Clinical trials: Diabetic Neuropathy Peripheral
Diabetic Peripheral Neuropathy
Effect of Structured Training Program in Diabetic Patients
Diabetic neuropathy, a challenging condition resulting from poorly managed type-1 or type-2 diabetes mellitus, often proves resistant to conventional medications when it comes to alleviating the associated symptoms.
- Trial name
- NCT06262074
- Testing
- Structured Exercise Program, Non structured exercise program
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Insulin-like Growth Factor I, Insulin-like Growth Factor II
Neurotrophic Factors in Cerebrospinal Fluid in Diabetic Patients With Polyneuropathy
Background: The pathogenetic factors underlying development of diabetic polyneuropathy (DP) remain unclear. Reduced neurotrophic stimulation has been proposed as a possible mechanism.
- Conditions
- Insulin-like Growth Factor I, Insulin-like Growth Factor II, Diabetes Complications, Polyneuropathies
- Trial name
- NCT01718015
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Depressive Disorder, Major, Diabetic Neuropathies
Study Evaluating the Potential of DVS SR to Inhibit the CYP2D6 Pathway
To evaluate the effects of multiple oral doses of desvenlafaxine sustained release (DVS SR) and paroxetine on the biotransformation of codeine to morphine in healthy subjects.
- Conditions
- Depressive Disorder, Major, Diabetic Neuropathies, Fibromyalgia, Vasomotor Symptoms
- Trial name
- NCT00456898
- Testing
- desvenlafaxine sustained release (DVS SR), Paroxetine, Codeine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Diabetes Mellitus, Diabetic Neuropathy
Effects of Ankle Block on Postoperative Analgesia in Diabetic and Non-Diabetic Patients
This prospective observational study aims to evaluate the effects of ultrasound-guided ankle block on sensory and motor block characteristics and postoperative analgesic outcomes in patients undergoing lower extremity surgery.
- Conditions
- Diabetes Mellitus, Diabetic Neuropathy, Postoperative Pain Management
- Trial name
- ANKLE-DM (NCT07404124)
- Testing
- Ultrasound-Guided Ankle Block
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Diabetic Peripheral Neuropathy, Diabetes
Diabetes, Falls, and Fractures
Comparing severity of diabetic peripheral neuropathy (small and large fibers including autonomic neuroapthy) to postural control and vestibular measurements
- Conditions
- Diabetic Peripheral Neuropathy, Diabetes, Balance; Distorted, Vestibular Neuropathy
- Trial name
- DIAFALL (NCT05389566)
- Testing
- Quantative Sensory Testing, NCStat-DPN-Check, Composite Autonomic Symptom Score 31
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Healthy
Bioequivalence Study of Two Formulations of Pregabalin CR (Controlled-release) Table 150 mg
The purpose of this clinical trial is to (1) evaluate the bioequivalence(BE) of GLA5PR GLARS-NF3 tablet 150mg administered regular diet relative to GLA5PR GLARS-NF1 tablet 150mg administered regular diet and (2) determine the…
- Trial name
- NCT02955472
- Testing
- GLA5PR GLARS-NF3 tablet 150mg, GLA5PR GLARS-NF1 tablet 150mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GL Pharm Tech Corporation
Diabetic Polyneuropathy, Healthy Individuals (Controls)
PULP SENSIBILITY AND MASSETER INHIBITORY REFLEX IN DIABETIC POLYNEUROPATHY
Accurate evaluation of dental pulp health is essential to avoid unnecessary endodontic treatments. In routine dental practice, pulp sensibility is commonly assessed using electric pulp testing and thermal (cold) testing.
- Trial name
- NCT07369297
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Diabetic Neuropathy
Vitamin D Treatment for Painful Diabetic Neuropathy
The main objective of the study is to assess the effect of vitamin D treatment on painful diabetic neuropathy in Pakistan. This is a prospective study of diabetic patients with a DN score ≥ 4, administered a single dose of…
- Trial name
- NCT02737423
- Testing
- cholecalciferol
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Baqai Institute of Diabetology and Endocrinology
Diabetic Foot, Diabetes Mellitus, Type 2
Foot-Ankle Exercise and Walking Exercise on Diabetes Mellitus Patients
The primary purpose of this study is to determine the effectiveness of foot-ankle exercise and walking exercise on foot neuropathy, stress, and quality of life (QoL) among people with diabetes mellitus (PWDM).
- Conditions
- Diabetic Foot, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Diabetes Type 2
- Trial name
- NCT06518486
- Testing
- Foot-ankle exercise, Walking exercise, Usual care and health education
- Where
- 5 sites in Indonesia
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Diabetic Peripheral Neuropathy
Early Warning of Diabetic Peripheral Neuropathy by Using Infrared Thermography and the Effectiveness of Electroacupuncture in Its Prevention
Part Ⅰ:Infrared thermograms of four parts of the soles of the feet, dorsum of the feet, palms of the hands, and dorsum of the hands of healthy volunteers, diabetic patients, and patients with diabetic peripheral neuropathy were…
- Trial name
- NCT06074913
- Testing
- infrared thermography (IRT), Basal therapy+EA, Basal therapy
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhejiang Chinese Medical University
Diabetic Neuropathy Peripheral, Small Vessel Disease of Diabetes Mellitus
Microcirculatory Vasomotor Changes in Type 2 Diabetes With Peripheral Neuropathy
Microcirculatory flow is subject to cyclic changes under the influence of heart rate, respiration, myogenic activity, neurogenic factors and endothelial factors.
- Conditions
- Diabetic Neuropathy Peripheral, Small Vessel Disease of Diabetes Mellitus, Vasodilation, Vasoconstriction
- Trial name
- NEUROMICRO (NCT03847779)
- Testing
- "Rest", "Exercise", "Foot lowering"
- Where
- France
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Avignon
Lower Limb Amputees, Diabetes
PNS to Improve Vascular Function and Limb Health in Veterans
Establishing a sensitive, scalable physiological test for neurovascular reflex integrity and investigating whether targeted peripheral neural stimulation can enhance perfusion and vasodilatory responsiveness.
- Trial name
- NCT07696988
- Testing
- Chronically Implanted Neural and Muscular Interface, Peripheral Nerve Stimulation (PNS)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Diabetic Neuropathy
Role of Indicator Test (Neuropad) in Detecting Diabetic Neuropathy
Diabetes mellitus can result in damage to the nerves supplying the feet. Various tests can be used to assess nerve damage but no tests so far have been used to assess loss of sweating which can lead to dry skin, fissuring and…
- Trial name
- NCT00895440
- Where
- United Kingdom
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Tameside Hospital NHS Foundation Trust
Diabetic Neuropathies, Diabetic Foot
Thermal Screening for Early Diabetic Peripheral Neuropathy (DPN)
The goal of this research is to develop better tools for diagnosing illness of the feet and legs of people who have diabetes. Investigators will use thermal videos of the foot to aid in the refinement of a system designed to…
- Conditions
- Diabetic Neuropathies, Diabetic Foot, Diabetic Retinopathy
- Trial name
- NCT03069729
- Testing
- no intervention
- Where
- United States
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- VisionQuest Biomedical LLC
Healthy
Bioequivalence Study of Two Formulations of Pregabalin CR(Controlled-release) Table 300 mg
The purpose of this clinical trial is to (1) evaluate the bioequivalence(BE) of GLA5PR GLARS-NF3 tablet 300mg administered regular diet relative to GLA5PR GLARS-NF1 tablet 300mg administered regular diet and (2) determine the…
- Trial name
- NCT02952937
- Testing
- GLA5PR GLARS-NF3 tablet 300mg, GLA5PR GLARS-NF1 tablet 300mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GL Pharm Tech Corporation
Peripheral Neuropathy, Autonomic Neuropathy
Autonomic Nervous System Dysfunction and Peripheral Neuropathy in a Cohort of Asymptomatic Juvenile Diabetic Patients (Type I): A Case-Controlled Study
This is a case-controlled study using an innovative, non-invasive, FDA approved technology to measure the autonomic nervous system.
- Trial name
- NCT00466778
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Weintraub, Michael I., MD, FACP, FAAN
Neuropathic Pain
Safety, Tolerability, and Pharmacokinetics of ASCT-83 in Healthy Adults
The goal of this clinical trial is to learn if ASCT-83 is safe and well-tolerated and measure how ASCT-83 is absorbed, distributed, and eliminated from the body over time. The study will be conducted in healthy adults.
- Trial name
- NCT07363395
- Testing
- ASCT-83
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Alcamena Stem Cell Therapeutics
Diabetic Neuropathies, Diabetic Neuropathy Peripheral
A Study Evaluating Drug-Drug Interaction (DDI) Between HSK16149 Capsules and Metformin Hydrochloride Tablets
This study is a single-center, open, single-arm study, conducted in healthy Chinese populations, and plans to enroll 22 healthy adult subjects (the ratio of either sex is not less than 1/3).
- Trial name
- NCT04841720
- Testing
- HSK16149, Metformin Hydrochloride tablet, HSK16149+Metformin（phase 3）
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Diabetes Type 1, Proteomics
Proteomic Analysis in Paediatric Diabetes Type 1 (PAPD)
The aim of the present study is to investigate a targeted proteomic analysis in plasma of children - of Greek origin- with type 1 diabetes (DT1) and its correlation with the electrophysiological findings that accompany diabetic…
- Conditions
- Diabetes Type 1, Proteomics, Diabetic Peripheral Neuropathy
- Trial name
- PAPD (NCT04257877)
- Testing
- Blood sampling
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki