NeuropathyRCTNCT07141992
Comparison of Active vs Passive Neural Mobilizations Effects in Improving Burning Pain, Muscular Strength, and Range of Motion in Patients With Diabetic Neuropathy
A study testing Active Neural Mobilzations and Passive Neural Mobilzations in people with Neuropathy and Diabete Mellitus, run by Dow University of Health Sciences at 1 site in Pakistan.
Trial summary
Randomized controlled trial evaluating active and passive neurodynamic techniques for diabetic neuropathy. Sample size: 60 patients (30 per group), aged 40 to 65 years, diagnosed with diabetes mellitus. Exclusion criteria: Systemic diseases, pregnancy, fractures, foot ulceration, amputation, osteoarthritis. Read more about this study
- Who is it for?
- Ages 40 to 65 years
- Conditions the study is for
- Neuropathy, Diabete Mellitus, Diabetic Neuropathy
- What is being tested?
- Active Neural Mobilzations and Passive Neural Mobilzations
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 sitePakistan
- Study dates
- 4 Jun 2025to 1 Sep 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Both male and female individuals
- Aged between 40 and 65 years
- Diagnosed with Diabetes Mellitus (Type I and Type II)
- Diagnosis confirmed by a physician
Who cannot join
- One with any systemic disease
- Medical conditions (neurological disorders, fractures, acute inflammatory conditions, recent surgeries)
- Foot Ulceration
- Amputation
- OA of Ankle or Knee Joint
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site
Dow University of Health Sciences / Baqai Institute of Diabetology and Endocrinology
Karachi, Sindh, 75280
About this study
Official title: Comparison of Active vs Passive Neural Mobilizations Effects in Improving Burning Pain, Muscular Strength, and Range of Motion in Patients With Diabetic Neuropathy: A Randomized Control Trial
- Randomized controlled trial evaluating active and passive neurodynamic techniques for diabetic neuropathy.
- Sample size: 60 patients (30 per group), aged 40 to 65 years, diagnosed with diabetes mellitus.
- Exclusion criteria: Systemic diseases, pregnancy, fractures, foot ulceration, amputation, osteoarthritis.
- Study will be conducted at physiotherapy OPDs of Dow Ojha Hospital, DIPMR,NIDE and Baqai Institute of Diabetology and Endocrinology.
- Participants randomly assigned into two groups using a computer-generated randomization sheet.
Group A: Active neurodynamics (neural flossing) - patient-controlled nerve gliding movements.
Read more
Group B: Passive neurodynamics (tensioners) - therapist-applied nerve stretches.
- Standard treatment includes gait training, lower limb strengthening exercised, and stationary bike sessions.
- Treatment: 12 sessions over 4 weeks (3 sessions per week, 30 minutes each session).
- Assessments will be done at baseline and post-intervention by a blinded physical therapist.
- Outcome measures: DN-4 (pain), MMT (muscle strength), Goniometry (ROM), LLTT (nerve mobility).
- Data were analyzed using SPSS Version 27. A one-way ANOVA was performed to compare the results before and after the intervention.
- Study duration: 9 months, including approval, pilot study, data collection, and final presentation.
- Study aims to determine the most effective neurodynamic technique for pain relief, mobility, and muscle strength.
- Findings will guide better rehabilitation strategies for improved patient outcomes and quality of life.
Read the detailed description
Diabetic neuropathy is a common complication of diabetes mellitus that presents with neuropathic pain, muscle weakness, and restricted mobility in the lower limbs. These impairments negatively affect quality of life and increase the risk of falls, foot ulcers, and amputations. Pharmacological treatments are available but frequently provide incomplete symptom relief and may cause adverse effects, creating the need for effective non-pharmacological interventions.
Neural mobilization techniques have been reported to improve nerve mobility and decrease pain sensitivity. Two forms will be applied in this trial: active neural mobilization (neural flossing) and passive neural mobilization (tensioners). Both approaches aim to restore normal neural dynamics but differ in their application principles.
This randomized controlled trial will be conducted in the physiotherapy outpatient departments of Dow Ojha Hospital, the National Institute of Diabetology and Endocrinology (NIDE), and the Baqai Institute of Diabetology and Endocrinology (BIDE). A total of 60 participants with clinically diagnosed diabetic neuropathy, aged 40-65 years, will be recruited and randomly assigned to either an active neural mobilization group or a passive neural mobilization group.
Each group will receive 12 treatment sessions over a 4-week period. Both groups will additionally perform conventional physiotherapy, including gait training, strengthening exercises, and stationary cycling. Outcomes will be assessed at baseline and post-intervention. Measures will include:
Neuropathic pain using the DN-4 questionnaire
Muscle strength using manual muscle testing (MMT)
Joint range of motion using goniometry
The primary objective of the study will be to compare the effectiveness of active versus passive neural mobilization in reducing neuropathic pain and improving muscle strength and joint mobility. Secondary objectives will include determining clinical applicability and the potential role of these interventions in rehabilitation protocols for diabetic neuropathy.
Limitations of the trial will include the inability to blind participants, possible variability in treatment adherence, and potential influence of external factors such as concurrent analgesic use. Randomization and standardized intervention protocols will be employed to minimize bias.
- Conditions
- Neuropathy, Diabete Mellitus, Diabetic Neuropathy
- Being tested
- Active Neural Mobilzations, Passive Neural Mobilzations
- Keywords
- Active Neural mobilizations, Passive Neural mobilizations, diabetic neuropathy, neuropathic pain, muscle strength improvement, ROM improvement, pain reduction
- Medical subject headings
- Diabetes Mellitus, Diabetic Neuropathies, Neuralgia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Active Neural MobilzationsOther
Participants in this group will receive active neural mobilization in the form of neural flossing techniques. These involve controlled, repeated movements performed actively by the patient to mobilize peripheral nerves without placing them under excessive tension. The goal is to restore neural mobility, reduce mechanosensitivity, and relieve neuropathic symptoms such as burning pain.
Passive Neural MobilzationsOther
Participants in this group will receive passive neural mobilization using neural tensioning techniques. These techniques involve therapist-applied passive limb movements that place a controlled tensile load on the neural structures. The objective is to improve neural gliding, reduce nerve compression, and decrease neuropathic pain, particularly in cases of restricted neural tissue mobility.
| Study group | Role | What they receive |
|---|---|---|
| Effect of Active Neural Mobilization on Pain, Strength, and ROM in Diabetic Neuropathy | Experimental | Participants in the active neural mobilization group will receive neural flossing techniques, aimed at improving nerve mobility and reducing neuropathic symptoms. Along with neural mobilization, participants will follow a standardized physiotherapy protocol, including:
Gait training on both smooth and rough surfaces Strengthening exercises: leg press, ankle press, isometric exercises for knee and ankle extensors, bridging, and pelvic rolling All exercises will be performed in 3 sets of 12 repetitions, with 30 seconds of rest between sets Stationary cycling will be included as part of cardiovascular conditioning The intervention will be delivered over 12 sessions, scheduled three times per week for four weeks. This program aims to reduce burning pain, and enhance muscle strength and range of motion in patients with diabetic neuropathy. Receives: Other: Active Neural Mobilzations |
| Effect of Passive Neural Mobilization on Pain, Strength, and ROM in Diabetic Neuropathy | Experimental | Participants in the passive neural mobilization group will receive neural tensioning techniques, which involve therapist-guided passive movements to mobilize the neural structures. In addition to passive mobilization, participants will undergo the same standardized physiotherapy protocol, which includes:
Gait training on both smooth and rough surfaces Strengthening exercises: leg press, ankle press, isometric exercises for knee and ankle extensors, bridging, and pelvic rolling Exercises will be performed in 3 sets of 12 repetitions, with 30 seconds of rest between sets Stationary cycling will be used for cardiovascular conditioning This group will also receive 12 treatment sessions, conducted three times per week over four weeks, with the goal of improving pain, strength, and mobility in individuals with diabetic neuropathy. Receives: Other: Passive Neural Mobilzations |
What is being measured
The primary outcome is the main question the study is designed to answer.
Lower Limb Tension Test
Lower Limb Tension Test (LLTT) Purpose: Assess neural mechanosensitivity of lower limb nerves, especially sciatic, tibial, and peroneal nerves.
Also Known As: Straight Leg Raise (SLR), Slump Test, Prone Knee Bend Test, etc.
Indications:
Radiating leg pain Suspected lumbar radiculopathy Neural tension syndromes
Procedure Includes:
Hip flexion, knee extension, ankle dorsiflexion, and/or foot inversion/eversion based on nerve bias
Positive Sign:
Reproduction of neuropathic symptoms (burning, tingling, shooting pain) Symptoms change with sensitizing maneuvers
Used In:
Neuropathy Sciatica Disc herniation Piriformis syndrome
Measured: 12 sessions for 4 weeks
DN-4 (Douleur Neuropathique en 4 questions)
DN-4 Questionnaire (Douleur Neuropathique en 4 questions) Purpose: To screen for neuropathic pain and distinguish it from nociceptive pain.
Total Items: 10 7 sensory descriptors (e.g., burning, electric shocks, tingling, numbness) 3 clinical examination findings (e.g., hypoesthesia to touch or pinprick, pain on brushing)
Scoring:
Each "yes" = 1 point Total Score Range: 0 to 10 Score ≥ 4 indicates likely neuropathic pain Time Required: Less than 5 minutes
Advantages:
Quick and easy to administer Non-invasive High sensitivity and specificity
Used In:
Diabetic neuropathy Post-stroke pain
Sciatica
Postherpetic neuralgia
Measured: 12 sessions in 4 weeks
Goniometery (Joint Range of Motion)
Goniometry Purpose: Measure joint range of motion (ROM) accurately Instrument: Goniometer (standard)
Components:
Axis: Placed over the joint Stationary arm: Aligned with proximal segment Moving arm: Aligned with distal segment
Procedure:
Explain to patient → Proper positioning → Stabilize proximal joint → Move limb through ROM → Read measurement
Used To Assess:
Joint mobility limitations Effectiveness of treatment Progress tracking in rehabilitation Common Areas: Knee, hip, ankle, shoulder, elbow, wrist, cervical spine
Measured: 12 sessions for 4 weeks
Manual Muscle Testing
Manual Muscle Testing (MMT) Purpose: Evaluate muscle strength manually
Grading Scale (0-5):
0 = No contraction
- = Flicker/trace of contraction
- = Full ROM in gravity-eliminated position
- = Full ROM against gravity
- = Full ROM with some resistance
- = Full ROM with maximum resistance (normal)
Procedure:
Proper positioning → Isolate target muscle → Apply resistance gradually → Grade based on performance
Used In:
Neuromuscular conditions Orthopedic rehab Stroke, SCI, peripheral nerve injuries
Advantages:
Quick and cost-effective Useful in baseline assessment and progress monitoring
Measured: 12 sessions in 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Aug 2025
- Study start4 Jun 2025
- Primary completion23 Aug 2025 (estimated)
- Study completion1 Sep 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for NeuropathyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Dow University of Health Sciences
- Sponsor type
- University, hospital or other
- Collaborators
- Baqai Institute of Diabetology and Endocrinology
- Responsible party
- Principal investigator, MUHAMMAD MEHRAN HAIDER, Dow University of Health Sciences
- Investigators
- Farhan Ishaque Khan, PhD, Study director, Dow Institute of Physical Medicine and Rehabilitation, Dow University of Health Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07141992
- Sponsor's protocol ID
- IRB No. 3966
- Acronym
- RCT
- Status last verified
- Aug 2025
- First submitted
- 19 Aug 2025
- Last updated
- 3 Sep 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual Participant Data (IPD) will not be shared due to confidentiality concerns. Protecting the privacy and anonymity of participants is a top priority, and sharing IPD may risk breaching this confidentiality. Additionally, the data is securely stored and intended solely for use within the scope of this study; therefore, it will not be shared with other researchers.
Publications
Goyat M, Saxena A, Goyal M. Study Protocol titled as "Effectiveness of neural mobilization in improving the ankle ROM and plantar pressure distribution in patients with diabetic peripheral neuropathy: A single group, pre post, quasi experimental study protocol". J Diabetes Metab Disord. 2022 Aug 15;21(2):2035-2041. doi: 10.1007/s40200-022-01106-z. eCollection 2022 Dec.
PubMed 36404825
Study at a glance
From the registry record, last updated by the sponsor on 3 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Active vs Passive Neural Mobilizations Effects in Improving Burning Pain, Muscular Strength, and Range of Motion in Patients With Diabetic Neuropathy: A Randomized Control Trial
- ClinicalTrials.gov ID
- NCT07141992
- Acronym / sponsor ID
- RCT / IRB No. 3966
- Conditions
- Neuropathy, Diabete Mellitus, Diabetic Neuropathy
- Keywords
- Active Neural mobilizations, Passive Neural mobilizations, diabetic neuropathy, neuropathic pain, muscle strength improvement, ROM improvement, pain reduction
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Dow University of Health SciencesUniversity, hospital or other
- Collaborators
- Baqai Institute of Diabetology and Endocrinology
- Study start
- 4 Jun 2025 (actual)
- Primary completion
- 23 Aug 2025 (estimated)
- Study completion
- 1 Sep 2025 (estimated)
- First posted
- 26 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
- Randomized controlled trial evaluating active and passive neurodynamic techniques for diabetic neuropathy.
- Sample size: 60 patients (30 per group), aged 40 to 65 years, diagnosed with diabetes mellitus.
- Exclusion criteria: Systemic diseases, pregnancy, fractures, foot ulceration, amputation, osteoarthritis.
- Study will be conducted at physiotherapy OPDs of Dow Ojha Hospital, DIPMR,NIDE and Baqai Institute of Diabetology and Endocrinology.
- Participants randomly assigned into two groups using a computer-generated randomization sheet.
Group A: Active neurodynamics (neural flossing) - patient-controlled nerve gliding movements.
Group B: Passive neurodynamics (tensioners) - therapist-applied nerve stretches.
- Standard treatment includes gait training, lower limb strengthening exercised, and stationary bike sessions.
- Treatment: 12 sessions over 4 weeks (3 sessions per week, 30 minutes each session).
- Assessments will be done at baseline and post-intervention by a blinded physical therapist.
- Outcome measures: DN-4 (pain), MMT (muscle strength), Goniometry (ROM), LLTT (nerve mobility).
- Data were analyzed using SPSS Version 27. A one-way ANOVA was performed to compare the results before and after the intervention.
- Study duration: 9 months, including approval, pilot study, data collection, and final presentation.
- Study aims to determine the most effective neurodynamic technique for pain relief, mobility, and muscle strength.
- Findings will guide better rehabilitation strategies for improved patient outcomes and quality of life.
Detailed description
Diabetic neuropathy is a common complication of diabetes mellitus that presents with neuropathic pain, muscle weakness, and restricted mobility in the lower limbs. These impairments negatively affect quality of life and increase the risk of falls, foot ulcers, and amputations. Pharmacological treatments are available but frequently provide incomplete symptom relief and may cause adverse effects, creating the need for effective non-pharmacological interventions.
Neural mobilization techniques have been reported to improve nerve mobility and decrease pain sensitivity. Two forms will be applied in this trial: active neural mobilization (neural flossing) and passive neural mobilization (tensioners). Both approaches aim to restore normal neural dynamics but differ in their application principles.
This randomized controlled trial will be conducted in the physiotherapy outpatient departments of Dow Ojha Hospital, the National Institute of Diabetology and Endocrinology (NIDE), and the Baqai Institute of Diabetology and Endocrinology (BIDE). A total of 60 participants with clinically diagnosed diabetic neuropathy, aged 40-65 years, will be recruited and randomly assigned to either an active neural mobilization group or a passive neural mobilization group.
Each group will receive 12 treatment sessions over a 4-week period. Both groups will additionally perform conventional physiotherapy, including gait training, strengthening exercises, and stationary cycling. Outcomes will be assessed at baseline and post-intervention. Measures will include:
Neuropathic pain using the DN-4 questionnaire
Muscle strength using manual muscle testing (MMT)
Joint range of motion using goniometry
The primary objective of the study will be to compare the effectiveness of active versus passive neural mobilization in reducing neuropathic pain and improving muscle strength and joint mobility. Secondary objectives will include determining clinical applicability and the potential role of these interventions in rehabilitation protocols for diabetic neuropathy.
Limitations of the trial will include the inability to blind participants, possible variability in treatment adherence, and potential influence of external factors such as concurrent analgesic use. Randomization and standardized intervention protocols will be employed to minimize bias.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Effect of Active Neural Mobilization on Pain, Strength, and ROM in Diabetic Neuropathy | Experimental | Other: Active Neural MobilzationsParticipants in the active neural mobilization group will receive neural flossing techniques, aimed at improving nerve mobility and reducing neuropathic symptoms. Along with neural mobilization, participants will follow a standardized physiotherapy protocol, including: Gait training on both smooth and rough surfaces Strengthening exercises: leg press, ankle press, isometric exercises for knee and ankle extensors, bridging, and pelvic rolling All exercises will be performed in 3 sets of 12 repetitions, with 30 seconds of rest between sets Stationary cycling will be included as part of cardiovascular conditioning The intervention will be delivered over 12 sessions, scheduled three times per week for four weeks. This program aims to reduce burning pain, and enhance muscle strength and range of motion in patients with diabetic neuropathy. |
| Effect of Passive Neural Mobilization on Pain, Strength, and ROM in Diabetic Neuropathy | Experimental | Other: Passive Neural MobilzationsParticipants in the passive neural mobilization group will receive neural tensioning techniques, which involve therapist-guided passive movements to mobilize the neural structures. In addition to passive mobilization, participants will undergo the same standardized physiotherapy protocol, which includes: Gait training on both smooth and rough surfaces Strengthening exercises: leg press, ankle press, isometric exercises for knee and ankle extensors, bridging, and pelvic rolling Exercises will be performed in 3 sets of 12 repetitions, with 30 seconds of rest between sets Stationary cycling will be used for cardiovascular conditioning This group will also receive 12 treatment sessions, conducted three times per week over four weeks, with the goal of improving pain, strength, and mobility in individuals with diabetic neuropathy. |
Who may qualify
- Ages
- 40 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Both male and female individuals
- Aged between 40 and 65 years
- Diagnosed with Diabetes Mellitus (Type I and Type II)
- Diagnosis confirmed by a physician
Key exclusion criteria (5 listed)
- One with any systemic disease
- Medical conditions (neurological disorders, fractures, acute inflammatory conditions, recent surgeries)
- Foot Ulceration
- Amputation
- OA of Ankle or Knee Joint
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Active Neural MobilzationsParticipants in this group will receive active neural mobilization in the form of neural flossing techniques. These involve controlled, repeated movements performed actively by the patient to mobilize peripheral nerves without placing them under excessive tension. The goal is to restore neural mobility, reduce mechanosensitivity, and relieve neuropathic symptoms such as burning pain. | Other | Effect of Active Neural Mobilization on Pain, Strength, and ROM in Diabetic Neuropathy |
| Passive Neural MobilzationsParticipants in this group will receive passive neural mobilization using neural tensioning techniques. These techniques involve therapist-applied passive limb movements that place a controlled tensile load on the neural structures. The objective is to improve neural gliding, reduce nerve compression, and decrease neuropathic pain, particularly in cases of restricted neural tissue mobility. | Other | Effect of Passive Neural Mobilization on Pain, Strength, and ROM in Diabetic Neuropathy |
Primary outcome
Lower Limb Tension Test
Time frame: 12 sessions for 4 weeks
Lower Limb Tension Test (LLTT) Purpose: Assess neural mechanosensitivity of lower limb nerves, especially sciatic, tibial, and peroneal nerves. Also Known As: Straight Leg Raise (SLR), Slump Test, Prone Knee Bend Test, etc. Indications: Radiating leg pain Suspected lumbar radiculopathy Neural tension syndromes Procedure Includes: Hip flexion, knee extension, ankle dorsiflexion, and/or foot inversion/eversion based on nerve bias Positive Sign: Reproduction of neuropathic symptoms (burning, tingling, shooting pain) Symptoms change with sensitizing maneuvers Used In: Neuropathy Sciatica Disc herniation Piriformis syndrome
DN-4 (Douleur Neuropathique en 4 questions)
Time frame: 12 sessions in 4 weeks
DN-4 Questionnaire (Douleur Neuropathique en 4 questions) Purpose: To screen for neuropathic pain and distinguish it from nociceptive pain. Total Items: 10 7 sensory descriptors (e.g., burning, electric shocks, tingling, numbness) 3 clinical examination findings (e.g., hypoesthesia to touch or pinprick, pain on brushing) Scoring: Each "yes" = 1 point Total Score Range: 0 to 10 Score ≥ 4 indicates likely neuropathic pain Time Required: Less than 5 minutes Advantages: Quick and easy to administer Non-invasive High sensitivity and specificity Used In: Diabetic neuropathy Post-stroke pain Sciatica Postherpetic neuralgia
Goniometery (Joint Range of Motion)
Time frame: 12 sessions for 4 weeks
Goniometry Purpose: Measure joint range of motion (ROM) accurately Instrument: Goniometer (standard) Components: Axis: Placed over the joint Stationary arm: Aligned with proximal segment Moving arm: Aligned with distal segment Procedure: Explain to patient → Proper positioning → Stabilize proximal joint → Move limb through ROM → Read measurement Used To Assess: Joint mobility limitations Effectiveness of treatment Progress tracking in rehabilitation Common Areas: Knee, hip, ankle, shoulder, elbow, wrist, cervical spine
Manual Muscle Testing
Time frame: 12 sessions in 4 weeks
Manual Muscle Testing (MMT) Purpose: Evaluate muscle strength manually Grading Scale (0-5): 0 = No contraction 1. = Flicker/trace of contraction 2. = Full ROM in gravity-eliminated position 3. = Full ROM against gravity 4. = Full ROM with some resistance 5. = Full ROM with maximum resistance (normal) Procedure: Proper positioning → Isolate target muscle → Apply resistance gradually → Grade based on performance Used In: Neuromuscular conditions Orthopedic rehab Stroke, SCI, peripheral nerve injuries Advantages: Quick and cost-effective Useful in baseline assessment and progress monitoring
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Sep 2025.
- Background: PubMed 36404825Goyat M, Saxena A, Goyal M. Study Protocol titled as "Effectiveness of neural mobilization in improving the ankle ROM and plantar pressure distribution in patients with diabetic peripheral neuropathy: A single group, pre post, quasi experimental study protocol". J Diabetes Metab Disord. 2022 Aug 15;21(2):2035-2041. doi: 10.1007/s40200-022-01106-z. eCollection 2022 Dec.
- Study Protocol titled as "Effectiveness of neural mobilization in improving the ankle ROM and plantar pressure distribution in patients with diabetic peripheral neuropathy: A single group, pre post, quasi experimental study protocol"Link provided by the sponsor.
- Effects of foot and ankle mobilisations combined with home stretches in people with diabetic peripheral neuropathy: a proof-of-concept RCTLink provided by the sponsor.
- Effects of Neural Mobilization in Diabetic Peripheral Neuropathy: A Scoping ReviewLink provided by the sponsor.
- Individual participant dataSharing planned: No. Individual Participant Data (IPD) will not be shared due to confidentiality concerns. Protecting the privacy and anonymity of participants is a top priority, and sharing IPD may risk breaching this confidentiality. Additionally, the data is securely stored and intended solely for use within the scope of this study; therefore, it will not be shared with other researchers.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Farhan Ishaque Khan, PhD study director
Dow Institute of Physical Medicine and Rehabilitation, Dow University of Health Sciences
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Active Neural Mobilzations and Passive Neural Mobilzations in people with Neuropathy and Diabete Mellitus, run by Dow University of Health Sciences at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 3 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Lower Limb Tension Test (time frame: 12 sessions for 4 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07141992, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Sep 2025.