Clinical trials: Diabetes in Adolescence
Type 1 Diabetic Nephropathy
The Impact of Sitagliptin as an Add on Therapy With Closed Loop Control in Adolescents With Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the most frequent microvascular complications of diabetes mellitus, affecting 25 to 40% of patients with type 1 diabetes (T1DM).
- Trial name
- NCT06115460
- Testing
- oral sitagliptin supplementation
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Ain Shams University
Type 1 Diabetes (T1D)
Introducing Biosimilar Insulin Glargine to the Treatment Regimen of Children and Youth with Type 1 Diabetes in Mali
This study aimed to evaluate the impact on blood glucose control and quality of life in children and youth with type 1 diabetes in Mali by switching the insulin regimen from human insulin via needle and syringe, to long-acting…
- Trial name
- NCT06624943
- Testing
- biosimilar insulin glargine
- Where
- Mali
- Volunteers
- 260 people
- Sponsor
- Life for a Child Program, Diabetes Australia
Diabetes Mellitus, Type 1, Autoimmune Diseases
Exercise Snacks and Glutamine to Improve Glucose Control in Adolescents With Type 1 Diabetes
This project will assess the feasibility and efficacy of the use of exercise and dietary supplementation with a non essential amino acid - glutamine - a component of most protein supplements, on the regulation of plasma glucose…
- Conditions
- Diabetes Mellitus, Type 1, Autoimmune Diseases, Diabetes Mellitus, Endocrine System Diseases
- Trial name
- NCT03199638
- Testing
- Exercise
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes Mellitus
Pizza-Salami Study in Children and Adolescents With Type 1 Diabetes
The Pizza-Salami-Study aims to investigate the efficacy of carbohydrate plus fat/protein (CFP) counting compared with carbohydrate (CARB) counting using normal and dual-wave bolus in sensor-augmented pump therapy in children and…
- Trial name
- NCT01400659
- Testing
- CFP counting, CARB counting
- Volunteers
- 42 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes
Sleep Screening and Intervention for Adolescents With Type 1 Diabetes in a Clinical Diabetes Center
This study is evaluating an in-clinic sleep screening and intervention algorithm for youth with type 1 diabetes. This study will assess health care provider feasibility of completion of intervention and long term follow up for…
- Trial name
- NCT07494188
- Testing
- Sleep intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Diabetic Kidney Disease, Hyperuricemia
Uric Acid Lowering Trial in Youth Onset T2D
Adolescents and young adults with youth-onset type 2 diabetes (T2D) are disproportionally impacted by hyperuricemia compared to non-diabetic peers and youth with type 1 diabetes (T1D).
- Conditions
- Diabetic Kidney Disease, Hyperuricemia, Diabetes, Diabetes Mellitus, Type 2
- Trial name
- ULTRA-T2D (NCT03899883)
- Testing
- Pegloticase 8 MG/ML [Krystexxa]
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Colorado, Denver
Diabetes
CSII Pilot in Adolescents With Type 2 Diabetes
This feasibility pilot is intended to understand whether adolescents with Type 2 Diabetes (2DM) can be transitioned to a continuous subcutaneous insulin injection (CSII) and if so, assess whether CSII is a feasible treatment…
- Trial name
- NCT02748122
- Testing
- MMT 723
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- NYU Langone Health
Type 2 Diabetes Treated With Insulin, Obesity
Dulaglutide Versus Liraglutide in Obese Type 2 Diabetic Adolescents Using Metformin
To compare the efficacy and effect on glycemic control of Dulaglutide versus Liraglutide in obese Type 2 diabetic adolescents using metformin
- Conditions
- Type 2 Diabetes Treated With Insulin, Obesity, Adolescent Obesity
- Trial name
- NCT04829903
- Testing
- Dulaglutide, Liraglutide
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Corporacion Parc Tauli
Diabetes type1
Simple Initiation of Advanced Hybrid Closed Loop System
Background and Aim. The new and advanced hybrid closed loop (AHCL) system MiniMed 780G automatically adjusts basal insulin delivery in addition to automated bolus corrections, based on continuous glucose monitoring (CGM)…
- Trial name
- 780GGS (NCT05069727)
- Testing
- Regular Protocol with advanced carbohydrate counting, Simplified Protocol with fixed carbohydrate content
- Where
- Qatar
- Volunteers
- 34 people
- Sponsor
- Sidra Medicine
Type 1 Diabetes Mellitus
Exercise Training Intervention in Children With Type 1 Diabetes
Type 1 diabetes mellitus (T1DM) is associated with multiple co-morbidities, such as hypertension, dyslipidemia, coronary heart disease and osteoporosis. The foundation of these conditions lays in childhood.
- Trial name
- Diabex (NCT01220479)
- Testing
- Exercise training program
- Where
- Switzerland
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Type 1 Diabetes
Closing the Loop in People with Type 1 Diabetes
The main objective of this study is to determine whether home use of fully closed-loop glucose control applying age-approved ultra-rapid insulin (Phase 2) is superior to standard insulin pump therapy with continuous glucose…
- Trial name
- CLEAR Phase 2 (NCT05653050)
- Testing
- CamAPS HX, Standard insulin pump therapy with CGM
- Where
- 4 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Cambridge
Diabetes Mellitus, Type 1
A Study on the Effect of 2 Pen Devices on HbA1c
The purpose of this study is to test the hypothesis that the HumaPen Memoir with memory function, when used over 24 weeks for prandial insulin injections achieves superior glycemic control, when compared to the conventional…
- Trial name
- NCT00985712
- Testing
- Insulin Lispro, Huminsulin Regular, HumaPen Memoir
- Where
- 29 sites in Germany
- Volunteers
- 263 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetic Nephropathy
Resveratol in Diabetic Nephropathy
Background: Food-derived compounds have been shown to have beneficial effects in type 1 diabetes mellitus (T1DM). Among these compounds, resveratrol (3,5,4'-trihydroxystilbene) which is found in grapes, peanuts, cranberries.
- Trial name
- NCT07332819
- Testing
- Resveratol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, MODY
Screening for Genetic Forms of Diabetes in Convention of Care for Children and Adolescents With Diabetes (GENEPEDIAB)
Background/Aims: Diabetes, which affects 420 million people worldwide with a continuously rising incidence, is defined by a state of chronic hyperglycemia; a criterion referring to a heterogeneous group of diseases with various…
- Trial name
- GENEPEDIAB (NCT04021199)
- Testing
- Mody test
- Where
- Belgium
- Volunteers
- 446 people
- Sponsor
- Université Catholique de Louvain
Type 1 Diabetes Mellitus
Comparison of the Safety and Efficacy of HOE901-U300 With Lantus in Children and Adolescents With Type 1 Diabetes Mellitus
Primary Objective: To compare the efficacy of a new formulation of insulin glargine (HOE901-U300) to Lantus in terms of change of HbA1c from baseline to endpoint (month 6) in children and adolescents with type 1 diabetes…
- Trial name
- EDITION JUNIOR (NCT02735044)
- Testing
- Insulin glargine,300 U/mL, Insulin glargine (100 units /mL), Background therapy
- Where
- 107 sites in United States, Argentina and 22 more
- Volunteers
- 463 people
- Sponsor
- Sanofi
Dairy Consumption, Metabolic Health
The Effect of Dairy Intake on Body Weight and Composition and Metabolic Health in Adolescents and Seniors
The goal of this study is to examine how regular dairy intake affects body weight, body composition, and metabolic health in overweight and obese adolescents (ages 15-18) and older adults (ages 60-80) over six months.
- Conditions
- Dairy Consumption, Metabolic Health, Obesity Prevention
- Trial name
- NCT06879652
- Testing
- Counselling to follow Canada's Food Guide and 3 daily servings of Dairy (long-term study), Dairy (short-term study), Counselling to follow Canada's Food Guide (long-term study)
- Where
- 2 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Toronto
Diabetes Mellitus, Type 1
The Impact of Mobile Technology on Clinical Outcomes in Children and Adolescents With Type 1 Diabetes
The purpose of this study is to determine whether a simple text message reminder sent to the parent of an child/adolescent with Type 1 Diabetes(or parent and adolescent) is effective in helping the individual(or parent) become…
- Trial name
- Edu4U (NCT02619487)
- Testing
- text message to parent only, text message to parent and adolescent
- Where
- United States
- Sponsor
- University of Louisville
Type 1 Diabetes
Simple Meal Management Using Automated Insulin Delivery System
Carbohydrate counting is an essential component of diabetes management in both adults and children, and together with an intensive insulin plan and increased blood glucose monitoring was associated with lower HbA1c.
- Trial name
- SMMAID (NCT06130215)
- Testing
- Simple meal management, Precise meal management
- Where
- Qatar
- Volunteers
- 34 people
- Sponsor
- Sidra Medicine
Type 1 Diabetes Mellitus
Effect of Splitting Mealtime Insulin Doses After Mixed Meals High in Fat and Protein
The current management of type 1 diabetes mellitus (T1DM) depends on the use of intensive insulin therapy - either by insulin pump therapy or multiple daily injection (MDI) therapy - and the use of carbohydrate counting to…
- Trial name
- NCT04783376
- Testing
- : Insulin, lispro and regular insulin
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Sohag University
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Efficacy and Safety of Insulin Degludec in Children and Adolescents With Type 1 Diabetes Mellitus
This trial is conducted in Africa, Asia, Europe and the United States of America (USA). The aim of this trial is to investigate the efficacy and safety of insulin degludec in children and adolescents with type 1 diabetes mellitus.
- Trial name
- BEGIN™ (NCT01513473)
- Testing
- insulin degludec, insulin detemir, insulin aspart
- Where
- 81 sites in United States, Bulgaria and 10 more
- Volunteers
- 350 people
- Sponsor
- Novo Nordisk A/S