Clinical trials: Diagnostic Imaging Utilization
Cocaine Use, Cocaine Dependence
rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder
The goal of the study is to investigate the feasibility, safety, and effect of rTMS on mPFC/dACC activity using a combination of fMRI and clinical outcome measures, when used as an augmentation to CBT.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Use Disorder, Cocaine Use Disorder, Moderate
- Trial name
- COAST (NCT05974202)
- Testing
- Active H7-coil repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder
Psilocybin-assisted Therapy for Treatment of Alcohol Use Disorder
Note: The trial is only eligible for citizens of Denmark. The purpose of this project is to assess the treatment efficacy of a single high dose of psilocybin administered within a protocol of psychological support to patients…
- Trial name
- NCT05416229
- Testing
- Psilocybin, Maltodextrin
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Total Thyroidectomy, Bilateral Neck Exploration for Primary Hyperparathyroidism
Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery
Reliable identification of parathyroid glands is critical to the success of thyroid and parathyroid surgery. In thyroid surgery, inadvertent injury to parathyroid glands may cause temporary or permanent hypoparathyroidism (low…
- Trial name
- NCT02089542
- Testing
- MB and fluorescent imaging
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Chronic Pain, Opioid-use Disorder
Imaging the Effects of rTMS on Chronic Pain
Chronic pain is highly prevalent in patients with opioid use disorder on methadone maintenance therapy, and associated with problems related to psychosocial functioning, medical and psychiatric health, and substance craving and…
- Trial name
- NCT02687360
- Testing
- Active rTMS treatment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- New York State Psychiatric Institute
Fibroid Uterus, Endometriosis
ICG to Assess Ovarian Perfusion
To assess the feasibility of using intravenous ICG to characterize the vascular perfusion of ovaries during gynecologic surgery
- Conditions
- Fibroid Uterus, Endometriosis, Uterus Myoma, Uterine Fibroid
- Trial name
- NCT03927651
- Testing
- ICG
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Nicotine Dependence
State and Trait Mediated Response to TMS in Substance Use Disorder
OBJECTIVES: The current protocol seeks to develop brain-based intermediate phenotypes of response to transcranial magnetic stimulation (TMS) in chronic substance use disorder (SUD).
- Trial name
- NCT03707600
- Testing
- TMS
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Coronary Artery Disease
Optina Eye to Heart Connection
This is a prospective cross-sectional, single-center retinal imaging study expecting to enroll approximately 400 male and female subjects ≥ 18 years of age.
- Trial name
- NCT05199428
- Where
- Canada
- Volunteers
- 308 people
- Sponsor
- Optina Diagnostics Inc.
Healthy
Use of [18F]FECNT in Positron Emission Tomography
This study will examine the use of a new radioactive tracer called [18F]FECNT in positron emission tomography (PET) scanning for measuring dopamine transporter (DAT) in the brain.
- Trial name
- NCT00083629
- Testing
- PET
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Diagnostic Imaging Utilization
Effect of Diagnostic Imaging Utilization Reports
Diagnostic imaging (DI) tests (for example, x-ray tests, ultrasounds, CT scans, or MRIs) are used by health care providers to help diagnose patient illness, but decisions regarding when these tests should be ordered are…
- Trial name
- NCT02917837
- Testing
- Usual QCNL DI utilization report, New DI utilization report, Detailing
- Where
- Canada
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Impulsive Behavior
Examination of Transcranial Focused Ultrasound on Brain Activity in Adults
The investigators aim to examine the immediate effect of transcranial focused ultrasound (tFUS) on brain activity in healthy adults.
- Trial name
- NCT06477029
- Testing
- tFUS
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mary Phillips, MD MD (Cantab)
Breast Carcinoma, Calcification
64 Cu-DOTA-alendronate PET Imaging in Localizing and Characterizing Breast Calcifications in Participants Before Undergoing Mastectomy
This early phase I pilot trial studies how well 64Cu-DOTA-alendronate positron emission tomography (PET) imaging work in localizing and characterizing breast calcifications (small calcium deposits) in participants before…
- Trial name
- NCT03542695
- Testing
- Computed Tomography, Copper Cu-64-DOTA-alendronate, Pharmacokinetic Study
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- City of Hope Medical Center
Healthy
A Study to Evaluate Laser Speckle Contrast Imaging to Assess Changes in Chemical Agent-Induced Skin Blood Flow in Healthy Participants (MK-0000-420)
Pain is a significant issue and there is a need for better treatments for pain management. Local changes in skin blood flow can be used as an indicator of pain in the body.
- Trial name
- NCT06809569
- Testing
- Allyl Isothiocyanate (AITC), Capsaicin, Vehicle for AITC
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Celiac Disease
Evaluate the Use of Optical Frequency Domain Imaging (OFDI) for Celiac Disease in Children, Adolescents and Young Adults
The goal of this research is to conduct a pilot clinical study to image Celiac disease characteristic mucosal lesions and compare Optical Frequency Domain Imaging (OFDI) images to histologic evaluation in children, adolescents…
- Trial name
- NCT01439035
- Testing
- MGH OFDI Imaging
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Use of Molecular Breast Imaging (MBI) to Detect Additional Disease in Women With Breast Cancer Who Are About to go to Surgery
Conventional mammography is not a reliable method for determining the extent of disease in women with breast cancer. Molecular Breast Imaging (MBI) is a new nuclear medicine technique that allows the breast to be imaged in a…
- Trial name
- MBI (NCT00776308)
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Mayo Clinic
Alcohol Use Disorder
Brain Connectivity Between Networks Implied in Inhibition and Cue-reactivity in Alcohol Use Disorder
Research about patients with alcohol use disorder has shown that task-related brain activation patterns as well as resting-state connectivity (measured with functional magnetic resonance imaging) change with clinical parameters…
- Trial name
- NIQA (NCT05843435)
- Testing
- Go-Nogo-task during functional magnetic resonance imaging, Resting-state functional magnetic resonance imaging
- Where
- Switzerland
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Bern
Heart Failure, Ischemic Heart Disease
Cardiac FDG PET Viability Registry
Positron Emission Tomography (PET) is a non-invasive, unique nuclear imaging technique that allows the evaluation of blood flow in the heart and provides information about the cell activity of specific organs such as the heart…
- Conditions
- Heart Failure, Ischemic Heart Disease, Myocardial Dysfunction
- Trial name
- CADRE (NCT00766987)
- Where
- 4 sites in Canada
- Volunteers
- 2,000 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Paraesophageal Hernia
Fundoplication in Laparoscopic PEH Repair Based on FLIP
Prospective randomized controlled trial to identify a sub-set of patients that do not benefit from the routine addition, and added morbidity, of a fundoplication during laparoscopic paraesophageal hernia repair.
- Trial name
- PEHFLIP (NCT05807763)
- Testing
- Laparoscopic paraesophageal hernia repair without fundoplication
- Where
- 2 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- The Foundation for Surgical Innovation and Education
Breast Cancer
Intraoperative Radiotherapy for Early Stage Breast Cancer
Up to 200 patients with biopsy proven early stage breast cancer selecting Wide Local Excision (WLE) will undergo mammography, ultrasound (of affected breast and ipsilateral axilla) and contrast enhanced-magnetic resonance imaging…
- Trial name
- IORT (NCT01189851)
- Testing
- Intraoperative Radiotherapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Hoag Memorial Hospital Presbyterian
Cervical Spondylotic Myelopathy
Diffusion MRI in Cervical Spondylotic Myelopathy
diffusion MRI in evaluates and predicts prognosis in CSM
- Trial name
- NCT04952831
- Testing
- diffusion MRI (dMRI)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Alcohol Use Disorder, Post Traumatic Stress Disorder
Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat
The overall objective of this study it to use Positron Emission Tomography (PET) brain imaging and a radiotracer that measures the epigenetic marker Histone Deacetylase 6 (HDAC6) to examine HDAC6 expression in people with…
- Trial name
- NCT06371404
- Testing
- Bavarostat
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yale University