Clinical trials: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
Single-center Clinical Study of Early Diagnosis of Diabetic Cardiomyopathy With FLIM
Diabetic Cardiomyopathy (DCM) is disease of myocardial structure and function which is independent of hypertension, coronary heart disease, heart valve abnormalities, and other types of heart disease.
- Trial name
- NCT04534894
- Testing
- fluorescence lifetime imaging microscopy
- Volunteers
- 243 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Diabetic Cardiomyopathies
Diabetic Cardiomyopathy
Diabetes represents one of the 10 leading causes of death in the world and concerns 5% of the French population (> 3.3 million patients). About 30% of diabetic patients will develop heart failure.
- Trial name
- CarDiab (NCT04593173)
- Where
- France
- Volunteers
- 77 people
- Sponsor
- University Hospital, Strasbourg, France
Type 2 Diabetes, High Blood Pressure
Polypill for Prevention of Cardiomyopathy
This study will investigate the utility of a polypill-based strategy for patients with type 2 diabetes mellitus and high risk of heart failure (HF), as assessed via the WATCH-DM risk score.
- Trial name
- PolyPreventHF (NCT06143566)
- Testing
- Polypill, Combined prescription of the individual medications
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
T2DM (Type 2 Diabetes Mellitus)
Nutritional Therapy for Diabetic Cardiomyopathy
The goal of this study is to determine if nutritional therapy can effectively treat/prevent T2DM and its consequent cardiomyopathy.
- Trial name
- NCT01373814
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Washington University School of Medicine
Cardiomyopathy, Diabetic
Impact of Pharmacist in Cardiology Service
The coverage of the diabetes is a multidisciplinary care, with practitioners' implication(hospital and liberal), and other medical and paramedical profession: doctor, pharmacist, male nurse, nutritionist, etc.
- Trial name
- NCT03206294
- Testing
- pharmacist assessment
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Heart Failure, Diabetic Cardiomyopathies
The DAPA-MEMRI Trial
Diabetes mellitus is among the top 10 causes of death worldwide with an increasing incidence. Patients with diabetes are at risk of developing heart failure which is characterised by significant changes in the heart muscle…
- Trial name
- DAPA-MEMRI (NCT04591639)
- Testing
- Dapagliflozin 10 milligrams [Farxiga]
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Reperfusion Injuries, Myocardial
The Role of Mitochondrial Respiration in the Cardioprotective Capacity of IPC in Diabetic and Non-diabetic Patients
The overall aim of this study is to examine the role of mitochondrial respiration in human diabetic tissue before and after ischemia.
- Trial name
- NCT02993484
- Testing
- Dimethyl Malonate, Ischemic preconditioning, Ischemia reperfusion
- Volunteers
- 39 people
- Sponsor
- University of Aarhus
Type 2 Diabetes Mellitus, Cardiovascular Diseases
Soluble TREM-1 in Diabetes-Associated Cardiovascular Complications
Cardiovascular disease is the leading cause of illness and death among individuals with type 2 diabetes mellitus (T2DM). Chronic low-grade inflammation contributes significantly to blood vessel damage, atherosclerosis, and…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Diseases, Coronary Artery Disease, Heart Failure
- Trial name
- NCT07847112
- Volunteers
- 85 people
- Sponsor
- Assiut University
Type2 Diabetes, Heart Failure With Reduced Ejection Fraction
The Effects of SGLTi on Diabetic Cardiomyopathy
Diabetic cardiomyopathy is associated with significant morbidity and mortality. It is considered as a cardiac muscle disorder secondary to diabetes mellitus (DM).
- Trial name
- SGLTi (NCT04200586)
- Testing
- Dapagliflozin
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The University of Hong Kong
Cardiomyopathy
Reversal of Obese/Diabetic Cardiomyopathy After Gastric Bypass Surgery
The overall purpose of this study is to evaluate the effect of gastric bypass surgery-induced weight loss on the heart's function and on fat deposits in the heart muscle.
- Trial name
- DRTC (NCT01067209)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
Ischemic Cardiomyopathy, Diabetes Mellitus
Alpha-lipoic Acid in Diabetic Patients With Ischemic Cardiomyopathy
The aim of this study is to investigate the effect of alpha-lipoic acid on inflammatory markers and cardiac fibrosis markers in diabetic patients with Ischemic Cardiomyopathy.
- Trial name
- NCT06056687
- Testing
- Alpha Lipoic Acid 600 MG Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour University
Cardiopathy, Diabetes
Diabetic/Metabolic Cardiomyopathy: Prevalence and Phenotype
"Little is known about the prevalence, determinants and phenotypes of the cardiomyopathy associated with diabetes and/or metabolic syndrome.
- Conditions
- Cardiopathy, Diabetes, Metabolic Syndrome
- Trial name
- METAB-HEART (NCT05181631)
- Testing
- Biobanking
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Cardiomyopathies
Safety and Efficacy of AT-001 in Patients With Diabetic Cardiomyopathy
This is a multicenter, randomized, placebo-controlled, 2-part study to evaluate the safety and efficacy of AT-001 in adult patients (N=675) with Diabetic Cardiomyopathy at high risk of progression to overt heart failure.
- Trial name
- NCT04083339
- Testing
- AT-001
- Where
- 79 sites in United States, Australia and 8 more
- Volunteers
- 675 people
- Sponsor
- Applied Therapeutics, Inc.
Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies
In and ex Vivo Mitochondrial Function of the Heart
It has been suggested that mitochondrial dysfunction might play a role in the development of diabetic cardiomyopathy. From animal studies, it has been suggested that an altered PPAR and PGC1 expression is involved in the reduced…
- Trial name
- 31P (NCT03049228)
- Testing
- 31P-MRS scan and cardiac MRI scan, Atrial biopsy for high-resolution respirometry, Blood analysis
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Maastricht University Medical Center
Cardiomyopathy, Diabetic
CARdiomyopathy in Type 2 DIAbetes Mellitus
The objective of the CARDIATEAM clinical study is to assess the uniqueness of diabetic cardiomyopathy (DCM) relative to other forms of cardiomyopathy using unsupervised clustering approaches based on deep phenotyping (clinical…
- Trial name
- CARDIATEAM (NCT04303364)
- Where
- 17 sites in France, Germany and 3 more
- Volunteers
- 1,256 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Diabetes Mellitus, Type 1
Alteration of Myocardial Deformations in Diabetes: Relationship to Micro-angiopathy
Despite careful monitoring of patients with diabetes, it is so far difficult to predict the occurrence of cardiac events in the evolution.
- Trial name
- ECHO-DIAB (NCT01220349)
- Testing
- Echocardiographic 2D strain analysis
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Bordeaux
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
HFpEF - Heart Failure With Preserved Ejection Fraction, Diabetic Cardiomyopathies
Tailored Exercise Training Study Among Adults With HFpEF
Heart failure with preserved ejection fraction (HFpEF) is associated with a high morbidity and mortality burden. There are limited pharmacological options available for the treatment of HFpEF.
- Trial name
- TEXPEF (NCT07223242)
- Testing
- Moderate-intensity continuous training (MCT), Resistance training, Weight loss
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies
Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes Mellitus
Background: Heart failure is a major cause of morbidity and mortality in diabetes mellitus, but its pathophysiology is poorly understood.
- Trial name
- PREDICT (NCT03132129)
- Testing
- Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography, Computed tomography coronary artery calcium scoring
- Where
- United Kingdom
- Volunteers
- 593 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Type II Diabetes Mellitus, Diabetes Complications
Lipid Biomarkers for Diabetic Heart Disease
This study will test whether lowering the delivery of excess fats to the heart in persons with type-2 diabetes mellitus improves heart muscle function.
- Trial name
- NCT01752842
- Testing
- Fenofibrate
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine