Clinical trials: Diabetes in Adolescence
Type 1 Diabetes
The Effects of Different Exercise Modalities in Adolescents With Type 1 Diabetes Using AID Systems
Objective: The overall objective of this study is to assess the efficacy of the current recommended guidelines for physical activity (PA) in response to acute moderate intensity continous exercise (MICE) and high intensity…
- Trial name
- MODE2022 (NCT05619198)
- Testing
- High Intensity Interval Exercise, Moderate Intensity Continous Exercise
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes, Cardiovascular Complications
Vascular Complications in Children From T1D Diagnosis
Cardiovascular disease is a complication of type 1 diabetes (T1D), a life-long disease, usually diagnosed in childhood. The goal of this project is to determine the timing and factors leading to vascular damage in children from…
- Conditions
- Type 1 Diabetes, Cardiovascular Complications, Child, Adolescent
- Trial name
- NCT05790785
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of British Columbia
Type 1 Diabetes
Early High-Dose Vitamin D and Residual β-Cell Function in Pediatric Type 1 Diabetes
The project aims to study the effect of early high-dose vitamin D supplementation on type 1 diabetes in children and adolescents receiving intensive insulin therapy.
- Trial name
- NCT05270343
- Testing
- Cholecalciferol (Vit D3) 400Unit Cap
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Type 1 Diabetes
Simplified Meal Approach Using Hybrid Closed-loop Insulin Delivery in Youth and Young Adults With Type 1 Diabetes
The purpose of the study is to examine whether a simplified meal approach (as compared to exact carbohydrate counting) can alleviate the need of carbohydrate counting without worsening postprandial control in youth and young…
- Trial name
- SMASH (NCT05481034)
- Testing
- SMA bolus option, Exactly estimated carbohydrate content bolus option
- Where
- 2 sites in Switzerland
- Volunteers
- 46 people
- Sponsor
- Lia Bally
Type 1 Diabetes
Precision Administration of Anti-thymocyte Globulin With or Without Verapamil
T cell directed therapy, anti-thymocyte globulin (ATG), in low doses, has been shown to lower HbA1c and preserve endogenous insulin production (measured by C-peptide) in individuals with recently diagnosed type 1 diabetes (T1D).
- Trial name
- NCT06455319
- Testing
- Anti-thymocyte globulin (ATG), verapamil extended release capsule
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Type2 Diabetes, Type 2 Diabetes Mellitus in Obese
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g.
- Conditions
- Type2 Diabetes, Type 2 Diabetes Mellitus in Obese, Dysglycemia, Microvascular Complications
- Trial name
- Metabrain (NCT05277558)
- Testing
- Observational
- Where
- 2 sites in United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Type 1 Diabetes Mellitus
A Study of LY900014 in Participants With Type 1 Diabetes Mellitus
The purpose of this study is to compare LY900014 with insulin lispro (Humalog) in participants with type 1 diabetes mellitus. There are 2 parts to this study.
- Trial name
- NCT03465878
- Testing
- LY900014, Insulin Lispro
- Where
- 2 sites in Canada, Germany
- Volunteers
- 56 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes
Effect of CGM With Predictive Alarm on Hypoglycemia in Young Patients With T1D.
The use of continuous glucose monitoring (CGM) is becoming the new standard in glycometabolic control in patients with Type 1 Diabetes Mellitus (T1DM) even in subjects in multiple daily insulin injections (MDI).
- Trial name
- CGMHYPO (NCT05574023)
- Testing
- Use of Predictive Alarm for hypoglycaemia or hyperglycaemia, Use of Alarm on Threshold for hypoglycaemia or hyperglycaemia
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Type 1 Diabetes, Continuous Glucose Monitoring
Research on Optimizing the Use of Technology With Education
Consistent use of continuous glucose monitors (CGM) has the potential to improve glycemic control and related type 1 diabetes (T1D) health outcomes, however young adolescents with T1D are the least likely age group to begin and…
- Conditions
- Type 1 Diabetes, Continuous Glucose Monitoring, Behavioral Intervention, Parent-Child Relations
- Trial name
- ROUTE-T1D (NCT05564481)
- Testing
- diabetes education and parent coaching support
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's National Research Institute
Contact Dermatitis, Type 1 Diabetes Mellitus
Exploring Skin Barrier Function, Recurrence of Diabetes Device-Related Contact Dermatitis, and Evaluation of Hydrocolloid and Silicone-Based Patches for Its Prevention in Children and Adolescents With Type 1 Diabetes
The goal of this clinical trial is to ensure that contact dermatitis does not prevent any person with diabetes from accessing optimal diabetes treatment.
- Trial name
- StenoAD1 (NCT07767461)
- Testing
- hydrocolloid patch as patch used in the Sandwich method, Silicone-based patch as patch used in the Sandwitch method
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type1diabetes, Adolescent Behavior
Sleep, Glycemic Control, and Insulin Resistance in Adolescents With Type 1 Diabetes
Despite advancements in care, most adolescents with T1D have higher BMI and significantly higher HbA1c than recommended and are markedly IR, placing them at increased risk for CVD1,2.
- Conditions
- Type1diabetes, Adolescent Behavior, Sleep
- Trial name
- SunDIAL (NCT03832790)
- Testing
- observation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Phase 1 Study to Explore the Safety and Pharmacokinetics of DAPAglifozin in Adolescents and Adults With Type 1 Diabetes
Dapagliflozin has been effective at lowering glucose and hemoglobin A1c (HbA1C) in subjects with tpye 2 diabetes (T2DM), when studied as monotherapy as well as in combination with insulin or oral anti-diabetic medications.This…
- Trial name
- DAPA-IIT1 (NCT02325206)
- Testing
- dapagliflozin
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Diabetes Mellitus, Type 1
Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study A
Glutathione is normally present at high (millimolar) levels in blood and plays an important role in the body's defense against oxidative stress, that is, against the damage caused to the body by reactive oxygen species produced…
- Trial name
- NCT00858897
- Testing
- Cysteine isotope infusion at normoglycemia vs hyperglycemia, Regular Insulin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nemours Children's Clinic
Diabetes Mellitus, Type 2
Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM
The purpose of this research study is to evaluate the efficacy and safety of an empagliflozin dosing regimen and one dose of linagliptin in patients with type 2 diabetes who are aged 10 to below 18 years and are currently taking…
- Trial name
- NCT03429543
- Testing
- Metformin, Insulin, Linagliptin
- Where
- 83 sites in United States, Argentina and 12 more
- Volunteers
- 175 people
- Sponsor
- Boehringer Ingelheim
Metabolic Syndrome, Insulin Resistance
FTO rs9939609 and PPARy rs1801282 Polymorphisms in Mexican Adolescents
Background and Aims: The presence of the FTO rs9939609 and PPARy rs1801282 polymorphisms suggests changes in energy metabolism; this variation may be responsible for the development of various diseases including obesity.
- Trial name
- NCT02886013
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Asociación Científica Latina A.C.
Mental Disorder in Adolescence, Behavioral Symptoms
Effects of Web-Based Training on HbA1c, Quality of Life and Depression Levels in Adolescents With Type 1 Diabetes
Objective: This study was conducted to determine the effect of diabetes training on HbA1c, levels of depression and quality of life of Type 1 Diabetes Mellitus adolescents by using the Web-Based Watson Human Care Model.
- Conditions
- Mental Disorder in Adolescence, Behavioral Symptoms, Problem Behavior
- Trial name
- NCT04888780
- Testing
- The web-based Watson's Human Care Theory oriented training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gaziantep Islam Science and Technology University
Type 1 Diabetes Mellitus
Check It! Positive Psychology Intervention to Improve Adherence in Adolescents With T1D
Problems with diabetes management in adolescents with type 1 diabetes are common - occurring at rates as high as 93% - and have serious health consequences, including poor blood sugar control and risk for later complications.
- Trial name
- NCT02746627
- Testing
- Positive Affect, Education
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes
Testing a Conversion Factor for a More Rapidly Acting Insulin in an Automated Insulin Delivery System Among Adolescents With T1D
A randomized controlled trial of Control-IQ, assessing glycemic control (time-in-range 70-180 mg/dL) for Lyumjev insulin (in which the insulin settings have been determined using an experimental conversion factor) as compared to…
- Trial name
- Lpad Lyumjev (NCT06948760)
- Testing
- Control-IQ insulin pump with Lyumjev insulin, Control-IQ insulin pump with Humalog or Novolog
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mark D. DeBoer, MD, MSc., MCR
Type 1 Diabetes, Asthma
EmoTIChealth: Promoting Adolescent Health Through a Serious Game.
The intervention program targets adolescents between 12 and 16 years of age. The intervention program is designed for adolescents during a critical developmental stage marked by significant life transitions, where building strong…
- Conditions
- Type 1 Diabetes, Asthma, Allergic Rhinitis, Food Allergy
- Trial name
- NCT07212530
- Testing
- EmoTIChealth
- Where
- Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Pediatric Obesity
Phentermine/Topiramate in Adolescents With Type 2 Diabetes and Obesity
As the prevalence of obesity rises in the U.S., so does the incidence of pediatric type 2 diabetes (T2D), which is associated with more aggressive disease progression than in adults.
- Trial name
- NCT04881799
- Testing
- Phentermine/Topiramate (Qsymia)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Minnesota