Clinical trials: Diagnostics
Respiratory Tract Infections
Point of Care Polymerase Chain Reaction (PCR) Diagnostics of Respiratory Tract Infections in General Practice
The present study will assess the effect and cost-effectiveness of the availability of point-of-care (POC) PCR testing, in respiratory tract infections (RTIs) in general practice, compared with usual care.
- Trial name
- NCT06120153
- Testing
- POC PCR-test device
- Where
- Denmark
- Volunteers
- 5,700 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Obstetric Ultrasound Biometric Measurements With or Without IA
Comparison of EXperts and IA-assisted Residents
Obstetric ultrasound is the cornerstone of fetal growth assessment. It provides essential biometric measurements for estimating fetal weight, monitoring growth and identifying conditions such as intrauterine growth retardation…
- Trial name
- BIOMEDEXIA (NCT07133165)
- Testing
- standard biometric ultrasound
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
HIV - Human Immunodeficiency Virus, HBV (Hepatitis B Virus)
MAGIA H3S Point of Care Test Performance for HIV, HBV, HCV, and Syphilis Screening in Pregnant Women in DR Congo
Performance study to evaluate the clinical performance of the In-Vitro Diagnostic Medical Device MagIA H3S (a Multiplex Point-of-Care test for the combined detection of Human Immunodeficiency Virus (HIV), Hepatitis B and C and…
- Conditions
- HIV - Human Immunodeficiency Virus, HBV (Hepatitis B Virus), Hepatitis C Virus (HCV), Syphilis
- Trial name
- MAGICS MAM (NCT07388979)
- Testing
- MAGIA H3S
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- Gardiens de Vies
Multiple Sclerosis, miRNA
miRNA Biomarkers in Multiple Sclerosis
Multiple Sclerosis (MS) characterized by demyelination and axonal degeneration is a chronic inflammatory disease of the central nervous system (CNS).
- Conditions
- Multiple Sclerosis, miRNA, Epigenetic, Biomarker
- Trial name
- NCT04772495
- Testing
- miRNA
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Hypothyroidism
Improvement of Laboratory Diagnostics in Hypothyroid Patients Using Levothyroxine
Hypothyroidism is a thyroid disorder and one of the most common endocrine disorders. Hypothyroidism can have multiple causes; most patients suffer from primary autoimmune hypothyroidism (Hashimoto's disease), but also central…
- Trial name
- ANTICIPATE (NCT06083636)
- Testing
- Single extra blood draw and completion of single questionnaire, Single blood draw and completion of single questionnaire
- Where
- Netherlands
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Tuberculosis, Pulmonary
Integrated Discovery and Development of Innovative TB Diagnostics
The long term goal of this project is to provide information critical to the development and use of a low-cost, point-of-care, rapid, simple, and highly accurate diagnostic tool that can help clinicians make a microbiological…
- Trial name
- (CETR) (NCT06624501)
- Testing
- Observational cohort study
- Volunteers
- 1,450 people, healthy volunteers welcome
- Sponsor
- Harvard University Faculty of Medicine
Inflammatory Bowel Diseases, Ulcerative Colitis
Evaluate Established Anti-DEFA5 mAbs Diagnostic Efficacy and Safety in IBD
Investigators propose to validate efficacy and safety of the detection of DEFA5 in the diagnosis of the colonic IBD using longitudinal vs.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Colitis, Indeterminate Colitis
- Trial name
- NCT05663671
- Testing
- Diagnostic Test
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Meharry Medical College
Adrenal Insufficiency, Congenital Adrenal Hyperplasia
Dynamic Hormone Diagnostics in Endocrine Disease
The study will investigate 27 hour profiles of hormones in the subcutaneous tissue of healthy subjects and patients with Addison's, Congenital Adrenal Hyperplasia, Growth Hormone Deficiency, acromegaly, Cushings and Primary…
- Conditions
- Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Cushing Syndrome, Growth Hormone Deficiency
- Trial name
- ultradian (NCT02934399)
- Testing
- 27 hour subcutaneous fluid sampling
- Where
- 4 sites in Greece, Norway and 2 more
- Volunteers
- 528 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Neurological Disorders, Cognitive Impairment
Validation of the VIRADIA App for Neurological and Cognitive Diagnostics in Virtual Reality
The VIRADIA study aims to validate and assess the reliability of a newly developed Virtual Reality (VR) diagnostic platform designed for neurological and cognitive testing.
- Conditions
- Neurological Disorders, Cognitive Impairment, Motor Impairment, Neurodegenerative Diseases
- Trial name
- VIRADIA (NCT07268079)
- Testing
- VIRADIA - Virtual Reality Diagnostic Platform
- Where
- Slovakia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gametherapy
Prostate Cancer
From PSA to Stockholm3: Study Part 1
This part of the project aims to analyze the effectiveness of the Stockholm3 test in regular clinical practice, both in general practice and in the specialist health care, as a tool for detecting patients who need further…
- Trial name
- PSA2STHLM3/1 (NCT03381105)
- Testing
- PSA and Stockholm3
- Where
- Norway
- Volunteers
- 13,431 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Sarcopenia, Muscle Weakness
SARCOPEDIA - Sarcopenia Diagnostics in Aging Medicine
Musculoskeletal aging is one of the major responsibilities and challenges for public health. In particular, sarcopenia correlates with an increased risk of falls and increased morbidity and mortality.
- Conditions
- Sarcopenia, Muscle Weakness, Frailty
- Trial name
- SARCOPEDIA (NCT05263596)
- Testing
- dual x-ray absorptiometry, body impedance analysis, muscle strength measurements, ultrasound
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Department of Geriatric Medicine FELIX PLATTER
Tumors, Carcinoma, Bronchogenic
Clinic Study of 18F-Al-NOTA-PRGD2 in Cancer Diagnostics
The purpose of this study is to determine whether 18F-Al labeled RGD is safety and effective for cancer diagnosis and therapy response.
- Conditions
- Tumors, Carcinoma, Bronchogenic, Breast Carcinoma, Cancer of Head and Neck
- Trial name
- NCT02441972
- Testing
- 18F-Al-NOTA-PRGD2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wuxi No. 4 People's Hospital
Hepatitis C
Rapid Point-of-care Testing for Hepatitis C in Community Clinics (RAPID-EC) Pilot Study
The Rapid-EC pilot study will determine feasibility of providing rapid point-of-care (POC) testing for HCV in community clinics, and whether the availability of POC testing increases uptake of testing, engagement in care and…
- Trial name
- NCT03231930
- Testing
- OraQuick HCV Ab test, Xpert HCV viral load test
- Where
- 3 sites in Australia
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
Chronic Cerebrospinal Venous Insufficiency
Doppler Sonography, MR Venography, Plethysmography for the Diagnosis of CCSVI
This study is aimed at evaluation of diagnostic value of Doppler sonography, MR venography and air-plethysmography for the assessment of abnormalities in the internal jugular veins, with catheter venography as the reference test.
- Trial name
- NCT01425554
- Testing
- Doppler sonography of internal jugular veins, Magnetic resonance venography of internal jugular veins, Air-plethysmography of the neck
- Where
- Poland
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Euromedic Specialist Clinics, Poland
HIV Infections, Hepatitis B Infections
Rapid Diagnostics for HIV and Hepatitis
The purpose of this study is to determine the efficacy of two rapid diagnostic tests in plasma, venipuncture whole blood, and fingerstick whole blood.
- Conditions
- HIV Infections, Hepatitis B Infections, Hepatitis C Infections
- Trial name
- NCT02190305
- Testing
- Multiplo HBc/HIV/HCV and Reveal HBsAg
- Where
- 4 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- MedMira Laboratories Inc.
Breast Cancer Diagnosis
Comparison of Low-dose Spiral Breast CT With MRI in Major Indications of MRI for Breast Diagnostics
Comparison between two diagnostic modalities for breast cancer diagnosis. Two different imaging systems are compared to evaluate the performance of the two systems
- Trial name
- NCT05989022
- Testing
- Injection of contrast enhancing agent Gadovist for MRI investigation, Injection of contrast enhancing agent Imeron for B-CT investigation
- Where
- 4 sites in Germany, Netherlands
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- AB-CT - Advanced Breast-CT GmbH
Vitamin B 12 Deficiency
Cobalamin Deficiency - Diagnosis and Therapy
In a retrospective study with existing values of vitamin B12 and holotranscobalamin 4 strategies are simulated and the results and costs are compared. Generally, cobalamin ist substituted by intramuscular administration.
- Trial name
- NCT04243707
- Where
- Switzerland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Endometrial Cancer
Development of a Non-invasive IVD for Endometrial Cancer Screening on High-risk Populations
CYTOMARK, a non-invasive in vitro diagnostic (IVD) test measuring a defined panel of protein biomarkers in cervical fluid, can accurately detect endometrial cancer in both symptomatic and asymptomatic women at high risk for the…
- Trial name
- NCT07148154
- Testing
- Cytology
- Where
- 2 sites in Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- MiMARK Diagnostics, S.L.
Brain Diseases, Central Nervous System Diseases
Digital Diagnostics and Intervention Services for Parkinson's Disease
People with Parkinson's have infrequent clinical consultation (once every 12-18 months) and limited rehabilitation. Assessment play an important role in these consultations to help clinicians understand patients' health status…
- Conditions
- Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Joint Diseases
- Trial name
- NCT06534177
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Impaired Blood Glucose Level, Overweight
Early Diagnosis of Diabetes Mellitus Type 2 (DM2)
Rationale: The global prevalence of diabetes, along with its devastating effects on life expectancy and quality of life, continues to increase.
- Conditions
- Impaired Blood Glucose Level, Overweight, Obesity
- Trial name
- 7348 (NCT00469287)
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TNO