Clinical trials: Diabetic Polyneuropathy
Diabetic Polyneuropathy
Serum Neurofilament Light Chain Levels and Neuropathy Severity in Diabetic Polyneuropathy
Diabetic polyneuropathy (DPN) is one of the most common chronic complications of diabetes mellitus and is characterized by peripheral nerve damage caused by long-term hyperglycemia.
- Trial name
- DPN-NFL (NCT07480330)
- Testing
- Blood Sample Collection and Clinical Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Diabetic Peripheral Neuropathy (DPN)
Effects of Insole Vibration With Proprioceptive Training in Patients With Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes, profoundly affecting quality of life with sensory disturbances and associated complications.
- Trial name
- NCT07128836
- Testing
- proprioceptive training exercise and receive insole vibrator, proprioceptive training exercise along with simple insoles without vibration
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Healthy
Bioequivalence Study of Two Formulations of Pregabalin CR (Controlled-release) Table 150 mg
The purpose of this clinical trial is to (1) evaluate the bioequivalence(BE) of GLA5PR GLARS-NF3 tablet 150mg administered regular diet relative to GLA5PR GLARS-NF1 tablet 150mg administered regular diet and (2) determine the…
- Trial name
- NCT02955472
- Testing
- GLA5PR GLARS-NF3 tablet 150mg, GLA5PR GLARS-NF1 tablet 150mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GL Pharm Tech Corporation
Diabetic Ulcer of Plantar Aspect of Left Foot, Diabetic Ulcer of Plantar Aspect of Right Foot
Nerve Decompression for Ulcer Recurrence Avoidance (DURA)
Anecdotal reports and scientific literature suggest that the risk of recurrence of diabetic foot ulcers can be minimized by nerve decompression procedures at anatomic sites of nerve pinching and entrapment.
- Conditions
- Diabetic Ulcer of Plantar Aspect of Left Foot, Diabetic Ulcer of Plantar Aspect of Right Foot, Diabetic Polyneuropathy
- Trial name
- DURA (NCT01762085)
- Testing
- nerve decompression
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- Association of Extremity Nerve Surgeons
Diabetic Polyneuropathy
Efficacy and Safety Study of Topical Capsaicin in Painful Diabetic Neuropathy
Painful diabetic neuropathy is the most common cause of neuropathic pain. 0.075% topical capsaicin has been used to treat the pain, but there is no data in lower concentration.
- Trial name
- NCT00993070
- Testing
- Capsaicin
- Where
- Thailand
- Volunteers
- 33 people
- Sponsor
- Thammasat University
Diabetic Neuropathy
A Safety and Efficacy Study for Tapentadol (CG5503) Extended Release for Patients With Painful Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of Tapentadol (CG5503) extended release (ER) (base) compared to placebo in patients with moderate to severe pain from diabetic…
- Trial name
- NCT00455520
- Testing
- CG5503
- Volunteers
- 395 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Oxidative Stress, Diabetic Polyneuropathy
Statins for Oxidative Stress and Mitochondrial Function in Diabetic Polyneuropathy
Aims: To evaluate the effect of ezetimibe/simvastatin and rosuvastatin on oxidative stress and mitochondrial function in patients with DPN.
- Trial name
- NCT02129231
- Testing
- calcined magnesia, Ezetimibe/simvastatin, Rosuvastatin
- Where
- Mexico
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Painful Diabetic Neuropathy, Neuropathic Pain
Peripheral Nerve Block in Patients With Painful Diabetic Polyneuropathy
The purpose of the present study is to evaluate the role of peripheral afferent input for spontaneous pain in painful diabetic polyneuropathy
- Conditions
- Painful Diabetic Neuropathy, Neuropathic Pain, Neuropathy;Peripheral
- Trial name
- NCT04699734
- Testing
- Xylocaine 1%, NaCl 9mg/ml
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- University of Aarhus
Diabetic Neuropathic Pain
the Effectiveness of Intermittent Pneumatic Compression on Neuropathic Pain in Patients With Diabetic Polyneuropathy
In this study,the effectiveness of intermittent pneumatic compression therapy on neuropathic pain and quality of life in patients with neuropathic pain due to type 2 diabetes was investigated
- Trial name
- NCT06336486
- Testing
- intermittent pneumatic compression +pregabalin group, pregabalin group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Busra Gunes
Diabetic Neuropathies, Diabetes Mellitus, Type 2
A Study To Evaluate The Effect Of Topiramate On Clinical And Electrophysiological Parameters In Subjects With Diabetic Peripheral Polyneuropathy
The purpose of the study is to evaluate the effect of topiramate on clinical and electrophysiological parameters in patients with diabetic peripheral polyneuropathy.
- Conditions
- Diabetic Neuropathies, Diabetes Mellitus, Type 2, Polyneuropathies
- Trial name
- NCT00231673
- Testing
- Topiramate
- Volunteers
- 72 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Diabetic Polyneuropathy, Diabetic Neuralgia
A Study of Phyllanthus Niruri and Sida Cordifolia in Diabetic Peripheral Polyneuropathy
The purpose of the study is to determine whether phyllanthus niruri and sida cordifolia are effective in treatment of diabetic polyneuropathy compared to placebo.
- Conditions
- Diabetic Polyneuropathy, Diabetic Neuralgia, Diabetic Neuropathies, Diabetic Neuropathy
- Trial name
- VEDICINE (NCT02107469)
- Testing
- Sida cordifolia roots, Phyllanthus niruri, Sida cordifolia roots extract
- Where
- India
- Volunteers
- 98 people
- Sponsor
- Rosenberg European Academy of Ayurveda
Postherpetic Neuralgia, Diabetic Polyneuropathy
Efficacy and Safety of Lidocaine Infusion Treatment in Management of Neuropathic Pain
The investigators conducted a randomized, Double blind, and Controlled Study to evaluate the Efficacy and safety of Lidocaine Infusion Treatment in Management of Neuropathic pain.
- Conditions
- Postherpetic Neuralgia, Diabetic Polyneuropathy, Peripheral Neuropathy
- Trial name
- NCT02597257
- Testing
- Lidocaine HCl, Normal saline
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Herpes Zoster, Neuralgia
An Open-Label Extension Study of NGX-4010 for the Treatment of Neuropathic Pain
This study is an open-label, multicenter, extension study for subjects who completed NeurogesX Study C111 and received treatment with NGX-4010 (Capsaicin Patch) within 12 weeks (up to +7days) before entry into Study C114
- Conditions
- Herpes Zoster, Neuralgia, Pain, HIV Infections
- Trial name
- NCT00089557
- Testing
- Capsaicin Dermal Patch
- Sponsor
- NeurogesX
Diabetic Neuropathy, Painful, Diabetic Neuralgia
Treatment of Painful Diabetic Neuropathy With Photon Stimulation
1. Objectives: 1. To assess the efficacy of Photon Stimulation compared with placebo, in treating the pain of diabetic neuropathy. 2.
- Conditions
- Diabetic Neuropathy, Painful, Diabetic Neuralgia, Diabetic Polyneuropathy, Diabetic Mononeuropathy
- Trial name
- NCT00539175
- Testing
- infrared light
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- East Bay Institute for Research and Education
Diabetic Polyneuropathy
Effects of Antigravity Treadmill Training on Gait and Balance in Patients With Diabetic Polyneuropathy
Aging can be defined as sequential deterioration that occurs in elderly people including weakness, loss of mobility, decline of physical capabilities, increase susceptibility to disease and many other age-related physiological…
- Trial name
- NCT05088993
- Testing
- Antigravity treadmill training, Conventional exercise program
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Umm Al-Qura University
Diabetic Polyneuropathy
Spinal Cord Stimulation for Diabetic Polyneuropathy
To obtain preliminary estimates of the safety and efficacy of the ANS Eon™ Implantable Pulse Generator with ANS leads in the treatment of subjects with diabetic polyneuropathy.
- Trial name
- NCT01536236
- Testing
- ANS Eon™ Implantable Pulse Generator (Permanent Implant)
- Where
- United States
- Sponsor
- Abbott Medical Devices
Diabetic Neuropathies
Efficacy and Safety of TAK-583 in Subjects With Diabetic Peripheral Neuropathy
The purpose of this study is to determine the safety and effectiveness of TAK-583, once daily (QD), in the treatment of neuropathy caused by diabetes mellitus.
- Trial name
- NCT00760955
- Testing
- TAK-583
- Where
- 38 sites in United States, Canada
- Volunteers
- 338 people
- Sponsor
- Takeda