Clinical trials: Diabetic Gastroparesis
Diabetes Mellitus, Diabetes Mellitus Complications
Phase 2 Study to Evaluate Safety & Efficacy of RM-131 Administered to Patients With Diabetic Gastroparesis
The purpose of this study is to evaluate the effects of RM-131 on gastric emptying, gastroparesis symptoms, and the safety and tolerability of RM-131 compared to placebo in patients with Type 1 and Type 2 diabetes mellitus and…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus Complications, Gastroparesis
- Trial name
- NCT01571297
- Testing
- RM-131
- Where
- 30 sites in United States
- Volunteers
- 204 people
- Sponsor
- Motus Therapeutics, Inc.
Diabetic Gastroparesis
Study of Promethazine for Treatment of Diabetic Gastroparesis
Adult diabetic patients (ages 18-65) with gastric emptying scintigraphy-confirmed delayed gastric emptying will be recruited to participate in the study.
- Trial name
- NCT02130622
- Testing
- Promethazine, Sugar pill
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Functional Dyspepsia, Diabetic Gastroparesis
Assessment of Gastro-Intestinal Function to a Mixed Meal by Non-invasive Imaging
Dyspeptic symptoms, such as pain after eating, bloating and nausea all have major impact on quality of life and health care costs. When no structural cause is identified, patients are diagnosed with functional dyspepsia.
- Trial name
- NCT01919021
- Testing
- Magnetic Resonance Imaging MRI, Gamma Scintigraphy, Assessment of Gastric motor and sensory function
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Idiopathic Gastroparesis, Diabetic Gastroparesis
Open Label Safety Study of Tradipitant in Idiopathic and Diabetic Gastroparesis
This is a multicenter, open label, 3-month safety study with tradipitant in patients with idiopathic and diabetic gastroparesis.
- Conditions
- Idiopathic Gastroparesis, Diabetic Gastroparesis, Gastroparesis
- Trial name
- NCT06836557
- Testing
- Tradipitant
- Where
- 3 sites in Belgium, Germany
- Volunteers
- 17 people
- Sponsor
- Vanda Pharmaceuticals
Gastroparesis, Diabetic Gastroparesis
Gastroparesis Registry 3
The purpose of this study is to create a new registry of patients with gastroparesis in order to better understand the characteristics of patients with gastroparesis and follow how their condition changes over time.
- Conditions
- Gastroparesis, Diabetic Gastroparesis, Idiopathic Gastroparesis
- Trial name
- GpR3 (NCT03680859)
- Where
- 6 sites in United States
- Volunteers
- 406 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Diabetic Gastroparesis
Thoracic Neuromodulation for Diabetic Gastroparesis
The global incidence of diabetes is rising. Gastroparesis is a significant complication of diabetes that results in debilitating symptoms and affects quality of life.
- Trial name
- TNM-DGp (NCT05273788)
- Testing
- 2400 ThorS-MagNT Stimulations at 1Hz, 2400 ThorS-MagNT Stimulations at 10Hz
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Medical University of South Carolina
Gastroparesis
A Study to Evaluate the Effect of Camicinal on Gastroparesis Symptoms in Type 1 and 2 Diabetic Subjects With Gastroparesis
This study is a randomized, double-blind, placebo controlled trial designed to confirm the symptomatic effects of camicinal treatment vs. placebo, on gastroparesis symptoms in type 1 and 2 diabetic subjects with gastroparesis.
- Trial name
- NCT02210000
- Testing
- Camicinal
- Where
- 34 sites in United States
- Volunteers
- 114 people
- Sponsor
- GlaxoSmithKline
Gastroparesis
Per-oral Endoscopy Pyloromyotomy (G-POEM) in the Treatment of Refractory Diabetic Gastroparesis : Prospective Evaluation of Efficacy
The objective of the study is to document the clinical efficacy and complications of endoscopic pyloromyotomy in patients with refractory gastroparesis (diabetic, post-operative and idiopathic), compared to Botulinic toxin…
- Trial name
- G-POEM (NCT02927886)
- Testing
- Per-oral endoscopy pyloromyotomy, Intrapyloric injection of Botulinum toxin
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Gastroparesis
Gastric Pacemaker Implantation for Gastroparesis
Gastric pacemakers and/or temporary gastric stimulators will be implanted in eligible patients.
- Trial name
- HUD (NCT00568373)
- Testing
- Enterra Gastric Pacemaker
- Sponsor
- Indiana University
Gastroparesis
Study Evaluating the Effect of TC-6499 on Gastric Emptying Time in Diabetic Subjects With Gastroparesis
Gastroparesis, also referred to as delayed gastric emptying, is a debilitating, chronic disorder that slows or stops the passage of food from the stomach to the small intestine.
- Trial name
- NCT02187094
- Testing
- TC-6499
- Where
- 8 sites in United States
- Volunteers
- 80 people
- Sponsor
- Targacept Inc.
Diabetic Gastroparesis
A Randomized, Open-label, Two-way Crossover Trial to Determine the Pharmacokinetics of Metoclopramide When Administered as the Orally Disintegrating Tablet Compared to Reglan® Tablets in Subjects With Diabetic Gastroparesis
To determine whether a new Orally Disintegrating Tablet of Reglan (metoclopramide) is metabolized faster than the conventional Reglan tablet in patients with diabetic gastroparesis, pharmacokinetics following a single 10 mg dose…
- Trial name
- NCT00139893
- Testing
- Reglan ODT
- Where
- United States
- Sponsor
- UCB Pharma
Gastroparesis, Diabetes Mellitus, Type 1
Affects of Once-daily Oral Administration of TZP-102 on the Treatment of Symptoms Associated With Diabetic Gastroparesis
The purpose of this study is to test the safety and effectiveness of two dosage levels (10mg and 20mg) of TZP-102 compared to placebo (capsule that looks like the study drug but contains no active drug), administered once-daily…
- Conditions
- Gastroparesis, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01452815
- Testing
- 10mg TZP-102, 20mg TZP-102
- Where
- 52 sites in United States, Belgium and 6 more
- Volunteers
- 201 people
- Sponsor
- Tranzyme, Inc.
Gastroparesis
A Phase 2 Study of CIN-102 in Adults With Idiopathic and Diabetic Gastroparesis
This is a randomized, double-blind, placebo-controlled Phase 2A study to evaluate safety, efficacy, PK, and dose response of oral CIN-102 in adults with idiopathic and diabetic gastroparesis.
- Trial name
- NCT04026997
- Testing
- CIN-102 Dose 1, CIN-102 Dose 2, CIN-102 Dose 3
- Where
- 19 sites in United States
- Volunteers
- 72 people
- Sponsor
- CinDome Pharma, Inc.
Gastroparesis With Diabetes Mellitus
Trial Investigating Efficacy of G-POEM
The goal of this randomized sham-controlled trial is to ivestigate efficacy and safety of G-POEM in treatment of diabetic gastroparesis and explore impact of G-POEM on glucose metabolism and incretine hormones.
- Trial name
- G-POEM (NCT05830994)
- Testing
- G-POEM
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
Diabetes Mellitus, Type 1, Gastroparesis
The Effect of Gluten-free Diet in Type 1 Diabetics With Dyspepsia Symptoms
Patients with type-1 diabetes are more susceptible to motility-related upper gastrointestinal symptoms. Dietary interventions are one of the treatment pillars for these symptoms.
- Conditions
- Diabetes Mellitus, Type 1, Gastroparesis, Dyspepsia, Gluten Sensitivity
- Trial name
- NCT03089632
- Testing
- Gluten-free diet
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Diabetic Gastroparesis
Thoracic Splanchnic Magnetic Neuromodulation Therapy (ThorS-MagNT) for Grade 3 Diabetic Gastroparesis: Pilot Study
Diabetic gastroparesis (DG) is an under recognized and significant complication of diabetes with lack of effective treatments. Recently, a 4-fold increase in hospitalizations has been seen in DG patients with refractory symptoms…
- Trial name
- ThorS-MagNT (NCT04706832)
- Testing
- Thoracic Splanchnic Magnetic Neuromodulation Therapy
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Augusta University
Gastroparesis, Gastroparesis Nondiabetic
Study of Enterra Programming with Nocturnal Cycling in Gastroparetics
The purpose of this research study is to evaluate if different Enterra® device programming methods active during sleeping hours can maintain gastroparesis-related symptom relief and quality of life measures.
- Conditions
- Gastroparesis, Gastroparesis Nondiabetic, Gastroparesis Due to Diabetes Mellitus
- Trial name
- RESTING (NCT05980455)
- Testing
- Enterra® Therapy System
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Enterra Medical, Inc.
Gastroparesis, Gastroparesis Postoperative
Safety and Efficacy of GPOEM in the Treatment of Gastroparesis
The purpose of this study is to assess the clinical efficacy and safety in the treatment of gastroparesis.
- Conditions
- Gastroparesis, Gastroparesis Postoperative, Gastroparesis With Diabetes Mellitus
- Trial name
- NCT04349670
- Testing
- GPOEM - gastric per-oral endoscopic myotomy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Raffaele