Clinical trials: Diabetes in Adolescence
Diabetes
Efficacy of Automated Insulin Therapy Early Initiated After Diagnosis on Blood Glucose Control in Children and Adolescents With Type 1 Diabetes
The main objective is to assess whether hybrid closed-loop (HCL) insulin delivery initiated early after diagnosis of Type 1 diabetes (T1D) allows a better efficacy on glucose control than conventional standard insulin therapy…
- Trial name
- APATDIAGNOSIS (NCT06283797)
- Testing
- OmniPod 5, Dexcom G6, PAID questionnaires
- Where
- 4 sites in France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Montpellier
Diabetes Mellitus
Effectiveness and Safety Study of the DexCom™ G4 Continuous Glucose Monitoring System in Children and Adolescents With Type 1 Diabetes Mellitus
The purpose of this study is to evaluate the safety and effectiveness of the G4 System when worn for up to 7-days by children and adolescent subjects (6 to <18 years-old) with type 1 diabetes mellitus.
- Trial name
- NCT01185496
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- DexCom, Inc.
Type 1 Diabetes Mellitus
Effects of Vitamin C and E on Endothelial Function in Adolescent Diabetes
The endothelium is the lining of the blood vessels that helps prevent damage to the vessels. The endothelium does not function as well as it should in adolescents with type 1 diabetes. This causes future diabetes complications.
- Trial name
- NCT02019186
- Testing
- Vitamin C, Vitamin E
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Nationwide Children's Hospital
Diabetes, Diabetes Mellitus, Type 1
Safety Follow-up on Children and Adolescents With Type 1 Diabetes Treated With Insulin Detemir. An Extension to Trial NN304-1689
This trial is conducted in Europe. The aim of this research is to assess the safety of continuous treatment with insulin detemir following participation in trial NN304-1689 (NCT00435019) on antibody development.
- Trial name
- NCT00623194
- Testing
- insulin detemir, insulin aspart
- Where
- 32 sites in Bulgaria, Czechia and 9 more
- Volunteers
- 146 people
- Sponsor
- Novo Nordisk A/S
Diabetes
Prebiotics and Metformin Improve Gut and Hormones in Type 2 Diabetes in Youth (MIGHTY-fiber)
Background: Metformin is a pill youth with type 2 diabetes take. It can cause side effects like diarrhea and upset stomach. Researchers want to see if a fiber supplement can help decrease these side effects.
- Trial name
- NCT04209075
- Testing
- Biomebliss, Metformin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes (T1D)
Lactobacillus Johnsonii in Children and Adolescents With T1D
While genetics demonstrated a major risk factor for the development of type 1 diabetes (T1D), microbiota dysbiosis has been suggested as an elicitor in immunological tolerance and of beta cell autoimmunity.
- Trial name
- NCT03961854
- Testing
- L. johnsonii Probiotic
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Type 2 Diabetes
Artificial Intelligence-based Methods to Predict Disease Progression in Youth With Type 2 Diabetes
Currently, clinicians are unable to predict a patient's risk of long-term disease progression and development of a long-term complication based on the data that is available to them.
- Trial name
- NCT07116902
- Testing
- phone application, Standard of Care (SOC)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Type 1 Diabetes
Exercise in Adolescents With Type 1 Diabetes
Regular physical activity is an important part of diabetes management in adolescents with type 1 diabetes (T1D). Increased physical activity has several beneficial effects such as improved lipid profile, insulin sensitivity and…
- Trial name
- NCT04418869
- Testing
- Exercise bouts
- Volunteers
- 8 people
- Sponsor
- Region Örebro County
Type 2 Diabetes
The Role of Amylin and Incretins on Postprandial Metabolisms in Adolescents With Type 2 Diabetes Mellitus (T2DM).
To study postprandial metabolism in lean, obese and T2DM adolescents using a mixed meal challenge. Specifically we will be measuring the following parameters of postprandial metabolism: 1.
- Trial name
- NCT00361946
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Type 1 Diabetes Mellitus
Phase Angle and TyG Index as Markers of Glycaemic Control, Adiposity and Cardiovascular Risk in T1D Adolescents
This study aimed to identify new clinical biomarkers that may improve the follow-up and health outcomes of adolescents with type 1 diabetes.
- Trial name
- NCT07021326
- Testing
- there is no intervention
- Where
- Spain
- Volunteers
- 73 people
- Sponsor
- University of Alicante
Diabetes Mellitus, Type 1
Study of Calcium Metabolism in Teenage Girls With Type 1 Diabetes
The proposed pilot study will enroll 33 adolescent females with type 1 diabetes for the assessment of whole body calcium metabolism using dual stable calcium isotopes.
- Trial name
- NCT03156179
- Testing
- calcium isotope analysis
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Rochester
Diabetes Mellitus, Type 1
A Pilot Study of Biomarkers of Stress in Youth Who Use Teens.Connect
This feasibility/pilot study has three purposes. First, the investigators will determine the feasibility of collecting saliva to measure stress biomarkers over three days at home in youth.
- Trial name
- NCT02970656
- Testing
- Teens.Connect
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Yale University
Type 1 Diabetes, Puberty: >Tanner 2 Breast Development or Testis >4ml
Rosiglitazone and Insulin in T1DM Adolescents
Type 1 Diabetes is the most common life-long disorder with onset in childhood. Patients need insulin injections, blood sugar monitoring several times each day, and adhere to a strict diet.
- Trial name
- NCT00372086
- Testing
- Rosiglitazone
- Where
- Australia
- Volunteers
- 32 people
- Sponsor
- The University of New South Wales
Type 1 Diabetes Mellitus, Hypoglycemia
How to be Safe With Alcoholic Drinks in Diabetes
The purpose of this study is to show that during and after drinking beer a treatment strategy by insulin bolus and reduction of basal rate reduces the rate of hyperglycaemia without an increase of hypoglycaemic events compared to…
- Trial name
- BEER (NCT02518022)
- Testing
- Insulin
- Where
- Germany
- Sponsor
- Kinderkrankenhaus auf der Bult
Arginine Vasopressin Deficiency, Oxytocin Deficiency
Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease
An open-labeled, interventional pilot trial, 10 youth with AVP-D and 10 PD matched for age, sex, and BMI will be recruited from Pediatric Endocrinology and Neuroendocrinology at Massachusetts General Hospital and in the…
- Conditions
- Arginine Vasopressin Deficiency, Oxytocin Deficiency, Pediatric Disease, Hypopituitarism
- Trial name
- Pedi-EVOLVE (NCT07568509)
- Testing
- Norethindrone Acetate-Ethinyl Estradiol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes Mellitus, T1D
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
This study is a Phase 1b/2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple ascending doses of CNP-103.
- Conditions
- Type 1 Diabetes Mellitus, T1D, T1DM, T1DM - Type 1 Diabetes Mellitus
- Trial name
- NCT06783309
- Testing
- CNP-103
- Where
- 45 sites in United States
- Volunteers
- 72 people
- Sponsor
- COUR Pharmaceutical Development Company, Inc.
Type 1 Diabetes Mellitus
Communication and Coping for Mothers of Adolescents With Type 1 Diabetes
Mothers of adolescents with type 1 diabetes experience high levels of depressive symptoms, which impair their ability to monitor and manage diabetes treatment effectively.
- Trial name
- T1D (NCT03818711)
- Testing
- Communication & Coping Intervention, Education & Check Ins
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- Vanderbilt University Medical Center
Type 2 Diabetes
Pharmacokinetic Study of CYCLOSET ® 0.8 mg Tablets in Children and Adolescent Type 2 Diabetes Mellitus Subjects
The objective of this study is to evaluate the relative bioavailability, and the rate and extent of absorption of bromocriptine in male and female children and adolescent Type 2 Diabetes Mellitus patients, aged 10 to less than…
- Trial name
- NCT02078440
- Testing
- Bromocriptine mesylate
- Where
- 5 sites in United States
- Volunteers
- 18 people
- Sponsor
- VeroScience
Type1 Diabetes Mellitus
Evaluation of the Dreamed Advisor Pro for Automated Insulin Pump Setting Adjustments in Children and Adolescents With Type 1 Diabetes- The Advice4U Pro Study
The DreaMed Advisor Pro is a software which automatically analyses treatment information, learns patient's needs and accordingly suggests adjustments in insulin dosing.
- Trial name
- Advice4U (NCT03003806)
- Testing
- DreaMed Advisor Pro, Medical guided recommendation
- Where
- 7 sites in United States, Germany and 2 more
- Volunteers
- 122 people
- Sponsor
- Rabin Medical Center
Diabetes Mellitus Type 1
Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis
Hypothesis: Basal insulin analogs with continuous 24-hour delivery of insulin improve glycemic control during the first year of treatment of children/adolescents with type 1 diabetes mellitus (T1DM)by preserving endogenous…
- Trial name
- BAS (NCT01271517)
- Testing
- NPH insulin, Glargine, Detemir
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Karolinska Institutet