Clinical trials: Diabetic Retinal Disease
Proliferative Diabetic Retinopathy
OCT and OCT-A Afer Diabetic Vitrectomy in PDR
Detection of any structural or vascular changes at the macula after Pars Plana Vitrectomy ( PPV ) in cases with complicated proliferative diabetic retinopathy ( PDR )
- Trial name
- NCT05938491
- Testing
- OCT and OCT-A
- Volunteers
- 30 people
- Sponsor
- Assiut University
Diabetic Retinopathy
Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy
Recently, intravitreal bevacizumab (Avastin) injection has gained popularity as a potential treatment of intraocular neovascularization (CNV) associated with age related macular degeneration and diabetic retinopathy.
- Trial name
- NCT00423059
- Testing
- bevacizumab
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Visual Acuity Reduced Transiently, Macular Edema, Cystoid
Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab
The aim of the prospective randomized study is to investigate whether a intensified diabetic control program leads to better final visual acuity and less frequent diabetic ocular complications in patients with diabetic…
- Trial name
- DORO (NCT02665689)
- Testing
- ranibizumab
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- Prof. Dr. Antonia M. Joussen
Proliferative Diabetic Retinopathy
Intravitreal Injection of Ranibizumab Versus Sham Before Vitrectomy in Patients With Proliferative Diabetic Retinopathy
Certain percent of the eyes with proliferative diabetic retinopathymay require pars plana vitrectomy (PPV) due to vitreous haemorrhage, proliferative membrane, and tractional retinal detachment.
- Trial name
- NCT02857491
- Testing
- ranibizumab, pars plana vitrectomy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sun Yat-sen University
Eye Diseases, Retinitis Pigmentosa
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAION
This trial will study the safety and efficacy of intranasal delivery of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of non-arteritic ischemic optic neuropathy
- Conditions
- Eye Diseases, Retinitis Pigmentosa, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT05147701
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Diabetic Retinopathy, Diabetes Complications
Study Evaluating Efficacy and Safety of PF-04523655 Versus Laser in Subjects With Diabetic Macular Edema
To evaluate the effectiveness of study drug in improving visual acuity compared to laser treatment in the patients with diabetic macular edema
- Trial name
- DEGAS (NCT00701181)
- Testing
- Laser Treatment, PF-04523655 high, PF-04523655 middle
- Where
- 53 sites in United States, Denmark and 6 more
- Volunteers
- 184 people
- Sponsor
- Quark Pharmaceuticals
Proliferative Diabetic Retinopathy
Propranolol for Diabetic Retinopathy
This study is investigating if the oral beta antagonist propranolol can induce regression of retinal neovascularization associated with proliferative diabetic retinopathy.
- Trial name
- NCT01535495
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Wisconsin, Madison
Diabetic Retinopathy, NPDR - Non Proliferative Diabetic Retinopathy
A Study to Evaluate the Efficacy and Safety of Orally Administered VX-01
The goal of this clinical trial is to evaluate the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of VX-01 as stand-alone treatment for Diabetic Retinopathy of Non-Proliferative Type (NPDR).
- Trial name
- NCT06770933
- Testing
- VX-01
- Where
- 27 sites in United States, Australia and 3 more
- Volunteers
- 100 people
- Sponsor
- Vantage Biosciences Ltd
Proliferative Diabetic Retinopathy
PASCAL Laser Versus ETDRS Laser Associated With Intravitreal Ranibizumab (IVR) Versus Only IVR for Proliferative Diabetic Retinopathy
Objectives: Primary objective: To evaluate the effects on retinal morphophysiology of full scatter single target panretinal photocoagulation (PRP) versus full scatter multiple target panretinal photocoagulation (both combined…
- Trial name
- NCT02005432
- Testing
- Intravitreal Ranibizumabe, panfotocoagulation (PASCAL), panfotocoagulation (PRP) single shoot (ETDRS)
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo
Proliferative Diabetic Retinopathy (PDR)
Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of PDR
This randomized trial will compare treatment strategies for proliferative diabetic retinopathy (PDR). Participants will receive either combination a of faricimab + PRP or vitrectomy + endolaser.
- Trial name
- AP (NCT06790784)
- Testing
- Vitrectomy, Endolaser, Faricimab
- Where
- 34 sites in United States
- Volunteers
- 426 people
- Sponsor
- Jaeb Center for Health Research
Macular Degeneration, Retinal Vein Occlusion
Intravitreal v. Sub-tenon Injections of Triamcinolone Acetonide for Macular Edema in Retinal Disorders
The use of intravitreal injections of corticosteroid (triamcinolone acetonide) appears to be a promising treatment for a variety of ocular diseases associated with inflammation.
- Conditions
- Macular Degeneration, Retinal Vein Occlusion, Diabetic Retinopathy
- Trial name
- NCT00101764
- Testing
- Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Eye Institute (NEI)
Proliferative Diabetic Retinopathy, Macular Holes
Macular Hole After Diabetic Vitrectomy
To present the clinical characteristics and rational treatment of macular hole (MH) after the diabetic vitrectomy (DV) in patients with proliferative diabetic retinopathy (PDR).
- Trial name
- NCT03525899
- Testing
- Pars plana vitrectomy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Retinal Vein Occlusion, Macular Edema
A Retrospective Study of Anti-Vascular Endothelial Growth Factor (VEGF) Injections for Retinal Vein Occlusion or Diabetic Macular Edema
This retrospective data review study will evaluate anti-VEGF injections for retinal vein occlusion (RVO) or diabetic macular edema (DME).
- Trial name
- NCT01918371
- Testing
- Anti-VEGF
- Where
- United States
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Allergan
Diabetic Retinopathy, Macula Edema
Transfoveal Micropulse Laser for Center Involving Diabetic Macular Edema
Anti-vascular endothelial growth factor (VEGF) therapy is currently the mainstay of treatment for diabetic macular edema (DME). One of the main obstacles of anti-VEGF therapy is the need of repeated injections, which carries both…
- Trial name
- NCT04359771
- Testing
- Yellow micro-pulse laser, Diode micro-pulse laser
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Cairo University
Eye Diseases, Ophthalmic Trauma
Mitochondrial DNA in Vitreous Fluid and Blood in Patients With Eye Disease or Ocular Trauma.
This study is to characterize mitochondrial DNA (mtDNA) populations in adults with eye injuries and eye diseases. The eye exam is often hindered by the clouding of tissues involved in injury or disease.
- Conditions
- Eye Diseases, Ophthalmic Trauma, Mitochondrial DNA, Age Related Macular Degeneration
- Trial name
- NCT04334499
- Testing
- Sample collection from tissue discard
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Diabetic Macular Edema, Macular Edema
Influence of Systemic Parameters in Diabetic Macular Edema - LIPSIA Study
This study aims to evaluate the influence and prognostic value of systemic factors (such as the cardiovascular and metabolic status) on the treatment response to anti-VEGF therapy in macular edema due to diabetes or retinal vein…
- Conditions
- Diabetic Macular Edema, Macular Edema, Retinal Vein Occlusion
- Trial name
- NCT03762226
- Testing
- Anti-VEGF
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Diabetic Retinopathy
Collaborative Care for Depression and Diabetic Retinopathy in African Americans
In this feasibility/pilot study, we will develop, refine, and evaluate the feasibility of a novel mental health/ophthalmologic intervention called, "Collaborative Care for Depression and Diabetic Retinopathy" (CC-DDR), which aims…
- Trial name
- CC-DDR (NCT02121340)
- Testing
- Behavioral Activation
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Thomas Jefferson University
Wet Age-related Macular Degeneration, Retinal Vein Occlusion
Exploratory Study to Investigate the Bioactivity, Ocular and Systemic Safety, Tolerability, and Pharmacokinetics Following Single and Multiple Intravitreal Administrations of KSI-301 in Subjects With wAMD, DME and RVO
This is a Phase 1b open-label study to assess the bioactivity, ocular and systemic safety, tolerability, and pharmacokinetics of repeated injections of KSI-301 at two dose levels: 2.5 mg and 5 mg
- Conditions
- Wet Age-related Macular Degeneration, Retinal Vein Occlusion, Diabetic Macular Edema
- Trial name
- NCT03790852
- Testing
- KSI-301
- Where
- 11 sites in United States
- Volunteers
- 121 people
- Sponsor
- Kodiak Sciences Inc
Diabetic Macular Edema
Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Patients With Diabetic Macular Edema
The purpose of this study is to determine the efficacy of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) on the best corrected visual acuity (BCVA) assessed by the early treatment diabetic retinopathy study (ETDRS)…
- Trial name
- VISTA DME (NCT01363440)
- Testing
- Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321), Macular Laser Photocoagulation
- Where
- 51 sites in United States
- Volunteers
- 466 people
- Sponsor
- Regeneron Pharmaceuticals
Wet AMD, Macular Oedema
Intravitreal Bevacizumab for Retinal Disorders
Bevacizumab is an anti-VEGF agent used in approved for use in metastatic colorectal carcinoma (FDA Approved). This study analyzes the safety and efficacy of off-label Intravitreal Injection of bevacizumab (Avastin) for CNVM…
- Conditions
- Wet AMD, Macular Oedema, Proliferative Diabetic Retinopathy
- Trial name
- NCT00403026
- Testing
- Bevacizumab ( Avastin)
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Narayana Nethralaya