Clinical trials: Diabetic Retinopathy, completed
Macular Edema, Diabetic Mellitus
A Phase 3 Study To Compare The Efficacy And Safety Of 0.3 MG Pegaptanib Sodium To Sham Injections In Subjects With Diabetic Macular Edema
The purpose of the study to assess the efficacy of pegaptanib sodium 0.3 mg comparing sham injection and to confirm safety of pegaptanib sodium 0.3 mg in subjects with diabetic macular edema.
- Conditions
- Macular Edema, Diabetic Mellitus, Retinal Disease
- Trial name
- NCT01100307
- Testing
- pegaptanib sodium
- Where
- 43 sites in Japan
- Volunteers
- 243 people
- Sponsor
- Pfizer
Diabetic Macular Edema, Non-proliferative Diabetic Retinopathy
Ozurdex for Treatment of Recalcitrant Diabetic Macular Edema
The purpose of this study is to test the efficacy of an 0.7 mg intravitreal dexamethasone implant (Ozurdex®) on macular leakage and visual acuity for patients with recalcitrant diabetic macular edema.
- Conditions
- Diabetic Macular Edema, Non-proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy
- Trial name
- NCT01571232
- Testing
- dexamethasone intravitreal implant, intravitreal bevacizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Retina Macula Institute
Diabetic Retinopathy, DR
Epivascular Glia Regression and Macular Pigment Restoration After Faricimab in Diabetic Retinopathy
The aim of the study is to evaluate in diabetic patients affected by diabetic retinopathy epivascular glia regression and macular pigment restoration after faricimab injection in diabetic retinopathy in a 1 year follow up
- Trial name
- GLIA-MAC (NCT07526857)
- Testing
- Faricimab Injection [Vabysmo], Aflibercept (2.0 mg)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federico II University
Diabetes Mellitus, Diabetic Retinopathy
A Study to Evaluate the Safety of THR-149 in Subjects With Diabetic Macular Edema (DME)
This study is conducted to evaluate the safety of a single intravitreal injection of THR-149.
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- NCT03511898
- Testing
- THR-149 dose level 1, THR-149 dose level 2, THR-149 dose level 3
- Where
- 7 sites in United States
- Volunteers
- 12 people
- Sponsor
- ThromboGenics
Pain
Oral Diclofenac for Retinal Photocoagulation in Diabetic Retinopathy
The purpose of this study was to evaluate the analgesic effect of oral potassium diclofenac in patients with proliferative diabetic retinopathy submitted to retinal photocoagulation.
- Trial name
- NCT01009021
- Testing
- potassium diclofenac
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Retinopathy, Diabetic
Evaluation of a Health Education Program for Type 2 Diabetes Patients
The goal of this, Retrospective and Prospective Low- Interventional study, is to implement health education interventions to promote self-care and reduce disease complications in DM Type 2 patients at higher risk of…
- Trial name
- EDUCA-DM (NCT06066021)
- Testing
- health educational sessions in diabetic patients type 2.
- Where
- Portugal
- Volunteers
- 27 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Proliferative Diabetic Retinopathy
Treatment With Intravitreal Aflibercept Injection For Proliferative Diabetic Retinopathy, The A.C.T Study
To assess the safety of intravitreal aflibercept injection in the treatment of proliferative diabetic retinopathy (PDR) by evaluating the incidence and severity of adverse events.
- Trial name
- ACT (NCT01813773)
- Testing
- Intravitreal Aflibercept Injection (IAI)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ophthalmic Consultants of Long Island
Diabetic Retinopathy
Pilot Study of Laser Photocoagulation Therapy for Diabetic Macular Edema
This study will compare the side effects of two laser treatments for diabetic macular edema, a common condition in patients with diabetes.
- Trial name
- NCT00069056
- Testing
- Laser Treatment
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- National Eye Institute (NEI)
Diabetes Mellitus, Type 2
Evaluation of Macular Structural and Functional Function Following Extensive Retinal Laser Therapy in Patients With Proliferative Diabetic Retinopathy
The present study is a semi-experimental clinical trial that 20 patients (40 eyes) with PDR underwent PRP with ARC with a spot number of 1,200 to 1,500 per eye and spot size 500 micron with a duration of 200 ms.
- Trial name
- NCT04436900
- Testing
- Panretinal Photocoagulation (PRP)
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Baqiyatallah Medical Sciences University
Diabetic Retinopathy
Evaluation of Progression of Diabetic Retinopathy With Rapid Correction of Hyperglycemia
The investigators are doing this research for two reasons. The first is to see how the retina (back of your eye) changes when your blood sugar is treated with medication for the first time.
- Trial name
- NCT02326259
- Testing
- Initiation of treatment of diabetes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Temple University
Diabetic Retinopathy
Blood Factors and Diabetic Retinopathy
This study will determine whether certain factors in the blood are associated with the severity of diabetic retinopathy. Patients age 10 years and older with diabetes mellitus and diabetic retinopathy may be eligible for this…
- Trial name
- NCT00005761
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Macular Edema (DME)
Safety, Tolerability and Evidence of Activity Study of UBX1325 in Patients With Diabetic Macular Edema (BEHOLD)
This study is intended to assess the exposure, safety, biological activity, and durability of UBX1325, a phosphate pro-drug, and its active parent molecule (UBX0601) following a single intravitreal (IVT) injection of UBX1325 in…
- Trial name
- NCT04857996
- Testing
- UBX1325
- Where
- 22 sites in United States, Canada
- Volunteers
- 65 people
- Sponsor
- Unity Biotechnology, Inc.
Diabetic Retinopathy
High Blood Pressure and Sleep Apnea in Diabetic Macular Edema
Macular edema remains a major cause of vision impairment in diabetic patients. Its pathogenesis is multifactorial and incompletely understood.
- Trial name
- OMHADIA (NCT00970723)
- Testing
- high blood pressure treatment, sleep apnea treatment, diabetic macular edema treatment
- Where
- 5 sites in France
- Volunteers
- 86 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Retinopathy, Diabetic Macular Edema
Bangladesh PRODUCTIVity in Eyecare Trial
The purpose of this study is to assess the impact of using autonomous artificial intelligence (AI) system for identification of diabetic retinopathy (DR) and diabetic macular edema on productivity of retina specialists in…
- Trial name
- B-PRODUCTIVE (NCT05182580)
- Testing
- Results utilized from autonomous AI diagnostic system for diabetic retinopathy and/or diabetic macular edema
- Where
- Bangladesh
- Volunteers
- 993 people, healthy volunteers welcome
- Sponsor
- Orbis
Diabetic Retinopathy, Blindness
Diabetic Retinopathy Study (DRS)
To determine whether photocoagulation helps prevent severe visual loss from proliferative diabetic retinopathy. To determine whether a difference exists in the efficacy and safety of argon versus xenon photocoagulation for…
- Trial name
- NCT00000160
- Testing
- Xenon Photocoagulation, Argon Photocoagulation, Photocoagulation
- Sponsor
- National Eye Institute (NEI)
Intravitreal Bevacizumab Injection, Pars Plana Vitrectomy
Preoperative Injection of Bevacizumab Prior to Vitreoretinal Surgery in Diabetic Tractional Retinal Detachment
Vitreoretinal surgery for epiretinal proliferation tractional retinal detachment associated with proliferative diabetic retinopathy (PDR) is often complicated by hemorrhage from fibrovascular tissue.
- Conditions
- Intravitreal Bevacizumab Injection, Pars Plana Vitrectomy, Tractional Retinal Detachment, Diabetic Retinopathy
- Trial name
- NCT00548197
- Testing
- Bevacizumab
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Iran University of Medical Sciences
Diabetic Retinopathy, Retinal Diseases
Intravitreal Ranibizumab Combined With Panretinal Photocoagulation in Patients With Proliferative Diabetic Retinopathy
To evaluate the efficacy of combination therapy with ranibizumab (RBZ) and panretinal photocoagulation (PRP) versus PRP alone in patients with treatment-naive bilateral proliferative diabetic retinopathy (PDR) as measured by mean…
- Conditions
- Diabetic Retinopathy, Retinal Diseases, Eye Diseases, Diabetic Angiopathies
- Trial name
- NCT01746563
- Testing
- Ranibizumab, Laser therapy
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Diabetic Retinopathy
A Study That Uses Data From Routine Eye Examinations of Patients Participating in Studies FIDELIO-DKD and FIGARO-DKD to Explore Whether Finerenone Can Delay the Progression of a Diabetes Complication That Affects the Eyes (Diabetic Retinopathy ,DR)
Diabetic retinopathy (DR) is a diabetes complication caused by damage to the small blood vessels inside the retina at the back of the eye. Diabetic retinopathy may cause mild vision problems or eventually blindness.
- Trial name
- ReFineDR (NCT04477707)
- Testing
- Finerenone (BAY94-8862)
- Where
- 62 sites in United States, Argentina and 13 more
- Volunteers
- 206 people
- Sponsor
- Bayer
Proliferative Diabetic Retinopathy, Vitrectomy
Observation of the Efficacy of Different Vitrectomy Systems to Treat Proliferative Diabetic Retinopathy
In recent years, vitrectomy has moved toward a minimally invasive vitrectomy surgery (MIV) system, which could effectively reduce the occurrence of operation complications, while reducing the time of post-operation recovery.
- Trial name
- NCT05446948
- Testing
- beveled 27G+ vitrectomy system, standard 25G+ vitrectomy system
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Tianjin Medical University Eye Hospital
Proliferative Diabetic Retinopathy
Vitreous Levels of Cysteine-rich 61 in Patients With Proliferative Diabetic Retinopathy
To determine the vitreous levels of fractalkine, cysteine-rich 61 (Cyr61), and VEGF in patients with PDR. Verifying that it is greater to that found in non-diabetic patients with different non-angiogenetic diseases.
- Trial name
- VL (NCT01920984)
- Testing
- intravitreal injection of 1.25 mg of bevacizumab
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital