Clinical trials: Diagnostic Uncertainty
Intrauterine Pregnancy, Ectopic Pregnancy
Pregnancies of Uncertain Location or Viability Research
Study to determine the diagnostic accuracy of the double decidual sac sign to predict an intrauterine pregnancy prior to ultrasonographic visualisation of embryonic contents using modern ultrasound technology.
- Trial name
- PULoVR (NCT02700789)
- Testing
- Transvaginal ultrasound scan
- Where
- United Kingdom
- Volunteers
- 79 people
- Sponsor
- University of Nottingham
Parkinson's Disease, Primary Parkinsonism
A Trial of 18F-AV-133 Positron Emission Tomography (PET) Imaging to Differentiate Subjects With Parkinson's Disease (PD) From Other Movement Disorders
The purpose of this study is to determine whether 18F-AV-133 PET scans can be used to differentiate subjects with Parkinson's Disease from other movement disorders.
- Conditions
- Parkinson's Disease, Primary Parkinsonism, Lewy Body Parkinson's Disease
- Trial name
- NCT01550484
- Testing
- 18F-AV-133
- Where
- 15 sites in United States, Australia
- Volunteers
- 170 people
- Sponsor
- Avid Radiopharmaceuticals
Uncertainty, Communication Research
Trial of Simulation-based Mastery Learning to Communicate Diagnostic Uncertainty
The goal of this study is to teach emergency medicine resident physicians to communicate more effectively with patients at the time of emergency department discharge in the setting of diagnostic uncertainty (i.e.
- Conditions
- Uncertainty, Communication Research, Emergency Medicine
- Trial name
- NCT04021771
- Testing
- Educational Curriculum Intervention
- Where
- 2 sites in United States
- Volunteers
- 109 people
- Sponsor
- Thomas Jefferson University
Multiple Sclerosis
Single Test to ARrive at MS Diagnosis. Using a Single MRI Brain Scan to Help Diagnose Multiple Sclerosis
This is a pilot study (a small scale study testing procedures so that the investigators can apply this to a larger scale study).
- Trial name
- STAR-MS (NCT02485223)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Nottingham
Fetal Membranes, Premature Rupture, Ultrasonography
The Cervical Cap in the Diagnosis of Rupture of Membranes in the Second Trimester
Early preterm premature rupture of membranes (PPROM) complicates 0.7% of pregnancies. When PPROM occurs before the 24th week,the risk of fetal and neonatal death is 70%.
- Trial name
- NCT01063686
- Testing
- insemination cervical cap
- Where
- Israel
- Sponsor
- Rabin Medical Center
Malignant Melanoma of Skin, Other and Unspecified Malignant Neoplasm of Skin
Using an Artificial Intelligence (AI) Tool for Melanoma Diagnosis
The purpose of this study is to learn whether a computer-based support tool called DEXI (Dermoscopy EXplainable Intelligence) can help dermatologists decide whether a lesion may be melanoma, a serious type of skin cancer.
- Conditions
- Malignant Melanoma of Skin, Other and Unspecified Malignant Neoplasm of Skin, Melanoma in Situ, Carcinoma in Situ of Skin
- Trial name
- NCT07890415
- Testing
- Clinical decision support tool
- Where
- 8 sites in United States
- Volunteers
- 14,000 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Diagnoses Disease
GP Response to Decontextualised Risk
Decontextualised risk information is any information pertaining to diagnosis, which is introduced into a clinical consultation, or a diagnostic thought process, without being requested by the clinician.
- Trial name
- NCT05399511
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Coronary Heart Disease (CHD)
Scalable Clinical Oversight of Large Language Models Via Uncertainty Triangulation
This prospective, multi-reader, randomized crossover trial evaluates SCOUT (Scalable Clinical Oversight via Uncertainty Triangulation), a model-agnostic meta-verification framework that selectively defers unreliable large…
- Trial name
- SCOUT (NCT07414966)
- Testing
- SCOUT-Assisted Review Workflow, Standard Manual Review Workflow
- Volunteers
- 7 people
- Sponsor
- China National Center for Cardiovascular Diseases
Breast Lesions of Uncertain Malignant Potential, PTEN
Gene Methylation for Diagnosis of Breast Lesions
Breast lesions of uncertain malignant potential represent a diagnostic challenge, as conventional histopathological assessment does not always reliably distinguish between benign and malignant changes.
- Trial name
- NCT07428733
- Testing
- Gene Methylation Analysis of BRCA1, RASSF1A and PTEN
- Where
- Slovenia
- Volunteers
- 401 people
- Sponsor
- Institute of Oncology Ljubljana
Spondylarthropathy, Ankylosing Spondyloarthitis
Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy
The purpose of this study is to evaluate the interest of enthesis sonography for the diagnosis of spondylarthritis, in patients with uncertain diagnosis consulting for clinical symptoms suggestive of spondylarthritis
- Conditions
- Spondylarthropathy, Ankylosing Spondyloarthitis, Spondyloarthritis
- Trial name
- EchoSpA (NCT00794404)
- Where
- 6 sites in France
- Volunteers
- 489 people
- Sponsor
- Dr Maria-Atonietta D'AGOSTINO
Diagnostic Uncertainty
Targeted EHR-based Communication of Diagnostic Uncertainty in the ED
The goal of the clinical trial is to evaluate the preliminary effectiveness and the implementation feasibility of the Targeted EHR-based Communication about Uncertainty (TECU) strategy in improving the quality of care transitions…
- Trial name
- TECU (NCT06638021)
- Testing
- Targeted EHR-based Communication of Diagnostic Uncertainty (TECU)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Thomas Jefferson University
Neurogenetic Diseases
Use of Omics Methods to Classify Variations of Uncertain Significance and Improve Diagnosis of Neurogenetic Diseases
Many neurological disorders show a strong genetic basis, from hereditary diseases caused by a single mutation in a given gene, to diseases caused by combinations of strong genetic risk factors.
- Trial name
- OMID-NEURO (NCT06955624)
- Testing
- RNA and/or DNA methylation and/or protein analysis
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Neurodevelopmental Disorders, Intellectual Disability
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
LEOPARD is a multicenter study aimed at improving the genetic diagnosis of patients with neurodevelopmental disorders (NDDs) of unknown etiology, particularly those with moderate-to-severe intellectual disability.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Autism Spectrum Disorder, Genetic Diseases, Inborn
- Trial name
- LEOPARD (NCT07884227)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Parkinsonian Syndrome
Study of Individuals With Parkinson's Symptoms But in Whom There is Diagnostic Uncertainty
The overall goal of this study is to evaluate the use of dopamine transporter (DAT) imaging as a diagnostic tool in subjects with early parkinsonian symptoms, in whom Parkinson's disease (PD) or parkinsonian syndrome (PS) is…
- Trial name
- NCT00129675
- Testing
- [123I]ß CIT
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Institute for Neurodegenerative Disorders
Pulmonary Embolism, Diagnostic Uncertainty
The Visualization of Uncertainty in Clinical Diagnostic Reasoning for Pulmonary Embolism
Medical reasoning is a form of inquiry that examines the thought processes involved in making medical decisions. When physicians are faced with patients' symptoms or signs, their thought processes follow either direct shortcuts…
- Conditions
- Pulmonary Embolism, Diagnostic Uncertainty, Clinical Reasoning, Evidence Based Medicine
- Trial name
- NCT01752673
- Testing
- Visualized pulmonary embolism computer task model, Didactic review lecture
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Skin Lesions
Human-AI Uncertainty Callibration for Improved Skin Lesion Segmentation
The goal of this randomized controlled study is to compare the effect of a new, personalized uncertainty-aware decision model (FDM) to a standard image recognition model in improving the diagnostic accuracy while reducing…
- Trial name
- NCT07468357
- Testing
- Base Model, FDM
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Borderline Ovarian Clear Cell Tumor, Borderline Ovarian Serous Tumor
Collecting Tumor Samples From Patients With Gynecological Tumors
This laboratory study is collecting tumor tissue and blood samples from patients with gynecologic tumors. Collecting and storing samples of tumor tissue and blood from patients with cancer to study in the laboratory may help in…
- Conditions
- Borderline Ovarian Clear Cell Tumor, Borderline Ovarian Serous Tumor, Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
- Trial name
- NCT00897442
- Testing
- Laboratory Biomarker Analysis
- Where
- 187 sites in United States
- Volunteers
- 275 people
- Sponsor
- Gynecologic Oncology Group
Breast Cancer, Breast Lesions of Uncertain Malignant Potential (B3 Lesions)
BRCA1, RASSF1A and PTEN Methylation in Breast Lesions of Uncertain Malignant Potential
This prospective interventional diagnostic study evaluates the clinical utility of methylation analysis of BRCA1, RASSF1A and PTEN genes in breast lesions of uncertain malignant potential (B3 lesions).
- Trial name
- NCT07416500
- Testing
- MS-MLPA Methylation Analysis
- Where
- Slovenia
- Volunteers
- 301 people
- Sponsor
- Institute of Oncology Ljubljana