Clinical trials: Diabetic Eye Diseases
Retinopathy, Retinal Vein Occlusion
Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium
The objective of this study is to evaluate the safety and image quality of the investigational dye, MB-102, compared to the control dye (fluorescein sodium) in healthy and diseased eyes using fluorescent angiography for retinal…
- Conditions
- Retinopathy, Retinal Vein Occlusion, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT04008121
- Testing
- Fluorescein sodium and Zeiss FF450 fundus camera, MB-102 and Zeiss FF450 fundus camera, Fluorescein sodium and commercially available optical angiography imaging system
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Uveitis, Diabetic Retinopathy
Biomarkers of Common Eye Diseases
To identify biomarkers of common eye diseases based on single-cell sequencing technologies using PBMC samples. These diseases include uveitis, diabetic retinopathy, age-related macular degeneration and polypoid choroidal…
- Conditions
- Uveitis, Diabetic Retinopathy, Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy
- Trial name
- NCT04101604
- Testing
- Collection of blood samples
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Diabetic Maculopathy, Age Related Macular Degeneration
Reading Analysis in Ophthalmologic Patients
Investigation of the reading parameters and fixation behavior in patients with different ocular diseases (age-related macular degeneration, glaucoma, diabetic maculopathy, epiretinal membrane) and healthy subjects.
- Conditions
- Diabetic Maculopathy, Age Related Macular Degeneration, Glaucoma, Epiretinal Membrane
- Trial name
- NCT03750149
- Testing
- EyeTracker
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Diabetic Retinopathy, Melatonin
Diabetic Retinopathy: Effects of Melatonin Treatment on Visual Functions and Circadian Rhythm
This study evaluates the effect of melatonin 4 mg on circadian rhythm and visual function of patients with diabetes mellitus. Half of the patients will receive melatonin (arm-1) and the other half will receive placebo (arm-2)…
- Conditions
- Diabetic Retinopathy, Melatonin, Circadian Dysrhythmia, Circadian Rhythm Sleep Disorder, Unspecified Type
- Trial name
- NCT03478306
- Testing
- Melatonin 4 mg Tablet
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Diabetic Retinopathy
Nesvategrast (OTT166) in Diabetic Retinopathy (DR)
This study will evaluate the safety and efficacy of OTT166 Ophthalmic solution in participants with Diabetic Retinopathy.
- Trial name
- NCT05409235
- Testing
- OTT166, Vehicle control
- Where
- 68 sites in United States, Puerto Rico
- Volunteers
- 225 people
- Sponsor
- OcuTerra Therapeutics, Inc.
Diabetic Macular Edema
Efficacy & Safety Trial of Intravitreal Injections Combined With PRP for CSME Secondary to Diabetes Mellitus (DAVE)
This study is a Phase I/II, multicenter, randomized, study of the efficacy and safety of ranibizumab injection monotherapy verses a duel therapy of 0.3mg ranibizumab combined with ultra wide, 200° field angiography guided pan…
- Trial name
- DAVE (NCT01552408)
- Testing
- 0.3 mg ranibizumab, Targeted Pan Retinal Photocoagulation
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- David M. Brown, M.D.
Diabetic Retinopathy, Periodontitis
Periodontitis Severity in Patients With Diabetic Retinopathy
The aim of this observational study is to investigate the relationship between periodontal disease severity and retinal layer thickness in patients diagnosed with diabetic retinopathy (DR), using optical coherence tomography…
- Trial name
- NCT07137013
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Diabetes Mellitus, Diabetic Retinopathy
Multicenter RCT of Eye-Brain Imaging in Diabetes Neurovascular Coupling
This study intends to take the critical pathological mechanism of diabetic neurovascular coupling injury (NCI) as the starting point and utilize multi-modal imaging (MMI) technology of the eyes and brain as a means to conduct…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Cognitive Impairment, Neurovascular Coupling
- Trial name
- TCM-MMI (NCT06813274)
- Testing
- hypoglycemic treatment, Tangshen'an Granules, Ginkgo Leaf Tablets
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Hejiang Ye
Diabetes Mellitus
Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients
Comparison of aqueous and plasma glucose level in diabetic patients High glucose concentrations in aqueous humor are thought to be related of diabetic ocular injury, including cataract and diabetic keratopathy.
- Trial name
- NCT02750098
- Testing
- Glucose measurement
- Volunteers
- 25 people
- Sponsor
- Sheba Medical Center
Diabetic Retinopathy
Pharmacological Intervention in Diabetic Retinopathy
The purpose of this study is to determine if diabetic retinopathy can be treated with prostaglandin analogues, prostaglandin synthesis inhibitors or carbonic anhydrases inhibitors.
- Trial name
- XAVOT (NCT00619034)
- Testing
- Latanoprost, diclofenac and dorzolamide (eyedrops), Diclofenac, Dorzolamide
- Where
- Denmark
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diabetic Macular Edema
NSAID Phase II for Non-central Involved Diabetic Macular Edema (DME)
This study is being conducted to assess the effects of topical nonsteroidal anti-inflammatories (NSAIDs) on macular retinal volume compared with placebo in eyes with non-central diabetic macular edema (DME).
- Trial name
- NCT01331005
- Testing
- nepafenac 0.1% drops, Nepafenac Vehicle
- Where
- 32 sites in United States
- Volunteers
- 125 people
- Sponsor
- Jaeb Center for Health Research
Diabetic Retinopathy (DR), Macular Edema (ME)
Video Intervention to Improve Understanding of Diabetic Retinopathy at Zuckerberg San Francisco General Hospital and Trauma Center
The study will evaluate whether videos can improve understanding of diabetic eye disease, and follow-up rates in the eye clinic.
- Trial name
- NCT07519707
- Testing
- Animated Videos
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Training Group, Sensitivity
Developing and Testing a Low Cost Opportunistic Glaucoma Screening Model by Non-physician Graders in Vietnam
This study aims to develop a training course for screening glaucoma using fundus images obtained during diabetic retinopathy screening by non-physician graders.
- Trial name
- NCT05151757
- Testing
- A standard image training set
- Where
- Vietnam
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Macular Edema
Macular Thickness and Visual Acuity in Diabetic Hypertensive Patients
In this study, measurements of central macular thickness using optical coherence tomography along with examination of visual acuity by Snellen's chart in diabetic hypertensive patients will be done .
- Trial name
- NCT05209971
- Volunteers
- 100 people
- Sponsor
- Sohag University
Diabetic Retinopathy
Multicenter Diagnostic Clinical Performance Study For Automated Detection of Diabetic Retinopathy
This study is a retrospective study to assess the efficacy and accuracy of the EyeCheckup software in screening for diabetic retinopathy in healthcare settings.
- Trial name
- NCT05471986
- Testing
- Color Fundus Photography/Non-Mydriatic Opthalmic Cameras
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Ural Telekomunikasyon Sanayi Ticaret Anonim Sirketi
Diabetic Retinopathy
Effects of a Therapy With INTRAVIT® Tablets in Patients With Diabetic Retinopathy
Evaluation of the effect of a therapy with INTRAVIT® tablets, on retinal edema considering also the central retinal sensitivity (Microperimetry) and the visual acuity in course of diabetic retinopathy.
- Trial name
- NCT04742829
- Testing
- INTRAVIT ®
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Molise
Age Related Macular Degeneration, Diabetic Retinopathy
Effect of Video Viewing on Intravitreal Injection Experience
Study Objective The goal of this clinical trial is to evaluate whether viewing a procedural video can improve the patient experience and reduce the incidence and severity of subconjunctival hemorrhage in individuals undergoing…
- Conditions
- Age Related Macular Degeneration, Diabetic Retinopathy, Choroidal Neovascularization, Retinal Vein Occlusion
- Trial name
- NCT07002372
- Testing
- Procedure video viewing
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Proliferative Diabetic Retinopathy, Vitrectomy
Macular Appearance After Diabetic Vitrectomy
Vitrectomy is one of the major treatment methods for complications of diabetic retinopathy. As surgical techniques and instruments improve, high anatomical success may be achieved; however, functional results are less favorable.
- Trial name
- NCT00737022
- Where
- Taiwan
- Volunteers
- 108 people
- Sponsor
- National Taiwan University Hospital
Age Related Macular Degeneration, Diabetic Macular Edema
Change in Ocular Perfusion After Intravitreal Anti-VEGF in Patients with Age-related Maculopathy or Diabetic Macula Edema
This prospective study will include patients with neovascular age-related macular degeneration or diabetic macular edema, scheduled for intravitreal aflibercept.
- Trial name
- NCT06878573
- Testing
- Intravitreal Aflibercept Injection, Laser speckle flowgraphy
- Where
- Austria
- Volunteers
- 36 people
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Diabetic Retinopathy
A Multi-center Study to Evaluate Performance of an Automated Device for the Detection of Diabetic Retinopathy
Diabetes affects 30.3 million people or 9.3% of the population of the United States. Results of a study by the Eye Diseases Prevalence Research Group reveal that 40% of diabetes patients have some degree of diabetic retinopathy…
- Trial name
- NCT02963441
- Testing
- LumineticsCore (formerly IDX-DR)
- Volunteers
- 900 people
- Sponsor
- Digital Diagnostics, Inc.