Clinical trials: Diagnostic Value
Endometrial Neoplasms, Ovarian Neoplasms
Serum Biomarkers in Diagnosis and Predicting Prognosis of Ovarian Cancers
This study evaluates the usefulness of serum levels of trefoil factor 3 (TFF3), secreted frizzled related protein 4 (sFRP-4), reactive oxygen species modulator 1 (Romo1) and nuclear factor (NF)-κB as potential diagnostic and…
- Trial name
- NCT03112733
- Testing
- TFF3, SFRP4, Romo1, NFKB
- Where
- Turkey (Türkiye)
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Ilker Kahramanoglu
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Esophageal Cancer
The Diagnostic Value of Nitrogen Element (N) in Esophagus Cancer
The purpose of this study is to determine the diagnostic value of various nitrogen components in oral gas for esophagus cancer (ESCA) .
- Trial name
- NCT05494359
- Testing
- The nitrogen isotope
- Where
- 3 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Spondyloarthropathy and Sacroilitis
Added Value of Diffusion Weighted MRI in Evaluation of Sacroiliitis in Newly Diagnosed Patients of Spondyloarthropathy.
Spondyloarthropathy encompasses a group of chronic immune-mediated rheumatic inflammatory diseases characterized by axial joint inflammation, peripheral arthritis, enthesitis, dactylitis and extra-articular features.
- Trial name
- NCT05655533
- Testing
- Magnetic resonance Imaging scanners of sacroiliac joints.
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gastroesophageal Reflux Disease
Narrow-band Imaging, Autofluorescence Imaging and Gastroesophageal Reflux Disease
Aim of this study is to compare the efficacy of narrow band imaging (NBI) and autofluorescence imaging (AFI) to distinguish subtle mucosal change related to acid reflux that is not visible in standard white light imaging (WLI)…
- Trial name
- NCT01504971
- Testing
- symptom questionaire, pH monitoring, Tri-modal imaging endoscopy
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Sepsis, Septic Shock
We Collected Blood Samples From Septic Shock Patients and Measured ELABELA, Creatinine, and NGAL Levels. Survival After 7 Days Was Recorded and Analyzed to Evaluate the Potential of Serum ELABELA as an Early Diagnostic Marker for Sepsis-associated Acute Kidney Injury.
The investigators selected patients diagnosed with sepsis who were admitted to the Intensive Care Unit (ICU) of Huai'an First People's Hospital between June 2022 and December 2023, as well as healthy individuals with normal…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- ELABELA（ELA） (NCT06001294)
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xiangcheng Zhang
Sepsis, Autophagy
Regulatory Network and Diagnostic Value of Key Autophagy-related Genes in Sepsis
Autophagy plays an important role in the occurrence and development of sepsis. This study aims to explore and verify the key autophagy-related genes in sepsis, then construct their regulatory networks and evaluate their potential…
- Trial name
- NCT05524376
- Testing
- no intervention
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cardiac Disease, Diagnoses Disease
Diagnostic Value of CircRNA-Uck2 for Acute Myocardial Infarction
This is an observational diagnostic study that aims to evaluate the diagnostic value of circRNA-Uck2 in Acute Myocardial Infarction (AMI) in adults as compared to healthy and unstable angina controls.
- Conditions
- Cardiac Disease, Diagnoses Disease, Acute Myocardial Infarction
- Trial name
- NCT03170830
- Testing
- the diagnosis value of cUck2 in acute myocardial infarction.
- Where
- China
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Beijing Haidian Hospital
Epilepsy, Psychogenic Non-epileptic Seizures
Study on the Rapid Diagnostic Value of Sudden Clap Provocation Test in Psychogenic Nonepileptic Seizures
To explore the clinical value of the sudden clap provocation test in the differential diagnosis between epileptic seizures and psychogenic non-epileptic seizures, so as to provide a new strategy for rapid, low-cost differential…
- Trial name
- PNES ACPT (NCT07742709)
- Testing
- Abrupt Clap Provocation Test
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Hepatoblastoma, Hepatic Hemangioendothelioma
PIVKA-II Combined With Alpha-Fetoprotein for Diagnostic and Prognostic Value of Hepatic Tumors in Infants
Although hepatic tumors are uncommon in the perinatal period they are associated with significant morbidity and mortality in affected patients.
- Trial name
- PIVKA-II (NCT03645655)
- Testing
- PIVKA-II
- Where
- China
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Shanghai Children's Medical Center
IUGR
HMGB1 Levels at Fetal Growth Restriction
The primary aim of this study is to evaluate HMGB1 levels in cases of intrauterine growth restriction (IUGR). The secondary aim is to determine whether the cerebroplacental ratio interacts with these levels.
- Trial name
- NCT07857525
- Testing
- hmgb1
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Alzheimer´s Disease
Vagus Somatosensory Evoked Potentials and Near-infrared Spectroscopy in the Early Diagnosis of Dementia
In its long preclinical course, AD shows a spreading pattern of specific pathology in a uniform sequence of predictable steps including brainstem nuclei in early stages.
- Trial name
- Vogel (NCT02224326)
- Where
- Germany
- Volunteers
- 604 people, healthy volunteers welcome
- Sponsor
- University of Wuerzburg
Prostate Cancer, Risk Assessment
PROstate Cancer Risk Calculator for ACTionable Clinical Decision-making in Nigeria
This study is a pilot trial that builds on findings from the validation of prostate cancer risk calculators in Nigerian men. The goal of the overall study is to improve the early detection of prostate cancer in a high-risk…
- Conditions
- Prostate Cancer, Risk Assessment, Clinical Decision Support Systems, Predictive Value of Tests
- Trial name
- PROACT (NCT07733440)
- Testing
- (a) Training and (b) Supported risk assessment
- Where
- Nigeria
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University
Infection
Biological Markers for the Diagnosis of Central Nervous System Infective Diseases
Bacterial meningitis is a potentially life-threatening disease that is associated with substantial neurological morbidity and mortality. Accurate diagnosis is essential to improve outcome and prevent antibiotic overuse.
- Trial name
- NCT02278016
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Endometriosis
Diagnosis of Pelvic Endometriosis in MRI
Purpose： Evaluate the feasibility of R2 star multiple fast gradient recalled echo (R2*MFGRE) imaging in the diagnosis of pelvic endometriosis.
- Trial name
- NCT06157528
- Testing
- Magnetic resonance imaging
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhenshen Ma
Pre-Eclampsia
Diagnostic Value of MicroRNA 210 In Preeclampsia
Pre-eclampsia is a disorder of pregnancy characterized by hypertension (defined as systolic blood pressure 140mmHg or diastolic blood pressure ⩾90 mmHg) and proteinuria (300 mg or greater in a 24 h urine specimen and/or protein…
- Trial name
- NCT03193554
- Where
- 2 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gastric Cancer
The Value of TFF3 in Diagnosis of Gastric Cancer
Gastric cancer (GC), is a cancer developing from the inner lining of the stomach .The most common cause is infection by the bacterium Helicobacter pylori,which accounts for 60% of cases.
- Trial name
- NCT03894384
- Testing
- Trefoil factor family 3 (TFF3),Pepsinogen 1(PG1)
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Neonatal Bacterial Infection
Value for Cord Blood Procalcitonin to Diagnose Early Neonatal Bacterial Infection
After birth, in the presence of risk factors for early neonatal bacterial infection (IBNP), the pediatrician must make a difficult decision quickly or not to prescribe additional examinations and / or hospitalize or not the…
- Trial name
- PCT_CORDON (NCT02858700)
- Testing
- dosage of the umbilical cord blood Procalcitonin for diagnosing of IBNP
- Where
- France
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Heart Failure, Acute Coronary Syndromes
A Cut-off Value Study of N-terminal Brain Natriuretic Peptide （Chemiluminescence Method）
The aim of the study is to evaluate diagnostic performance of N-terminal Brain natriuretic Peptide (NT-proBNP) in acute heart failure among Chinese population.
- Trial name
- NT-proBNP，HF (NCT06691477)
- Testing
- No Interventions
- Where
- 4 sites in China
- Volunteers
- 1,104 people, healthy volunteers welcome
- Sponsor
- Beckman Coulter, Inc.
Complicated Twin Pregnancy
The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies
Recent years, women with infertility have become more and more and thus assisted reproductive technology has been applied in a broad range. And the quantities of twin pregnancies are larger and larger.
- Trial name
- NCT02732717
- Testing
- ultrasound (observation)
- Where
- China
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University