Clinical trials: Diaphragm Disease
Respiratory Insufficiency in Children, Newborn Rds
Diaphragmatic Work During HFNC and CPAP Support
The goal of this randomised controlled, cross-over clinical trial is to compare High Flow Nasal Cannulas (HFNC) and Continuous Positive Airways Pressure (CPAP) in neonates over 34 weeks' amenorrhoea (SA) up to children weighing…
- Conditions
- Respiratory Insufficiency in Children, Newborn Rds, Nasal Cannula, CPAP Ventilation
- Trial name
- DiaWorkHFNC (NCT06249009)
- Testing
- Non invasive ventilation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Heart Failure
Epiphrenic III Pilot Trial
The Epiphrenic III Pilot Trial investigates whether a diaphragmatic stimulation by interventionally placed electrodes may improve heart function, symptoms and functional capacity in patients with severe heart failure.
- Trial name
- NCT01837771
- Testing
- Diaphragmatic stimulation
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- Luzerner Kantonsspital
Congenital Diaphragmatic Hernia
Smart Removal for Congenital Diaphragmatic Hernia
The purpose of this study is to demonstrate the ability to prenatally deflate and to evaluate the safety of the Smart-TO device for fetoscopic endoluminal tracheal occlusion (FETO) in fetuses with congenital diaphragmatic hernia…
- Trial name
- SmartRemoval (NCT05100693)
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion with the Smart-TO Balloon
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stroke
Effects of Inspiratory Muscle Training on Stroke Rehabilitation Outcomes
This study is designed to explore the effects of a 4-week protocol of inspiratory muscle training (IMT) at 50% maximum inspiratory pressure (MIP) on respiratory function, diaphragm thickness, balance control, exercise capacity…
- Trial name
- NCT06640101
- Testing
- IMT-stable group (sitting on a stable surface), IMT-unstable group (sitting on an unstable surface), Conventional treatment
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Hong Kong Metropolitan University
Breathing, Mouth
Impact of Diaphragmatic Breathing Coaching on Deep Inspiration Breath Hold Reproducibility and Organ Protection
To learn if coaching participants on diaphragmatic breathing will help participants to take larger, more reproducible breaths and feel less anxiety about their treatments.
- Trial name
- NCT06747533
- Testing
- CT simulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Oesophageal Atresia, Congenital Diaphragmatic Hernia
Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries
This study is a multi-centre, international, prospective cohort study of congenital anomalies to compare outcomes between LMICs and high-income countries (HICs) globally.
- Conditions
- Oesophageal Atresia, Congenital Diaphragmatic Hernia, Intestinal Atresia, Gastroschisis
- Trial name
- NCT03666767
- Testing
- Comparisons will be made between LMICs and HICs
- Where
- United Kingdom
- Volunteers
- 3,850 people
- Sponsor
- King's College London
Muscular Dystrophy, Muscular Disease
Studying Skeletal Muscle, Heart, and Diaphragm Imaging in Boys With Duchenne Muscular Dystrophy
Background: Duchenne muscular dystrophy (DMD) is a disease in which the muscles are unable to make the protein dystrophin. Without this protein, the muscles become gradually weaker.
- Trial name
- NCT01451281
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Abdominoplasty Surgery
Correlation Between Intra-abdominal Pressure and Diaphragmatic Mobility in Women Submitted to Abdominoplasty After Bariatric Surgery
Background: Plication of the rectus abdominis muscles leads to an increase in intra-abdominal pressure (IAP), which may negatively impact the respiratory system due to its effects on diaphragmatic mobility (DM).
- Trial name
- NCT06648694
- Testing
- Abdominoplasty surgery, Abdominoplasty
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Amyotrophic Lateral Sclerosis (ALS)
Diaphragm Pacing System (DPS) In Participants With Amyotrophic Lateral Sclerosis (ALS)
The study is being conducted to determine if DPS treatment for people with ALS and hypoventilation is associated with improved survival or diaphragm function.
- Trial name
- DPS in ALS (NCT01938495)
- Testing
- NeuRx® Diaphragm Pacing System™ (DPS)
- Where
- 25 sites in United States
- Volunteers
- 52 people
- Sponsor
- Barrow Neurological Institute
Congenital Diaphragmatic Hernia
Fetal Endoscopic Tracheal Occlusion (FETO) Trial for Congenital Diaphragmatic Hernia (CDH)
This is a single site pilot trial to assess the feasibility and safety of treating severe CDH with Fetal Endoscopic Tracheal Occlusion with the Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter…
- Trial name
- FETO (NCT04052828)
- Testing
- FETO with Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter (BALTACCI-BDPE100)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Dr Erin Perrone
Sarcopenia
The Effects of Inspiratory Muscle Training on Diaphragm Thickness, Inspiratory Muscle Strength and Exercise Capacity in Individuals With Sarcopenia
Sarcopenia, according to EWGSOP2(European Working Group on Sarcopenia in Older People-2019), is a progressive and generalised skeletal muscle disorder that is associated with increased likelihood of adverse outcomes including…
- Trial name
- NCT05668975
- Testing
- Inspiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul University
Intrauterine Adhesion
Clinical Study on a Novel Anti-adhesion Barrier Film
The aim of this clinical study was to verify the effectiveness and safety of the anti-adhesion diaphragm in preventing intrauterine adhesions.
- Trial name
- NCT05888545
- Testing
- anti-adhesion diaphragm
- Where
- 8 sites in China
- Volunteers
- 1,176 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Gastroesophageal Reflux, Dysphagia
Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry
The goal of this study is to determine which position, maneuvers or combination thereof generates the highest pressure at the EGJ as assessed by high-resolution esophageal manometry and thus greater or more robust contraction of…
- Conditions
- Gastroesophageal Reflux, Dysphagia, Esophageal Motility Disorders
- Trial name
- NCT06329583
- Testing
- diaphragmatic breathing
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lung Cancer
Pleural Ultrasonography in Lung Cancer
Lung cancer remains the leading cause of mortality from malignant diseases in both men and women worldwide. Accurate diagnosis, staging and therapeutic targeting of lung cancer and other pulmonary pathology are vital with regards…
- Trial name
- CT0018 (NCT01141946)
- Testing
- thoracic ultrasound, pleural aspiration
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Copd
Efficacy of Osteopathic Manipulative Techniques in Patients With Chronic Obstructive Pulmonary Disease
This study will test the efficiency of rib rising technique and thoracic lymphatic pump technique combining with manual diaphragmatic release technique in patients with chronic obstructive pulmonary disease
- Trial name
- NCT06865703
- Testing
- diaphragmatic release technique, rib raising technique in group A, THORACIC LYMPHATIC PUMP TECHNIGUE
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Beni-Suef University
Asymptomatic Condition
Investigating Diaphragm Thickness and Mobility in Healthy Parous and Nulliparous Volunteers Using RUSI
The purpose of this study is to evaluate the intra-rater and inter-rater reliability of diaphragm thickness and excursion measurements by applying Rehabilitative Ultrasound Imaging (RUSI) in a diverse cohort of healthy women…
- Trial name
- NCT06048237
- Testing
- Diagnostic Ultrasound Imaging of the diaphragm
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Evdokia Billis
Gastroesophageal Reflux Disease
True Short Esophagus in Gastroesophageal Reflux Disease
True short esophagus is controversial in surgery for gastroesophageal reflux disease and hiatus hernia. Recently, it was published that extensive esophageal mobilization achieved an esophageal length adequate to perform around…
- Trial name
- NCT03848494
- Testing
- Surgery
- Volunteers
- 311 people
- Sponsor
- University of Bologna
Sepsis, Disease of Diaphragm
Ultrasound Diaphragmatic Thickening to Monitor Its Dysfunction in Patients With Sepsis
Diaphragmatic dysfunction is associated with sepsis severity and pejorative prognosis. Aim of this study is to assess diaphragmatic function with the Diaphragmatic Thickening Fraction (DTF) ultrasound measure in patients with…
- Conditions
- Sepsis, Disease of Diaphragm, Defect of Diaphragm, Intensive Care Neuropathy
- Trial name
- US-Diamonds (NCT02474797)
- Testing
- Diaphragmatic ultrasonography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Respiratory Paralysis, Diaphragmatic Paralysis
Diaphragmatic Pacemaker in Tetraplegic Patients With Spinal Cord Injuries
Permanent dependency of breathing apparatus due to spinal cord injury is traditionally treated with different types of mechanical ventilation.
- Conditions
- Respiratory Paralysis, Diaphragmatic Paralysis, Spinal Cord Injury
- Trial name
- NCT01385384
- Testing
- NeuRx RA/4 diaphragmatic pacemaker
- Where
- 2 sites in Brazil
- Volunteers
- 5 people
- Sponsor
- University of Sao Paulo
Colorectal Neoplasms, Gastrectomy
The Impact of Laparotomy and Analgesia Methods on Diaphragm
Major abdominal surgeries are traditionally performed via laparotomy. Analgesia is routinely administered during the postoperative period.
- Trial name
- NCT06403540
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization