Clinical trials: Dialysis; Complications
Acute Kidney Injury
Automated Peritoneal Dialysis Versus Intermittent Hemodialysis in Acute Kidney Injury
This is a multi-center randomized clinical trial study. The purpose of this study is to examine safety, feasibility and efficacy of automated peritoneal dialysis as compared with intermittent hemodialysis for AKI patients with…
- Trial name
- SAFE-APD (NCT03598387)
- Testing
- Automated peritoneal dialysis, Intermittent hemodialysis
- Where
- 5 sites in China
- Volunteers
- 100 people
- Sponsor
- Limeng Chen
Hypertension Secondary to Renal Disease
Treatment of Resistant Hypertension by Renal Sympathetic Denervation in Patients Undergoing Dialysis Therapy
The study is designed to investigate the efficacy of renal nerve denervation in treating drug-resistant hypertension in patients with end stage renal disease.
- Trial name
- TreatDialRDN (NCT01881035)
- Testing
- Renal nerve denervation
- Where
- Finland
- Volunteers
- 6 people
- Sponsor
- Turku University Hospital
Chronic Kidney Diseases, End Stage Renal Disease on Dialysis
A Study of Wrist Worn Accelerometers in End-Stage Renal Disease
The kidneys are important at getting rid of toxins and excess water from the body. If they fail, then toxins and excess water builds up within the body.
- Conditions
- Chronic Kidney Diseases, End Stage Renal Disease on Dialysis, Frailty
- Trial name
- W-WARD (NCT04860440)
- Testing
- GeneActiv wrist worn accelerometer
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Atrial Fibrillation and Flutter, Stroke
The Danish Warfarin-Dialysis Study - Safety and Efficacy of Warfarin in Patients With Atrial Fibrillation on Dialysis
The study aims to evaluate the appropriateness of initiating oral anticoagulation for stroke risk reduction in dialysis populations with atrial fibrillation.
- Conditions
- Atrial Fibrillation and Flutter, Stroke, Major Bleed, End-stage Renal Disease
- Trial name
- DANWARD (NCT03862859)
- Testing
- Warfarin
- Where
- 13 sites in Denmark
- Volunteers
- 718 people
- Sponsor
- Nicholas Carlson
Dialysis Patients
Intradialytic Exercise With Blood Flow Restriction in Hemodialysis Patients
The main objective is to evaluate in hemodialysis patients the effects of two intradialytic rehabilitation programs based on physical exercise, with or without the application of blood flow restriction, on myocardial stunning and…
- Trial name
- ERO-CARD (NCT07269379)
- Testing
- Chronic phase - HDEX/HDBFRE, Acute phase - HDEX/HDBFRE
- Where
- 2 sites in France
- Volunteers
- 108 people
- Sponsor
- University of Avignon
Chronic Renal Failure (CRF), Dialysis Dependent Chronic Kidney Disease
Peritoneal Transport With a New Bicarbonate-based Peritoneal Dialysis Solution Compared to Conventional Solution.
Cross-over study. Patients treated with peritoneal dialysis are investigated twice with a single 4h dwell study: once with Bicarbonate-Lactate solution as buffer (Physioneal TM) and once with conventional lactate PD solution…
- Trial name
- NCT07621627
- Testing
- Test of peritoneal transport with bicarbonate-lactate buffered peritoneal dialysis solution and lactate solutin
- Where
- Sweden
- Volunteers
- 7 people
- Sponsor
- Karolinska Institutet
End Stage Renal Disease on Dialysis (Diagnosis)
Targeted Deprescribing in Patients on Hemodialysis
Hemodialysis (HD) patients take more pills per day on average than any other chronically ill patient population. On average, an HD patient takes 19 medications per day, of which 70% may not be appropriate.
- Trial name
- NCT03733262
- Testing
- De-prescribing Trial
- Where
- 4 sites in Canada
- Volunteers
- 480 people
- Sponsor
- University Health Network, Toronto
Renal Insufficiency, Chronic, Kidney Failure, Chronic
First-in-human Study to Examine Safety of a New Peritoneal Dialysis Device (WEAKID) in End-stage Kidney Disease Patients
The goal of this first-in-human clinical trial is to examine the safety and efficacy of treatment with a new peritoneal dialysis (PD) device called WEAKID (WEarable Artificial KIDney for peritoneal dialysis).
- Conditions
- Renal Insufficiency, Chronic, Kidney Failure, Chronic, Chronic Kidney Diseases
- Trial name
- CORDIAL (NCT06314503)
- Testing
- WEAKID
- Where
- 3 sites in Italy, Netherlands and 1 more
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Hemodialysis, Healthy
Study to Evaluate the Pharmacokinetics and Metabolism of [14C] CR845 (Difelikefalin) in Patients With End Stage Renal Disease on Hemodialysis and in Healthy Subjects
The objectives of this study are to evaluate the in vivo metabolite profiling and characterization of CR845 administered intravenously (IV) in patients on hemodialysis (HD) and in healthy subjects; and to determine the…
- Trial name
- NCT03947970
- Testing
- [14C] CR845
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cara Therapeutics, Inc.
Kidney Failure, Chronic
Trial of Aerobic Exercise in Patients Undergoing Outpatient Hemodialysis
Randomized controlled trial comparing effects of ergometer exercise during hemodialysis to effects of pedometer use outside of hemodialysis on exercise capacity, functional status, quality of life and adequacy of hemodialysis.
- Trial name
- NCT00492362
- Testing
- ergometer exercise during hemodialysis, pedometer activity outside of hemodialysis
- Where
- 4 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Manitoba
Peritoneal Dialysis Associated Peritonitis, Peritoneal Dialysis (PD)
Pharmacokinetics of Meropenem and Aztreonam After Intraperitoneal Administration Via Cycler-therapy in APD Patients Without Peritonitis
Peritoneal dialysis-associated peritonitis (PDAP) remains one of the most serious complications in patients undergoing peritoneal dialysis (PD), contributing significantly to hospitalization, technique failure, and mortality.
- Conditions
- Peritoneal Dialysis Associated Peritonitis, Peritoneal Dialysis (PD), Peritoneal Dialysis, Peritoneal Dialysis, Continuous Ambulatory
- Trial name
- NCT07113574
- Testing
- Meropenem 1000 mg, Aztreonam 2000 mg, automated peritoneal dialysis with following long time dwell
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Karl Landsteiner Insitute for Nephrology and Haemato-Oncology
Kidney Failure, Chronic
Evaluation of the Integrated Home Dialysis Model
The purpose of this study is to evaluate which home dialysis modality pattern (home hemodialysis [HHD], peritoneal dialysis [PD] or a combination of both, e.g.
- Trial name
- NCT02278159
- Testing
- Peritoneal dialysis, Home hemodialysis
- Volunteers
- 11,600 people
- Sponsor
- Princess Alexandra Hospital, Brisbane, Australia
Chronic Kidney Disease Stage 4
Effect of Henagliflozin on Renal Outcomes in Non-dialysis Patients With Advanced Chronic Kidney Disease : A Multicenter Prospective, Randomized Controlled Trial（HERO -aCKD）
This is a multicenter, prospective, randomized, controlled study that will enroll approximately 429 subjects. The screening period will last 4-8 weeks.
- Trial name
- NCT07027774
- Testing
- Henagliflozin 5 mg Group, Henagliflozin 10 mg Group, Conventional therapy group
- Volunteers
- 429 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
End-Stage Renal Disease
Chinese Medicine on Deferring Dialysis Initiation
Stage 5 chronic kidney disease (CKD), also end stage renal disease(ESRD), usually presents overt clinical symptoms and is a critical stage when patients are encountered with dialysis.
- Trial name
- C-MODDI (NCT02194946)
- Testing
- CM therapies, CKD-related management
- Where
- 29 sites in China
- Volunteers
- 875 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
End Stage Renal Disease on Dialysis
pH, Hypoxia and Haemodialysis
End-stage renal disease typically requires haemodialysis to help replace kidney function. However, changes in oxygen uptake during haemodialysis have been linked to increased all-cause mortality.
- Trial name
- pHHd (NCT04501159)
- Testing
- blood sample pre, during and post HD, Non invasive cardiac output assessment
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Coventry University
Chronic Kidney Diseases
Intradialisis Physical Exercise in Quality of Life and Health
Evaluate the effectiveness of different modalities of physical exercise about clinical health indicators and quality of life of patients with chronic kidney disease undergoing hemodialysis.
- Trial name
- EJERINTRA (NCT05207527)
- Testing
- cardiovascular exercise, Muscle strength, Mixed
- Volunteers
- 120 people
- Sponsor
- Universidad del Rosario
Kidney Disease, Chronic
Impact of Reducing the Dialysate Flow Rate in Chronic Hemodialysis on Dialysis Quality and Environmental Impact on Water Consumption
In France, 60,000 patients are receiving renal replacement therapy via dialysis in 2022, 90% of whom are on hemodialysis. This technique is based on the principle of exchange across a membrane between the patient's blood and the…
- Trial name
- ReDeDia (NCT07718568)
- Testing
- Dialysate flow at 400mL/min, Dialysate flow at 500mL/min
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
End Stage Renal Disease
The Impact of Delflex on Mesothelial Cell Viability and Peritoneal Transport
The purpose of this study is to evaluate the impact of Delflex neutral pH (a biocompatible peritoneal dialysis solution) on mesothelial cell viability and peritoneal transport.
- Trial name
- Delflex (NCT01292863)
- Testing
- Active Comparator: Conventional peritoneal dialysis solution, Experimental: Novel biocompatible dialysis solution
- Sponsor
- University of North Carolina, Chapel Hill
End-Stage Renal Disease, Stage 5 Chronic Kidney Disease
Effect of Dialysis on the Pharmacokinetics of Telavancin in Patients With Chronic Kidney Disease Stage 5
Chronic Kidney Disease Stage 5 (CKD5) patients receiving maintenance hemodialysis are at an increased risk for developing bloodstream infections.
- Trial name
- NCT02392208
- Testing
- Telavancin, Pharmacokinetic Blood Sampling
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Michigan
ESRD, CKD (Chronic Kidney Disease) Stage 5D
Effect of Canagliflozin on Ultrafiltration & Fibrosis in Patients on Peritoneal Dialysis
This is a phase II, proof-of-concept, placebo-controlled, double-blind, cross-over randomized clinical trial, assessing the effect of canagliflozin on peritoneal membrane function in patients on PD.
- Trial name
- CAN-PD (NCT06913647)
- Testing
- Canagliflozin 300 MG
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
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