Clinical trials: Diabetes in Pregnancy
Type 2 Diabetes Mellitus
Role of Canagliflozin on CD34+ Cells in Patients With Type 2 Diabetes
The investigators hypothesize that Cana may be able to improve number and function of CD34+ endothelial progenitor cells. The investigators also propose that this expected cardiovascular benefit is independent of HbA1C reduction.
- Trial name
- NCT02964585
- Testing
- Canagliflozin
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- George Washington University
Type 2 Diabetes Mellitus, Renal Impairment
Gla-300 and IDeg-100 in Insulin-Naïve People With Type 2 Diabetes Mellitus and Renal Impairment
The TRENT trial is designed to confirm the efficacy and safety of Gla-300 compared with IDeg-100 in insulin-naïve patient (participants who have not tried insulin) with Type 2 Diabetes Mellitus (T2DM) and renal impairment.
- Trial name
- TRENT (NCT05552859)
- Testing
- Insulin glargine 300 U/mL, Insulin degludec 100 U/mL
- Where
- 68 sites in United States, Czechia and 3 more
- Volunteers
- 62 people
- Sponsor
- Sanofi
Diabetes in Pregnancy
Incentives and Glucose Adherence in Diabetes
Diabetes in pregnancy carries significant pregnancy specific risks and requires frequent glucose monitoring to reduce these risks.
- Trial name
- NCT03338829
- Testing
- Positive incentive, Loss aversion
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Type 2 Diabetes, Chronic Kidney Disease
Metformin Use in Chronic Kidney Disease: The CKD-Met Study
Metformin is the most widely prescribed oral treatment for diabetes, and the only one that showed a survival benefit. Yet, there is no consensus on the optimal dose and withdrawal of metformin in chronic kidney disease (CKD)…
- Trial name
- CKD-Met (NCT02844153)
- Testing
- modalities of metformin prescription
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Hospices Civils de Lyon
Pre-diabetes
Metformin and Sitagliptin in Women With Previous Gestational Diabetes
The goal of the present research is to compare the effects of treatment with metformin and sitagliptin, alone or in association, in women with previous gestational diabetes to evaluate the impact of the two drugs on beta-cell…
- Trial name
- NCT01336322
- Testing
- Metformin, Sitagliptin, Sitagliptin + Metformin
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pisa
Chronic Kidney Disease
A Phase 1, Open-label Safety Study of NKA in Patients With Type 2 Diabetes
The purpose of this study is to determine if selected renal cells, obtained by biopsy from a patient with chronic kidney disease (CKD) and Type 2 Diabetes (i.e., autologous cells) can be safely implanted back into the patient.
- Trial name
- NCT02008851
- Testing
- Neo-kidney augment
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- Tengion
Gestational Diabetes Mellitus in Pregnancy, Diabetes Self Management
Effect of Digital Storytelling Intervention on Diabetes Self-Management in Pregnant Women With Gestational Diabetes
The aim of this study is to evaluate the effect of digital storytelling intervention on diabetes self-management in women with gestational diabetes. It is a quasi-experimental study with a pretest-posttest control group.
- Trial name
- NCT06148688
- Testing
- Digital Story
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Izmir Katip Celebi University
Gestational Diabetes Mellitus in Pregnancy
Comparison of Metformin and Insulin for Management of Gestational Diabetes Mellitus
Gestational diabetic mellitus (GDM) patients randomised to metformin or insulin group.Aim was to achieve blood sugar levels of Blood sugar fasting (BSF) <5.3 mmol/l and 1 hour post meal<7.8mmol/l.
- Trial name
- NCT03320694
- Testing
- Metformin, Insulin
- Where
- Pakistan
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Chronic Renal Failure, Diabete Type 2
Symbiotics and Systemic Inflammation in Chronic Kidney Disease
Main objective: To assess the effectiveness of treatment with symbiotics on the chronic systemic inflammation observed in chronic renal failure 4 months after the start of treatment.
- Conditions
- Chronic Renal Failure, Diabete Type 2, Systemic Inflammation
- Trial name
- SISMIC (NCT04769687)
- Testing
- probiotic Vivomixx®, prebiotic Orafti®Synergy1
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Type 2 Diabetes, Hypertension
Effect of Pioglitazone on Cardiovascular Outcome on Higashi-Saitama Trial in Patients With Type 2 Diabetes
We want to investigate the effects of pioglitazone on cardiovascular events in Japanese patients with type 2 diabetes.
- Conditions
- Type 2 Diabetes, Hypertension, Dyslipidemia, Diabetic Nephropathy
- Trial name
- NCT00419484
- Testing
- pioglitazone
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Dokkyo Medical University
Pain, Neuropathic, Diabetic Nephropathy
Pain Neuroscience Education in Diabetic Neuropathy
To determine the effects of Pain Neuroscience Education in Diabetic Neuropathy
- Trial name
- NCT04721847
- Testing
- Pain Neuroscience Education, Conventional Physical therapy
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Riphah International University
Type 2 Diabetes
Salt Intake and Antiproteinuric Effect of Paricalcitol in Type 2 Diabetes
Proteinuria is an independent risk factor for cardiovascular morbidity and mortality and for renal disease progression. More proteinuria is associated with faster progression, whereas treatments that reduce proteinuria are…
- Trial name
- PROCEED (NCT01393808)
- Testing
- Paricalcitol
- Where
- 6 sites in Italy
- Volunteers
- 112 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Gestational Diabetes
Immediate Postpartum Glucose Tolerance Testing
The objective of this study is to compare the accuracy of a 2hr glucose tolerance test administered during the postpartum hospitalization with the standard of care glucose tolerance testing (administered at 6 weeks postpartum).
- Trial name
- NCT04199676
- Testing
- Glucose tolerance test
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- MemorialCare Health System
Diabetes Mellitus Pregnancy
Effect of Adding Metformin to Insulin in Uncontrolled Diabetic Patients During the 3rd Trimester of Pregnancy
Background Diabetes mellitus (DM) is a significant contributor to adverse obstetric and perinatal outcome. There is now clear and unequivocal evidence that adverse pregnancy outcomes are strongly linked to maternal hyperglycemia…
- Trial name
- NCT05479214
- Testing
- Metformin, Insulin
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Diabetic Kidney Disease (DKD)
Mechanisms Underlying SGLT2i Kidney Effect in DKD Progression
This is a multicentre and multi-national non-pharmacological, uncontrolled interventional study conducted in a clinical practice setting in DKD patients with CKD stages 1 to 3 with moderate or severe risk of renal function…
- Trial name
- PERSONALISEDKD (NCT07270198)
- Testing
- MRI
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Gestational Diabetes, Pregnancy
Integrating the Use of Calibration-Free Continuous Monitoring for Pregnancy Glucose Profiling: I-Profile Study
This study aims to test the following hypotheses in a longitudinal, observational study in pregnant women who will be randomized to received either a Blinded or Unblinded CGM sensor and followed-up 6-12 weeks after delivery: 1.
- Trial name
- I-Profile (NCT05123248)
- Testing
- Blinded Group, Unblinded group
- Where
- Singapore
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Gestational Diabetes
miRNA (microRNA) and FGF21 (Fibroblast Growth Factor-21) Profile in First Trimester and Gestational Diabetes Prediction
The goal of this observational study is to compare miRNA and FGF21 in pregnancy with and without GDM (Gestational Diabetes) The main question it aims to answer that miRNA and FGF21 are different between two groups.
- Trial name
- NCT05632055
- Testing
- blood draw
- Where
- Thailand
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Gestational Diabetes Mellitus, Pregnancy
GooDMoMS: A Multimodel Pregnancy and Postpartum Intervention for Gestational Diabetics
This study includes a behavioral educational intervention that focuses on healthy eating and physical activity during pregnancy and the postpartum among women newly diagnosed with gestational diabetes mellitus (GDM).
- Trial name
- NCT01600534
- Testing
- lifestyle counseling
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Advancing Care Coordination Between Cancer and Primary Care Teams for Complex Cancer Survivors
The purpose of this randomized clinical trial is to learn if 'complex' cancer patients who receive care guided by a health system intervention, Primary Care Connect (PC2) have their risks of cardiovascular disease (CVD) managed…
- Conditions
- Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3), Bladder Cancer, Prostate Cancer (Adenocarcinoma)
- Trial name
- ACCESS-PC (NCT06834204)
- Testing
- PC2: Primary Care Connect
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Rutgers, The State University of New Jersey
Diabetic Kidney Disease
IvaBradinE to Treat MicroalbumiNuria in Patients With Type 2 Diabetes and Coronary Heart Disease
To explore the efficacy of Ivabradine for the treatment of microalbuminuria in patients with type 2 diabetes and coronary heart disease.
- Trial name
- BENCH (NCT03105219)
- Testing
- Ivabradine
- Where
- China
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
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