Clinical trials: Diabetic Neuropathy With Neurologic Complication
Diabetic Polyneuropathy
Correlation of HbA1c With Electrophysiological Studies and Gait Performance in Diabetic Polyneuropathy Patients
This study will be conducted to investigate the relationship between glycosylated hemoglobin (HbA1c) and nerve conduction studies (NCS) with gait performance in patients with DPN.
- Trial name
- NCT05457192
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Shereen Saad Eldin Mohamed Ali
Diabetic Neuropathies, Diabetic Neuropathy, Painful
Effect of TENS on Sensory Parameters in Diabetic Polyneuropathy
Diabetic polyneuropathy is a common complication of diabetes that damages the nerves of the feet and legs. Besides causing pain, it gradually reduces the ability to feel light touch on the sole of the foot.
- Conditions
- Diabetic Neuropathies, Diabetic Neuropathy, Painful, Peripheral Nervous System Diseases
- Trial name
- NCT07807748
- Testing
- High-Frequency TENS, Low-Frequency TENS
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Diabetic Neuropathies
Safety and Feasibility Study of Autologous Progenitor Cell Transplantation in Diabetic Neuropathy
Treatment of patients with diabetic neuropathy by intraarterial progenitor cell transplantation.
- Trial name
- NCT00282685
- Testing
- Intraarterial bone marrow progenitor cell transplantation
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Diabetic Neuropathies
Efficacy and Safety of TAK-583 in Subjects With Diabetic Peripheral Neuropathy
The purpose of this study is to determine the safety and effectiveness of TAK-583, once daily (QD), in the treatment of neuropathy caused by diabetes mellitus.
- Trial name
- NCT00760955
- Testing
- TAK-583
- Where
- 38 sites in United States, Canada
- Volunteers
- 338 people
- Sponsor
- Takeda
Diabetic Polyneuropathy
Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Diabetic Polyneuropathy (Stage 1 or 2)
To assess clinical efficacy and safety of long-term orally administered thioctic acid in the treatment of diabetic polyneuropathy.
- Trial name
- NATHAN1 (NCT00977483)
- Testing
- Thioctic Acid
- Where
- 38 sites in United States, Croatia and 7 more
- Volunteers
- 460 people
- Sponsor
- MEDA Pharma GmbH & Co. KG
Diabetic Neuropathy
Role of Indicator Test (Neuropad) in Detecting Diabetic Neuropathy
Diabetes mellitus can result in damage to the nerves supplying the feet. Various tests can be used to assess nerve damage but no tests so far have been used to assess loss of sweating which can lead to dry skin, fissuring and…
- Trial name
- NCT00895440
- Where
- United Kingdom
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Tameside Hospital NHS Foundation Trust
Diabetic Neuropathies
A Study for the Treatment of Diabetic Peripheral Neuropathic Pain
The purpose of the study is to determine if duloxetine can help patients with painful diabetic neuropathy.
- Trial name
- NCT00552175
- Testing
- Duloxetine hydrochloride - 40 mg, Duloxetine hydrochloride - 60 mg
- Where
- 25 sites in Japan
- Volunteers
- 339 people
- Sponsor
- Eli Lilly and Company
Diabetic Neuropathy
The Effect of Random Vibrations on Perception and Balance
The purpose of this study is to investigate the effects of vibrating insoles on vibration perception threshold (VPT) and balance of people with diabetic neuropathy.
- Trial name
- NCT02989831
- Testing
- Vibrating insoles 'on'
- Volunteers
- 40 people
- Sponsor
- University Medical Center Groningen
Diabetic Peripheral Neuropathy
Effects of Vibration Therapy in Addition to Routine Physical Therapy in Patients With Diabetic Neuropathy
The study is aimed to determine the effects of sole-foot vibration therapy on pain intensity, static and dynamic balance, functional status and satisfaction to the intervention applied on patients with peripheral neuropathy due…
- Trial name
- NCT05580705
- Testing
- Routine Physical Therapy, Vibration Therapy
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Diabetic Neuropathy
Less Neuropathy After Yoga- Managing Diabetic Neuropathy With Yoga
The long-term goal is to identify and establish effective mind-body interventions (as an aspect of complementary and alternative medicine) to improve health and Quality of Life (QoL) for people with disabilities.
- Trial name
- LeNY (NCT02659007)
- Testing
- yoga
- Volunteers
- 15 people
- Sponsor
- Colorado State University
Painful Diabetic Neuropathy
Efficacy and Safety Study of ARC-4558 for Management of Pain Associated With Painful Diabetic Neuropathy
The purpose of this study is to determine whether ARC-4558 is effective in managing pain associated with painful diabetic neuropathy.
- Trial name
- NCT00695565
- Testing
- Clonidine Topical Gel (ARC-4558)
- Where
- 16 sites in United States
- Volunteers
- 180 people
- Sponsor
- Arcion Therapeutics Inc
Neuropathy, Diabete Mellitus
Comparison of Active vs Passive Neural Mobilizations Effects in Improving Burning Pain, Muscular Strength, and Range of Motion in Patients With Diabetic Neuropathy
Randomized controlled trial evaluating active and passive neurodynamic techniques for diabetic neuropathy. Sample size: 60 patients (30 per group), aged 40 to 65 years, diagnosed with diabetes mellitus.
- Conditions
- Neuropathy, Diabete Mellitus, Diabetic Neuropathy
- Trial name
- RCT (NCT07141992)
- Testing
- Active Neural Mobilzations, Passive Neural Mobilzations
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Dow University of Health Sciences
Neuralgia, Postherpetic, Diabetic Neuropathy
Neuropathic Pain Syndrome Patient Study (MK-0000-072)
The purpose of this study is to determine the best way to conduct clinical trials in patients with neuropathic pain (nerve pain). This study will see if generic pregabalin has any effect on neuropathic pain.
- Conditions
- Neuralgia, Postherpetic, Diabetic Neuropathy, Painful Small-Fiber Neuropathy, Idiopathic Distal Sensory Polyneuropathy
- Trial name
- NCT00570310
- Testing
- Comparator: pregabalin
- Volunteers
- 104 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetic Neuropathy, Painful
A Study in Participants With Diabetic Peripheral Neuropathic Pain in China
The purpose of this trial is to assess the efficacy of duloxetine 60 milligrams (mg) once daily (QD) compared with placebo, on the change in pain severity from baseline to 12 weeks as measured by the weekly mean of the daily pain…
- Trial name
- NCT01179672
- Testing
- Duloxetine
- Where
- 15 sites in China
- Volunteers
- 405 people
- Sponsor
- Eli Lilly and Company
Diabetic Polyneuropathy, Postherpetic Neuralgia
Efficacy, Safety, Tolerability and Pharmacokinetics of Concomitant Administration of Tramadol With Duloxetine or Pregabalin
Tramadol is an opioid analgesic, which is widely used in the treatment of acute and neuropathic pain. Treatment of neuropathic pain often requires a combination of pain medications due to the complex nature of neuropathic pain…
- Trial name
- NCT01116531
- Testing
- Tramadol, Duloxetine, Pregabalin
- Where
- Finland
- Sponsor
- Turku University Hospital
Diabetic Neuropathies
Effect of Educational Booklet for Foot-related Exercises for Prevention and Treatment in People With Diabetic Neuropathy
The main objective of this trial is to investigate the effect of an educational booklet foot-related exercise in diabetic neuropathy status, functional outcomes and gait biomechanics in people with diabetic neuropathy.
- Trial name
- FOCA-II (NCT04008745)
- Testing
- Educational and home-based physical therapy by foot-related exercises
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetes Mellitus, Type 1, Type 1 Diabetes Mellitus
Treatment of Diabetic Neuropathy With Liraglutide
The purpose of this trial is to explore whether liraglutide has a long term effect on clinical symptoms and biomarkers in patients with diabetic neuropathy.
- Trial name
- TODINELI (NCT02138045)
- Testing
- Liraglutide treatment
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Aalborg University Hospital
Diabetic Neuropathies, Diabetes Mellitus
Phase I Study of BM2216 ER vs. Melogabalin Besilate: Safety, PK, and Food Effect in Healthy Adults
A Phase I Clinical Study Evaluating the Safety, Pharmacokinetics, Food Effect, Single-Dose Proportionality, and Multiple-Dose Pharmacokinetic Comparison with Melogabalin Besilate Tablets after Single and Multiple Oral…
- Trial name
- NCT06846567
- Testing
- BM2216 Extended-Release tablets（5.5mg）, Mirogabalin Besilate Tablets, BM2216 Extended-Release Tablets(11mg)
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zhejiang Anglikang Pharmaceutical Co., Ltd.
Diabetic Foot Ulcer, Diabetic Neuropathy
Differential Characteristics of Neuropathy in Type 2 Diabetics With and Without Lower Extremity Wounds
The primary purpose of this study is to determine the degree of loss of epidermal nerve fibers near a foot wound in patients with diabetic foot ulcers.
- Conditions
- Diabetic Foot Ulcer, Diabetic Neuropathy, Type 2 Diabetes
- Trial name
- NCT02347709
- Testing
- Diabetic Foot Ulcer Biopsy, Survey, Comprehensive Neuropathy Assessment
- Where
- United States
- Sponsor
- Winthrop University Hospital
Diabetic Polyneuropathy
Effects of Antigravity Treadmill Training on Gait and Balance in Patients With Diabetic Polyneuropathy
Aging can be defined as sequential deterioration that occurs in elderly people including weakness, loss of mobility, decline of physical capabilities, increase susceptibility to disease and many other age-related physiological…
- Trial name
- NCT05088993
- Testing
- Antigravity treadmill training, Conventional exercise program
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Umm Al-Qura University