Clinical trials: Diabetic Neuropathy
Lower Extremity Amputee, Diabetic Peripheral Neuropathy
Functional and Neuroprotective Effects of Restoring Lower Limb Sensation After Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the effectiveness of providing sensation of the missing limb to individuals with above and below the knee limb loss.
- Trial name
- NCT04658693
- Testing
- Implanted Multi contact stimulating electrode and intramuscular electromyography recording electrode
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Office of Research and Development
Painful Diabetic Neuropathy (PDN), Diabetic Nephropathies
Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy
The research team will perform a comparative-effectiveness sequential, multiple assignment, randomized trial in painful diabetic neuropathy (PDN) patients for 8 total months, divided into two 4-month stages.
- Trial name
- MCPAIN (NCT07795593)
- Testing
- Cognitive Behavioral Therapy (CBT), Oral Medication, Topical Medication
- Where
- 23 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of Michigan
Type 2 Diabetes Mellitus, Diabetic Polyneuropathy
Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Diabetic Polyneuropathy
This study aimed to evaluate talar cartilage thickness in individuals with diabetic polyneuropathy using ultrasonography and to compare the findings with those of healthy individuals.
- Trial name
- NCT07801131
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy
Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic Neuropathy
Painful diabetic peripheral neuropathy (DPN) is a frequent and disabling complication of diabetes that commonly causes persistent foot pain, sleep impairment, and decreased quality of life.
- Conditions
- Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy, Diabetic Foot Pain, Neuralgia
- Trial name
- NCT07882238
- Testing
- Botulinum Toxin Type A, Duloxetine
- Volunteers
- 56 people
- Sponsor
- Assiut University
Diabetic Neuropathy
Activity for Diabetic Polyneuropathy
The proposed study will randomize participants with diabetic peripheral neuropathy into two groups. One group of participants will receive standard-of-care counseling while the other group will undergo supervised exercise and…
- Trial name
- ADAPT (NCT02341261)
- Testing
- Standard Care Counseling, Supervised Exercise and Counseling
- Where
- 2 sites in United States
- Volunteers
- 197 people
- Sponsor
- University of Utah
Eye Diseases, Retinitis Pigmentosa
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAION
This trial will study the safety and efficacy of intranasal delivery of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of non-arteritic ischemic optic neuropathy
- Conditions
- Eye Diseases, Retinitis Pigmentosa, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT05147701
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Diabetic Neuropathy, Diabetes Mellitus (DM)
Effect of Golden Rice-Piper Crocatum Cookies on Neuropathy Prevention in Diabetes
Diabetes mellitus is a chronic disease that can cause many complications, one of the most common being diabetic neuropathy. This condition occurs due to long-term high blood sugar levels that damage the nerves.
- Conditions
- Diabetic Neuropathy, Diabetes Mellitus (DM), Functional Food, Nutritional Intervention
- Trial name
- GRIP-DN (NCT07272993)
- Testing
- Golden Rice Cookies With Piper Crocatum, Golden Rice Cookies Without Piper Crocatum
- Where
- Indonesia
- Volunteers
- 102 people
- Sponsor
- Hasanuddin University
Diabetic Peripheral Neuropathy Type 2
Neural Mobilization vs Cervical Neuromodulation in DPN
This study is a three-arm, assessor-blinded, randomized controlled pilot feasibility trial. The primary goal is to evaluate the feasibility and acceptability of conducting a full-scale randomized controlled trial (RCT) comparing…
- Trial name
- NCT07537270
- Testing
- Manual Neural Mobilization, Cervical Neuromodulatory Intervention, Standard Care
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Abeer Abdrabo
Diabetic Foot, Diabetic Peripheral Neuropathy
Activity Reduction vs Advice for Plantar Hotspots in Diabetes
This randomized proof-of-concept trial will evaluate whether an individualized, objectively monitored temporary reduction in walking activity can accelerate resolution of plantar thermal hotspots in adults with diabetes who are…
- Trial name
- MONITOR (NCT07840300)
- Testing
- Individualized Objectively Monitored Activity Reduction, Standard Activity-Reduction Advice
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Shifa International Hospital
Type 2 Diabetes, Cardiovascular Autonomic Neuropathy
Neurovascular Coupling and Autonomic Neuropathy in Type 2 Diabetes
Diabetes is a growing global health care challenge. Diabetes patients may also suffer from cardiovascular autonomic neuropathy (CAN) which may affect cerebral perfusion.
- Trial name
- NCT04625751
- Testing
- CO2-enriched air, Meal response test
- Where
- 2 sites in Denmark
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Hartwig R. Siebner
Diabetic Peripheral Neuropathy (DPN)
Plantar Intrinsic Muscles Exercises and Three-dimensional Ankle Foot Exercises Comparative Effect in DPN
The aim of this study is to determine the comparative effects of plantar intrinsic muscles exercises and three-dimensional ankle foot exercises on balance, gait and fall risk in patients with diabetic peripheral neuropathy.
- Trial name
- NCT07576179
- Testing
- Plantar intrinsic foot exercises, Three-Dimensional ankle foot exercises
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Balance Impairment in Peripheral Diabetic Neuropathy
" Effects of Task Oriented Training on Balance With or Without Textured Insoles in Patient With Peripheral Diabetic Neuropathy."
Introduction Peripheral diabetic neuropathy (PDN) is a common complication of diabetes that can cause sensory impairment, poor balance, and increased risk of falls.
- Trial name
- NCT07830173
- Testing
- Task oriented balance training, task oriented training with textured insoles
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Superior University
Diabetic Neuropathies, Diabetic Neuropathy, Painful
Effect of TENS on Sensory Parameters in Diabetic Polyneuropathy
Diabetic polyneuropathy is a common complication of diabetes that damages the nerves of the feet and legs. Besides causing pain, it gradually reduces the ability to feel light touch on the sole of the foot.
- Conditions
- Diabetic Neuropathies, Diabetic Neuropathy, Painful, Peripheral Nervous System Diseases
- Trial name
- NCT07807748
- Testing
- High-Frequency TENS, Low-Frequency TENS
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Diabetic Neuropathies, Rehabilitation
Comparative Effects of Reactive Balance Training and Task-Oriented Training on Postural Stability in Patients With Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) is a common complication of prolonged hyperglycemia that damages peripheral nerves, leading to impaired sensory function, increased fall risk, and reduced quality of life.
- Conditions
- Diabetic Neuropathies, Rehabilitation, Reaction Time, Activities of Daily Living
- Trial name
- NCT07827417
- Testing
- Reactive Balance Training, TASK ORIENTED TRAINING
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Foundation University Islamabad
Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN)
SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.
The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain treatments in participants…
- Conditions
- Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN), Chemotherapy Induced Peripheral Neuropathy (CIPN), Idiopathic Peripheral Neuropathy
- Trial name
- NCT06614322
- Testing
- Pregabalin, Duloxetine
- Where
- 7 sites in United States
- Volunteers
- 190 people
- Sponsor
- University of Rochester
Neuropathic Pain, Quality of Life
Neuropathic Pain and Type II Diabetic Patients
Diabetes Mellitus (DM) is a common metabolic disease characterized by hyperglycemia resulting from insufficiency, deficiency or absence of the insulin hormone.
- Conditions
- Neuropathic Pain, Quality of Life, Diabetic Neuropathies
- Trial name
- NCT06798181
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Vasculitic Neuropathy
Polyneuropathy, Impairments and Physical Activity - The PolyImPAct Study
The project aims to investigate the validity, and reliability of outcome measures of muscle strength, functioning (gait, balance, and fine motor skills), physical activity, and patient-reported outcome measures of functioning…
- Conditions
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Vasculitic Neuropathy, POEMS Syndrome, Multifocal Motor Neuropathy
- Trial name
- PolyImPAct (NCT06040567)
- Testing
- Validity and reliability of outcome measures in polyneuropathy, Healthy controls
- Where
- Denmark
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Neuropathy, Painful Diabetic
Neurofeedback for the Management of Neuropathic Pain in People With Diabetes
We will conduct a high-quality, blinded, randomized controlled trial (RCT) to rigorously test the effectiveness of EEG-based NF in patients with diabetes-related neuropathic pain.
- Trial name
- NCT06603792
- Testing
- EEG-neurofeedback
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Southern Denmark
Diabetic Peripheral Neuropathy
Effects of Functional Magnetic Stimulation in Sensory and Motor Function in Diabethic Neuropathy
This study evaluated whether a 2-week course of functional magnetic stimulation applied to the plantar region of the foot could improve sensory function, foot muscle force, postural control, and functional mobility in adults with…
- Trial name
- NCT07818993
- Testing
- Functional Magnetic Stimulation
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University of Primorska
Diabetes Mellitus, Type 2, Diabetic Peripheral Neuropathy
A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy
This study will look at the effects of CagriSema in people with both type 2 diabetes and painful diabetic peripheral neuropathy, compared to placebo.
- Trial name
- NCT06797869
- Testing
- CagriSema (Cagrilintide B and Semaglutide I)
- Where
- 55 sites in United States, Canada and 5 more
- Volunteers
- 142 people
- Sponsor
- Novo Nordisk A/S