Clinical trials: Diabetic Oculopathy
Diabetic Macular Edema
Intravitreous Bevacizumab and Standard Metabolic Control for Diabetic Macular Edema - A Contrast Sensitivity Study
To evaluate the effects on contrast sensitivity (CS) measurements of intravitreal bevacizumab injections associated with standard metabolic control in eyes with diabetic macular edema (DME) associated with standard metabolic…
- Trial name
- NCT02308644
- Testing
- intravitreal bevacizumab injection(1.25mg)
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- University of Sao Paulo
Age-Related Maculopathy, Diabetic Macular Edema
Validation of a New Methodology for Mapping the Human Blood-Retinal Barrier Function
To validate a new methodology, named Retinal Leakage Analysis (RLA), for mapping the human Blood-Retinal Barrier (BRB) function, in the clinical practice.
- Trial name
- NCT00759044
- Where
- Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Non-Proliferative Diabetic Retinopathy, Cataract
Nepafenac Once Daily for Macular Edema - Study 2
The purpose of this study is to demonstrate superiority of Nepafenac Ophthalmic Suspension, 0.3% dosed once daily relative to Nepafenac Vehicle based upon clinical outcomes among diabetic participants following cataract surgery.
- Trial name
- NCT01872611
- Testing
- Nepafenac Ophthalmic Suspension, 0.3%, Vehicle, Prednisolone acetate
- Volunteers
- 819 people
- Sponsor
- Alcon Research
Diabetic Retinopathy, Glaucoma
Evaluation of The Performance of Retinow AI Software
Eye diseases are a major public health problem worldwide and one of the main causes of vision loss. Diseases such as diabetic retinopathy, glaucoma and macular degeneration in particular can lead to serious vision loss and…
- Conditions
- Diabetic Retinopathy, Glaucoma, Macular Degeneration
- Trial name
- NCT06645964
- Where
- Turkey (Türkiye)
- Volunteers
- 915 people, healthy volunteers welcome
- Sponsor
- Retinow Health Technologies and R&D Industry Joint Stock Company
Corneal Ulcer, Neurotrophic Corneal Ulcer
Topical Insulin in Neurotrophic Keratopathy After Diabetic Vitrectomy
Various treatment options have been proposed in managing NK such as preservative-free lubrication (PF-L), withdrawal of epitheliotoxic medication, prophylactic antibiotics, applying of bandage contact lenses, using…
- Conditions
- Corneal Ulcer, Neurotrophic Corneal Ulcer, Diabetes Mellitus
- Trial name
- NCT05940376
- Testing
- rapid acting insulin
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Neovascularization, Macular Degeneration
Ziv-aflibercept in Ocular Disease Requiring Anti-VEGF Injection
Background/aims: Aflibercept is an approved therapy for neovascular macular degeneration (AMD), diabetic macular edema (DME), retinal vein occlusion and other retinal conditions.
- Conditions
- Neovascularization, Macular Degeneration, Diabetic Retinopathy, Retinal Vein Occlusion
- Trial name
- Zaltrap (NCT02486484)
- Testing
- ziv-aflibercept
- Where
- Lebanon
- Volunteers
- 100 people
- Sponsor
- Rafic Hariri University Hospital
Diabetic Retinopathy, Vitreous Hemorrhage
Preoperative Bevacizumab for Vitreous Hemorrhage
The purpose of this study is to determine whether preoperative intravitreal bevacizumab is effective in reducing intra-operative and postoperative bleeding in diabetic patients submitted to pars plana vitrectomy for vitreous…
- Trial name
- IBEVI (NCT00596297)
- Testing
- bevacizumab, pars plana vitrectomy
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- University of Sao Paulo
Moderate Non-proliferative Diabetic Retinopathy
The Use of Alpha Lipoic Acid for the Treatment and Prevention of Diabetic Retinopathy
The purpose of this study is to evaluate the role of alpha lipoic acid in patients who have moderate non-proliferative diabetic retinopathy.
- Trial name
- ALA-TPD (NCT01880372)
- Testing
- Alpha Lipoic Acid
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Ferris State University
Diabetes Mellitus, Diabetic Retinopathy (DR)
Improving Patient-centered Care for Diabetes in Bangladesh Through "Dynamic Integration" of Vision Care on the Supply Side
The goal of this clinical trial is to determine whether integration of vision care into the DM treatment system, by providing specific recommendations to doctors for management of diabetes alongside feedback on positive eye exams…
- Trial name
- NCT06968637
- Testing
- care recommendations
- Where
- 2 sites in Bangladesh
- Volunteers
- 336 people
- Sponsor
- Orbis
Diabete Mellitus, Retina Vein Occlusion
Serum Cholinesterases, Paraoxonase, and Cardiovascular Risk After Intravitreal Bevacizumab
Bevacizumab, an anti-VEGF (vascular endothelial growth factor) agent used in the treatment of diabetic retinopathy and macular edema associated with retinal vein occlusion, is commonly administered in ophthalmology clinics…
- Conditions
- Diabete Mellitus, Retina Vein Occlusion, Age Macular Degeneration
- Trial name
- NCT07550777
- Testing
- blood test
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Diabetic Macular Edema
Efficacy Study of Triamcinolone and Bevacizumab Intravitreal for Treatment of Diabetic Macular Edema
Triamcinolone and Bevacizumab Intravitreal for Treatment of Diabetic Macular Edema
- Trial name
- ATEMD (NCT00737971)
- Testing
- Bevacizumab intravitreal, Triamcinolone, Triamcinolone + Bevacizumab
- Where
- Brazil
- Volunteers
- 142 people
- Sponsor
- Rubens Belfort Jr.
Macular Edema, Mellitus Diabetes
Micropulsed Laser in Association With Anti-VEGF for the Treatment of Macular Edema in Diabetic Patients (LAMED).
Diabetes is a major cause of blindness in adults in the developed countries. The retinal damages associated with diabetes lead to gradual loss of vision, which is accentuated when the macula is affected.
- Trial name
- LAMED (NCT02650050)
- Testing
- Micropulsed laser photocoagulation
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Diabetic Retinopathy
Effect of Panretinal Photocoagulation on Optic Nerve Head Topography
The purpose of this study is to evaluate the optic nerve head changes consequent to panretinal photocoagulation done for diabetic retinopathy.
- Trial name
- PRP (NCT00767884)
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- University of Nebraska
Diabetic Retinopathy, Macular Degeneration
Screening for Studies on Retinovascular Diseases
This screening protocol is designed to help recruit patients for National Eye Institute (NEI) studies of the retina, such as diabetic retinopathy and macular degeneration.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Pathologic Neovascularization, Retinal Disease
- Trial name
- NCT00001733
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Diabetic Macular Edema (DME)
Phase 3 Study of Intravitreal OLN324 in Adults With Diabetic Macular Edema (DME) (OLN324-CP-02)
This is a Phase 3 study of an investigational drug called OLN324, which is being developed by Ollin Biosciences as a treatment for patients with diabetic macular edema (DME).
- Trial name
- ATACAMA (NCT07841899)
- Testing
- OLN324, Aflibercept
- Volunteers
- 450 people
- Sponsor
- Ollin Biosciences, Inc.
Diabetic Macular Edema
IVI Aflibercept Before and After Phaco in DME.
To study whether or not cataract surgery should be deferred until treating the co-existing diabetic macular edema (DME) using intravitreal (IVI) anti-vascular endothelial growth factor (anti-VEGF).
- Trial name
- NCT05731089
- Testing
- Phacoemulsification with IVI of aflibercept
- Where
- Kuwait
- Volunteers
- 40 people
- Sponsor
- Al Hadi Hospital
Macular Edema, Macular Degeneration
Study to Evaluate Home Vision Testing in Participants Who Receive Ranibizumab (Lucentis®)
This pilot study will evaluate home vision testing using a mobile medical application in participants with diabetic macular edema (DME) or neovascular age-related macula degeneration (nAMD) who receive intravitreal ranibizumab…
- Trial name
- NCT02420132
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Hoffmann-La Roche
Diabetic Macular Edema, Diabetic Retinopathy
Reading Center - Occurence of Diabetic Macular Edema in Patients With Diabetes Mellitus in Slovak Republic
The aim of the study is to find out prevalence of diabetic macular edema (DME) in patients with diabetes mellitus in Slovak Republic.The outcome of the project will be epidemiology survey, prevalence of wet form of Diabetic…
- Trial name
- NCT02063321
- Volunteers
- 762 people
- Sponsor
- Emil Martinka
Diabetic Macular Edema, Diabetes
Combined Ranibizumab and Iluvien for Diabetic Macular Oedema
This trial investigated whether adding Iluvien sustained release steroid intravitreal eye implant at the beginning of regular anti-VEGF (anti Vascular Endothelial Growth Factor) intravitreal eye injection treatment for diabetic…
- Trial name
- CASSIE (NCT03784443)
- Testing
- Iluvien 0.19 MG Drug Implant, Ranibizumab Injection [Lucentis]
- Sponsor
- Imperial College London
Pseudophakic Macular Edema, Diabetic Nephropathies
Diabetic Nephropathy, Glycemic Control and Pseudophakic Macular Edema After Cataract Surgery
This retrospective cohort study examines whether the kidney complications of diabetes (diabetic nephropathy) and blood-sugar control before surgery help predict swelling of the central retina, called pseudophakic macular edema…
- Conditions
- Pseudophakic Macular Edema, Diabetic Nephropathies, Diabetes Mellitus, Type 2, Cataract (Post-operative Cataract Surgery Follow-up)
- Trial name
- NCT07723846
- Testing
- Phacoemulsification with posterior-chamber IOL
- Where
- Thailand
- Volunteers
- 428 people
- Sponsor
- Thammasat University Hospital