Clinical trials: Diagnoses Diseases
Uterine Fibroid, Uterine Sarcoma
Radiomics-Based Non-Invasive MRI Differentiation of Uterine Sarcomas and Fibroids
This retrospective case-control study aims to develop and validate a diagnostic model based on multimodal big data and artificial intelligence to differentiate uterine leiomyoma from uterine sarcoma.
- Conditions
- Uterine Fibroid, Uterine Sarcoma, Diagnose Disease, AI (Artificial Intelligence)
- Trial name
- NCT07129005
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Tongji Hospital
Plasmodium Falciparum Malaria, Pregnancy Malaria
Clinical Performance of the Histidine Rich Protein 2 (HRP2) Highly Sensitive Rapid Diagnostic Test (HS-RDT) for Malaria Diagnosis in Pregnant Women in Papua New Guinea
Malaria during pregnancy remains an important public health issue in endemic countries. Most cases of malaria in pregnant women are asymptomatic, and can contribute to adverse outcomes, such as maternal and neonatal anaemia as…
- Conditions
- Plasmodium Falciparum Malaria, Pregnancy Malaria, Diagnoses Disease
- Trial name
- NCT03462615
- Testing
- HS-RDT
- Where
- Papua New Guinea
- Volunteers
- 930 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Bronchopulmonary Disease, Diagnoses Disease
Optimizing Bronchopulmonary Cancer Screening
The aim of this study is to evaluate the feasibility of performing a first screening for bronchopulmonary cancer by thoracic scanner in a French cohort within a dedicated, effective and structured network in the pilot centers…
- Trial name
- OPTI-DEPIST (NCT06439901)
- Testing
- Screening, Inclusion, Chest CTscan and follow-up
- Where
- 9 sites in France
- Volunteers
- 500 people
- Sponsor
- Institut Curie
Diagnoses Disease
HEARTBEAT-TROP. Polyethylene Glycol Precipitation to Unmask Macrotroponin
Troponin elevation can, among others, be due to myocardial infarction, acute inflammation or structural heart disease. Formation of macrocomplexes against troponin is an underestimated cause for persistent troponin elevation.
- Trial name
- MACRO-TROP (NCT07726420)
- Testing
- Polyethylene glycol precipitation, Transthoracic echocardiography
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Treatment Related Cancer, Diagnoses Disease
Socioeconomic Inequalities in the Diagnosis and Treatment of Colon and Ovarian Cancer in England Between 2016-2017
This study is a population-based, patient-level analysis of colon and ovarian cancer diagnoses in England over a 2-year period using a dataset created by linking NCRAS and NHS digital datasets.
- Conditions
- Treatment Related Cancer, Diagnoses Disease, Equality, Gender
- Trial name
- NCT05185388
- Where
- United Kingdom
- Volunteers
- 45,831 people
- Sponsor
- University of Hull
Cataract, High Myopia
Artificial Intelligence for Highly Myopic Cataract
This study aims to establish a multi-center artificial intelligence model for the accurate calculation of intraocular lens and its clinical application in highly myopic cataract, so as to improve the accuracy of the prediction of…
- Conditions
- Cataract, High Myopia, Myopia, Automatic Judgement
- Trial name
- AI-HMC (NCT06616506)
- Testing
- newly-invented AI model
- Where
- China
- Volunteers
- 500,000 people
- Sponsor
- Shanghai High Myopia Study Group
Central Nervous System Disease, MRI
Validation on Clinical Adaptability of the Foundation Model Specific to Neuroimaging Diagnosis
This clinic trial aims to investigate whether artificial intelligence (AI) diagnostic tools at neurological diseases diagnosis on brain CT/MRI can improve the work efficiency of specialized neuroimaging physicians, with a…
- Conditions
- Central Nervous System Disease, MRI, CT, AI (Artificial Intelligence)
- Trial name
- NCT07471984
- Testing
- Foundation Model Specific to Neurological Diagnosis
- Where
- China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Yaou Liu
Tuberculosis, Diagnoses Disease
Evaluating a New Stool Based qPCR for Diagnosis of Tuberculosis in Children and People Living With HIV
Stool4TB aims to evaluate an innovative stool-based qPCR diagnostic platform (with the capacity to become a POC diagnostic tool) in the high TB and HIV burden settings of Mozambique, Eswatini and Uganda, under the hypothesis that…
- Trial name
- Stool4TB (NCT05047315)
- Where
- 3 sites in Eswatini, Mozambique and 1 more
- Volunteers
- 1,967 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Pancreatic Cancer, Diagnose Disease
AI-Powered Precision Decision-Making for Pancreatic Diseases
This multicenter clinical trial evaluates an artificial intelligence (AI) system designed to assist in the diagnosis and management of pancreatic diseases.
- Conditions
- Pancreatic Cancer, Diagnose Disease, IPMN, Pancreatic, Pancreatic Cystic Lesions
- Trial name
- NCT07439757
- Testing
- Diagnosis by Artificial Intelligence model
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Peroxisomal Disorders, Diagnoses Disease
Evaluation of a New Strategy for the Diagnosis of Peroxisomal Diseases
The principal aim of the study is to avoid the diagnostic wanderings of patients suffering from a peroxisomal disorder. For this purpose, a new diagnostic strategy is proposed.
- Trial name
- PEROXY4G (NCT03163771)
- Where
- 4 sites in France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Lille
Diagnoses Disease
Evaluation of Clinical Decision Support System-mPDia for Neurodegenerative Parkinsonism Using MRI Images
mPDia is a software that has been pre-learned based on a neurodegenerative parkinsonism diagnosis model using Nigrosome 1 MRI images, and clinical decision support system for diagnosing neurodegenerative parkinsonism by…
- Trial name
- NCT04334902
- Testing
- mPDia
- Where
- 10 sites in South Korea
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Heuron Inc.
Diagnoses Disease, Lymphedema
Measuring Skin Elasticity in Lymphedema Patients
This protocol will utilize the lymphedema indentometer, or durometer (a novel, noninvasive piece of equipment that measures skin elasticity), to better characterize disease progression in patients with lymphedema.
- Trial name
- NCT03313999
- Testing
- Lymphedema Indentometer
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Beth Israel Deaconess Medical Center
Periodontitis, Diagnose Disease
Hypoxia and Kynurenine Pathway in Periodontal Inflammation
The kynurenine pathway (KP), the primary route for tryptophan (TRP) metabolism, is activated during inflammation and hypoxic conditions, contributing to immune dysregulation and oxidative stress.
- Trial name
- NCT07182448
- Testing
- Saliva and serum sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul Medipol University Hospital
Asthma, Dyspnea; Asthmatic
Asthma Diagnosis Verified by Lung Function
Guidelines suggests that asthma should not be treated prior to a reversibility test and/or an assessment with peak expiratory flow (PEF) unless there is a clinical urgency for the patient to be treated.
- Conditions
- Asthma, Dyspnea; Asthmatic, Diagnoses Disease
- Trial name
- ADVERT (NCT04652141)
- Testing
- AsthmaTuner
- Where
- Sweden
- Volunteers
- 146 people
- Sponsor
- Björn Nordlund
Diagnoses Disease
Early Detection of Endometrial/Ovarian Cancer and Hereditary Predisposition of These Cancers
Early stage high-grade cancer, endometrial and ovarian, has few, if any, symptoms or signs. When symptoms appear, the disease is commonly in advanced stage meaning it has left the gynaecological organs and metastasized to the…
- Trial name
- NCT04891029
- Testing
- DOvEEgene test
- Where
- 2 sites in Canada
- Volunteers
- 5,600 people, healthy volunteers welcome
- Sponsor
- McGill University
Diagnoses Disease
GP Response to Decontextualised Risk
Decontextualised risk information is any information pertaining to diagnosis, which is introduced into a clinical consultation, or a diagnostic thought process, without being requested by the clinician.
- Trial name
- NCT05399511
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Tuberculosis, Diagnoses Disease
TB-CAPT CORE Truenat Trial
A cluster randomized controlled trial to evaluate the effect of placing Truenat platform/TB assays at primary health care clinics combined with rapid communication of results on time to treatment initiation of microbiologically…
- Trial name
- NCT04568954
- Testing
- Truenat TB platform/TB assays
- Where
- 4 sites in Mozambique, Tanzania
- Volunteers
- 3,987 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Tuberculosis, HIV Coinfection
TB-CAPT EXULTANT - HIV
The overall aim of this study is to assess the potential of an expanded TB testing strategy to increase the number of HIV-positive patients with microbiologically diagnosed TB who are started on treatment in adult wards of…
- Conditions
- Tuberculosis, HIV Coinfection, Diagnoses Disease
- Trial name
- NCT04568967
- Testing
- Concentrated urine with Xpert Ultra, Stool with Xpert Ultra
- Where
- 4 sites in Mozambique, Tanzania
- Volunteers
- 1,172 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Onchocerciasis, Loiasis
Evaluation of the Diagnosis Performances of DEC LTS-2 Skin Patch for Onchocerciasis in Central Africa
This study aims at evaluating the diagnosis performances of the LTS-2 DEC patch for onchocerciasis compared to the gold standard which are the skin snips.
- Conditions
- Onchocerciasis, Loiasis, Diagnoses Disease, Neglected Diseases
- Trial name
- EOLoa (NCT04035174)
- Testing
- LTS-2 DEC patch, Skin snips
- Where
- Cameroon
- Volunteers
- healthy volunteers welcome
- Sponsor
- Center for Research on Filariasis and Other Tropical Diseases, Cameroon
Squamous Cell Carcinoma, Breath Test
Early Diagnosis of Upper Digestive Tract Disease
Upper digestive tract cancer (UDC) is a major disease burden worldwide encompassing all cancers involving the digestive tract (from oral cavity to duodenum).
- Conditions
- Squamous Cell Carcinoma, Breath Test, Digestive System Disease, Diagnose Disease
- Trial name
- E-DIGEST (NCT04475952)
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imperial College London