Clinical trials: Diabetic Retinal Disease
Diabetic Macular Edema
Efficacy of Aliskiren in the Treatment of Diabetic Macular Edema
To assess the efficacy of oral aliskiren as a therapy for diabetic macular edema
- Trial name
- NCT00768040
- Testing
- Aliskiren
- Where
- 12 sites in United States, Denmark
- Volunteers
- 39 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Retinopathy
Treating Early Stage Diabetic Retinopathy
To determine if levodopa will slow the appearance of blood vessel changes in the eyes of patients with diabetes. Treatment will be started in patients with diabetes show delays in the electrical activity of the retina when…
- Trial name
- TESDR (NCT05132660)
- Testing
- Sinemet CR
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- VA Office of Research and Development
Diabetes Mellitus, Type 2 Diabetes
The Hong Kong Diabetes Biobank
Asia is in the midst of an epidemic of diabetes. Epidemiological figures suggest that there are more than 110 million people affected by diabetes in China, with a significant proportion of young adults already affected.
- Conditions
- Diabetes Mellitus, Type 2 Diabetes, Type 1 Diabetes, Diabetic Nephropathies
- Trial name
- HKDB (NCT05282680)
- Testing
- prospective observational study
- Where
- Hong Kong
- Volunteers
- 48,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Diabetic Retinopathy, Diabetes Mellitus
Serum Endocan, Alarin, and Galanin-Like Peptide Levels in Diabetic Retinopathy
This prospective cross-sectional study aims to evaluate the association between serum endocan, alarin, and galanin-like peptide levels and the stages of diabetic retinopathy (DR), as well as their relationship with optical…
- Conditions
- Diabetic Retinopathy, Diabetes Mellitus, Retinal Microvascular Disease
- Trial name
- NCT07434362
- Testing
- Venous Blood Sampling, Optical Coherence Tomography (OCT)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Anesthesia, Local, Intravitreal Injection
Long Term Safety of Cooling Anesthesia for Intravitreal Injection
The purpose of this clinical study is to evaluate the long term safety and efficacy of cooling anesthesia application to the eye as anesthesia for intravitreal injection using a novel cooling anesthesia device.
- Conditions
- Anesthesia, Local, Intravitreal Injection, Macular Edema, Macular Degeneration
- Trial name
- COOL-2 (NCT03956797)
- Testing
- Recens Cooling Anesthesia Device
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Recens Medical, Inc.
Diabetic Retinopathy
Effect of OMEGA3 Supplementation in Diabetic Retinopathy
The main objective of this study is to evaluate the efficacy at 6 months of omega 3 supplementation on macular capillary density measured in optical coherence tomography angiography in patients with minimal or moderate non…
- Trial name
- OMEDIA (NCT04499820)
- Testing
- Nutrof, Meralut
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Proliferative Diabetic Retinopathy, Tractional Retinal Detachment
Conbercept Injection in Treatment of Severe Proliferative Diabetic Retinopathy
To evaluate efficacy of different intravitreal Conbercept injection therapy in the treatment of severe proliferative diabetic retinopathy.
- Trial name
- NCT02816710
- Testing
- Conbercept
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Ruijin Hospital
Retinal Diseases, Diabetic Retinopathy
Evaluation of Diabetic Retinopathy Using Ultra-Widefield Fundus Images Compared With Two-Field Fundus Images
This study aims to compare the accuracy of evaluating diabetic retinopathy using ultra-widefield fundus images versus two-field fundus images.
- Conditions
- Retinal Diseases, Diabetic Retinopathy, Diabetes Complications, Diabetes Mellitus
- Trial name
- NCT05836194
- Where
- China
- Volunteers
- 769 people
- Sponsor
- Ningbo Eye Hospital
The Mechanism of Retinal Neovascularization of Diabetic, Retinopathy.
Clinical Research on Retinal Neovascularization of Diabetic Retinopathy
Retinal neovascularization of diabetic retinopathy might be associated with genetic risk factors and environmental risk factors.
- Trial name
- NCT01229540
- Testing
- genetic analyzer
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Proliferative Diabetic Retinopathy
25-G Vitrectomy With Ranibizumab or Triamcinolone Acetonide on PDR in China-Randomized Clinical Trial
Proliferative diabetic retinopathy(PDR) is the leading cause of visual loss in diabetic patients. Operation is an efficient method to treat PDR.
- Trial name
- aiRTo-PDR (NCT02447185)
- Testing
- Ranibizumab, Triamcinolone Acetonide
- Where
- China
- Volunteers
- 200 people
- Sponsor
- JUNYAN ZHANG
Retinal Disease, Diabetic Retinopathy
Diagnostic Possibilities in Ophthalmological Diseases Using Swept Source Optical Coherence Tomography
In this pilot study we want to investigate morphological features acquired by the novel image modality and gain information regarding disease pathomechanism, development and future possible influence on disease management for…
- Conditions
- Retinal Disease, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT06074731
- Testing
- SS-OCT system Plex Elite 9000
- Where
- Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Johannes Kepler University of Linz
Proliferative Diabetic Retinopathy
Compliance to Ophthalmic Follow-up Examinations and Surgical Outcome for Proliferative Diabetic Retinopathy
The relationship between the surgical outcome of vitreous surgery for proliferative diabetic retinopathy and the compliance to ophthalmic follow-up examinations was evaluated.
- Trial name
- NCT01307072
- Testing
- Vitrectomy
- Where
- Japan
- Volunteers
- 94 people
- Sponsor
- Kyorin University
Diabetic Macular Edema
Intravitreal Triamcinolone Acetonide Versus Intravitreal Bevacizumab for Refractory Diabetic Macular Edema (IBEME Study)
Intravitreal triamcinolone has been effective for central macular thickness reduction and concomitant visual acuity improvement in patients with diabetic macular edema (DME).
- Trial name
- IBEME (NCT00468351)
- Testing
- Intravitreal Injection of 1,5 mg of bevacizumab, Intravitreal injection of 4 mg of Triamcinolone acetonide
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Proliferative Diabetic Retinopathy
Safety and Efficacy of Low-Fluence PRP for PDR
To determine the safety and efficacy of a single session of low-fluence panretinal photocoagulation when compared to full-fluence PRP.
- Trial name
- NCT01737957
- Testing
- Low-fluence PRP with 532nm green LASER, Full-Fluence PRP with 532nm LASER
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Macular Edema, Diabetic
Treat-and-extend Regimen of Aflibercept in Diabetic Macular Edema (VIBIM Study)
Efficacy of Treat-and-extend regimen (TER) using aflibercept in diabetic macular edema (DME) will be evaluated.
- Trial name
- VIBIM (NCT02788877)
- Testing
- aflibercept
- Where
- 8 sites in South Korea
- Volunteers
- 48 people
- Sponsor
- Pusan National University Hospital
Diabetic Retinopathy, Posterior Vitreous Detachment
A Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total PVD in Subjects With NPDR
The purpose of this study is to assess the efficacy and safety of up to 3 intravitreal injections of ocriplasmin (0.0625mg or 0.125mg), in subjects with moderate to very severe non-proliferative diabetic retinopathy (NPDR), to…
- Conditions
- Diabetic Retinopathy, Posterior Vitreous Detachment, Disease Progression
- Trial name
- CIRCLE (NCT02681809)
- Testing
- ocriplasmin 0.0625mg, ocriplasmin 0.125mg
- Where
- 38 sites in United States, Czechia and 7 more
- Volunteers
- 48 people
- Sponsor
- ThromboGenics
Biomarkers of Diabetic Retinopathy
Study of Natural Course Progression of Diabetic Retinopathy
The goal of this observational study is to observe the formation and development of the non-perfusion area of diabetic retinopathy in the posterior area of the retina in type 2 diabetes patients aged 18-75 years old, who can…
- Trial name
- NCT06269419
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jie Li
Retinal Vascular, Retinal Disease
Perifoveal Vascular Network Assessed by OCT-Angiography in Type I Diabetes Mellitus
This study is directed to evaluate the role of Optical Coherence Tomography Angiography (OCT-A) in the evaluation of the perifoveal vascular network in type 1 diabetic patients, and to investigate the relationship between…
- Conditions
- Retinal Vascular, Retinal Disease, Retinal Ischemia, Retinal Ischaemia Due to Type 1 Diabetes Mellitus
- Trial name
- NCT03422965
- Testing
- Optical Coherence Tomography Angiography, Blood test, Urine test
- Where
- 2 sites in Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Proliferative Diabetic Retinopathy, PDR
The Individually-Marked Panretinal Laser phoTocoagulation for Proliferative Diabetic Retinopathy Study (TREAT)
Background Diabetic eye disease is the most frequent complication among the 320,000 Danes with diabetes. The formation of new vessels (PDR) in the inner part of the eye (retina) is a feared complication and a leading cause of…
- Conditions
- Proliferative Diabetic Retinopathy, PDR, Diabetes
- Trial name
- NCT03113006
- Testing
- Panretinal Photocoagulation
- Where
- Denmark
- Volunteers
- 53 people
- Sponsor
- Odense University Hospital
Diabetes Type 1, Diabetic Retinopathy
Assessment of Retinal Microcirculation in Patients With Type 1 Diabetes Mellitus
Type 1 diabetes mellitus (T1DM) is associated with an increased lifetime risk of developing diabetic retinopathy, a leading cause of visual impairment among working-age adults worldwide.
- Conditions
- Diabetes Type 1, Diabetic Retinopathy, Microvascular Circulation, Retinal Microvascular Disease
- Trial name
- NCT07705321
- Testing
- Optical Coherence Tomography Angiography (OCTA)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
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