Clinical trials: Diagnostic
Diabetic Peripheral Neuropathy (DPN)
The Diagnostic Value of Shear Wave Elastography and Viscosity Imaging Techniques in Diabetic Peripheral Neuropathy
The main objective of this observational study is to evaluate the diagnostic value of multimodal ultrasound for diabetic peripheral neuropathy (DPN).
- Trial name
- NCT06773793
- Where
- 2 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
ADHD
A Comparative Study to Evaluate a Novel Algorithm As a Diagnostic Aid for ADHD in Youth Ages 6-17.
This study aims to demonstrate the accuracy of the MT1 algorithm using the MindTension biometric sensor device as a diagnostic aid for healthcare providers in diagnosing ADHD in youth ages ≥ 6 to ≤17 years.
- Trial name
- NCT06728969
- Testing
- MT1 Auditory startle response patterns analysis algorithm, T.O.V.A. Continuous Performance Test
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MindTension
Appendicitis
The Circulating Fibrocyte - a Novel and Accurate Biomarker in Diagnosing Acute Appendicitis in Adults
Accurate diagnostic biomarkers for acute appendicitis (AA) are lacking. Circulating fibrocytes (CFs) are increased in inflammatory states. It is not known whether they are altered in appendicitis.
- Trial name
- NCT03988660
- Testing
- Circulating fibrocytes
- Where
- Ireland
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital of Limerick
Acute Infection
Establish MeMed BV™ Performance for Differentiating Bacterial From Viral Infection in Suspected Acute Infection Patients (APOLLO STUDY)
Prospective, multi-center, observational, blinded study, enrolling pediatric and adult subjects. Eligible ED\Urgent care and hospital admitted patients with symptoms consistent with acute bacterial or viral infection and healthy…
- Trial name
- Apollo (NCT04690569)
- Testing
- MeMed BV
- Where
- 11 sites in United States, Israel
- Volunteers
- 1,384 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Periodontitis, Gingivitis
Evaluation of Matrix Metalloproteinase 8 Salivary Test for Diagnosis of Periodontitis
Despite the great progress in understanding the causes of infertility, the reason for the failure of pregnancy has not been discovered among 25% of infertile couples.
- Conditions
- Periodontitis, Gingivitis, Infertility
- Trial name
- NCT03542630
- Testing
- salivary MMP8 test, periodontal examination, blood tests
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Major Depression, Mania
Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
The primary aims of this study are to assess: 1. The inter-rater and test-retest reliability of the MINI-KID 2. The validity of the standard MINI-KID interview in relation to the parent rated pencil/paper version (MINI-KID-P) and…
- Conditions
- Major Depression, Mania, Anxiety Disorders, Psychotic Disorder
- Trial name
- NCT00579267
- Testing
- MINI-KID
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Sleep Apnea, Obstructive, Larynx
Accuracy of the Sensory Test Using the Laryngopharyngeal Endoscopic Esthesiometer in Obstructive Sleep Apnea
This is a prospective double blinded randomized crossover controlled trial aiming at validating the measurement of laryngopharyngeal mechanosensitivity in patients with suspected OSA using a recently developed laryngopharyngeal…
- Conditions
- Sleep Apnea, Obstructive, Larynx, Sensory Disorder
- Trial name
- NCT03109171
- Testing
- Laryngopharyngeal sensory test
- Where
- 2 sites in Colombia
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Fundación Neumologica Colombiana
Diagnosis
Physician Reasoning on Diagnostic Cases With Large Language Models
This study will evaluate the effect of providing access to GPT-4, a large language model, compared to traditional diagnostic decision support tools on performance on case-based diagnostic reasoning tasks.
- Trial name
- NCT06157944
- Testing
- GPT-4
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sinonasal Disorder, Chronic Rhinosinusitis (Diagnosis)
The Sinonasal Microbiome
Chronic rhinosinusitis is an inflammatory disease of the sinonasal mucosa with significant impact and limited treatment options.
- Trial name
- NCT06822725
- Testing
- Control Group, Chronic rhinosinusitis (CRS) with and without Nasal Polyposis
- Where
- United States
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Abnormal Glucose Complicating Pregnancy
Diagnosis of Gestational Diabetes Based on a 50-gram Glucose Challenge
The aim of this study is to determine a 1-hour glucose tolerance test (GTT) value at which the diagnosis of gestational diabetes can be made without undergoing a 3-hour test.
- Trial name
- NCT07643987
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Methodist Health System
Schizophrenia, Dual Diagnosis
Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment?
In this translational research proposal, based on our formulation, we seek to confirm and expand upon data obtained in our pilot study suggesting that cannabis and the cannabinoid agonist dronabinol, given in low dose to patients…
- Conditions
- Schizophrenia, Dual Diagnosis, Psychotic Disorder, Cannabis Use Disorder
- Trial name
- NCT01964404
- Testing
- Marijuana, Dronabinol
- Where
- 2 sites in United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Early Diagnosis, Cancer
Role of Genomic Imprinting in Cancer Diagnosis
The current research focus for cancer diagonosis is classical genetics, named "driving genes". However, not all cancer patients have typical genetic alterations, especially at early stage.
- Conditions
- Early Diagnosis, Cancer, Biomarker, Genomic Imprinting
- Trial name
- NCT03882684
- Testing
- In-situ imprinting detection
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chinese Alliance Against Lung Cancer
Breast Cancer
Evaluation of the Efficacy of Digital Breast Tomosynthesis Imaging
The primary objective of this protocol is to collect the 2-dimensional (2D) screening and diagnostic images, and 3-dimensional (3D) Digital Breast Tomosynthesis (DBT) scans from patient mammography examinations acquired on…
- Trial name
- DBT (NCT01373671)
- Testing
- SIEMENS INSPIRATION DIGITAL BREAST TOMOSYNTHESIS (DBT) SYSTEM
- Where
- United States
- Volunteers
- 764 people, healthy volunteers welcome
- Sponsor
- Siemens Medical Solutions USA - CSG
Vertigo
Diagnosis Of Vertigo With New Imaging
The purpose of this study is to determine the potential usefulness of new functional MRI in diagnostic assessment of patients presenting with vertigo.
- Trial name
- NCT00593216
- Testing
- Functional MRI imaging
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Boston University
Being Between 40-80 Years Old, Being Diagnosed With Haemiplegia
The Relationship Between Lower Limb Functionality, Foot Joint Position Sensation and Balance in Haemiplegic Patients
Stroke is defined as a neurological disorder resulting from acute focal damage to the central nervous system caused by vascular factors, which may include cerebral infarction, intracerebral haemorrhage and subarachnoid…
- Conditions
- Being Between 40-80 Years Old, Being Diagnosed With Haemiplegia, Getting 20 Points or More in the Mini Mental Test, Volunteering to Participate in the Study
- Trial name
- NCT06043960
- Testing
- Humac Norm İsokinetic Machine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Brain Concussion, Brain Injuries
An Evaluation of HS-1000 Device Capabilities in the Diagnosis and Assessment of Patients After Concussion
The HeadSense (HS) HS-1000 device, a new non-invasive brain monitor is expected to safely and accurately monitor concussed patients with minimal discomfort, potentially providing a new modality for concussion measurement.
- Trial name
- NCT02699346
- Testing
- HS-1000 recording
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HeadSense Medical
Healthy, Osteopenia
Clinical Study to Estimate Bone Mineral Density With the POROUS Ultrasound Device
Osteoporosis is a widespread medical condition among older people. It causes the bones to weaken and become more likely to break.
- Conditions
- Healthy, Osteopenia, Osteoporosis
- Trial name
- POROUS-BMD (NCT07187518)
- Testing
- Measurements with the POROUS R4C ultrasound device at the midshaft tibia, DXA measurement of the hip and lumbar spine
- Where
- 2 sites in Germany
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- POROUS GmbH
Other Acute Illnesses Presenting to the Hospital, Heart Failure
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
This VA QUERI Partnered Evaluation Initiative will evaluate the impact of an immersive Point-of-care Ultrasound (POCUS) Training Course on provider skill acquisition and retention; the frequency of POCUS use by trained providers…
- Conditions
- Other Acute Illnesses Presenting to the Hospital, Heart Failure, Pneumonia, Deep Venous Thrombosis
- Trial name
- NCT03296280
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alzheimer Disease, Dementia
Exploratory Clinical Study and Validation of Blood Biomarkers for Alzheimer's Disease
This is a 24-month, monocentric, exploratory and observational clinical study aimed at developing and validating a blood-based diagnostic test for Alzheimer's disease (AD).
- Conditions
- Alzheimer Disease, Dementia, Neurodegenerative Disorders, Cognitive Decline
- Trial name
- ADKIT (NCT07294586)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Amoneta Diagnostics SAS
Metabolic Dysfunction-associated Steatotic Liver Disease
Guerbet Liver Fibrosis
The goal of this study is to assess the value of liver dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and texture analysis post gadopiclenol for liver fibrosis staging, in comparison with MR elastography, T1…
- Trial name
- NCT06703450
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
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