Clinical trials: Diabetic Vascular Diseases
Diabetic Foot, Educational Intervention
Effectiveness of Educational Intervention on Footcare Among Individuals Having Type 2 Diabetes at Slums of Karachi, Pakistan.
There are multiple studies conducted in Pakistan that supports the topic of foot care knowledge among individual with type 2 diabetes but all are descriptive cross-sectional studies and investigators cannot develop cause effect…
- Conditions
- Diabetic Foot, Educational Intervention, Foot Care, Foot Ulcer, Diabetic
- Trial name
- NCT06358846
- Testing
- Self-care behavior to promote foot care through educational guidance among individual with diabetes
- Where
- Pakistan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- SINA Health Education and Welfare Trust
Diabetic Foot Ulcers (DFUs), Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer)
Miro3D Wound Matrix Study for Diabetic Foot Ulcers and Wound Healing
This study is a prospective, randomized controlled trial designed to evaluate the effectiveness of Miro3D Wound Matrix plus Standard of Care (SOC) compared to SOC alone in treating Wagner Grade 1 diabetic foot ulcers (DFUs) and…
- Trial name
- STRIDDDE (NCT06939686)
- Testing
- Miro3D Wound Matrix, Standard of Care (SOC)
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Reprise Biomedical, Inc.
Diabetic Foot
Foot Intervention Study Utilizing Commercially Available Infrared Thermometers With Individuals With Diabetes
Foot self-management is important in preventing diabetic foot ulcers. However, even when individuals care for their feet, the signs of inflammation are often missed.
- Trial name
- NCT03506776
- Testing
- Education and Thermometer Group, Education Only Group
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- Memorial University of Newfoundland
Diabetic Retinopathy
Ozurdex in Reducing PVR After Vitreotomy in PDR
Diabetic retinopathy is a significant source of visual morbidity in the adult population. Complications of diabetic retinopathy include ischemic maculopathy, macular edema, and sequelae of fibrovascular proliferation, such as…
- Trial name
- NCT05415826
- Testing
- slow-release dexamethasone implant
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Diabetic Foot Ulcers
Open, Non-comparative, Multi-centre Post Marketing Clinical Follow-up Investigation to Evaluate Performance and Safety on Diabetic Foot Ulcer, DFU When Using Fast Gelling Dressing as Intended.
The primary objective of this post market clinical follow-up (PMCF) investigation is to evaluate performance and safety of fast gelling dressing when used as intended in Diabetic Foot Ulcer (DFU).
- Trial name
- CHEXU 01 (NCT02091778)
- Testing
- Fast gelling dressing
- Where
- 2 sites in United Kingdom
- Volunteers
- 21 people
- Sponsor
- Molnlycke Health Care AB
Neovascular Age-related Macular Degeneration, Age-related Macular Degeneration
SD-OCT Angiography
The objective of this study is to image retinal vascular alterations in patients with retinal disease using the AngioVue OCT-A system and understand the information these images provide.
- Conditions
- Neovascular Age-related Macular Degeneration, Age-related Macular Degeneration, Diabetic Retinopathy, Retinal Vein Occlusion
- Trial name
- NCT02510885
- Testing
- AngioVue SD-OCT
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Duke University
Severe Nonproliferative Diabetic Retinopathy, Diabetic Retinopathy
PRP vs PRP+IVC for Severe nPDR
The randomized clinical trial aims to compare the therapeutic effects between panretinal photocoagulation(PRP) and PRP combined with intravitreal conbercept (IVC) injection in severe nPDR with/without diabetic macular edema…
- Conditions
- Severe Nonproliferative Diabetic Retinopathy, Diabetic Retinopathy, Diabete Mellitus
- Trial name
- NCT03863535
- Testing
- Conbercept, Panretinal coagulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Diabetic Polyneuropathy, Diabetic Foot Ulcer
TempTouch IR Thermometry & Diabetic Patient Self-Care
Foot ulcers develop in diabetics with neuropathy because of cumulative injury over the course of several days. These patients do not feel pain, and do not recognize their foot is being injured until a wound develops.
- Conditions
- Diabetic Polyneuropathy, Diabetic Foot Ulcer, Diabetes, Foot Infection
- Trial name
- NCT00289497
- Testing
- TempTouch®
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Diabetica Solutions Inc.
Diabetic Foot
Effect of Photobiomodulation as a Preventive Treatment for Diabetic Foot
This study seeks to evaluate the effect of photobiomodulation (PBM) in the prevention of Diabetic foot (DF), in patients at moderate and high risk for its development, through a controlled, randomized, double-blind clinical…
- Trial name
- NCT06353568
- Testing
- Photobiomodulation, Simulation of Photobiomodulation, Therapeutic education
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- University of Nove de Julho
Uveitis, Diabetic Retinopathy
Intravitreal Adalimumab in Refractory Diabetic Retinopathy, Choroidal Neovascularization or Uveitis: A Pilot Study
Direct intravitreal administration of medication is the preferred method of treatment for uveitis and retinal vascular disorders.
- Conditions
- Uveitis, Diabetic Retinopathy, Choroidal Neovascularization
- Trial name
- ADA01 (NCT00855608)
- Testing
- adalimumab
- Where
- Lebanon
- Volunteers
- 15 people
- Sponsor
- Rafic Hariri University Hospital
Diabetic Foot Ulcers
Effect of Topic Pirfenidone in Diabetic Ulcers
Pirfenidone is a synthetic molecule, which acts as a potent modulator of the effect of various cytokines (TNF-α, transforming growth factor-β, platelet derived growth factor and vascular endothelial growth factor, among others)…
- Trial name
- PirDFI (NCT02222376)
- Testing
- Pirfenidone, Debridement
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Dermatologic Disease, Onychomycosis of Toenail
Photodynamic Therapy and Topical Antifungal for Onychomycosis in Patients With Diabetes.
There are different therapeutic alternatives for onychomycosis. Systemic therapy is widely used due to its easy accessibility, low cost and high efficacy, but may be associated with systemic adverse events and drug-drug…
- Conditions
- Dermatologic Disease, Onychomycosis of Toenail, Diabetic Foot, Diabetes Mellitus
- Trial name
- NCT06485050
- Testing
- Photodynamic therapy
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Universidad Complutense de Madrid
Venous Insufficiency
Obtaining and Storing Blood Samples and Debridement Samples for Wound Related Research
The intent of this protocol is to obtain blood samples from subjects with or without a wound, so the blood can be used in wound-related scientific studies.
- Trial name
- NCT00762697
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Southwest Regional Wound Care Center
Diabetes Mellitus, Diabetic Retinopathy
Evaluation of Early Retinal Nerve Injury in Type 2 Diabetes Patients Without Diabetic Retinopathy
The object of this study is to investigate the damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex layer (GCL+) in diabetic patients without retinal microangioma as detected by fundus fluorescein angiography…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Nerve Injury
- Trial name
- NCT03970161
- Testing
- routine ophthalmic examination
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Hypertension, Diabetes
Safety Study to Lower the Risk of Heart Failure is Also Effective in Reducing Stiffness of the Arteries
The study is being done to see if a drug shown to lower the risk of heart failure is also effective in reducing the stiffness of the arteries.
- Trial name
- EFFORT (NCT00829296)
- Testing
- nebivolol, Metoprolol
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Diabetic Retinopathy
A Study of PER-001 in Participants With Diabetic Retinopathy
This is a Phase 2a, randomized, single-masked (participant), sham controlled clinical study.
- Trial name
- NCT06003751
- Testing
- PER-001 Intravitreal Implant - Low Dose, PER-001 Intravitreal Implant - High Dose
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Perfuse Therapeutics, Inc.
Diabetic Foot, Cardiopulmonary
Feasibility and Acceptability of Non Weight-bearing Physical Activity for People With Diabetic Foot Ulceration
Intervention in the form of a PA (physical activity) program combining aerobic, resistance, and flexibility exercises adapted for wearing a lower limb offloading device and limiting weight-bearing on the feet, with a duration of…
- Conditions
- Diabetic Foot, Cardiopulmonary, Physical Inactivity
- Trial name
- DB-ACTIV (NCT06092827)
- Testing
- Non weight-bearing physical activity program
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Université du Québec à Trois-Rivières
Chronic Kidney Disease, Anemia
SGLT2 Inhibitors in Non-Diabetic CKD: Effects on Vascular Calcification and Anemia
The goal of this clinical trial is to learn if the drug dapagliflozin (an SGLT2 inhibitor) can help protect the kidneys, improve anemia, and support heart health in adults with chronic kidney disease (CKD) who do not have…
- Conditions
- Chronic Kidney Disease, Anemia, Cardiovascular Calcification
- Trial name
- NCT07344922
- Testing
- Dapagliflozin (10Mg Tab) along with standard medical therapy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Macular Degeneration, Diabetic Retinopathy
Patient Comfort Following Intravitreal Injections Using Iheezo Versus Standard Anesthesia
Prospective comparative clinical study. One hundred eyes of 50 patients were included. All patients received bilateral same-day intravitreal injections, with Iheezo administered to only one randomly selected eye and standard…
- Conditions
- Macular Degeneration, Diabetic Retinopathy, Retinal Vein Occlusion (RVO)
- Trial name
- NCT07779356
- Testing
- Iheezo, Lidocaine pledget
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Retina Consultants of Delmarva
Vascular Complication, Diabetic
Neutrophil-lymphocyte and Platelet-lymphocyte Ratios and Their Relations to Vascular Comlications and Glycemic Control in Patients With Type 2 Diabetes Attending The Diabetes Center of Assiut University Hospitals
Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM
- Trial name
- NCT06073756
- Testing
- Echocardiogram
- Volunteers
- 106 people
- Sponsor
- Assiut University
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