Clinical trials: Diabetic Vascular Diseases
Diabetic Retinopathy, Diabetic Macular Edema
Efficacy Study of Lucentis in the Treatment of Diabetic Macular Edema
This study will evaluate the clinical efficacy of intra-vitreal injections of Ranibizumab (Lucentis) in the treatment of Diabetic Macular Edema as compared to grid/focal laser.
- Trial name
- NCT00387582
- Testing
- Ranibizumab (Lucentis), Argon Laser
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Rocky Mountain Retina Consultants
Diabetic Foot
Reflexology and Quality of Life
This is a randomized, controlled and blind clinical trial with 60 type 2 diabetes patients divided into 2 groups of 30 patients each, Control Group (CG) and Treatment Group (TG).
- Trial name
- NCT03280524
- Testing
- reflexology, self-care guidelines with feet
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Diabetes Mellitus, Diabetic Kidney Disease
DiEtary Sodium Intake Effects on Ertugliflozin-induced Changes in GFR, reNal Oxygenation and Systemic Hemodynamics: the DESIGN Study
SGLT2 inhibitors such as ertugliflozin improve blood pressure and kidney outcomes in people living with diabetes through incompletely understood mechanisms, however, not all patients treated with SGLT2 inhibition have improved…
- Conditions
- Diabetes Mellitus, Diabetic Kidney Disease, Hypertension
- Trial name
- DESIGN (NCT05727579)
- Testing
- Salt-Diet and/or Ertugliflozin, Ertugliflozin 15 mg
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Amsterdam UMC, location VUmc
Age-related Macular Degeneration, Diabetic Vascular Diseases
Comfort and Antimicrobial Efficacy of Chlorhexidine vs Betadine for Intravitreal Injections
The purpose of this prospective interventional study is to compare patient experience, ocular surface irritation, and bacterial colony counts and microbial spectrum between povidine iodine and aqueous chlorhexidine as ocular…
- Conditions
- Age-related Macular Degeneration, Diabetic Vascular Diseases, Proliferative Retinopathy, Retina Vein Occlusion
- Trial name
- NCT03571100
- Testing
- Chlorhexidine, Povidine-Iodine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- MidAtlantic Retina
Diabetic Foot Ulcer
Proof of Concept Open Label, Clinical Trial to Evaluate the Safety and Efficacy of the "FITT" Device in Diabetic Foot Ulcers Patients
The TriO FITT device is designed to improve the symptoms of chronic diabetic ulcers. The mechanism of action of the device optimizes and combines the administration known supproting treatments to chronic diabetic ulcers.
- Trial name
- TriO FITT (NCT06003400)
- Testing
- Study treatment administration (TriO FITT), Physical Examination, Vital Signs
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Tri.O Medical LTD
Diabetic Retinopathy
Pivotal Trial to Assess the Clinical Performance of Ophthal-360 for the Detection of Diabetic Retinopathy
Multicenter, prospective, study to assess the performance of the Ophthal-360 platform in the diagnosis of more-than-mild Diabetic Retinopathy (mtmDR) in diabetic patients with no previous diagnosis of DR.
- Trial name
- NCT05806957
- Testing
- Fundus Photography
- Volunteers
- 500 people
- Sponsor
- Ophthalytics, Inc.
Type 2 Diabetes Mellitus, Cardiovascular Diseases
Soluble TREM-1 in Diabetes-Associated Cardiovascular Complications
Cardiovascular disease is the leading cause of illness and death among individuals with type 2 diabetes mellitus (T2DM). Chronic low-grade inflammation contributes significantly to blood vessel damage, atherosclerosis, and…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Diseases, Coronary Artery Disease, Heart Failure
- Trial name
- NCT07847112
- Volunteers
- 85 people
- Sponsor
- Assiut University
Diabetic Retinopathy
Diabetic Retinopathy Screening in Private Practice
Introduction: Diabetic mellitus (DM) is a prevalent disease in Hong Kong (HK) and diabetic retinopathy (DR) is one of the most common complications of DM.
- Trial name
- NCT02866734
- Testing
- Free screening group, Pay screening group ($150), Pay screening group ($300)
- Where
- Hong Kong
- Volunteers
- 238 people
- Sponsor
- The University of Hong Kong
Diabetic Foot Ulcer
Inflammatory Biomarkers to Diagnose and Monitor Diabetic Foot Osteomyelitis
The investigators plan to do a retrospective chart review of 500 patients admitted to the hospital between January 1, 2010 and December 31, 2015 with diabetic foot infections.
- Trial name
- NCT04025853
- Where
- United States
- Volunteers
- 455 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes
ULCERS - Electrical Stimulation in Diabetic Foot Ulceration
The investigators hypothesise that use of a medical device, that increases blood flow to the foot, will speed up ulcer healing in symptomatic diabetes
- Trial name
- NCT02211495
- Testing
- GEKO device, Best Medical Therapy
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Imperial College London
Diabetic Foot, Diabetic Neuropathies
US & HILT Comparative Effect on Neuropathic Pain, Strength & QOF in Diabetic Foot
To compare the effects of therapeutic ultrasound and high intensity laser therapy on neuropathic pain , strength and quality of life in patients with diabetic foot
- Trial name
- NCT06479577
- Testing
- ultrasound, high intensity laser therapy
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Staphylococcal Skin Infections
Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin-structure Infections
This study will evaluate the safety and efficacy of daptomycin against complicated skin and skin-structure infections in adults
- Trial name
- NCT00463801
- Testing
- Daptomycin
- Where
- 2 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Novartis
Diabetes Mellitus, Amputation Stumps
Phototherapy in DM Amputation Ulcers.
Diabetes mellitus is a major public health problem and it is estimated that 300 million individuals will be affected by the year 2030.
- Conditions
- Diabetes Mellitus, Amputation Stumps, Diabetic Foot
- Trial name
- NCT02883751
- Testing
- LED, Control group
- Where
- Brazil
- Sponsor
- University of Nove de Julho
Cataract, Glaucoma
The Effects of a Large Language Model on Clinical Questioning Skills
The researchers have used the ophthalmology textbook, clinical guideline consensus, the Internet conversation data and knowledge base of Zhongshan Ophthalmology Center in the early stage, combined with artificial feedback…
- Conditions
- Cataract, Glaucoma, Diabetic Retinopathy, Keratitis
- Trial name
- NCT06229379
- Testing
- "Digital twin patient", Interaction with real patients
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Diabetic Foot, Pedal Ulcers
Randomized, Prospective Evaluation of the Toad Brace in Plantar Ulcer Off-loading and Healing
The TOAD Medical Corporation Brace is a novel device that completely off-loads the foot and has been shown to heal ulcers at a rapid rate in preliminary experience in patients with plantar ulcers.
- Trial name
- NCT02052817
- Testing
- Optimal Medical Therapy Debridement + Toad Brace, Optimal Medical Therapy - Debridement
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Toad Medical Corporation
Diabetic Macular Edema, Obstructive Sleep Apnea
Obstructive Sleep Apnea and Diabetic Macular Edema Inflammatory Mediators
Obstructive sleep apnea (OSA) is characterized by intermittent nocturnal hypoxemia, frequent arousals, fragmented sleep and daytime sleepiness.
- Conditions
- Diabetic Macular Edema, Obstructive Sleep Apnea, Diabetic Retinopathy
- Trial name
- NCT04648618
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Uptown Eye Specialists
Neovascular Age-related Macular Degeneration (nAMD), Wet Age-related Macular Degeneration (AMD)
An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World Setting
The purpose of this research study is to observe the patient's clinical care and how EYLEA® HD is used as a treatment in real-world settings.
- Conditions
- Neovascular Age-related Macular Degeneration (nAMD), Wet Age-related Macular Degeneration (AMD), Diabetic Macular Edema (DME), Visual Impairment
- Trial name
- SPECTRUM-US (NCT06398080)
- Testing
- aflibercept 8 mg
- Sponsor
- Regeneron Pharmaceuticals
Wound Open, Chronic Venous Hypertension (Idiopathic) With Ulcer
Efficacy of Laser Debridement on Pain and Bacterial Load in Chronic Wounds
Bacterial load is frequently associated with impaired healing of chronic wounds. As well, sharp debridement is often associated with pain, causing patient distress, and thereby occasionally contributing to inadequacy of…
- Conditions
- Wound Open, Chronic Venous Hypertension (Idiopathic) With Ulcer, Diabetic Foot Ulcer
- Trial name
- NCT03182582
- Testing
- Erbium:Yttrium-Aluminum-Garnet (Er:YAG) Laser Debridement, Scalpel/Curette Debridement
- Volunteers
- 22 people
- Sponsor
- Stanford University
Diagnosis, Diabetic Retinopathy
Efficacy of Using Large Language Model to Assist in Diabetic Retinopathy Detection
With the increase in population and the rising prevalence of various diseases, the workload of disease diagnosis has sharply increased.
- Trial name
- NCT05231174
- Testing
- A self-evlaution tool based on Large Language Model
- Where
- China
- Volunteers
- 535 people
- Sponsor
- Sun Yat-sen University
Diabetes Mellitus, Foot Osteomyelitis
Assessment of PCR Multiplex Tests as a Tool to Obtain a Quicker Diagnosis of Bacteria Responsible for Foot Osteomyelitis Than Usual Cultures
Bone samples from infected diabetic feet will be collected and tests will be performed for the diagnosis of causative bacteria. Samples will be processed by PCR multiplex tests and usual cultures for identification of causative…
- Trial name
- RAPDIAGOS (NCT03434288)
- Testing
- Bone sampling
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Montpellier
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