMBG and Libre Pro
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- University of Minnesota
Obesity and Type 2 Diabetes, Metabolic Diseases
Effects of HIIT vs. TRE on Type 2 Diabetes Risk
The primary aim of this randomized controlled trial is to examine the effects of a 4-week high-intensity interval training (HIIT) and time-restricted eating (TRE) intervention on cardiometabolic biomarkers in adolescents and…
- Conditions
- Obesity and Type 2 Diabetes, Metabolic Diseases, High-intensity Interval Training, Time-restricted Eating
- Trial name
- NCT07215533
- Testing
- High-intensity interval training, Time-restricted eating
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Psychological Distress, Eating Disorders
Psychological Factors and Self-Care Behaviors in Spanish Youth With Type 1 Diabetes: Age- and Sex-Based Comparisons and Associations
This is a multicenter, observational, cross-sectional study of young people aged 10 to 25 with type 1 diabetes in Spain, affiliated with a diabetes association or federation.
- Conditions
- Psychological Distress, Eating Disorders, Self Care, Type 1 Diabetes Mellitus (T1DM)
- Trial name
- SPAIN-T1DM (NCT07452393)
- Where
- Spain
- Volunteers
- 115 people
- Sponsor
- University of Alicante
Type 1 Diabetes
Promoting Adolescent Investment In Diabetes Care
Two financial incentive strategies targeting adolescents with type 1 diabetes will be compared to usual care for motivating adolescents to engage in improved self-care to manage their diabetes.
- Trial name
- InvesT1D (NCT04516694)
- Testing
- Financial incentive (gain), Financial incentive (loss)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Harvard Pilgrim Health Care
Obesity, Diabetes
Evaluation of the Clinical Spectrum of Diabetes and Obesity in Youth and Adults
Background: Diabetes and obesity are chronic diseases. They can affect blood flow and how the body processes nutrients, and complications over time can lead to early death.
- Conditions
- Obesity, Diabetes, Metabolic Disorders
- Trial name
- NCT07388537
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Type 2 Diabetes
Strength Training and Nutrition Development for African American Youth
The investigators are conducting an intervention study to examine the effects of a 16-week exercise and diet interventions on prevention of disease, specifically type 2 diabetes and heart disease, in African American youth.
- Conditions
- Obesity, Type 2 Diabetes, Cardiovascular Risk, Cancer
- Trial name
- STAND (NCT01441323)
- Testing
- Nutrition, Strength Training & Nutrition
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Sleep
Sleep Extension and Insulin Sensitivity in Adolescents
BACKGROUND: The influence of sleep extension on glucose homeostasis in adolescents at risk for type 2 diabetes is unknown. This issue is of high clinical relevance given the high prevalence of sleep deprivation in this population…
- Trial name
- NCT03754036
- Testing
- Sleep manipulation
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Children's Hospital of Eastern Ontario
Diabetes Type 1
Insul-In This Together: Leveraging Family Support and Diabetes Technology for Adolescents Living With Type 1 Diabetes
The goal of this clinical trial is to learn if the "Insul-In This Together" family program works to improve outcomes for adolescents living with type 1 diabetes.
- Trial name
- IITT (NCT07856836)
- Testing
- Insul-In This Together
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Type 1 Diabetes Mellitus
Mindfulness for Adolescents With Type 1 Diabetes
Adolescents with Type 1 Diabetes will be invited to the Mindfulness study. They will be randomly assigned to a Control or Active Group.
- Trial name
- NCT03942471
- Testing
- Mindfulness Based Stress Reduction
- Volunteers
- 65 people
- Sponsor
- Duquesne University
NAFLD, TYPE 2 DIABETES
Resveratrol for the Treatment of Non Alcoholic Fatty Liver Disease and Insulin Resistance in Overweight Adolescents
The current project is designed as a 30-day pilot trial to demonstrate the safety and tolerability of resveratrol therapy in overweight adolescents to decrease liver fat, and improve insulin sensitivity to prevent type 2 diabetes.
- Conditions
- NAFLD, TYPE 2 DIABETES, METABOLIC SYNDROME
- Trial name
- NCT02216552
- Testing
- Resveratrol
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Type 1 Diabetes, Adolescent Behavior
Incorporating Mind-body Skills With Diabetes Education in Adolescents With Type 1 Diabetes
Adolescence presents a challenging time for type 1 diabetes management, and despite a multitude of studies aimed at increasing disease compliance in this age group, none have been deemed superior.
- Trial name
- NCT05577169
- Testing
- Mind-body skills, Diabetes education
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Diabetes Mellitus, Type 1
What is the Dose Response of Varying Meal Content of Fat on Postprandial Glycaemia in Children With T1DM?
Background: Based on international evidence, current management of people with T1DM on intensive insulin therapy (IIT) use algorithms based on the meal carbohydrate content (MCC) to calculate the prandial insulin dose.
- Trial name
- REQINSOIL (NCT02371694)
- Testing
- Test drink
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- Cork University Hospital