Clinical trials: Diabetic Foot Osteomyelitis
Diabetic Foot Ulcer, Osteomyelitis Chronic
Mirragen Diabetic Foot Ulcer Study
This study is being done to collect data from treatment of patients who have diabetes with non-healing foot wounds and are being treated with a resorbable and biocompatible borate-based bioactive glass fiber matrix.
- Trial name
- NCT06598241
- Testing
- Borate-base Bioactive Glass Fiber Matrix (BBGFM)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetic Foot Ulcer
Inflammatory Biomarkers to Diagnose and Monitor Diabetic Foot Osteomyelitis
The investigators plan to do a retrospective chart review of 500 patients admitted to the hospital between January 1, 2010 and December 31, 2015 with diabetic foot infections.
- Trial name
- NCT04025853
- Where
- United States
- Volunteers
- 455 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetic Foot Infection
Comparison of FDG PET and Bone Scintigraphy/Labelled Leukocyte/Gallium Scintigraphy in Diabetic Foot Osteomyelitis
Diabetic foot osteomyelitis is a common and serious complication of diabetes. While the diagnosis of soft tissue infection can be made with simple physical examination in most cases, bone involvement can be harder to diagnose…
- Trial name
- NCT03712046
- Testing
- 18F-FDG PET-CT
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Diabetes Mellitus, Claudication, Intermittent
Additional Hyperbaric Oxygen After Lower Extremity Amputation
This study evaluates the effect of additional hyperbaric oxygen therapy after lower extremity amputation. The patients will be randomized after amputation to either a treatment group receiving hyperbaric oxygen therapy, or…
- Conditions
- Diabetes Mellitus, Claudication, Intermittent, Critical Limb Ischemia, Osteomyelitis
- Trial name
- AHOLEA (NCT03594344)
- Testing
- Hyperbaric oxygen therapy
- Where
- 2 sites in Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Diabetic Foot Osteomyelitis
Fungal Infection in Patients With Diabetic Foot Osteomyelitis
estimate the percentage of fungal infection in the pathogenesis of diabetic foot osteomyelitis and assess the outcome of patients with fungal diabetic foot osteomyelitis
- Trial name
- NCT04041739
- Testing
- fungal osteomyelitis culture and sensitivity
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Stage IV Pressure Ulcer, Diabetic Foot Osteomyelitis
Expanded Access Program (EAP) STIMULAN VG
Individual (single) patient expanded access may be considered.
- Trial name
- EAPSTIMVG (NCT06808568)
- Testing
- STIMULAN VG
- Sponsor
- Biocomposites Ltd
Osteomyelitis, Diabetic Foot Osteomyelitis
Bacteriophage Therapy in Patients With Diabetic Foot Osteomyelitis
This is a phase 2b randomized trial designed to evaluate bacteriophage therapy in subjects with diabetic foot osteomyelitis.
- Trial name
- DANCE (NCT05177107)
- Testing
- Bacteriophage Therapy
- Where
- 15 sites in United States
- Volunteers
- 41 people
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Diabetic Foot Disease
FDG-PET Imaging in Complicated Diabetic Foot
The main objective of the proposed research study is to determine the potential utilization of [18-F] Fluorodeoxyglucose (FDG) positron emission tomography (PET) in patients with complicated diabetic foot, especially in the…
- Trial name
- NCT00194298
- Testing
- FDG-PET Imaging
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Pennsylvania
Diabetic Foot Ulcers, Diabetes Mellitus
Assessment of Non Vascular Risk Factors for Severity of Diabetic Foot Ulcers (DFUs)
Diabetes mellitus is a chronic disease that occurs either when pancreas does not produce enough insulin or when the body can't use it effectively.
- Trial name
- DFUs (NCT07193992)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Infection; Diabetic Foot
Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061)
This study compared ertapenem sodium to piperacillin/tazobactam sodium for the treatment of moderate to severe diabetic foot infections.
- Trial name
- NCT01370616
- Testing
- Ertapenem sodium, Piperacillin/tazobactam sodium, Amoxicillin/clavulunate potassium
- Volunteers
- 565 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabete Mellitus, Foot Ulcer
Efficacy and Safety of Stimulan® for the Treatment of Diabetic Foot Osteomyelitis. The BIG D-FOOT Study
This study is designed as a double-blind, placebo-controlled, parallel series randomized trial aimed at verifying the effiicacy and safety of a local calcium-sulphate bio-absorbable antibiotic delivery (tobramicina+vancomicina)…
- Conditions
- Diabete Mellitus, Foot Ulcer, Osteomyelitis - Foot, Surgical Procedure, Unspecified
- Trial name
- BIG D-FOOT (NCT06262854)
- Testing
- Calcium-sulphate granules with tobramicina+vancomicina
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Osteomyelitis, Prosthetic Joint Infection
Short or Long Antibiotic Regimes in Orthopaedics
Research question: If adults with bone or joint infection have local antibiotic therapy, can they do without prolonged treatment with antibiotics by mouth (oral) or injection? Adults with bone or joint infections are usually…
- Conditions
- Osteomyelitis, Prosthetic Joint Infection, Diabetic Foot
- Trial name
- SOLARIO (NCT03806166)
- Testing
- Shorter Systemic Antibiotics, Standard treatment
- Where
- 23 sites in Germany, Portugal and 2 more
- Volunteers
- 500 people
- Sponsor
- Oxford University Hospitals NHS Trust
Diabetic Foot, Osteomyelitis
Risk Factors for Three Critical Stages of the Diabetic Foot Infections
In this study, it was aimed to evaluate the independent risk factors for osteomyelitis, amputation and major amputation of the diabetic foot infection in the forward direction without using standard scoring procedures.
- Trial name
- NCT02736253
- Where
- Turkey (Türkiye)
- Volunteers
- 379 people
- Sponsor
- Ege University
Diabetes Mellitus, Diabetes Complications
New Diagnostic Tool (MinION) for Identifying Microorganisms in Foot Wounds of Patients Living With Diabetic Foot Osteomyelitis
Diabetic foot wound infections are predominantly polymicrobial. However, 'conventional' microbiological culture does not identify all the bacteria potentially involved in these infections and requires time, which can have a…
- Conditions
- Diabetes Mellitus, Diabetes Complications, Diabetic Peripheral Neuropathy
- Trial name
- MINI-OS (NCT07391995)
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pneumonia, Syncope
Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)
The Next Day Clinic (NDC) is a quality improvement initiative that will be launched and operated by UCLA Health starting July 22, 2024. Its goals are to improve patient care and safety and to maximize cost effectiveness.
- Conditions
- Pneumonia, Syncope, Congestive Heart Failure, Cellulitis
- Trial name
- NDC (NCT06526884)
- Testing
- Next Day Clinic
- Where
- United States
- Volunteers
- 570 people
- Sponsor
- University of California, Los Angeles
Osteomyelitis, Diabetic Foot
Efficacy of Surgical Treatment of Osteomyelitis in Diabetic Foot Ulcers
Hypothesis:Surgical treatment of osteomyelitis in diabetic foot is more effective that medical treatment through antibiotherapy and leads wound healing in ulcers complicated with bone infection.Material and Methods: Randomized…
- Conditions
- Osteomyelitis, Diabetic Foot, Diabetic Foot Ulcers
- Trial name
- NCT01137903
- Testing
- Conservative surgery, Ciprofloxacin, Amoxicillin-Potassium Clavulanate Combination
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Universidad Complutense de Madrid
Bone and Joint Infections
Clinical Evaluation of Daptomycin Bone Penetration
Bone and joint infections are commonly due to Gram-positive bacteria. Treatment of these infections is difficult because of the need of prolonged duration of antimicrobial agents in combination with surgical procedure.
- Trial name
- DAPTO-HUS (NCT01306825)
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Strasbourg, France
Diabetic Foot Infection
[124I]FIAU PET-CT Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection
This protocol will evaluate the sensitivity and specificity of [124I]FIAU as a diagnostic imaging agent for the detection of osteomyelitis in patients with diabetic foot infection.
- Trial name
- NCT01764919
- Testing
- [124I]FIAU
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- BioMed Valley Discoveries, Inc
Subjects With Diabetes and DFU With a Suspicion of DFO
Bedside Bone Biopsy in Diabetic Foot Osteomyelitis
During their lifetime, 15 to 25% of patients with diabetes mellitus will develop a Diabetic Foot Ulcer (DFU) related to neuropathy and/or peripheral arterial disease.
- Trial name
- BOLBOC (NCT06066801)
- Testing
- Bedside blind bone biopsy procedure
- Where
- France
- Volunteers
- 320 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Foot Osteomyelitis, Diabetic Foot Infection
Studying on the Difference Between Two Kinds of Osteomyelitis
To explore the microbial differences of diabetic foot osteomyelitis and osteomyelitis without diabetes.
- Conditions
- Diabetic Foot Osteomyelitis, Diabetic Foot Infection, Microbiome
- Trial name
- NCT04240964
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Nanfang Hospital, Southern Medical University