Clinical trials: Diagnostics
Community-acquired Pneumonia
Optimizing Care for Children Hospitalized With Community-acquired Pneumonia: Novel Diagnostics
Children are commonly hospitalized because of community-acquired pneumonia. Despite the fact that many of these children have viral disease, a majority is treated with antibiotics.
- Trial name
- PRESTO-1 (NCT06114888)
- Testing
- MeMed BV + Usual Care, Usual Care Alone
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Jeffrey Pernica
Pneumonia, Pneumococcal, Community-acquired Pneumonia
Quantitative Polymerase Chain Reaction for Improved Detection of Pneumococci in CAP "CAPTAIN"
The purpose of this study is to evaluate the added diagnostic value of a quantitative polymerase chain reaction targeting the lytA gene in detecting pneumococci in patients with community-acquired pneumonia.
- Trial name
- CAPTAIN (NCT03315403)
- Testing
- LytA targeted quantitative polymerase chain reaction (qPCR)
- Where
- 2 sites in Netherlands
- Volunteers
- 922 people, healthy volunteers welcome
- Sponsor
- Medical Center Alkmaar
Cervical Cancer
Lab-on-a-chip Detection of Cervical Cancer Tumour Markers
This study aims to establish whether tumour markers measured from cytological samples can improve cervical cancer detection both prior to treatment and after treatment during follow up.
- Trial name
- MODULAR (NCT03380741)
- Testing
- Tumour markers detection
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Gonorrhea Female, Chlamydia Females
The Integrated Female Sexually Transmitted Infection Testing for HIV Epidemic Control Through PrEP (IN-STEP) Study
Globally, new HIV infections are concentrated in eastern and southern Africa where the infections are largely acquired by women outside of known key populations.
- Conditions
- Gonorrhea Female, Chlamydia Females, Syphilis Female, Trichomonas Vaginalis
- Trial name
- IN-STEP (NCT06743204)
- Testing
- Self-Reported Risk Screening for PrEP and Diagnostic STI testing, Self-reported risk screening for PrEP and syndromic management for STIs
- Where
- Uganda
- Volunteers
- 5,560 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Benign Paroxysmal Positional Vertigo (BPPV)
Comparison of Two Mechanical Rotation Chairs With Diagnostics of Benign Paroxysmal Positional Vertigo.
This study aims to investigate whether the diagnosis of benign paroxysmal positional vertigo (BPPV) is equally good with two different mechanical rotation chairs (MRCs) (TRV rotary chair and the Rotundum rotary chair).
- Trial name
- ROTATE (NCT07772973)
- Testing
- TRV® (Interacoustics©, Middelfart, Denmark), mechanical rotational chair, Rotundum® (balcare GmbH©, Küsnacht, Switzerland), mechanical rotational chair.
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aalborg University Hospital
Brest Cancer, Lung Cancer (NSCLC)
The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling
The purpose of the CCANED-CIPHER study is to develop and validate an AI-based blood test for early cancer detection and to monitor treatment effectiveness in cancer patients.
- Conditions
- Brest Cancer, Lung Cancer (NSCLC), Pancreatic Cancer, Adult, Prostate Cancers
- Trial name
- CCANED-CIPHER (NCT06717295)
- Testing
- DiNanoQ: A multi-cancer early detection (MCED) blood test, DiNanoTrack: Therapeutic Response Monitoring Blood Test
- Where
- 4 sites in Argentina, Nigeria and 1 more
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Javier Toledo
Cervical Cancer
Improving Diagnostics in Cervical Dysplasia
Cervical cancer is the fourth most common cancer in women worldwide. It is caused by an infection with human papillomavirus (HPV).
- Trial name
- IDEAL (NCT05283421)
- Testing
- Estrogen
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Aarhus
Tuberculosis, Pulmonary, Rifampicin Resistant Tuberculosis
GeneXpert Performance Evaluation for Linkage to Tuberculosis Care
The investigators' overall objective is to assess the effectiveness, implementation and costs of a streamlined TB diagnostic evaluation strategy based around rapid, onsite molecular testing.
- Trial name
- XPEL-TB (NCT03044158)
- Testing
- GeneXpert I, Process re-design, Performance Feedback
- Where
- 20 sites in Uganda
- Volunteers
- 10,644 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Psychosis
Multiomic Diagnostics in Youth With Psychosis
Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 15 children and adolescents who are admitted to Rady Children's Hospital Child and Adolescent Psychiatry Service with psychotic…
- Trial name
- NCT05457140
- Testing
- Genetic: Genomic sequencing and molecular diagnostic results, if any., Phage display ImmunoPrecipiation Sequencing (PhIP-Seq)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rady Pediatric Genomics & Systems Medicine Institute
Venous Leg Ulcer
Diagnostics in the Leg Ulcer Pathway
This project aims to investigate 'The minimum diagnostic requirements for patients presenting to primary care with suspected venous ulcers.' In order to do this, the investigators intend to run a series of questionnaires with…
- Trial name
- NCT06181708
- Testing
- N/A - Questionnaire based study
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Patients With Non-small Cell Lung Cancer
Development of Circulating Tumour Cell Molecular Diagnostics Using a Novel Microfluidic Device
1. To compare EGFR mutations between primary non-small cell lung cancer (NSCLC) tumours and corresponding CTCs isolated by a label-free microfluidic device-based system 2.
- Trial name
- NCT01193829
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- National University Hospital, Singapore
Intestinal Infectious Diseases, Neuroinfections
Differential Diagnostics of Etiology of Acute Infections
Method for diagnostics of the origin of infections (bacterial vs viral) based on the identification of activation markers of blood neutrophils and monocytes will be developed.
- Trial name
- NCT03161951
- Volunteers
- 169 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Alzheimer Disease, Frontotemporal Dementia
Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases
Double blinded, sham-controlled, randomized trial on repeated transcranial alternating current brain stimulation (tACS) in neurodegenerative diseases.
- Conditions
- Alzheimer Disease, Frontotemporal Dementia, Dementia With Lewy Bodies
- Trial name
- NCT05326750
- Testing
- Gamma tACS (40 Hz) over the superior parietal cortex
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Kuopio University Hospital
Stroke, Healthy
Study to Evaluate Performance, Usability, Safety of Microwave Technology When Collecting Data From Patients With Stroke
This is a prospective, open, multicenter study that will enroll patients admitted to and hospitalized at the Stroke Unit due to diagnosed stroke and healthy volunteers.
- Trial name
- NCT02266459
- Testing
- Microwave technology (Medfield Diagnostics)
- Where
- 3 sites in Sweden
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Medfield Diagnostics
Stroke, Acute
Optimizing Acute Ischemic Stroke Diagnostics Using Artificial Intelligence
Prospective observational multi-center study with the aim to organise and simplify the care pathway through a pragmatic approach to acute stroke imaging powered by cutting edge advances in image processing and artificial…
- Trial name
- AI-STROKE (NCT05652933)
- Testing
- Software for identifying vessel occlusion, infarct volume and penumbra
- Where
- 3 sites in Norway
- Volunteers
- 300 people
- Sponsor
- Oslo University Hospital
Cystic Fibrosis
Improving P. Aeruginosa Detection With Breath-based Diagnostics (IMPACT-Breath)
The study is a breath biomarker validation study. It is anticipated that 300 patients with cystic fibrosis (CF) from 5 clinical sites in the USA will be enrolled.
- Trial name
- IMPACT (NCT04735952)
- Where
- 7 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- University of British Columbia
Tuberculosis Infection
Evaluating Diagnostics for Paediatric Tuberculosis by Blood Culture
Detection of M. tuberculosis in clinical specimens of children has a low sensitivity because specimens are either difficult to collect or contain low levels of M. tuberculosis.
- Trial name
- NCT01434758
- Where
- Vietnam
- Volunteers
- 560 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Lung Cancer
Oral Microbiome Diagnostics of Lung Cancer
The study aims to develop a deep learning-based diagnostic method for lung cancer using the oral microbiome. This innovative approach involves establishing an observational cohort of 576 individuals, including lung cancer…
- Trial name
- NCT06270992
- Testing
- NCCN (National Comprehensive Cancer Network) diagnosis
- Where
- Turkey (Türkiye)
- Volunteers
- 676 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Myelodysplastic Syndromes, Acute Myeloid Leukemia
Could Ki-67 be Used as a Diagnostic or Prognostic Marker in Hemato-oncological Diagnostics?
Ki-67 is used as a marker for determination of the proliferative activity in solid tumors. The use within hemato-oncological malignancies is limited.
- Conditions
- Myelodysplastic Syndromes, Acute Myeloid Leukemia, Myelodysplastic Syndrome/Neoplasm
- Trial name
- NCT04517175
- Testing
- Flow cytometry
- Volunteers
- 300 people
- Sponsor
- Maastricht University
Cardiomyopathies, Primary, Arrhythmia
An Arrhythmia Risk Stratification and Genetic Trial
The prospective EUTrigTreat multi-center study is an observational, advanced diagnostics and genetic risk stratification trial in patients with standard indications for ICD treatment, with and without myocardial infarction in…
- Conditions
- Cardiomyopathies, Primary, Arrhythmia, Sudden Cardiac Death, Calcium Metabolism Disorders
- Trial name
- EUTrigTreat (NCT01209494)
- Where
- 4 sites in Belgium, Germany and 2 more
- Volunteers
- 672 people
- Sponsor
- University Medical Center Goettingen